H. Meurs

发表

A novel method to assess airway function parameters in chronically instrumented, unrestrained guinea-pigs.

T. W. van der Mark, R. Santing, H. Meurs, 1992, Pulmonary pharmacology.

Anti-Inflammatory Role of the cAMP Effectors Epac and PKA: Implications in Chronic Obstructive Pulmonary Disease

A. Halayko, W. Timens, E. Jansen, 2012, PloS one.

Muscarinic receptor signaling in the pathophysiology of asthma and COPD

Reinoud Gosens, A. Halayko, R. Gosens, 2006, Respiratory research.

Modulation of cholinergic airway reactivity and nitric oxide production by endogenous arginase activity

J. Boucher, S. Vadon-Le Goff, H. Meurs, 2000, British journal of pharmacology.

Arginase and pulmonary diseases

H. Meurs, H. Maarsingh, T. Pera, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke.

W. Timens, I. Heijink, Martina Schmidt, 2014, American journal of physiology. Cell physiology.

Role of tachykinin NK2‐receptor activation in the allergen‐induced late asthmatic reaction, airway hyperreactivity and airway inflammatory cell influx in conscious, unrestrained guinea‐pigs

H. Meurs, J. Zaagsma, M. Schuiling, 1999, British journal of pharmacology.

Role of tachykinin NK1 and NK2 receptors in allergen‐induced early and late asthmatic reactions, airway hyperresponsiveness, and airway inflammation in conscious, unrestrained guinea pigs

H. Meurs, J. Zaagsma, M. Schuiling, 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Involvement of tachykinin NK1 receptor in the development of allergen-induced airway hyperreactivity and airway inflammation in conscious, unrestrained guinea pigs.

H. Meurs, J. Zaagsma, M. Schuiling, 1998, American journal of respiratory and critical care medicine.

The integrin-blocking peptide RGDS inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma.

A. Halayko, R. Gosens, H. Meurs, 2010, American journal of respiratory and critical care medicine.

The laminin 1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in chonic asthma

A. Halayko, H. Meurs, J. Zaagsma, 2010 .

The laminin b 1-competing peptide YIGSR induces a hypercontractile , hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma

A. Halayko, H. Meurs, J. Zaagsma, 2010 .

The laminin b1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma

A. Halayko, H. Meurs, J. Zaagsma, 2010 .

The laminin β1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma

A. Halayko, H. Meurs, J. Zaagsma, 2010, Respiratory research.

Airway structural components drive airway smooth muscle remodeling in asthma.

R. Gosens, H. Meurs, H. Maarsingh, 2009, Proceedings of the American Thoracic Society.

Insulin-induced laminin expression promotes a hypercontractile airway smooth muscle phenotype.

T. Tran, H. Meurs, J. Zaagsma, 2009, American journal of respiratory cell and molecular biology.

Protein kinase C potentiates homologous desensitization of the β2-adrenoceptor in bovine tracheal smooth muscle

H. Meurs, J. Zaagsma, Mark Boterman, 2006 .

Second M3 muscarinic receptor binding site contributes to bronchoprotection by tiotropium

C. Tautermann, Daniel Seeliger, R. Gosens, 2019, British journal of pharmacology.

Role of Rho-kinase in maintaining airway smooth muscle contractile phenotype.

R. Gosens, H. Meurs, J. Zaagsma, 2004, European journal of pharmacology.

The therapeutic potential of drugs targeting the arginase pathway in asthma

F. Ricciardolo, H. Meurs, J. Zaagsma, 2005, Expert opinion on investigational drugs.

Response to Ricciardolo: The functional significance of arginase in asthma is supported by gene expression

H. Meurs, J. Zaagsma, H. Maarsingh, 2003 .

Increased arginase activity underlies allergen‐induced deficiency of cNOS‐derived nitric oxide and airway hyperresponsiveness

H. Meurs, J. Zaagsma, H. Maarsingh, 2002, British journal of pharmacology.

Deficiency of nitric oxide in allergen‐induced airway hyperreactivity to contractile agonists after the early asthmatic reaction: an ex vivo study

W. Timens, H. Meurs, J. Zaagsma, 1996, British journal of pharmacology.

Protective effect of oral oxyphenonium bromide, terbutaline and theophylline against the bronchial obstructive effects of inhaled histamine, acetylcholine and propranolol

R. A. Zeeuw, H. Sluiter, H. Meurs, 2004, European Journal of Clinical Pharmacology.

Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke

F. Lezoualc’h, Junjun Cao, W. Timens, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Insulin induces a hypercontractile airway smooth muscle phenotype.

R. Gosens, H. Meurs, J. Zaagsma, 2003, European journal of pharmacology.

Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison

A. Halayko, R. Gosens, H. Meurs, 2007, European Respiratory Journal.

A new perspective on muscarinic receptor antagonism in obstructive airways diseases.

R. Gosens, L. Kistemaker, H. Meurs, 2013, Current opinion in pharmacology.

The Bronchoprotective Effect Of Olodaterol Against Histamine Is Synergistically Enhanced And Prolonged By Tiotropium Bromide

R. Gosens, H. Meurs, J. Zaagsma, 2011, ATS 2011.

Rho kinase inhibitors: a novel therapeutical intervention in asthma?

