Meng Lei

发表

3D-QSAR studies of boron-containing dipeptides as proteasome inhibitors with CoMFA and CoMSIA methods.

Qingzhi Gao, Yong-qiang Zhu, Meng Lei, 2009, European journal of medicinal chemistry.

Anti-tumor activity of a novel proteasome inhibitor D395 against multiple myeloma and its lower cardiotoxicity compared with carfilzomib

Meng Lei, Yongqiang Zhu, Jianyong Li, 2021, Cell Death & Disease.

Synthesis, in vitro and in vivo biological evaluation, and comprehensive understanding of structure-activity relationships of dipeptidyl boronic acid proteasome inhibitors constructed from β-amino acids.

Xinrong Zhu, Gang Wu, Meng Lei, 2010, Journal of medicinal chemistry.

Discovery of a new class of valosine containing protein (VCP/P97) inhibitors for the treatment of non-small cell lung cancer.

Meng Lei, Yongqiang Zhu, Jia Liu, 2019, Bioorganic & medicinal chemistry.

Design, synthesis, in vitro and in vivo evaluation, and structure-activity relationship (SAR) discussion of novel dipeptidyl boronic acid proteasome inhibitors as orally available anti-cancer agents for the treatment of multiple myeloma and mechanism studies.

Meng Lei, Yongqiang Zhu, Jing Shi, 2018, Bioorganic & medicinal chemistry.

Trifluoromethyl aryl sulfonates (TFMS): An applicable trifluoromethoxylation reagent

Chengjian Zhu, Jian Shen, Meng Lei, 2019, Tetrahedron Letters.

In vitro and in vivo efficacy of the novel oral proteasome inhibitor NNU546 in multiple myeloma

E. Izumchenko, Meng Lei, Yongqiang Zhu, 2020, Aging.

Dual-functionalized liposome by co-delivery of paclitaxel with sorafenib for synergistic antitumor efficacy and reversion of multidrug resistance

Meng Lei, Xiaoqing Du, Yongqiang Zhu, 2019, Drug delivery.

Discovery of novel tripeptide propylene oxide proteasome inhibitors for the treatment of multiple myeloma.

Hailong Liu, Wen Zhang, Meng Lei, 2021, Bioorganic & medicinal chemistry.

Preparation and biological evaluation of soluble tetrapeptide epoxyketone proteasome inhibitors.

Jian Shen, Meng Lei, Xiaoqing Du, 2019, Bioorganic & medicinal chemistry.

Discovery of a new class of valosine containing protein (VCP/P97) inhibitors for the treatment of colorectal cancer.

Meng Lei, Yongqiang Zhu, Xueyuan Wang, 2022, Bioorganic & medicinal chemistry.

Discovery of a novel dipeptidyl boronic acid proteasome inhibitor for the treatment of multiple myeloma and triple-negative breast cancer.

Meng Lei, Yongqiang Zhu, Jia Liu, 2019, Organic & biomolecular chemistry.

Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.

Meng Lei, Yongqiang Zhu, Hao Cheng, 2017, European journal of medicinal chemistry.

High anticancer potency on tumor cells of dehydroabietylamine Schiff-base derivatives and a copper(II) complex.

Xu-Min Cai, Meng Lei, Hai-Jun Xu, 2018, European journal of medicinal chemistry.

3D-QSAR-aided design, synthesis, in vitro and in vivo evaluation of dipeptidyl boronic acid proteasome inhibitors and mechanism studies.

Hailing Li, Meng Lei, Yongqiang Zhu, 2016, Bioorganic & medicinal chemistry.

Design, synthesis and docking studies of novel dipeptidyl boronic acid proteasome inhibitors constructed from αα- and αβ-amino acids.

Cheng Jiang, Meng Lei, Yongqiang Zhu, 2016, Bioorganic & medicinal chemistry letters.

Development of oral curcumin based on pH-responsive transmembrane peptide-cyclodextrin derivative nanoparticles for hepatoma.

Meng Lei, Yongqiang Zhu, Liefeng Zhang, 2021, Carbohydrate polymers.

Design and discovery of novel dipeptide boronic acid ester proteasome inhibitors, an oral slowly-released prodrug for the treatment of multiple myeloma.

Wen Zhang, Meng Lei, Yongqiang Zhu, 2023, European journal of medicinal chemistry.

Co-delivery of paclitaxel and gemcitabine via a self-assembling nanoparticle for targeted treatment of breast cancer

Meng Lei, Xiaoqing Du, Yongqiang Zhu, 2019, RSC advances.

KPT‐330 and Y219 exert a synergistic antitumor effect in triple‐negative breast cancer through inhibiting NF‐κB signaling

Meng Lei, Jing Shi, Jia Wang, 2023, FEBS open bio.

Design, synthesis, in vitro and in vivo evaluation, and structure-activity relationship (SAR) discussion of novel dipeptidyl boronic acid proteasome inhibitors as orally available anti-cancer agents for the treatment of multiple myeloma and mechanism studies.

Meng Lei, Yongqiang Zhu, Jing Shi, 2018, Bioorganic & medicinal chemistry.

Dual-functionalized liposome by co-delivery of paclitaxel with sorafenib for synergistic antitumor efficacy and reversion of multidrug resistance

Meng Lei, Xiaoqing Du, Yongqiang Zhu, 2019, Drug delivery.

An Efficient Preparation of Novel Epoxyketone Intermediates for the Synthesis of Carfilzomib and Its Derivatives

Meng Lei, Xiaoqing Du, Haoyang Zhang, 2016 .

Proteasome inhibitors FHND6091 enhance the ability of NK cells to kill tumor cells through multiple mechanisms.

Meng Lei, Tiantian Wen, Amin Liu, 2024, European journal of pharmacology.