T. Azam

发表

Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein

D. Yoon, C. Dinarello, Soohyun Kim, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Identification of Amino Acid Residues Critical for Biological Activity in Human Interleukin-18*

D. Yoon, C. Dinarello, Soohyun Kim, 2002, The Journal of Biological Chemistry.

Specific Inhibition of Histone Deacetylase 8 Reduces Gene Expression and Production of Proinflammatory Cytokines in Vitro and in Vivo*

A. Abbate, C. Dinarello, G. Fossati, 2014, The Journal of Biological Chemistry.

Role for nuclear interleukin-37 in the suppression of innate immunity

B. Palmer, C. Dinarello, C. Neff, 2019, Proceedings of the National Academy of Sciences.

A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity

C. Dinarello, Sanjay Kumar, Soohyun Kim, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Alpha-1-antitrypsin Therapy Ameliorates Acute Colitis and Chronic Murine Ileitis

C. Dinarello, J. Rivera-Nieves, P. Jedlicka, 2013, Inflammatory bowel diseases.

Triggering receptor expressed on myeloid cells‐1 (TREM‐1) amplifies the signals induced by the NACHT‐LRR (NLR) pattern recognition receptors

M. Netea, S. Girardin, C. Dinarello, 2006, Journal of leukocyte biology.

Inflammation-Restricted Activation Context-Specific and IL-1 Receptor Antagonist Chimeric Protein :

Y. Carmi, C. Dinarello, O. Guttman, 2015 .

Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion

D. G. Osborne, Morkos A. Henen, L. Joosten, 2021, Proceedings of the National Academy of Sciences.

Interleukin-32: a cytokine and inducer of TNFalpha.

D. Yoon, C. Dinarello, Soohyun Kim, 2005, Immunity.

IL-32 Promotes Angiogenesis

L. Joosten, B. Palmer, L. Farkas, 2014, The Journal of Immunology.

IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism.

M. Netea, S. Girardin, E. Abraham, 2005, Proceedings of the National Academy of Sciences of the United States of America.

THP-1 Human Macrophages in Differentiated Mycobacterium tuberculosis IL-32 Is a Host Protective Cytokine against

E. Chan, C. Dinarello, Soohyun Kim, 2010 .

IL-32 Is a Host Protective Cytokine against Mycobacterium tuberculosis in Differentiated THP-1 Human Macrophages

Hua Huang, E. Chan, C. Dinarello, 2010, The Journal of Immunology.

IL-1 Receptor Antagonist Chimeric Protein: Context-Specific and Inflammation-Restricted Activation

Y. Carmi, C. Dinarello, O. Guttman, 2015, The Journal of Immunology.

Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue

D. Seals, G. Cavalli, C. Tack, 2018, The Journal of Biological Chemistry.

A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling

E. Eisenmesser, C. Dinarello, S. Fischer, 2021, Journal of Biological Chemistry.

The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines

G. Fantuzzi, C. Dinarello, Soohyun Kim, 2002, Proceedings of the National Academy of Sciences of the United States of America.

The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines

C. Dinarello, Soohyun Kim, Eunsom Kim, 2013, Front. Immunol..

Generation and characterization of mice transgenic for human IL‐18‐binding protein isoform a

Andrea Vondracek, G. Fantuzzi, C. Dinarello, 2003, Journal of leukocyte biology.

Differences in signaling pathways by IL-1beta and IL-18.

C. Dinarello, Soohyun Kim, E. Lewis, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Identification of the most active interleukin‐32 isoform

D. Yoon, Chang-Kwon Lee, C. Dinarello, 2009, Immunology.

Proteinase 3-processed form of the recombinant IL-32 separate domain.

D. Yoon, C. Dinarello, Soohyun Kim, 2008, BMB reports.

Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFalpha and IL-1beta.

E. Chan, D. Yoon, C. Dinarello, 2010, Cytokine.

IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease

C. Dinarello, S. Fischer, M. Tolstrup, 2019, Nature Immunology.

NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

L. Joosten, C. Dinarello, M. Koenders, 2018, Arthritis Research & Therapy.

Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1β and by the induction of endogenous IL-1Ra

L. Joosten, M. Netea, C. Dinarello, 2015, Annals of the rheumatic diseases.

Interleukin-32 induces the differentiation of monocytes into macrophage-like cells

L. Joosten, M. Netea, C. Dinarello, 2008, Proceedings of the National Academy of Sciences.

Mycobacterium tuberculosis Induces Interleukin-32 Production through a Caspase- 1/IL-18/Interferon-γ-Dependent Mechanism

L. Joosten, M. Netea, E. Chan, 2006, PLoS medicine.

Individual LPS responsiveness depends on the variation of toll-like receptor (TLR) expression level.

