A. Leoni

发表

Imidazo[2,1 -b]thiazolylmethylene- and indolylmethylene-2-indolinones: a new class of cyclin-dependent kinase inhibitors. Design, synthesis, and CDK1/cyclin B inhibition.

L. Meijer, A. Cavalli, M. Recanatini, 2000, Anti-cancer drug design.

Determination of Estragole in Fennel Herbal Teas by HS-SPME and GC–MS

R. Gotti, J. Fiori, A. Leoni, 2014 .

Synthesis and Antitumor Activity of 1,5,6-Substituted E-3-(2-Chloro-3-indolylmethylene)-1,3-dihydroindol-2-ones1

A. Andreani, M. Granaiola, A. Leoni, 2002 .

6-(Hydroxyphenyl)imidazo[2,1- b ]thiazoles as Potential Antiinflammatory Agents: Effects on Human Neutrophil Functions

A. Andreani, A. Leoni, A. Locatelli, 2000 .

Synthesis and potential coanthracyclinic activity of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones

A. Andreani, A. Leoni, A. Locatelli, 1997 .

Molecular structure, characterization and stereochemical properties of new biologically interesting 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones

G. Giorgi, A. Andreani, A. Leoni, 2000 .

Potential antitumor agents. 25 [1]. Synthesis and cytotoxic activity of 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones.

A. Andreani, A. Leoni, A. Locatelli, 1996, Anticancer research.

Synthesis and potential coanthracyclinic activity of pyridylmethylene and indolylmethylene lactams

A. Andreani, A. Leoni, A. Locatelli, 1998 .

Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex

E. Novellino, B. Pagano, Jussara Amato, 2014, Front. Chem..

Ligand based approach to L-type calcium channel by imidazo[2,1-b]thiazole-1,4-dihydropyridines: from heart activity to brain affinity.

E. Novellino, R. Budriesi, P. Ioan, 2013, Journal of medicinal chemistry.

Novel thiazole derivatives: a patent review (2008 – 2012. Part 2)

A. Leoni, A. Locatelli, R. Morigi, 2014, Expert opinion on therapeutic patents.

Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose

E. Malucelli, A. Porcelli, S. Iotti, 2019, RSC advances.

Novel thiazole derivatives: a patent review (2008 – 2012; Part 1)

A. Leoni, A. Locatelli, R. Morigi, 2014, Expert opinion on therapeutic patents.

4-Imidazo[2,1-b]thiazole-1,4-DHPs and neuroprotection: preliminary study in hits searching.

R. Budriesi, M. Frosini, S. Cosconati, 2019, European journal of medicinal chemistry.

Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells

E. Novellino, B. Pagano, G. Capranico, 2020, Journal of medicinal chemistry.

Inhibition of MDR1 activity and induction of apoptosis by analogues of nifedipine and diltiazem: an in vitro analysis

R. Budriesi, P. Ioan, D. Spinelli, 2011, Investigational New Drugs.

Effects of new ubiquinone-imidazo[2,1-b]thiazoles on mitochondrial complex I (NADH-ubiquinone reductase) and on mitochondrial permeability transition pore.

M. Recanatini, G. Lenaz, C. Bergamini, 2004, Bioorganic & medicinal chemistry.

Synthesis of 6-substituted-4,5-dihydro-3(2H)-pyridazinones

A. Chiarini, S. Manfredini, P. Baraldi, 1990 .

Synthesis and antitubercular activity of imidazo[2,1-b]thiazoles.

A. Andreani, M. Granaiola, A. Leoni, 2001, European journal of medicinal chemistry.

Diethyl 4-(6-Chloroimidazo[2,1-b]thiazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate and Ethyl 4-(6-Chloroimidazo[2,1-b]thiazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

A. Leoni, A. Locatelli, R. Morigi, 2012 .

Recent Patents on Thiazole Derivatives Endowed with Antitumor Activity.

A. Leoni, A. Locatelli, R. Morigi, 2015, Recent patents on anti-cancer drug discovery.

Potential antitumor agents. 24. Synthesis and pharmacological behavior of imidazo[2,1-b]thiazole guanylhydrazones bearing at least one chlorine.

A. Andreani, A. Leoni, A. Locatelli, 1996, Journal of medicinal chemistry.

Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents.

S. Neidle, J. Hartley, L. Hurley, 1996, The Journal of organic chemistry.

2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008–2014)

A. Leoni, A. Locatelli, R. Morigi, 2016, Expert opinion on therapeutic patents.

Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.

