P. Hess

发表

Telemetry monitoring of pulmonary arterial pressure in freely moving rats.

J. Clozel, P. Hess, M. Clozel, 1996, Journal of applied physiology.

A fully automated image analysis method to quantify lung fibrosis in the bleomycin-induced rat model

Patrick Hess, Manuel Stritt, Enrico Vezzali, 2018, PLoS ONE.

Design and optimization of new piperidines as renin inhibitors.

L. Prade, A. Treiber, D. Bur, 2010, Bioorganic & medicinal chemistry letters.

Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors.

L. Prade, A. Treiber, S. Delahaye, 2009, Journal of medicinal chemistry.

New classes of potent and bioavailable human renin inhibitors.

L. Prade, A. Treiber, S. Delahaye, 2009, Bioorganic & medicinal chemistry letters.

Pharmacological Characterization of Aprocitentan, a Dual Endothelin Receptor Antagonist, Alone and in Combination with Blockers of the Renin Angiotensin System, in Two Models of Experimental Hypertension

J. Ménard, M. Iglarz, M. Clozel, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Selexipag Active Metabolite ACT-333679 Displays Strong Anticontractile and Antiremodeling Effects but Low β-Arrestin Recruitment and Desensitization Potential

M. Iglarz, M. Clozel, C. Gnerre, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Pharmacology of the Urotensin-II Receptor Antagonist ACT-058362: First Demonstration of a Pathophysiological Role of the Urotensin System

M. Clozel, O. Nayler, M. Scherz, 2004 .

Pharmacology of the Urotensin-II Receptor Antagonist Palosuran (ACT-058362; 1-[2-(4-Benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea Sulfate Salt): First Demonstration of a Pathophysiological Role of the Urotensin System

M. Clozel, O. Nayler, M. Scherz, 2004, Journal of Pharmacology and Experimental Therapeutics.

JPET # 169748 2 RUNNING TITLE PAGE Running Title : Selexipag and gastric function Corresponding

M. Clozel, P. Hess, R. Studer, 2010 .

Ro 40–5967, in Contrast to Diltiazem, Does Not Reduce Left Ventricular Contractility in Rats with Chronic Myocardial Infarction

M. Véniant, J. Clozel, P. Hess, 1991, Journal of Cardiovascular Pharmacology.

Short-term endothelin receptor blockade with tezosentan has both immediate and long-term beneficial effects in rats with myocardial infarction.

M. Clozel, J. Clozel, P. Hess, 2002, Journal of the American College of Cardiology.

Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use.

S. Roux, V. Breu, B. Löffler, 1999, The Journal of pharmacology and experimental therapeutics.

Chronic Endothelin Receptor Blockade Prevents Both Early Hyperfiltration and Late Overt Diabetic Nephropathy in the Rat

M. Clozel, P. Hess, Shuang-shuang Ding, 2003, Journal of cardiovascular pharmacology.

Age-dependent hypertension in Mpv17-deficient mice, a transgenic model of glomerulosclerosis and inner ear disease

H. Weiher, B. Löffler, M. Clozel, 1999, Experimental Gerontology.

Identification of Cathepsin L as a Potential Sex-Specific Biomarker for Renal Damage

A. Stalder, A. Klenk, M. Clozel, 2011, Hypertension.

Measurements of blood pressure and electrocardiogram in conscious freely moving guineapigs: a model for screening QT interval prolongation effects

P. Hess, M. Clozel, D. Wanner, 2007, Laboratory animals.

Bosentan, Sildenafil, and Their Combination in the Monocrotaline Model of Pulmonary Hypertension in Rats

M. Iglarz, M. Clozel, P. Hess, 2006, Experimental biology and medicine.

Vascular Effects of Endothelin Receptor Antagonists Depends on Their Selectivity for ETA Versus ETB Receptors and on the Functionality of Endothelial ETB Receptors

M. Iglarz, M. Clozel, P. Hess, 2015, Journal of cardiovascular pharmacology.

Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist

M. Bolli, M. Iglarz, M. Clozel, 2008, Journal of Pharmacology and Experimental Therapeutics.

The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist.

M. Bolli, M. Iglarz, M. Clozel, 2012, Journal of medicinal chemistry.

Hemodynamic Profile of Ro 40–5967 in Conscious Rats: Comparison with Diltiazem, Verapamil, and Amlodipine

M. Véniant, J. Clozel, P. Hess, 1991, Journal of cardiovascular pharmacology.

Combination of non-hypotensive doses of valsartan and enalapril improves survival of spontaneously hypertensive rats with endothelial dysfunction

P. Bruneval, B. Nuesslein-Hildesheim, J. Clozel, 2000, Journal of the renin-angiotensin-aldosterone system : JRAAS.

Chronic endothelin receptor blockade prevents renal vasoconstriction and sodium retention in rats with chronic heart failure.