A. Halayko, R. Gosens, H. Meurs, 2008, European journal of pharmacology.

Pro-inflammatory mechanisms of muscarinic receptor stimulation in airway smooth muscle

A. Halayko, P. Hiemstra, R. Gosens, 2010, Respiratory research.

Arginase Inhibition Prevents Inflammation and Remodeling in a Guinea Pig Model of Chronic Obstructive Pulmonary Disease

H. Meurs, J. Zaagsma, M. Menzen, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Cooperative regulation of GSK-3 by muscarinic and PDGF receptors is associated with airway myocyte proliferation.

A. Halayko, W. Gerthoffer, H. Unruh, 2007, American journal of physiology. Lung cellular and molecular physiology.

Interaction between Epac1 and miRNA-7 in airway smooth muscle cells

W. Timens, W. Kooistra, G. Krenning, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

Activation of WNT / β-Catenin Signaling in Pulmonary Fibroblasts by TGF-β1 Is Increased in Chronic Obstructive Pulmonary Disease

D. Postma, H. Kerstjens, W. Timens, 2011, PloS one.

Anti-inflammatory effects of targeted lung denervation in patients with COPD

D. Slebos, H. Kerstjens, R. Gosens, 2015, European Respiratory Journal.

Muscarinic receptors on airway mesenchymal cells: novel findings for an ancient target.

A. Halayko, R. Gosens, H. Meurs, 2013, Pulmonary pharmacology & therapeutics.

Muscarinic receptor stimulation augments TGF-β1-induced contractile protein expression by airway smooth muscle cells.

A. Halayko, R. Gosens, K. Racké, 2012, American journal of physiology. Lung cellular and molecular physiology.

Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling.

R. Gosens, H. Meurs, J. Zaagsma, 2005, American journal of respiratory and critical care medicine.

Protein kinase A and the exchange protein directly activated by cAMP (Epac) modulate phenotype plasticity in human airway smooth muscle

A. Halayko, S. Roscioni, Martina Schmidt, 2011, British journal of pharmacology.

Insulin increases the expression of contractile phenotypic markers in airway smooth muscle.

A. Halayko, H. Baarsma, G. Stelmack, 2007, American journal of physiology. Cell physiology.

Characterization of (-)-[3H]dihydroalprenolol binding to intact and broken cell preparations of human peripheral blood lymphocytes.

H. Meurs, H. Kauffman, W. van den Bogaard, 1982, European journal of pharmacology.

Combination therapy of tiotropium and ciclesonide attenuates airway inflammation and remodeling in a guinea pig model of chronic asthma

R. Gosens, L. Kistemaker, H. Meurs, 2016, Respiratory Research.

Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells

H. Kerstjens, M. van den Berge, P. Hiemstra, 2015, Thorax.

Epac as a novel effector of airway smooth muscle relaxation

A. Halayko, S. Roscioni, Martina Schmidt, 2011, Journal of cellular and molecular medicine.

PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells

A. Halayko, S. Roscioni, R. Gosens, 2009, Respiratory research.

Insulin induces airway smooth muscle contraction

R. Gosens, H. Meurs, J. Zaagsma, 2007, British journal of pharmacology.

RESEARCH PAPER Insulin induces airway smooth muscle contraction

R. Gosens, H. Meurs, J. Zaagsma, 2007 .

Role of L‐arginine in the deficiency of nitric oxide and airway hyperreactivity after the allergen‐induced early asthmatic reaction in guinea‐pigs

H. Meurs, J. Zaagsma, M. Duyvendak, 1999, British journal of pharmacology.

p42/p44 MAP kinase activation is localized to caveolae-free membrane domains in airway smooth muscle.

A. Halayko, W. Gerthoffer, H. Unruh, 2007, American journal of physiology. Lung cellular and molecular physiology.

b -Agonist-induced constitutive b 2 -adrenergic receptor activity in bovine tracheal smooth muscle

H. Meurs, J. Zaagsma, C. Elzinga, 2000 .

β‐Agonist‐induced constitutive β2‐adrenergic receptor activity in bovine tracheal smooth muscle

H. Meurs, J. Zaagsma, C. Elzinga, 2000 .

Cloning, pharmacological characterization, and polymorphism screening of the guinea pig β2-adrenoceptor

D. Postma, J. Oostendorp, H. Boddeke, 2002 .

Dual action of iNOS-derived nitric oxide in allergen-induced airway hyperreactivity in conscious, unrestrained guinea pigs.

H. Meurs, J. Zaagsma, M. Schuiling, 1998, American journal of respiratory and critical care medicine.

Role of nitric oxide in the development and partial reversal of allergen‐induced airway hyperreactivity in conscious, unrestrained guinea‐pigs

H. Meurs, J. Zaagsma, M. Schuiling, 1998, British journal of pharmacology.

GSK-3/beta-catenin signaling axis in airway smooth muscle: role in mitogenic signaling.

H. Kerstjens, A. Halayko, H. Baarsma, 2008, American journal of physiology. Lung cellular and molecular physiology.

Airway hyperresponsiveness in asthma: lessons from in vitro model systems and animal models

R. Gosens, H. Meurs, J. Zaagsma, 2008, European Respiratory Journal.

Inhibition of Rho-kinase normalizes nonspecific hyperresponsiveness in passively sensitized airway smooth muscle preparations.

