R. Harijan

发表

Structural and Mutational Studies on Substrate Specificity and Catalysis of Salmonella typhimurium D-Cysteine Desulfhydrase

S. Bisht, S. R. Bharath, R. Harijan, 2012, PloS one.

Coenzyme-A dependent catalysis: An overview of thiolase superfamily enzymes and drug discovery

R. Harijan, 2017 .

The SCP2‐thiolase‐like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolism

F. Bringaud, U. Bergmann, R. Wierenga, 2016, Proteins.

Structural characterization of a mitochondrial 3-ketoacyl-CoA (T1)-like thiolase from Mycobacterium smegmatis.

M. Murthy, R. Wierenga, T. Kiema, 2015, Acta crystallographica. Section D, Biological crystallography.

Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1.

V. Schramm, P. Tyler, A. D. Woolhouse, 2022, Journal of medicinal chemistry.

Small molecule inhibitors targeting the interaction of ricin toxin A subunit with ribosomes.

V. Schramm, N. Tumer, Xiao-Ping Li, 2020, ACS infectious diseases.

Cloning, expression, purification and preliminary X-ray diffraction studies of a putative Mycobacterium smegmatis thiolase.

M. Murthy, R. Wierenga, R. Harijan, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis.

G. Evans, V. Schramm, P. Tyler, 2017, Biochemistry.

Mutation update on ACAT1 variants associated with mitochondrial acetoacetyl‐CoA thiolase (T2) deficiency

R. Wierenga, T. Fukao, S. Yamaguchi, 2019, Human mutation.

Human Mutation

R. Wierenga, T. Fukao, S. Yamaguchi, 2019 .

Inhibition and Mechanism of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase.

V. Schramm, P. Tyler, S. Cahill, 2022, ACS chemical biology.

Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues

V. Schramm, P. Tyler, R. Harijan, 2021, Nature Communications.

Transition-State Analogues of Phenylethanolamine N-methyltransferase.

V. Schramm, R. Harijan, N. Mahmoodi, 2020, Journal of the American Chemical Society.

Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase.

G. Evans, V. Schramm, P. Tyler, 2019, Journal of medicinal chemistry.

Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase.

G. Evans, V. Schramm, P. Tyler, 2018, ACS Chemical Biology.

Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase.

G. Evans, V. Schramm, R. Harijan, 2017, ACS chemical biology.

The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities.

R. Wierenga, T. Fukao, T. Kiema, 2014, Acta crystallographica. Section D, Biological crystallography.

Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels

V. Schramm, S. Schwartz, D. Antoniou, 2018, Proceedings of the National Academy of Sciences.

Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase

V. Schramm, S. Schwartz, D. Antoniou, 2017, Proceedings of the National Academy of Sciences.

Genetic resistance to purine nucleoside phosphorylase inhibition in Plasmodium falciparum

V. Schramm, A. Fiser, J. Daily, 2018, Proceedings of the National Academy of Sciences.

A resistant mutant of Plasmodium falciparum purine nucleoside phosphorylase uses wild-type neighbors to maintain parasite survival

V. Schramm, R. Harijan, Y. V. Minnow, 2021, The Journal of biological chemistry.

Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design.

J. Y. Roberge, D. Augeri, N. Tumer, 2021, Journal of medicinal chemistry.

The characterization and evolutionary relationships of a trypanosomal thiolase.

F. Bringaud, R. Wierenga, P. Michels, 2011, International journal for parasitology.

Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop.

M. Murthy, M. Weiss, R. Wierenga, 2013, The Biochemical journal.

Development of MLPA for human ACAT1 gene and identification of a heterozygous Alu-mediated deletion of exons 3 and 4 in a patient with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency.

R. Wierenga, T. Fukao, N. Kondo, 2013, Molecular genetics and metabolism.

A binary arginine methylation switch on histone H3 Arginine 2 regulates its interaction with WDR5

S. Almo, J. B. Bonanno, D. Shechter, 2020, bioRxiv.

Phylogenetic relationships and classification of thiolases and thiolase-like proteins of Mycobacterium tuberculosis and Mycobacterium smegmatis.

M. Murthy, R. Wierenga, P. Michels, 2014, Tuberculosis.

Crystal Structure of a Monomeric Thiolase-Like Protein Type 1 (TLP1) from Mycobacterium smegmatis

M. Murthy, R. Wierenga, R. Harijan, 2012, PloS one.

Phylogenetic relationships and classification of thiolases and thiolase-like proteins of Mycobacterium tuberculosis and Mycobacterium smegmatis.

M. Murthy, R. Wierenga, P. Michels, 2014, Tuberculosis.

AI is a viable alternative to high throughput screening: a 318-target study

Eva M García-Cuesta, Frederick S. Vizeacoumar, Stephen J. Capuzzi, 2024, Scientific reports.

Human Mutation

R. Wierenga, T. Fukao, R. Harijan, 2019 .

Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1

F. Bringaud, R. Wierenga, P. Michels, 2017, Protein engineering, design & selection : PEDS.