M. Clozel, J. Clozel, P. Hess, 2002, Cardiovascular research.

Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension.

M. Iglarz, M. Clozel, P. Hess, 2014, Life sciences.

Role of endothelin in the maintenance of blood pressure in conscious rats with chronic heart failure. Acute effects of the endothelin receptor antagonist Ro 47-0203 (bosentan).

B. Löffler, M. Clozel, J. Teerlink, 1994, Circulation.

Respective role of humoral factors and blood pressure in cardiac remodeling of DOCA hypertensive rats.

D. Heudes, B. Löffler, J. Clozel, 1996, Cardiovascular research.

Endothelin ETA Receptor Blockade, by Activating ETB Receptors, Increases Vascular Permeability and Induces Exaggerated Fluid Retention

M. Iglarz, M. Clozel, D. Strasser, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Cenerimod, a novel selective S1P1 receptor modulator with unique signaling properties

N. Schmitz, M. Bolli, M. Clozel, 2017, Pharmacology research & perspectives.

Experimental carotid thrombosis in the guinea pig.

S. Roux, L. Falivene, J. Clozel, 1994, Thrombosis and haemostasis.

Characterization of a stable, hypertensive rat model suitable for the consecutive evaluation of human renin inhibitors

M. Percival, D. Riendeau, W. Cromlish, 2011, Journal of the renin-angiotensin-aldosterone system : JRAAS.

Combination of Low-Dose Valsartan and Enalapril Improves Endothelial Dysfunction and Coronary Reserve in Nω-Nitro-l-Arginine Methyl Ester–Treated Spontaneously Hypertensive Rats

E. Persohn, P. Germann, M. Clozel, 2002, Journal of cardiovascular pharmacology.

Endothelin plays a role in the maintenance of blood pressure in normotensive guinea pigs.

M. Véniant, J. Clozel, P. Hess, 1994, Life sciences.

Optimization of tissue targeting properties of macitentan, a new dual endothelin receptor antagonist, improves its efficacy in a rat model of pulmonary fibrosis associated with pulmonary arterial hypertension

M. Iglarz, M. Clozel, P. Hess, 2011, ATS 2011.

Effects of renin-angiotensin system blockade in guinea pigs.

M. Véniant, J. Clozel, P. Hess, 1992, Hypertension.

Superior in vivo efficacy of macitentan: Comparison to other endothelin receptor antagonists

M. Iglarz, M. Clozel, P. Hess, 2012 .

Inhibition of Converting Enzyme and Neointima Formation After Vascular Injury in Rabbits and Guinea Pigs

J. Clozel, P. Hess, C. Michael, 1991, Hypertension.

Novel benzo[1,4]diazepin-2-one derivatives as endothelin receptor antagonists.

J. Marfurt, M. Bolli, É. Thorin, 2004, Journal of medicinal chemistry.

RoleofEndothelin intheMaintenance ofBlood Pressure inConscious RatsWith Chronic HeartFailure AcuteEffects oftheEndothelin Receptor Antagonist Ro47-0203 (Bosentan)

B. Löffler, M. Clozel, J. Clozel, 1994 .

Endothelin Mediates the Altered Renal Hemodynamics Associated with Experimental Congestive Heart Failure

M. Clozel, J. Clozel, P. Hess, 2001, Journal of cardiovascular pharmacology.

Comparison of Macitentan and Bosentan on Right Ventricular Remodeling in a Rat Model of Non-vasoreactive Pulmonary Hypertension

M. Iglarz, M. Clozel, S. Delahaye, 2015, Journal of cardiovascular pharmacology.

Novel S1P1 receptor agonists--part 1: From pyrazoles to thiophenes.

M. Bolli, Stefan Abele, A. Treiber, 2013, Journal of medicinal chemistry.

The Selective Sphingosine 1-Phosphate Receptor 1 Agonist Ponesimod Protects against Lymphocyte-Mediated Tissue Inflammation

M. Bolli, M. Clozel, S. Froidevaux, 2011, Journal of Pharmacology and Experimental Therapeutics.

Desensitization by Progressive Up-Titration Prevents First-Dose Effects on the Heart: Guinea Pig Study with Ponesimod, a Selective S1P1 Receptor Modulator

M. Clozel, S. Delahaye, O. Nayler, 2013, PloS one.

Novel S1P1 receptor agonists - Part 5: From amino-to alkoxy-pyridines.

