K. Welsh

发表

Structure of and kinetic channelling in bifunctional dihydrofolate reductase–thymidylate synthase

David A. Matthews, Cheryl A. Janson, D. Knighton, 1994, Nature Structural Biology.

Isolation and characterization of the Escherichia coli mutH gene product.

P. Modrich, A. Lu, K. Welsh, 1987, The Journal of biological chemistry.

Repair of DNA base-pair mismatches in extracts of Escherichia coli.

P. Modrich, A. Lu, K. Welsh, 1984, Cold Spring Harbor symposia on quantitative biology.

Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis.

S R Jordan, D. Matthews, C. Janson, 1992, Journal of medicinal chemistry.

Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones.

D. Matthews, C. Janson, S. Webber, 1993, Journal of medicinal chemistry.

Transition-state structure in the yeast alcohol dehydrogenase reaction: the magnitude of solvent and alpha-secondary hydrogen isotope effects.

J. Klinman, K. Welsh, D. J. Creighton, 1980, Biochemistry.

Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.

D. Matthews, C. Janson, K. Appelt, 1996, Journal of medicinal chemistry.

Catalytic specificity of yeast inorganic pyrophosphatase for magnesium ion as cofactor. An analysis of divalent metal ion and solvent isotope effects on enzyme function.

B. Cooperman, K. Welsh, B. Springs, 1983, Biochemistry.

Epoxide inhibition of alcohol dehydrogenases. Identification of modified cysteines in yeast alcohol dehydrogenase and demonstration of reversible and irreversible inhibition of liver alcohol dehydrogenase by styrene oxide.

J. Klinman, K. Welsh, R. Hogue-Angeletti, 1977, Biochemistry.

Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate.

D. Matthews, S. Freer, C. Janson, 1990, Journal of molecular biology.

SOLVENT ISOTOPE EFFECTS IN THE YEAST ALCOHOL DEHYDROGENASE REACTION

J. Klinman, K. Welsh, D. J. Creighton, 1977 .

The zinc content of yeast alcohol dehydrogenase.

J. Klinman, K. Welsh, 1976, Biochemical and biophysical research communications.

Characterization of membrane-bound nicotinamide adenine dinucleotide glycohydrolase of Vibrio cholerae.

P. Fernandes, M. Bayer, K. Welsh, 1979, The Journal of biological chemistry.

Yeast inorganic pyrophosphatase. Functional and 113Cd2+ and 31P nuclear magnetic resonance studies of the Cd2+-enzyme.

B. Cooperman, K. Welsh, I. Armitage, 1983, Biochemistry.

Initiation of methyl-directed mismatch repair.

P. Modrich, P Modrich, K G Au, 1992, The Journal of biological chemistry.

Multiple protein-aspartate phosphatases provide a mechanism for the integration of diverse signals in the control of development in B. subtilis

Philippe Glaser, J. Hoch, M. Perego, 1994, Cell.

Isolation and characterization of the Escherichia coli mutL gene product.

P. Modrich, M. Grilley, K. Welsh, 1989, The Journal of biological chemistry.

Biochemical characterization of the essential GTP-binding protein Obg of Bacillus subtilis

J. Hoch, K. Welsh, K. Trach, 1994, Journal of bacteriology.

Synthesis and biological evaluation of novel 2,6-diaminobenz[cd]indole inhibitors of thymidylate synthase using the protein structure as a guide.

C. Janson, C. Bartlett, M. Varney, 1995, Journal of medicinal chemistry.

Thermodynamics, kinetics, and mechanism in yeast inorganic pyrophosphatase catalysis of inorganic pyrophosphate: inorganic phosphate equilibration.

B. Cooperman, K. Welsh, B. Springs, 1981, Biochemistry.

Evidence that catalysis by yeast inorganic pyrophosphatase proceeds by direct phosphoryl transfer to water and not via a phosphoryl enzyme intermediate.

B. Cooperman, M. Webb, K. Welsh, 1984, Biochemistry.

Crystal-structure-based design and synthesis of benz[cd]indole-containing inhibitors of thymidylate synthase.

C A Morse, R. Bacquet, C. Bartlett, 1992, Journal of medicinal chemistry.

le Protein-Aspartate Phosphatases Provi hanism for the Integration of Diverse Signal the Control of Development in B. subtilis

P. Glaser, C. Hanstein, K. Welsh, 1994 .

Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase.

D. Matthews, C. Janson, R. Bacquet, 1997, Journal of medicinal chemistry.

Calculation of solvation and binding free energy differences for folate-based inhibitors of the enzyme thymidylate synthase

D. Matthews, S. Freer, D. Zichi, 1992 .