J. Pezzuto, R. V. van Breemen, T. Kondratyuk, 2013, European journal of medicinal chemistry.

Synthesis of imidazo[2,1-b]thiazoles as herbicides

A. Andreani, A. Leoni, A. Locatelli, 1996 .

Synthesis of lactams with potential cardiotonic activity

A. Andreani, A. Leoni, A. Locatelli, 1993 .

New isatin derivatives with antioxidant activity.

R. Cervellati, A. Andreani, M. Granaiola, 2010, European journal of medicinal chemistry.

Antitumor activity of new substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and 3-(5-imidazo[2,1-b]thiadiazolylmethylene)-2-indolinones: selectivity against colon tumor cells and effect on cell cycle-related events.

R. Shoemaker, N. Calonghi, L. Masotti, 2008, Journal of medicinal chemistry.

New antitumor imidazo[2,1-b]thiazole guanylhydrazones and analogues.

R. Shoemaker, N. Radin, N. Calonghi, 2008, Journal of medicinal chemistry.

Potential antitumor agents. Part 29(1): synthesis and potential coanthracyclinic activity of imidazo[2,1-b]thiazole guanylhydrazones.

M. Recanatini, A. Andreani, A. Leoni, 2000, Bioorganic & medicinal chemistry.

Isatin Bis-Indole and Bis-Imidazothiazole Hybrids: Synthesis and Antimicrobial Activity

F. Bonvicini, G. Gentilomi, A. Leoni, 2022, Molecules.

Antitumor activity of bis-indole derivatives.

M. Kunkel, H. Fiebig, L. Landi, 2008, Journal of medicinal chemistry.

[2,1-c] [1,4]Benzodiazepine (PBD)-Distamycin Hybrid Inhibits DNA Binding to Transcription Factor Sp1

G. Spalluto, R. Gambari, N. Bianchi, 2000, Nucleosides, nucleotides & nucleic acids.

Imidazo[2,1-b]thiazole system: a scaffold endowing dihydropyridines with selective cardiodepressant activity.

E. Novellino, R. Budriesi, P. Ioan, 2008, Journal of medicinal chemistry.

Dihydropyridines bearing an imidazo[2,1-b]thiazole system

M. Bissoli, A. Andreani, A. Leoni, 1997 .

Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil.

A. Cavalli, M. Recanatini, A. Roda, 2001, Journal of medicinal chemistry.

Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors.

D. Scudiero, R. Shoemaker, D. Lannigan, 2011, European journal of medicinal chemistry.

Synthesis and Calcium Antagonist Activity of Dialkyl 1,4-Dihydro-2,6-dimethyl-4-(nitrogenous heteroaryl)-3,5-pyridine Dicarboxylates

B. Cacciari, R. Budriesi, A. Chiarini, 1992 .

Synthesis and cardiotonic activity of imidazo[2,l-b]thiazoles bearing a lactam ring

A. Andreani, A. Leoni, A. Locatelli, 1996 .

Antitumor activity of new substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and study of their effect on the cell cycle.

L. Masotti, G. Farruggia, S. Arora, 2005, Journal of medicinal chemistry.

Potential antitumor agents. 37. Synthesis and antitumor activity of guanylhydrazones from imidazo[2,1-b]thiazoles and from the new heterocyclic system thiazolo[2',3':2,3]imidazo[4,5-c]quinoline.

G. Lenaz, G. Farruggia, C. Bergamini, 2005, Journal of medicinal chemistry.

Synthesis and biological evaluation of thiazole derivatives on basic defects underlying cystic fibrosis.

N. Pedemonte, A. Leoni, A. Locatelli, 2020, Bioorganic & medicinal chemistry letters.

Synthesis of Lactams with Potential Cardiotonic Activity.

A. Andreani, A. Leoni, A. Locatelli, 1994 .

Synthesis and Cardiotonic Activity of Imidazo(2,1-b)thiazoles Bearing a Lactam Ring.

A. Andreani, A. Leoni, A. Locatelli, 2010 .

Cystic Fibrosis: A New Target for 4-Imidazo[2,1-b]thiazole-1,4-dihydropyridines

N. Pedemonte, L. Galietta, R. Budriesi, 2011, Journal of medicinal chemistry.

Potential antitumor agents. 34.(1) Synthesis and antitumor activity of guanylhydrazones from imidazo[2,1-b]thiazoles and from diimidazo[1,2-a: 1,2-c] pyrimidine.

G. Giorgi, A. Andreani, M. Granaiola, 2004, Anticancer research.

Ring‐ring interconversions. Part 3. On the effect of the substituents on the thiazole moiety in the ring‐opening/ring‐closing reactions of nitrosoimidazo[2,1‐b][1,3]thiazoles with hydrochloric acid

B. Cosimelli, D. Spinelli, A. Leoni, 2000 .

Potential Antitumor Agents. Part 24. Synthesis and Pharmacological Behavior of Imidazo(2,1-b)thiazole Guanylhydrazones Bearing at Least One Chlorine.

