E. Morretta

发表

Exosomal CD73 from serum of patients with melanoma suppresses lymphocyte functions and is associated with therapy resistance to anti-PD-1 agents

G. Madonna, P. Ascierto, E. Simeone, 2022, Journal for ImmunoTherapy of Cancer.

Mesoglycan exerts its fibrinolytic effect through the activation of annexin A2

M. Perretti, A. Filippelli, A. Tosco, 2020, Journal of cellular physiology.

Atorvastatin protects against liver and vascular damage in a model of diet induced steatohepatitis by resetting FXR and GPBAR1 signaling

S. Marchianò, Michele Biagioli, E. Distrutti, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Drug Repositioning for Fabry Disease: Acetylsalicylic Acid Potentiates the Stabilization of Lysosomal Alpha-Galactosidase by Pharmacological Chaperones

M. Cubellis, J. Lukas, B. Hay Mele, 2022, International journal of molecular sciences.

Discovering the Biological Target of 5-epi-Sinuleptolide Using a Combination of Proteomic Approaches

R. Riccio, R. Esposito, M. Monti, 2017, Marine drugs.

Beneficial effects of UDCA and norUDCA in a rodent model of steatosis are linked to modulation of GPBAR1/FXR signaling.

S. Marchianò, Michele Biagioli, E. Distrutti, 2022, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Involvement of 3′,5′‐cyclic inosine monophosphate in cystathionine γ‐lyase‐dependent regulation of the vascular tone

G. Caliendo, A. Papapetropoulos, R. d'Emmanuele di Villa Bianca, 2021, British journal of pharmacology.

Opposite effects of the FXR agonist obeticholic acid on Mafg and Nrf2 mediate the development of acute liver injury in rodent models of cholestasis.

A. Carino, S. Marchianò, Michele Biagioli, 2020, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma

Federica Moraca, S. Marchianò, V. Sepe, 2022, Cells.

Role of Intracellular and Extracellular Annexin A1 in MIA PaCa-2 Spheroids Formation and Drug Sensitivity

R. Tomasini, A. Petrella, E. Morretta, 2022, Cancers.

Drug affinity-responsive target stability unveils filamins as biological targets for artemetin, an anti-cancer flavonoid

A. Minassi, B. Stork, A. Tosco, 2022, Frontiers in Molecular Biosciences.

Label-Free Quantitative Proteomics to Explore the Action Mechanism of the Pharmaceutical-Grade Triticum vulgare Extract in Speeding Up Keratinocyte Healing

E. Cassese, C. Schiraldi, A. Petrella, 2022, Molecules.

Label-Free Quantitative Proteomics to Explore the Action Mechanism of the Pharmaceutical-Grade Triticum vulgare Extract in Speeding Up Keratinocyte Healing

E. Cassese, C. Schiraldi, A. Petrella, 2021, Molecules.

Serum CD73 is a prognostic factor in patients with metastatic melanoma and is associated with response to anti-PD-1 therapy

D. Schadendorf, G. Madonna, D. Mallardo, 2020, Journal for ImmunoTherapy of Cancer.

Synthesis, functional proteomics and biological evaluation of new 5-pyrazolyl ureas as potential anti-angiogenic compounds.

C. Brullo, M. Monti, Elda Meta, 2021, European journal of medicinal chemistry.

Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite

S. Wesselborg, P. Proksch, M. Mozzicafreddo, 2020, Biomolecules.

Crellastatin A, a PARP‐1 Inhibitor Discovered by Complementary Proteomic Approaches

M. Mozzicafreddo, A. Tosco, A. Casapullo, 2019, ChemMedChem.

Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma

Federica Moraca, S. Marchianò, V. Sepe, 2023, Frontiers in Oncology.

Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH

S. Marchianò, Michele Biagioli, E. Distrutti, 2023, Scientific Reports.

The Pyrazolyl-Urea Gege3 Inhibits the Activity of ANXA1 in the Angiogenesis Induced by the Pancreatic Cancer Derived EVs

C. Brullo, A. Petrella, O. Bruno, 2021, Biomolecules.

Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation

S. Marchianò, Michele Biagioli, E. Distrutti, 2019, Nutrients.

Serum Bile Acid Levels Before and After Sleeve Gastrectomy and Their Correlation with Obesity-Related Comorbidities

E. Distrutti, S. Fiorucci, G. Lupattelli, 2019, Obesity Surgery.

Curcumin Has Beneficial Effects on Lysosomal Alpha-Galactosidase: Potential Implications for the Cure of Fabry Disease

M. Cubellis, J. Lukas, B. Hay Mele, 2023, International journal of molecular sciences.

A multidisciplinary functional proteomics-aided strategy as a tool for the profiling of a novel cytotoxic thiadiazolopyrimidone.

S. Terracciano, I. Bruno, A. Petrella, 2023, Bioorganic chemistry.

Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor

G. Sbardella, S. Cosconati, S. Castellano, 2023, Journal of medicinal chemistry.

Targeting USP-7 by a Novel Fluorinated 5-Pyrazolyl-Urea Derivative

C. Brullo, A. Petrella, E. Morretta, 2023, International journal of molecular sciences.

Bile Acids Serve As Endogenous Antagonists Of The Leukemia Inhibitory Factor (LIF) Receptor in Oncogenesis

S. Marchianò, V. Sepe, Michele Biagioli, 2023, bioRxiv.

Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease.

S. Marchianò, Michele Biagioli, E. Distrutti, 2023, Biochemical pharmacology.

High levels of soluble CD73 unveil resistance to BRAF inhibitors in melanoma cells.

A. Tosco, E. Morretta, A. Voli, 2024, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Development of dual GPBAR1 agonist and RORγt inverse agonist for the treatment of inflammatory bowel diseases

S. Marchianò, V. Sepe, Michele Biagioli, 2024, Pharmacological Research.

H3K56 acetylation affects Candida albicans morphology and secreted soluble factors interacting with the host.

A. Tosco, E. Morretta, Marisa Conte, 2024, Biochimica et biophysica acta. Gene regulatory mechanisms.

Microbial-derived bile acid reverses inflammation in IBD via GPBAR1 agonism and RORγt inverse agonism.

S. Marchianò, V. Sepe, Michele Biagioli, 2024, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Defective Bile Acid Signaling Promotes Vascular Dysfunction, Supporting a Role for G‐Protein Bile Acid Receptor 1/Farnesoid X Receptor Agonism and Statins in the Treatment of Nonalcoholic Fatty Liver Disease

S. Marchianò, Michele Biagioli, E. Distrutti, 2023, Journal of the American Heart Association.

Design, Synthesis, and Pharmacological Evaluation of Dual FXR-LIFR Modulators for the Treatment of Liver Fibrosis.

S. Marchianò, V. Sepe, Michele Biagioli, 2024, Journal of medicinal chemistry.