H. Meurs, J. Zaagsma, D. Schaafsma, 2006, European journal of pharmacology.

Acetylcholine: a novel regulator of airway smooth muscle remodelling?

R. Gosens, H. Meurs, J. Zaagsma, 2004, European journal of pharmacology.

Plasticity of airway smooth muscle phenotype in airway remodeling

R. Gosens, H. Meurs, J. Zaagsma, 2018 .

Characterization of signaling properties of Epac in human airway smooth muscle and bronchial epithelial cells

Sophie, Harm, A. Halayko, 2018 .

Localization and Enhanced mRNA Expression of the Orphan Chemokine Receptor L-CCR in the Lung in a Murine Model of Ovalbumin-induced Airway Inflammation

D. Postma, J. Oostendorp, H. Boddeke, 2004, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Role for TAK1 in cigarette smoke-induced proinflammatory signaling and IL-8 release by human airway smooth muscle cells.

A. Halayko, H. Meurs, J. Zaagsma, 2012, American journal of physiology. Lung cellular and molecular physiology.

Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction

H. Meurs, J. Zaagsma, D. Schaafsma, 2006, Respiratory research.

Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma

H. Meurs, J. Zaagsma, H. Maarsingh, 2006, Respiratory research.

Differential desensitization of homozygous haplotypes of the beta2-adrenergic receptor in lymphocytes.

D. Postma, E. Bleecker, H. Boezen, 2005, American journal of respiratory and critical care medicine.

Arginase 1 and arginase 2 variations associate with asthma, asthma severity and β2 agonist and steroid response

D. Postma, J. Vonk, G. Koppelman, 2010, Pharmacogenetics and genomics.

Virodhamine and CP55,940 modulate cAMP production and IL‐8 release in human bronchial epithelial cells

M. Dröge, H. Meurs, J. Zaagsma, 2007, British journal of pharmacology.

β2 adrenoceptor promoter polymorphisms: extended haplotypes and functional effects in peripheral blood mononuclear cells

D. Postma, I. Hall, G. Koppelman, 2002, Thorax.

Regulation of the beta-receptor-adenylate cyclase system in lymphocytes of allergic patients with asthma: possible role for protein kinase C in allergen-induced nonspecific refractoriness of adenylate cyclase.

K. de Vries, H. Meurs, H. Kauffman, 1987, The Journal of allergy and clinical immunology.

Effects of endogenous superoxide anion and nitric oxide on cholinergic constriction of normal and hyperreactive guinea pig airways.

H. Meurs, J. Zaagsma, J. de Boer, 1998, American journal of respiratory and critical care medicine.

The importance of eosinophil activation for the development of allergen‐induced bronchial hyperreactivity in conscious, unrestrained guinea‐pigs

Y. Pasman, H. Meurs, J. Zaagsma, 1994, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Effects of salbutamol and enantiomers on allergen-induced asthmatic reactions and airway hyperreactivity

H. Meurs, J. Zaagsma, A. Zuidhof, 2005, European Respiratory Journal.

Glycogen synthase kinase-3 regulates cigarette smoke extract- and IL-1 (cid:1) -induced cytokine secretion by airway smooth muscle

H. Kerstjens, A. Halayko, H. Baarsma, 2011 .

Pharmacological Screening Identifies SHK242 and SHK277 as Novel Arginase Inhibitors with Efficacy against Allergen-Induced Airway Narrowing In Vitro and In Vivo

A. Dömling, M. van Faassen, I. Kema, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Integrins: therapeutic targets in airway hyperresponsiveness and remodelling?

H. Meurs, B. Dekkers, D. Wright, 2014, Trends in pharmacological sciences.

Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives

H. Meurs, J. Zaagsma, H. Maarsingh, 2009, British journal of pharmacology.

Arginase and asthma: novel insights into nitric oxide homeostasis and airway hyperresponsiveness.

H. Meurs, J. Zaagsma, H. Maarsingh, 2003, Trends in pharmacological sciences.

Pharmacology of airway smooth muscle proliferation.

S. Roscioni, R. Gosens, Martina Schmidt, 2008, European journal of pharmacology.

Arginase attenuates inhibitory nonadrenergic noncholinergic nerve-induced nitric oxide generation and airway smooth muscle relaxation

Marieke A Tio, H. Meurs, J. Zaagsma, 2005, Respiratory research.

The beta-adrenergic system and allergic bronchial asthma: changes in lymphocyte beta-adrenergic receptor number and adenylate cyclase activity after an allergen-induced asthmatic attack.

H. Kauffman, K. de Vries, H. Meurs, 1982, The Journal of allergy and clinical immunology.

Cross-talk between transforming growth factor-β₁ and muscarinic M₂ receptors augments airway smooth muscle proliferation.

A. Halayko, R. Gosens, H. Meurs, 2013, American journal of respiratory cell and molecular biology.

Extracellular matrix proteins differentially regulate airway smooth muscle phenotype and function.

H. Meurs, J. Zaagsma, D. Schaafsma, 2007, American journal of physiology. Lung cellular and molecular physiology.

Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle.

