A. Gulick

发表

p67: a cryptic lysosomal hydrolase in Trypanosoma brucei?

Terry K. Smith, J. Bangs, Carolina M. Koeller, 2020, Parasitology.

Structure–Function Studies of Hydrophobic Residues That Clamp a Basic Glutamate Side Chain during Catalysis by Triosephosphate Isomerase

R. Wierenga, J. Richard, M. Malabanan, 2016, Biochemistry.

1.2 Å resolution crystal structure of the periplasmic aminotransferase PvdN from Pseudomonas aeruginosa.

A. Gulick, E. Drake, 2016, Acta crystallographica. Section F, Structural biology communications.

X-ray Structures of the Dictyostelium discoideumMyosin Motor Domain with Six Non-nucleotide Analogs*

I. Rayment, J. Thoden, C. Bauer, 2000, The Journal of Biological Chemistry.

Cloning of the Orange Light‐Producing Luciferase from Photinus scintillans—A New Proposal on how Bioluminescence Color is Determined

M. Murtiashaw, B. Branchini, T. Southworth, 2017, Photochemistry and photobiology.

Mechanistic roles of tyrosine 149 and serine 124 in UDP-galactose 4-epimerase from Escherichia coli.

P. Frey, J. Kim, J. Thoden, 1997, Biochemistry.

An Open and Shut Case: The Interaction of Magnesium with MST Enzymes

A. Lamb, A. Gulick, K. Meneely, 2016, Journal of the American Chemical Society.

The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition.

A. S. Murkin, A. Gulick, D. Kreitler, 2018, ACS chemical biology.

Development of a High-Throughput Biochemical Assay to Screen for Inhibitors of Aerobactin Synthetase IucA

A. Gulick, M. Chernov, Daniel C Bailey, 2018, SLAS discovery : advancing life sciences R & D.

Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae

C. Aldrich, A. Gulick, E. Drake, 2018, The Journal of Biological Chemistry.

Structural and Functional Characterization of Aerobactin Synthetase IucA from a Hypervirulent Pathotype of Klebsiella pneumoniae

T. Grant, A. Gulick, E. Drake, 2016, Biochemistry.

Mutational substitution of residues implicated by crystal structure in binding the substrate glutathione to human glutathione S-transferase pi.

R. Huber, P. Reinemer, W. E. Fahl, 1992, Journal of molecular biology.

Structural studies on human glutathione S-transferase pi. Substitution mutations to determine amino acids necessary for binding glutathione.

R. Puchalski, W. E. Fahl, T. Manoharan, 1992, The Journal of biological chemistry.

Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme.

W. E. Fahl, A. Gulick, W. Fahl, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Expression of tandem glutathione S-transferase recombinant genes in COS cells for analysis of efficiency of protein expression and associated drug resistance.

P. J. Welch, R. Puchalski, W. E. Fahl, 1991, Molecular pharmacology.

Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions

Nicole M. Gaudelli, C. Townsend, A. Gulick, 2019, Nature Communications.

Siderophore natural products as pharmaceutical agents.

B. Pfeifer, A. Gulick, Girish Swayambhu, 2021, Current opinion in biotechnology.

Aerobactin Mediates Virulence and Accounts for Increased Siderophore Production under Iron-Limiting Conditions by Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae

T. Russo, R. Olson, U. MacDonald, 2014, Infection and Immunity.

The Siderophore Synthetase IucA of the Aerobactin Biosynthetic Pathway Uses an Ordered Mechanism.

A. Gulick, K. Patel, Daniel C Bailey, 2020, Biochemistry.

Modeling the Role of a Flexible Loop and Active Site Side Chains in Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase

A. Romero‐Rivera, S. C. Kamerlin, J. Richard, 2020, ACS catalysis.

Design, Synthesis and Biophysical Evaluation of Mechanism-Based Probes for Condensation Domains of Nonribosomal Peptide Synthetases.

C. Aldrich, C. Shi, A. Gulick, 2020, ACS chemical biology.

An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD

T. Wencewicz, A. Gulick, K. Patel, 2022, The Journal of biological chemistry.

Ironing out a new siderophore synthesis strategy.

A. Gulick, 2009, Nature chemical biology.

Structural insight into the necessary conformational changes of modular nonribosomal peptide synthetases.