A. Andreani, A. Leoni, A. Locatelli, 1996 .

Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.

A. Roda, M. Guardigli, A. Andreani, 2008, European journal of medicinal chemistry.

Synthesis and antisecretory activity of 6-substituted 5-cyanomethylimidazo[2,1-b]thiazoles and 2,6-dimethyl-5-hydroxymethylimidazo[2,1-b][1,3,4]thiadiazole.

W. Simon, A. Andreani, A. Leoni, 2011, Arzneimittel-Forschung.

Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines.

B. Cacciari, S. Rault, L. Kèlland, 1999, Journal of medicinal chemistry.

Substituted E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones with antitumor activity. In depth study of the effect on growth of breast cancer cells.

R. Shoemaker, N. Calonghi, L. Masotti, 2010, Journal of medicinal chemistry.

Synthesis and antiproliferative activity of imidazo[2,1-b][1,3,4]thiadiazole derivatives.

S. Raghavan, M. Hegde, V. Gopalakrishnan, 2014, Bioorganic & medicinal chemistry letters.

Synthesis of Sequence-Selective C8-Linked Pyrrolo(2,1-c)(1,4) benzodiazepine DNA Interstrand Cross-Linking Agents.

S. Neidle, J. Hartley, L. Hurley, 1997 .

Synthesis and antitumor activity of a new class of pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone analogs of pyrrolo[1,4]benzodiazepines (PBDs)

B. Cacciari, S. Manfredini, P. Baraldi, 1993 .

Synthesis and cardiotonic activity of 2-indolinones bearing pyridyl groups

A. Andreani, A. Leoni, A. Locatelli, 1993 .

Ring–Ring Interconversions of Nitrosoimidazoles. The Effect of some Condensed Six-Membered Rings on the Reactivity

B. Cosimelli, D. Spinelli, A. Andreani, 2000 .

Electronic nose and chiral-capillary electrophoresis in evaluation of the quality changes in commercial green tea leaves during a long-term storage.

Aldo Roda, Mara Mirasoli, Carolina Colliva, 2014, Talanta.

Synthesis and chemiluminescent high throughput screening for inhibition of acetylcholinesterase activity by imidazo[2,1-b]thiazole derivatives.

A. Roda, M. Guardigli, A. Andreani, 2005, European journal of medicinal chemistry.

Chemiluminescent high-throughput microassay for evaluation of acetylcholinesterase inhibitors

A. Roda, P. Pasini, M. Mirasoli, 2005 .

Antitumor activity of substituted E-3-(3,4,5-trimethoxybenzylidene)-1,3-dihydroindol-2-ones1.

M. Kunkel, A. Andreani, M. Granaiola, 2006, Journal of medicinal chemistry.

Substituted E-3-(2-Chloro-3-indolylmethylene)1,3-dihydroindol-2-ones with antitumor activity.

L. Masotti, G. Farruggia, A. Andreani, 2004, Bioorganic & medicinal chemistry.

Synthesis and Antitumor Activity of Guanylhydrazones from 6-(2,4-Dichloro-5-nitrophenyl)imidazo[2,1-b]thiazoles and 6-Pyridylimidazo[2,1-b]thiazoles1

M. Kunkel, L. Masotti, C. Stefanelli, 2006 .

2,7-dimethyl-3,8-dinitrodipyrazolo[1,5-a:1',5'-d]pyrazine-4,9-dione: a new labelling reagent for liquid chromatographic analysis of amino acids.

B. Cacciari, A. Leoni, R. Gatti, 2006, Analytica chimica acta.

Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives.

Stephan A. Ohnmacht, E. Novellino, B. Pagano, 2016, Journal of medicinal chemistry.

Synthesis of 6-methylimidazo[2,1-b]thiazole derivatives acting on neuromuscular transmission

A. Andreani, A. Leoni, A. Locatelli, 1996 .

Synthesis of 3-(Imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one Derivatives and Study of Their Antiviral Activity against Parvovirus B19

G. Gallinella, Gloria Bua, A. Leoni, 2019, Molecules.

Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif.

S. Neidle, M. Gunaratnam, S. Haider, 2010, Chemical communications.

Synthesis and Antisecretory Activity of 6-Substituted 5-Cyanomethylimidazo[2,1-b]-thiazoles and 2,6-Dimethyl-5-hydroxymethylimidazo[2,1-b][1,3,4]thiadiazole

W. Simon, A. Andreani, A. Leoni, 2000, Arzneimittelforschung.

A Patent Review on Thiazole Derivatives (2008-2013)

Aless, A. Leoni, R. Morigi, 2017 .