R. Gosens, H. Meurs, J. Zaagsma, 2003, American journal of respiratory cell and molecular biology.

Muscarinic M 3-Receptors Mediate Cholinergic Synergism of Mitogenesis in Airway Smooth Muscle

R. Gosens, H. Meurs, J. Zaagsma, 2003 .

The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchoconstriction, airway hyperresponsiveness, and inflammation.

H. Meurs, J. Zaagsma, D. Schaafsma, 2008, American journal of physiology. Lung cellular and molecular physiology.

inflammation in mice cigarette smoke-induced neutrophilic airway receptors on structural cells regulate

H. Kerstjens, M. Berge, P. Hiemstra, 2016 .

Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD

R. Gosens, R. Schoemaker, H. Meurs, 2011, European Respiratory Journal.

Role for TAK 1 in cigarette smoke-induced proinflammatory signaling and IL-8 release by human airway smooth muscle cells

A. Halayko, H. Meurs, J. Zaagsma, 2012 .

Potentiation of β-adrenoceptor function in bovine tracheal smooth muscle by inhibition of protein kinase C

H. Meurs, J. Zaagsma, C. Elzinga, 2005 .

Dissociation between bronchial hyperreactivity in vivo and reduced beta-adrenoceptor sensitivity in vitro in allergen-challenged guinea pigs.

R. Santing, H. Meurs, J. Zaagsma, 1994, European journal of pharmacology.

Role of phosphoinositide metabolism in functional antagonism of airway smooth muscle contraction by beta-adrenoceptor agonists.

H. Meurs, F. Brouwer, J. Zaagsma, 1989, European journal of pharmacology.

The role of the adrenergic system in allergy and bronchial hyperreactivity.

K. de Vries, H. Meurs, H. Kauffman, 1982, European journal of respiratory diseases. Supplement.

Specific immunological modulation of lymphocyte adenylate cyclase in asthmatic patients after allergenic bronchial provocation.

J. D. de Monchy, K. de Vries, H. Meurs, 1986, International archives of allergy and applied immunology.

Laminin α4 contributes to airway remodeling and inflammation in asthma.

M. P. van den Berg, N. T. ten Hacken, W. Timens, 2019, American journal of physiology. Lung cellular and molecular physiology.

Muscarinic control of airway function.

H. Meurs, J. Zaagsma, A. Roffel, 1997, Life sciences.

TGF‐β‐induced profibrotic signaling is regulated in part by the WNT receptor Frizzled‐8

D. Postma, M. Lindner, H. Baarsma, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Muscarinic M2 receptors do not participate in the functional antagonism between methacholine and isoprenaline in guinea pig tracheal smooth muscle.

H. Meurs, J. Zaagsma, C. Elzinga, 1993, European journal of pharmacology.

Extraction of cyclic AMP for the determination in the competitive protein binding assay.

H. Meurs, H. Kauffman, G. Koeter, 1980, Clinica chimica acta; international journal of clinical chemistry.

Effect of oral slow-release terbutaline on early morning dyspnoea

D. Postma, H. Meurs, G. Köeter, 2004, European Journal of Clinical Pharmacology.

Influence of slow-release terbutaline on the circadian variation of catecholamines, histamine, and lung function in nonallergic patients with partly reversible airflow obstruction.

D. Postma, H. Meurs, G. Koëter, 1986, The Journal of allergy and clinical immunology.

Effect of beta-adrenergic stimulation on the circulatory lymphocyte count: studies in normals and in patients with chronic airflow obstruction.

D. Postma, H. Sluiter, K. de Vries, 1985, Chronobiology international.

Protective Effect of Disodium Cromoglycate on Propranolol Challenge

H. Meurs, G. Koëter, J. Monchy, 1982, Allergy.

Muscarinic M₃ receptors contribute to allergen-induced airway remodeling in mice.

J. Wess, H. Kerstjens, P. Hiemstra, 2014, American journal of respiratory cell and molecular biology.

Identification, localization and function of muscarinic receptor subtypes in the airways

H. Meurs, J. Zaagsma, A. Roffel, 2001 .

Contribution of a cholinergic reflex mechanism to allergen‐induced bronchial hyperreactivity in permanently instrumented, unrestrained guinea‐pigs

Y. Pasman, R. Santing, H. Meurs, 1995, British journal of pharmacology.

Allergic sensitization enhances the contribution of Rho‐kinase to airway smooth muscle contraction

R. Gosens, H. Meurs, J. Zaagsma, 2004, British journal of pharmacology.

Glucocorticosteroids and β2-Adrenoceptor Agonists Synergize to Inhibit Airway Smooth Muscle Remodeling

H. Meurs, J. Zaagsma, B. Dekkers, 2012, Journal of Pharmacology and Experimental Therapeutics.

Functional consequences of human airway smooth muscle phenotype plasticity

H. Meurs, J. Zaagsma, B. Dekkers, 2010, British journal of pharmacology.

Targeting arginase and nitric oxide metabolism in chronic airway diseases and their co-morbidities.

R. Gosens, H. Meurs, M. P. van den Berg, 2018, Current opinion in pharmacology.

Increased arginase activity contributes to airway remodelling in chronic allergic asthma

H. Meurs, J. Zaagsma, M. Menzen, 2011, European Respiratory Journal.

Relationships among allergen-induced early and late phase airway obstructions, bronchial hyperreactivity, and inflammation in conscious, unrestrained guinea pigs.