A. Gulick, 2016, Current opinion in chemical biology.

Structural Biology of Non-Ribosomal Peptide Synthetases

A. Gulick, B. R. Miller, 2016 .

Alteration of the Flexible Loop in 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase Boosts Enthalpy-Driven Inhibition by Fosmidomycin

A. S. Murkin, G. Tombline, Juan Liu, 2014, Biochemistry.

Structural studies on human glutathione S-transferase pi. Family of native-specific monoclonal antibodies used to block catalysis.

W. E. Fahl, A. Gulick, A. Goihl, 1992, The Journal of biological chemistry.

The Role of Phosphate in a Multistep Enzymatic Reaction: Reactions of the Substrate and Intermediate in Pieces

A. S. Murkin, A. Gulick, S. A. Kholodar, 2015, Journal of the American Chemical Society.

Enzymes engineered to trap reaction intermediates

A. Gulick, 2018, Nature.

Molecular structures of the S124A, S124T, and S124V site-directed mutants of UDP-galactose 4-epimerase from Escherichia coli.

J. Thoden, H. Holden, A. Gulick, 1997, Biochemistry.

Trapping interactions between catalytic domains and carrier proteins of modular biosynthetic enzymes with chemical probes.

C. Aldrich, A. Gulick, 2018, Natural product reports.

Structural and bioinformatic characterization of an Acinetobacter baumannii type II carrier protein.

A. Gulick, C. L. Allen, 2014, Acta crystallographica. Section D, Biological crystallography.

Structure determination of the functional domain interaction of a chimeric nonribosomal peptide synthetase from a challenging crystal with noncrystallographic translational symmetry.

A. Gulick, J. Sundlov, 2013, Acta crystallographica. Section D, Biological crystallography.

Identification of Inhibitors of PvdQ, an Enzyme Involved in the Synthesis of the Siderophore Pyoverdine

S. Schreiber, B. Muñoz, M. Palmer, 2014, ACS chemical biology.

Structural characterization and high-throughput screening of inhibitors of PvdQ, an NTN hydrolase involved in pyoverdine synthesis.

A. Gulick, E. Drake, 2011, ACS chemical biology.

Evolution of enzymatic activities in the enolase superfamily: crystal structures of the L-Ala-D/L-Glu epimerases from Escherichia coli and Bacillus subtilis.

I. Rayment, J. Gerlt, D. M. Schmidt, 2001, Biochemistry.

Biosynthesis, Mechanism of Action, and Inhibition of the Enterotoxin Tilimycin Produced by the Opportunistic Pathogen Klebsiella oxytoca.

V. Guidolin, P. Villalta, S. Balbo, 2020, ACS infectious diseases.

Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors.

Hong-Gang Wang, Qing Lin, S. Edwardraja, 2012, Journal of the American Chemical Society.

Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii.

C. Aldrich, C. Barry, H. Boshoff, 2013, Journal of medicinal chemistry.

Evolution of enzymatic activities in the enolase superfamily: crystallographic and mutagenesis studies of the reaction catalyzed by D-glucarate dehydratase from Escherichia coli.

I. Rayment, J. Gerlt, B. Hubbard, 2000, Biochemistry.

The structural basis of N-acyl-alpha-amino-beta-lactone formation catalyzed by a nonribosomal peptide synthetase.

T. Wencewicz, J. Schaffer, A. Gulick, 2019 .

Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture*

Courtney C Aldrich, C. Aldrich, Andrew M Gulick, 2016, The Journal of Biological Chemistry.

Structure of PA1221, a nonribosomal peptide synthetase containing adenylation and peptidyl carrier protein domains.

C. Aldrich, C. Shi, C. Mitchell, 2012, Biochemistry.

Structural and functional investigation of the intermolecular interaction between NRPS adenylation and carrier protein domains.

C. Aldrich, Daniel J. Wilson, C. Shi, 2012, Chemistry & biology.

Nonribosomal peptide synthetase biosynthetic clusters of ESKAPE pathogens.

A. Gulick, 2017, Natural product reports.

Structural studies on myosin II: Communication between distant protein domains

I. Rayment, A. Gulick, 1997, BioEssays : news and reviews in molecular, cellular and developmental biology.

Biochemical and crystallographic analysis of substrate binding and conformational changes in acetyl-CoA synthetase.