2,5-Dimethyl-1H-pyrrole-3,4-dicarbaldehyde as a precolumn derivatization reagent for HPLC/UV detection of amino acids.

A. Andreani, A. Leoni, R. Gatti, 2010, Journal of pharmaceutical and biomedical analysis.

Photostability and phototoxicity studies on diltiazem.

R. Gotti, V. Andrisano, V. Cavrini, 2001, Journal of pharmaceutical and biomedical analysis.

Alberto Leoni, Rita Morigi, Mirella Rambaldi, 2008, Bioorganic & medicinal chemistry letters.

Antitumor activity and COMPARE analysis of bis-indole derivatives.

R. Shoemaker, L. Landi, Cecilia Prata, 2010, Bioorganic & medicinal chemistry.

Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents.

A. Brancale, G. Viola, Roberta Bortolozzi, 2019, European journal of medicinal chemistry.

N-Benzyl-2-chloroindole-3-carboxylic acids as potential anti-inflammatory agents. Synthesis and screening for the effects on human neutrophil functions and on COX1/COX2 activity.

A. Roda, M. Guardigli, A. Andreani, 2004, European journal of medicinal chemistry.

Thienylvinylindoles as inhibitors of mitochondrial NADH dehydrogenase.

A. Ghelli, M. Degli Esposti, A. Andreani, 1994, Pharmaceutica acta Helvetiae.

Thienylvinylindoles (I)‐(IV) as Inhibitors of Mitochondrial NADH Dehydrogenase.

A. Ghelli, M. Esposti, A. Andreani, 1995 .

Imidazo[2,1b ] Thiazole: Introduction, Current and Perspective

Aless, Alberto Leoni, ra Locatelli, 2017 .

Substituted E-3-(3-indolylmethylene)1,3-dihydroindol-2-ones with antiproliferative activity. Study of the effects on HL-60 leukemia cells.

C. Stefanelli, S. Iotti, M. Zini, 2014, European journal of medicinal chemistry.

Substituted E-3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones with antitumor activity. Effect on the cell cycle and apoptosis.

N. Calonghi, L. Masotti, C. Stefanelli, 2007, Journal of medicinal chemistry.

Thienylimidazo[2,1-b]thiazoles as inhibitors of mitochondrial NADH dehydrogenase.

A. Ghelli, M. Degli Esposti, M. Ratta, 1995, Journal of medicinal chemistry.

Synthesis, antibacterial activity and structure-activity relationships of N-substituted 4-diazo-pyrazole-5-carboxamides. 2.

M. Recanatini, B. Cacciari, S. Manfredini, 1991, Il Farmaco.

Photodegradation studies on Atenolol by liquid chromatography.

R. Gotti, V. Andrisano, V. Cavrini, 1999, Journal of pharmaceutical and biomedical analysis.

Synthesis and Biological Evaluation of New Bis-Indolinone Derivatives Endowed with Cytotoxic Activity

C. Fimognari, E. Catanzaro, C. Calcabrini, 2021, Molecules.

Potential coanthracyclinic activity of pyridylmethylene-2-indolinones.

A. Andreani, A. Leoni, A. Locatelli, 1998, Anticancer research.

Synthesis and antitumor activity of 1,5,6-substituted E-3-(2-chloro-3-indolylmethylene)-1,3-dihydroindol-2-ones.

A. Andreani, M. Granaiola, A. Leoni, 2002, Journal of medicinal chemistry.

Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells

B. Pagano, G. Capranico, Jussara Amato, 2022, Journal of medicinal chemistry.

Ayurvedic preparation of Zingiber officinale Roscoe: effects on cardiac and on smooth muscle parameters

R. Budriesi, A. Leoni, F. Poli, 2018, Natural product research.

4-Aminopyridine derivatives with antiamnesic activity.

C. Pietra, G. Villetti, A. Andreani, 2000, European journal of medicinal chemistry.

Determination of Phytomarkers in Pharmaceutical Preparations of Hemidesmus indicus Roots by Micellar Electrokinetic Chromatography and High-Performance Liquid Chromatography–Mass Spectrometry

R. Gotti, J. Fiori, P. Hrelia, 2014 .

Evaluation of Roasting Effect on Selected Green Tea Volatile Flavor Compound and Pyrazine Content by HS-SPME GC-MS

R. Gotti, J. Fiori, A. Leoni, 2021, Applied Sciences.

Synthesis and antitumor activity of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones.

A. Andreani, M. Granaiola, A. Leoni, 2001, Anti-Cancer Drug Design.