R. Santing, H. Meurs, J. Zaagsma, 1994, The Journal of allergy and clinical immunology.

A guinea pig model of acute and chronic asthma using permanently instrumented and unrestrained animals

T. W. van der Mark, H. Meurs, R. Remie, 2006, Nature Protocols.

inihibits airway smooth muscle phenotype modulation via Epac and PKA

S. Roscioni, Martina Schmidt, H. Meurs, 2018 .

cAMP inhibits modulation of airway smooth muscle phenotype via the exchange protein activated by cAMP (Epac) and protein kinase A

S. Roscioni, Martina Schmidt, H. Meurs, 2011, British journal of pharmacology.

Phorbol 12-myristate 13-acetate induces beta-adrenergic receptor uncoupling and non-specific desensitization of adenylate cyclase in human mononuclear leukocytes.

K. de Vries, H. Meurs, H. Kauffman, 1986, Biochemical pharmacology.

Reduced adenylate cyclase responsiveness to histamine in lymphocyte membranes of allergic asthmatic patients after allergen challenge.

H. Kauffman, K. de Vries, H. Meurs, 1985, International archives of allergy and applied immunology.

Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices

G. Groothuis, R. Gosens, H. Meurs, 2013, PloS one.

Bradykinin augments EGF-induced airway smooth muscle proliferation by activation of conventional protein kinase C isoenzymes.

R. Gosens, H. Meurs, J. Zaagsma, 2006, European journal of pharmacology.

Bradykinin augments growth factor- induced airway smooth muscle mitogenesis by activation of conventional PKC iso-enzymes

H. Meurs, J. Zaagsma, 2004 .

Chapter 8 Role of the L-citrulline / L-arginine cycle in iNANC nerve-mediated NO production and airway smooth muscle relaxation in allergic asthma

H. Meurs, J. Zaagsma, H. Maarsingh, 2018 .

Role of phosphoinositide metabolism in human bronchial smooth muscle contraction and in functional antagonism by beta-adrenoceptor agonists.

H. Meurs, F. Brouwer, J. Zaagsma, 1990, The American review of respiratory disease.

Heterologous amplification of homologous beta-adrenoceptor desensitization in airway smooth muscle

H. Meurs, J. Zaagsma, A. Nelemans, 2006 .

Role of histamine in allergen-induced asthmatic reactions, bronchial hyperreactivity and inflammation in unrestrained guinea pigs.

R. Santing, H. Meurs, J. Zaagsma, 1994, European journal of pharmacology.

Potentiation of beta-adrenoceptor function in bovine tracheal smooth muscle by inhibition of protein kinase C.

H. Meurs, J. Zaagsma, C. Elzinga, 2005, European journal of pharmacology.

Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs.

R. Santing, H. Meurs, J. Zaagsma, 1995, European journal of pharmacology.

L-thyroxine promotes a proliferative airway smooth muscle phenotype in the presence of TGF-β1.

A. Halayko, H. Meurs, M. Menzen, 2015, American journal of physiology. Lung cellular and molecular physiology.

Protein kinase C potentiates homologous desensitization of the beta2-adrenoceptor in bovine tracheal smooth muscle.

H. Meurs, J. Zaagsma, Mark Boterman, 2006, European journal of pharmacology.

Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.

J. Boucher, M. Duin, M. van Duin, 2008, American journal of respiratory and critical care medicine.

Recent Patents in Allergy/Immunology: Use of arginase inhibitors in the treatment of asthma and allergic rhinitis

M. van Duin, H. Meurs, J. Zaagsma, 2019, Allergy.

AIRWAY HYPERRESPONSIVENESS IN A GUINEA PIG MODEL OF CHRONIC ALLERGIC ASTHMA

H. Meurs, J. Zaagsma, H. Maarsingh, 2009 .

Effects of fenoterol on β-adrenoceptor and muscarinic M2 receptor function in bovine tracheal smooth muscle

H. Meurs, J. Zaagsma, A. Roffel, 2001 .

No evidence for a role of muscarinic M2 receptors in functional antagonism in bovine trachea

H. Meurs, J. Zaagsma, C. Elzinga, 1995, British journal of pharmacology.

Reply to: “Arginase inhibitors: An alternative in treatment of obese asthma?”

M. van Duin, H. Meurs, J. Zaagsma, 2020, Allergy.

Pre-treatment with α-hederin increases β-adrenoceptor mediated relaxation of airway smooth muscle.

H. Häberlein, R. Gosens, H. Meurs, 2011, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Chapter 5 L-Ornithine causes NO deficiency and airway hyperresponsiveness

H. Meurs, J. Zaagsma, H. Volders, 2018 .

In vivo effects of arginase inhibition and of L-arginine on allergen-induced airway hyperresponsiveness in a guinea pig model of allergic asthma

J. Boucher, M. Duin, H. Meurs, 2018 .

Chapter 10 Age-induced airway hyperresponsiveness in guinea pigs due to increased arginase activity and peroxynitrite

H. Meurs, J. Zaagsma, H. Maarsingh, 2018 .

Deficiency of nitric oxide in polycation‐induced airway hyperreactivity

H. Meurs, J. Zaagsma, M. Duyvendak, 1999, British journal of pharmacology.

Effects of Experimental Thyroid Dysfunction on the Reactivity of Isolated Tracheal Smooth Muscle in the Guinea Pig

M. Moin, A. Bahonar, H. Meurs, 2012 .

(Endo)cannabinoids mediate different Ca2+ entry mechanisms in human bronchial epithelial cells

M. Dröge, Martina Schmidt, H. Meurs, 2009, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effect of fenoterol-induced constitutive beta(2)-adrenoceptor activity on contractile receptor function in airway smooth muscle.