Andrew M Gulick, A. Reger, A. Gulick, 2007, Biochemistry.

Identification of New Drug Targets in Multi-Drug Resistant Bacterial Infections

T. Umland, L. Schultz, T. Russo, 2013 .

Aerobactin Synthesis Proteins as Antivirulence Targets in Hypervirulent Klebsiella pneumoniae.

T. Russo, A. Gulick, 2019, ACS infectious diseases.

Structure of the EntB multidomain nonribosomal peptide synthetase and functional analysis of its interaction with the EntE adenylation domain.

Andrew M Gulick, A. Gulick, Eric J Drake, 2006, Chemistry & biology.

Structural Biology of Nonribosomal Peptide Synthetases.

Andrew M Gulick, A. Gulick, Bradley R Miller, 2016, Methods in molecular biology.

High-level production and purification of biologically active proteins from bacterial and mammalian cells using the tandem pGFLEX expression system.

W. E. Fahl, H. Manoharan, J. Gallo, 1997, Gene.

Mammalian glutathione S-transferase: regulation of an enzyme system to achieve chemotherapeutic efficacy.

W. E. Fahl, A. Gulick, W. Fahl, 1995, Pharmacology & therapeutics.

Computational Screening of the Human TF-Glycome Provides a Structural Definition for the Specificity of Anti-Tumor Antibody JAA-F11

Robert J. Woods, David F. Smith, Kate Rittenhouse-Olson, 2013, PloS one.

Experimental Support for a Single Electron-Transfer Oxidation Mechanism in Firefly Bioluminescence.

Gary W Brudvig, David J. Vinyard, G. Brudvig, 2015, Journal of the American Chemical Society.

Crystal structure of firefly luciferase in a second catalytic conformation supports a domain alternation mechanism.

Bruce R Branchini, Tara L Southworth, Jesse A Sundlov, 2012, Biochemistry.

Crystal Structure of the Siderophore Binding Protein BauB Bound to an Unusual 2:1 Complex Between Acinetobactin and Ferric Iron.

T. Wencewicz, A. Gulick, D. Giblin, 2018, Biochemistry.

Biochemical and structural characterization of bisubstrate inhibitors of BasE, the self-standing nonribosomal peptide synthetase adenylate-forming enzyme of acinetobactin synthesis.

C. Aldrich, J. Neres, A. Gulick, 2010, Biochemistry.

Determination of the crystal structure of EntA, a 2,3-dihydro-2,3-dihydroxybenzoic acid dehydrogenase from Escherichia coli.

W. Duax, J. Garringer, A. Reger, 2006, Acta crystallographica. Section D, Biological crystallography.

Crystal structure of 4-chlorobenzoate:CoA ligase/synthetase in the unliganded and aryl substrate-bound states.

Xuefeng Lu, D. Dunaway-Mariano, Xuefeng Lu, 2004, Biochemistry.

Pentaerythritol propoxylate: a new crystallization agent and cryoprotectant induces crystal growth of 2-methylcitrate dehydratase.

I. Rayment, J. Thoden, A. Horswill, 2002, Acta crystallographica. Section D, Biological crystallography.

Human Glycerol 3-Phosphate Dehydrogenase: X-ray Crystal Structures That Guide the Interpretation of Mutagenesis Studies.

Shina Caroline Lynn Kamerlin, J. Richard, A. Gulick, 2019, Biochemistry.

Conformational dynamics in the Acyl-CoA synthetases, adenylation domains of non-ribosomal peptide synthetases, and firefly luciferase.

A. Gulick, 2009, ACS chemical biology.

Mechanism of 4-chlorobenzoate:coenzyme a ligase catalysis.

R. Wu, D. Dunaway-Mariano, Xuefeng Lu, 2008, Biochemistry.

Structures of Two Distinct Conformations of holo-Nonribosomal Peptide Synthetases

Georgios Skiniotis, G. Skiniotis, Jeffrey Tarrasch, 2015, Nature.

Structural characterization of a 140 degrees domain movement in the two-step reaction catalyzed by 4-chlorobenzoate:CoA ligase.