R. de Kanter, M. Bolli, C. Kohl, 2016, European journal of medicinal chemistry.

The use of sulfonylamido pyrimidines incorporating an unsaturated side chain as endothelin receptor antagonists.

M. Bolli, M. Clozel, P. Hess, 2003, Bioorganic & medicinal chemistry letters.

Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups.

R. de Kanter, M. Bolli, C. Kohl, 2016, European journal of medicinal chemistry.

A novel genomic signature with translational significance for human idiopathic pulmonary fibrosis.

Naftali Kaminski, Patrick Hess, John Tedrow, 2015, American journal of respiratory cell and molecular biology.

Major role of the renin angiotensin system in the neointima formation after vascular injury in guinea pigs.

H. Baumgartner, V. Breu, J. Clozel, 1994, Life sciences.

RECEPTORS BLOCKADE , BY ACTIVATING ET B RECEPTORS , INCREASES VASCULAR PERMEABILITY AND INDUCES EXAGGERATED FLUID RETENTION

M. Iglarz, M. Clozel, D. Strasser, 2017 .

Synthesis and Characterization of Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Antibacterial Activity against Gram-Negative Bacteria.

D. Ritz, H. Locher, P. Seiler, 2017, Journal of medicinal chemistry.

Monocrotaline‐Induced Pulmonary Hypertension in Wistar Rats

M. Clozel, P. Hess, M. Rey, 2009, Current protocols in pharmacology.

Piperidine-based renin inhibitors: upper chain optimization.

L. Prade, A. Treiber, D. Bur, 2010, Bioorganic & medicinal chemistry letters.

2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.

M. Bolli, Stefan Abele, A. Treiber, 2010, Journal of medicinal chemistry.

4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel.

D. Renneberg, M. Riederer, E. Meyer, 2015, Journal of medicinal chemistry.

Novel S1P(1) receptor agonists--part 3: from thiophenes to pyridines.

R. de Kanter, M. Bolli, Stefan Abele, 2014, Journal of medicinal chemistry.

Effects of Two Angiotensin Converting Enzyme Inhibitors and Hydralazine on Coronary Circulation in Hypertensive Rats

M. Véniant, J. Clozel, P. Hess, 1991, Hypertension.

Novel S1P(1) receptor agonists--part 2: from bicyclo[3.1.0]hexane-fused thiophenes to isobutyl substituted thiophenes.

R. de Kanter, M. Bolli, C. Kohl, 2014, Journal of medicinal chemistry.

Simultaneous pulmonary and systemic blood pressure and ECG Interval measurement in conscious, freely moving rats.

P. Hess, M. Rey, Markus Rey, 2012, Journal of the American Association for Laboratory Animal Science : JAALAS.

Promotion of sleep by targeting the orexin system in rats, dogs and humans

J. V. Gerven, M. Clozel, J. Dingemanse, 2007, Nature Medicine.

Novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram positive activity and improved safety profile.

D. Ritz, H. Locher, P. Seiler, 2015, Journal of medicinal chemistry.

Macitentan Does Not Interfere with Hepatic Bile Salt Transport

R. de Kanter, A. Treiber, P. Sidharta, 2014, The Journal of Pharmacology and Experimental Therapeutics.

The reversible P2Y12 antagonist ACT‐246475 causes significantly less blood loss than ticagrelor at equivalent antithrombotic efficacy in rat

M. Riederer, M. Clozel, P. Hess, 2017, Pharmacology research & perspectives.

The Urotensin-II Receptor Antagonist Palosuran Improves Pancreatic and Renal Function in Diabetic Rats

M. Clozel, P. Hess, M. Rey, 2006, Journal of Pharmacology and Experimental Therapeutics.

2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.

M. Bolli, Stefan Abele, A. Treiber, 2010, Journal of medicinal chemistry.

Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups.

R. de Kanter, M. Bolli, C. Kohl, 2016, European journal of medicinal chemistry.

Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist

M. Bolli, M. Iglarz, M. Clozel, 2008, Journal of Pharmacology and Experimental Therapeutics.

Endothelin ETA Receptor Blockade, by Activating ETB Receptors, Increases Vascular Permeability and Induces Exaggerated Fluid Retention

M. Iglarz, M. Clozel, D. Strasser, 2017, The Journal of Pharmacology and Experimental Therapeutics.

The Urotensin-II Receptor Antagonist Palosuran Improves Pancreatic and Renal Function in Diabetic Rats

M. Clozel, P. Hess, Shuang-shuang Ding, 2006, Journal of Pharmacology and Experimental Therapeutics.