H. Meurs, J. Zaagsma, A. Roffel, 2001, European journal of pharmacology.

contractile receptor function in airway smooth muscle

H. Meurs, J. Zaagsma, A. Roffel, 2001 .

Muscarinic M3 receptor‐dependent regulation of airway smooth muscle contractile phenotype

R. Gosens, H. Meurs, J. Zaagsma, 2004, British journal of pharmacology.

Functional characterization of serum‐ and growth factor‐induced phenotypic changes in intact bovine tracheal smooth muscle

R. Gosens, H. Meurs, J. Zaagsma, 2002, British journal of pharmacology.

Characterization of presynaptic vascular muscarinic receptors inhibiting endogenous noradrenaline overflow in the portal vein of the freely moving rat

H. Meurs, R. Remie, J. Zaagsma, 1990, British journal of pharmacology.

Growth factor-induced contraction of human bronchial smooth muscle is Rho-kinase-dependent.

R. Gosens, H. Meurs, J. Zaagsma, 2004, European journal of pharmacology.

Role of contractile prostaglandins and Rho-kinase in growth factor-induced airway smooth muscle contraction

R. Gosens, H. Meurs, J. Zaagsma, 2005, Respiratory research.

Non-Specific Binding of (-)3H-Dihydroalprenolol to Intact Human Lymphocytes and Lymphocyte Membranes

H. Meurs, H. Kauffman, P. Bruynzeel, 1982 .

Inhibition of Airway Smooth Muscle Remodeling in an Animal Model of Chronic Asthma by the Integrin-Blocking Peptide RGDS

A. Halayko, R. Gosens, H. Meurs, 2009, ATS 2009.

Lack of coupling of muscarinic receptors to phosphoinositide metabolism and adenylyl cyclase in human lymphocytes and polymorphonuclear leukocytes: studies in healthy subjects and allergic asthmatic patients.

J. D. de Monchy, H. Meurs, J. Zaagsma, 1993, International archives of allergy and immunology.

Differential Rho‐kinase dependency of full and partial muscarinic receptor agonists in airway smooth muscle contraction

H. Meurs, J. Zaagsma, D. Schaafsma, 2006, British journal of pharmacology.

TAK1 plays a major role in growth factor-induced phenotypic modulation of airway smooth muscle.

H. Meurs, J. Zaagsma, T. Pera, 2011, American journal of physiology. Lung cellular and molecular physiology.

NITRIC OXIDE AND NITROGEN OXIDES

H. Meurs, J. Zaagsma, H. Maarsingh, 2006 .

Changes in the beta-adrenergic system in bronchial asthma induced by terbutaline.

H. Sluiter, J. D. de Monchy, H. Meurs, 1983, Agents and actions. Supplements.

Modulation of agonist‐induced phosphoinositide metabolism, Ca2+ signalling and contraction of airway smooth muscle by cyclic AMP‐dependent mechanisms

H. Meurs, J. Zaagsma, M. Schuiling, 1996, British journal of pharmacology.

Characterization of the muscarinic receptor subtype involved in phosphoinositide metabolism in bovine tracheal smooth muscle

H. Meurs, J. Zaagsma, C. Elzinga, 1990, British journal of pharmacology.

Muscarinic receptors in human airway smooth muscle are coupled to phosphoinositide metabolism.

H. Meurs, F. Brouwer, J. Zaagsma, 1989, European journal of pharmacology.

Evidence for a direct relationship between phosphoinositide metabolism and airway smooth muscle contraction induced by muscarinic agonists.

H. Meurs, J. Zaagsma, H. Kauffman, 1988, European journal of pharmacology.

A synthetic peptide as an allosteric inhibitor of human arginase I and II

M. Groves, R. Gosens, Stephen Evans, 2021, Molecular Biology Reports.

Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells

K. Rabe, A. Halayko, D. Ninaber, 2009, European Respiratory Journal.

Comparison of antibody measurements against Aspergillus fumigatus by means of double-diffusion and enzyme-linked immunosorbent assay (ELISA).

H. Kauffman, S. van der Heide, K. de Vries, 1983, The Journal of allergy and clinical immunology.

Muscarinic Receptors in Airways Diseases

H. Meurs, J. Zaagsma, A. Roffel, 2001, Progress in Inflammation Research.

Allosteric interactions of three muscarine antagonists at bovine tracheal smooth muscle and cardiac M2 receptors.

H. Meurs, J. Zaagsma, C. Elzinga, 1989, European journal of pharmacology.

De novo synthesis of ß‐catenin via H‐Ras and MEK regulates airway smooth muscle growth

A. Halayko, H. Baarsma, I. Heijink, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Glycogen synthase kinase‐3 (GSK‐3) regulates TGF‐β1‐induced differentiation of pulmonary fibroblasts

D. Postma, H. Kerstjens, W. Timens, 2013, British journal of pharmacology.

Glycogen synthase kinase-3 regulates cigarette smoke extract- and IL-1β-induced cytokine secretion by airway smooth muscle.