R. Wu, D. Dunaway-Mariano, Debra Dunaway-Mariano, 2008, Biochemistry.

Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases

A. Gulick, K. Patel, Jit Singh, 2023, Natural product reports.

The structure of S. lividans acetoacetyl‐CoA synthetase shows a novel interaction between the C‐terminal extension and the N‐terminal domain

J. Escalante‐Semerena, C. Mitchell, A. Gulick, 2015, Proteins.

Analysis of the linker region joining the adenylation and carrier protein domains of the modular nonribosomal peptide synthetases

A. Gulick, E. Drake, B. R. Miller, 2014, Proteins.

The 2.1 Å crystal structure of an acyl‐CoA synthetase from Methanosarcina acetivorans reveals an alternate acyl‐binding pocket for small branched acyl substrates

Kerry S. Smith, A. Gulick, M. Shah, 2009, Proteins.

X-ray structures of the MgADP, MgATPgammaS, and MgAMPPNP complexes of the Dictyostelium discoideum myosin motor domain.

I. Rayment, J. Thoden, C. Bauer, 1997, Biochemistry.

The 1.75 A crystal structure of acetyl-CoA synthetase bound to adenosine-5'-propylphosphate and coenzyme A.

A. Horswill, J. Escalante‐Semerena, Alexander R Horswill, 2003, Biochemistry.

Rational redesign of the 4-chlorobenzoate binding site of 4-chlorobenzoate: coenzyme a ligase for expanded substrate range.

R. Wu, D. Dunaway-Mariano, Jian Cao, 2007, Biochemistry.

Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones.

C. Aldrich, Daniel J. Wilson, C. Shi, 2013, Biochemistry.

Anti-Zika candidates from a marine fungus with a remarkable biosynthetic repertoire.

A. Gulick, K. Patel, 2021, Journal of Biological Chemistry.

Structure‐based engineering of streptavidin monomer with a reduced biotin dissociation rate

Sheldon Park, K. Lim, D. Demonte, 2013, Proteins.

Mutagenesis and Structural Studies Reveal the Basis for the Activity and Stability Properties that Distinguish the Photinus Luciferases scintillans and pyralis.

B. Branchini, T. Southworth, A. Gulick, 2019, Biochemistry.

Structural Characterization of a 140° Domain Movement in the Two-Step Reaction Catalyzed by 4-Chlorobenzoate:CoA Ligase #

R. Wu, D. Dunaway-Mariano, A. Reger, 2008 .

Three-dimensional structures of Pseudomonas aeruginosa PvcA and PvcB, two proteins involved in the synthesis of 2-isocyano-6,7-dihydroxycoumarin.

A. Gulick, E. Drake, 2008, Journal of molecular biology.

Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site.

Yangzhou Wang, D. Ghosh, A. Gulick, 2005, Biochemistry.

The mechanism of domain alternation in the acyl-adenylate forming ligase superfamily member 4-chlorobenzoate: coenzyme A ligase.

Xuefeng Lu, R. Wu, D. Dunaway-Mariano, 2009, Biochemistry.

The structural basis of N-acyl-α-amino-β-lactone formation catalyzed by a nonribosomal peptide synthetase

T. Wencewicz, J. Schaffer, A. Gulick, 2019, Nature Communications.

The 1.8 Å Crystal Structure of PA2412, an MbtH-like Protein from the Pyoverdine Cluster of Pseudomonas aeruginosa*

R. Straubinger, Jin Cao, A. Gulick, 2007, Journal of Biological Chemistry.

X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution.

I. Rayment, S. Endow, H. Song, 1998, Biochemistry.

Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones.

C. Aldrich, Daniel J. Wilson, C. Shi, 2013, Biochemistry.

The structure of the monobactam-producing thioesterase domain of SulM forms a unique complex with the upstream carrier protein domain

Ryan A Oliver, A. Gulick, Ketan D. Patel, 2024, The Journal of biological chemistry.

The structure of the monobactam-producing thioesterase domain of SulM forms a unique complex with the upstream carrier protein domain

Ryan A Oliver, A. Gulick, Ketan D. Patel, 2024, bioRxiv.

Insights into resistance against lincosamide antibiotics.

A. Gulick, J. Sundlov, 2009, Structure.