H. Kerstjens, A. Halayko, H. Baarsma, 2011, American journal of physiology. Lung cellular and molecular physiology.

Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: I. Effects on lung remodeling and pathology

H. Kerstjens, H. Baarsma, A. Schols, 2013, Respiratory Research.

β-Catenin signaling is required for TGF-β1-induced extracellular matrix production by airway smooth muscle cells.

H. Kerstjens, A. Halayko, H. Baarsma, 2011, American journal of physiology. Lung cellular and molecular physiology.

The GSK-3/β-catenin-signalling axis in smooth muscle and its relationship with remodelling

R. Gosens, Martina Schmidt, H. Meurs, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice

J. Wess, M. Nawijn, H. Kerstjens, 2013, European Respiratory Journal.

MUSCARINIC RECEPTOR-MEDIATED INHIBITION OF ADENYLYL CYCLASE AND ITS ROLE IN THE FUNCTIONAL ANTAGONISM OF ISOPRENALINE IN AIRWAY SMOOTH-MUSCLE

H. Meurs, J. Zaagsma, C. Elzinga, 1993 .

Muscarinic receptor-Beta-adrenoceptor cross-talk in airways smooth muscle

H. Meurs, C. Elzinga, 2001 .

Focal Adhesion Kinase Regulates Collagen I–Induced Airway Smooth Muscle Phenotype Switching

H. Meurs, J. Zaagsma, B. Dekkers, 2013, The Journal of Pharmacology and Experimental Therapeutics.

The non-neuronal cholinergic system: basic science, therapeutic implications and new perspectives.

C. Kirkpatrick, K. Kawashima, S. Grando, 2012, Life sciences.

Mechanisms of glucocorticoid action and insensitivity in airways disease.

L. Chachi, A. Gavrila, H. Meurs, 2014, Pulmonary pharmacology & therapeutics.

Cigarette smoke and lipopolysaccharide induce a proliferative airway smooth muscle phenotype

R. Gosens, H. Meurs, J. Zaagsma, 2010, Respiratory research.

Arginine homeostasis in allergic asthma.

H. Meurs, J. Zaagsma, H. Maarsingh, 2008, European journal of pharmacology.

Arginase in Asthma - Recent Developments in Animal and Human Studies

D. Lana, H. Meurs, J. Zaagsma, 2010 .

Role of the L-citrulline/L-arginine cycle in iNANC nerve-mediated nitric oxide production and airway smooth muscle relaxation in allergic asthma.

H. Meurs, J. Zaagsma, H. Maarsingh, 2006, European journal of pharmacology.

l-Arginine deficiency causes airway hyperresponsiveness after the late asthmatic reaction

H. Meurs, J. Zaagsma, H. Volders, 2009, European Respiratory Journal.

Back to the future: re-establishing guinea pig in vivo asthma models.

G. Nilsson, S. Dahlén, M. Belvisi, 2020, Clinical science.

The novel compound Sul-121 inhibits airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease

R. Henning, A. Halayko, G. Krenning, 2016, Scientific Reports.

Influence of sensitization and allergen provocation procedures on the development of allergen-induced bronchial hyperreactivity in conscious, unrestrained guinea-pigs

R. Santing, H. Meurs, J. Zaagsma, 1995, Mediators of inflammation.

Monomeric G-proteins as signal transducers in airway physiology and pathophysiology.

S. Roscioni, Martina Schmidt, H. Meurs, 2008, Cellular signalling.

Regulation of airway inflammation and remodeling by muscarinic receptors: perspectives on anticholinergic therapy in asthma and COPD.

R. Gosens, L. Kistemaker, H. Meurs, 2012, Life sciences.

Delivery system for budesonide based on lipid‐DNA

A. Hirsch, Yun Liu, H. Meurs, 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Abstracts of papers Pharmacological meeting

N. Ramsey, J. M. Ree, M. Danhof, 1985, Pharmaceutisch Weekblad.

Airway and Extracellular Matrix Mechanics in COPD

Cécile M. Bidan, R. Gosens, C. Bidan, 2015, Front. Physiol..

remodeling, and bronchial hyperresponsiveness Lung parenchymal shear modulus, airway wall

V. Brusasco, A. James, P. Noble, 2015 .

Role of nitric oxide and superoxide in allergen‐induced airway hyperreactivity after the late asthmatic reaction in guinea‐pigs

L. Flendrig, H. Meurs, J. Zaagsma, 2001, British journal of pharmacology.

Polycation-induced l-arginine limitation, causes airway hyperreactivity after the late asthmatic reaction

H. Meurs, J. Zaagsma, H. Maarsingh, 2005 .

Bronchoprotection by Olodaterol Is Synergistically Enhanced by Tiotropium in a Guinea Pig Model of Allergic Asthma

R. Gosens, H. Meurs, J. Zaagsma, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Muscarinic M3 receptors on structural cells regulate cigarette smoke-induced neutrophilic airway inflammation in mice.

J. Wess, H. Kerstjens, M. van den Berge, 2015, American journal of physiology. Lung cellular and molecular physiology.

Small airway hyperresponsiveness in COPD: relationship between structure and function in lung slices

Cécile M. Bidan, W. Timens, B. Brook, 2019, American journal of physiology. Lung cellular and molecular physiology.

Exploring the Pharmacological Properties of 4 Sul Compounds as Potential Novel Treatments for COPD

A. Halayko, Martina Schmidt, H. Meurs, 2016 .

Caveolin-1 is required for contractile phenotype expression by airway smooth muscle cells

A. Halayko, W. Gerthoffer, G. Stelmack, 2011, Journal of cellular and molecular medicine.

The β2-subtype of adrenoceptors mediates inhibition of pro-fibrotic events in human lung fibroblasts

E. Kostenis, K. Mohr, R. Gosens, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Inflammatory cell distribution in guinea pig airways and its relationship to airway reactivity.

W. Timens, H. Meurs, J. Zaagsma, 2001, Mediators of inflammation.

Mapping Arginase Expression with 18F-Fluorinated Late-Generation Arginase Inhibitors Derived from Quaternary α-Amino Acids

A. Dömling, A. van Waarde, P. Elsinga, 2021, The Journal of Nuclear Medicine.

A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis

Y. Bossé, D. Postma, D. Nickle, 2016, Thorax.

Arginase in Asthma

H. Meurs, J. Zaagsma, H. Maarsingh, 2010 .

Contribution of Rho-kinase (ROCK) to airway smooth muscle (ASM) contraction after allergic sensitization

R. Gosens, H. Meurs, J. Zaagsma, 2005 .

Effects of (a Combination of) the Beta2-Adrenoceptor Agonist Indacaterol and the Muscarinic Receptor Antagonist Glycopyrrolate on Intrapulmonary Airway Constriction

W. Timens, Martina Schmidt, A. Oldenburger, 2021, Cells.

Disruption of AKAP-PKA Interaction Induces Hypercontractility With Concomitant Increase in Proliferation Markers in Human Airway Smooth Muscle

A. Halayko, H. Baarsma, Martina Schmidt, 2020, Frontiers in Cell and Developmental Biology.

Heterologous amplification of homologous beta-adrenoceptor desensitization in airway smooth muscle

H. Meurs, J. Zaagsma, D. Schaafsma, 2006 .

Feedforward control of agonist-induced Ca2+ signalling by protein kinase C in airway smooth muscle cells.

H. Meurs, J. Zaagsma, B. Hoiting, 1995, European journal of pharmacology.

Inflammatory cell distribution in guinea pig airways and its relationship to airway reactivity

W. Timens, H. Meurs, J. Zaagsma, 2014 .

Epac as a novel effector of airway smooth muscle relaxation

J. Schuur, S. Roscioni, H. Meurs, 2010 .

TAK 1 plays a major role in growth factor-induced phenotypic modulation of airway smooth muscle

H. Meurs, J. Zaagsma, Riham Sami, 2011 .

Muscarinic receptor signaling in the pathophysiology of asthma and COPD

A. Halayko, R. Gosens, H. Meurs, 2006, Respiratory research.

Mechanisms of glucocorticoid action and insensitivity in airways disease.

L. Chachi, A. Gavrila, H. Meurs, 2014, Pulmonary pharmacology & therapeutics.

Human-based Systems for Translational Research

P. Olinga, A. Casini, G. Groothuis, 2015 .

Protein kinase A and the exchange protein directly activated by cAMP (Epac) modulate phenotype plasticity in human airway smooth muscle

A. Halayko, S. Roscioni, Martina Schmidt, 2011, British journal of pharmacology.

Heparin normalizes allergen‐induced nitric oxide deficiency and airway hyperresponsiveness

H. Meurs, J. Zaagsma, H. Maarsingh, 2004, British journal of pharmacology.

GSK-3/beta-catenin signaling axis in airway smooth muscle: role in mitogenic signaling.

H. Kerstjens, A. Halayko, H. Baarsma, 2008, American journal of physiology. Lung cellular and molecular physiology.

Small Airway Hyperresponsiveness in COPD: Relationship Between

Cécile M. Bidan, W. Timens, B. Brook, 2018 .

Growth factor-induced contraction of human bronchial smooth muscle is Rho-kinase-dependent.

R. Gosens, H. Meurs, J. Zaagsma, 2004, European journal of pharmacology.

Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction

H. Meurs, J. Zaagsma, D. Schaafsma, 2006, Respiratory research.

Heterologous amplification of homologous beta-adrenoceptor desensitization in airway smooth muscle

H. Meurs, J. Zaagsma, C. Elzinga, 2006 .

Heterologous amplification of homologous beta-adrenoceptor desensitization in airway smooth muscle

H. Meurs, J. Zaagsma, C. Elzinga, 2006 .

Regulation of airway inflammation and remodeling by muscarinic receptors: perspectives on anticholinergic therapy in asthma and COPD.

R. Gosens, L. Kistemaker, H. Meurs, 2012, Life sciences.

Role of tachykinin NK1 and NK2 receptors in allergen‐induced early and late asthmatic reactions, airway hyperresponsiveness, and airway inflammation in conscious, unrestrained guinea pigs

H. Meurs, J. Zaagsma, M. Schuiling, 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.