M. Netea, Young Yang, E. Abraham, 2007, Journal of microbiology and biotechnology.

IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist

L. Joosten, M. Netea, C. Dinarello, 2012, Proceedings of the National Academy of Sciences.

Paradoxical effects of constitutive human IL-32γ in transgenic mice during experimental colitis

C. Dinarello, Soohyun Kim, Jaewoo Hong, 2010, Proceedings of the National Academy of Sciences.

Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8

B. Palmer, C. Garlanda, A. Mantovani, 2015, Proceedings of the National Academy of Sciences.

Peripheral Blood Neutrophil Activation Patterns Are Associated with Pulmonary Inflammatory Responses to Lipopolysaccharide in Humans1

E. Abraham, J. Nick, C. Dinarello, 2006, The Journal of Immunology.

This information is current as Lipopolysaccharide in Humans Inflammatory Responses to Patterns Are Associated with Pulmonary Peripheral Blood Neutrophil Activation

E. Abraham, J. Nick, C. Dinarello, 2006 .

Differential expression of interleukin‐32 in chronic rhinosinusitis with and without nasal polyps

A. Peters, C. Dinarello, R. Chandra, 2012, Allergy.

187: Interleukin 37 employs the IL-1 family inhibitory receptor SIGIRR and the alpha chain of the IL-18 receptor to suppress innate immunity

C. Garlanda, A. Mantovani, C. Dinarello, 2013 .

Interleukin-32: a cytokine and inducer of TNFalpha.

D. Yoon, C. Dinarello, Soohyun Kim, 2005, Immunity.

Menke's kinky hair syndrome--a rare medical condition.

T. Azam, Yaseer Al-Bitar, Azam-Jah-Samdani, 2005, JPMA. The Journal of the Pakistan Medical Association.

Lymphangioma circumscriptum: report of three cases from Saudi Arabia

T. Azam, A. Samdani, S. H. Bana, 2006, International journal of dermatology.

Unique expression of a small IL-32 protein in the Jurkat leukemic T cell line.

Soohyun Kim, Jun-Ho Lee, Suyoung Bae, 2008, Cytokine.

Proteinase 3 is an IL-32 binding protein.

Aharon Rabinkov, C. Dinarello, Soohyun Kim, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide.

C. Dinarello, Soohyun Kim, F. Gamboni-Robertson, 2004, The Biochemical journal.

Dexamethasone and OLT1177 Cooperate in the Reduction of Melanoma Growth by Inhibiting STAT3 Functions

C. Dinarello, T. Azam, Nicholas E. Powers, 2023, Cells.

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation

L. Joosten, R. Altman, A. D’Alessandro, 2018, Proceedings of the National Academy of Sciences.

Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.

J. Klawitter, Jihye Kim, A. Tan, 2015, The Journal of clinical investigation.

Protein prenyl transferase activities of Plasmodium falciparum.

D. Chakrabarti, C. M. Allen, Y. Park, 1998, Molecular and biochemical parasitology.

Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation

C. Dinarello, E. Lewis, P. Reddy, 2011, Proceedings of the National Academy of Sciences.

Identification of a Critical Ig-Like Domain in IL-18 Receptor α and Characterization of a Functional IL-18 Receptor Complex 1

D. Yoon, C. Dinarello, Soohyun Kim, 2003, The Journal of Immunology.

Rat interleukin-18 binding protein: cloning, expression, and characterization.

C. Dinarello, Soohyun Kim, S. Fuchs, 2002, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Structural Characteristics of Seven IL-32 Variants

Siyoung Lee, H. Jhun, T. Azam, 2019, Immune network.

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

J. Whisstock, C. Garlanda, A. Mantovani, 2015, Nature Immunology.

Enhanced Interleukin-1 Activity Contributes to Exercise Intolerance in Patients with Systolic Heart Failure

R. Arena, N. Voelkel, J. Canada, 2012, PloS one.

The Progression of SARS Coronavirus 2 (SARS-CoV2): Mutation in the Receptor Binding Domain of Spike Gene

E. Chan, L. Kang, Liping Yu, 2020, Immune network.

Interleukin-37 monomer is the active form for reducing innate immunity

E. Eisenmesser, J. Redzic, J. Kieft, 2019, Proceedings of the National Academy of Sciences.

Interleukin-32A Cytokine and Inducer of TNFα

D. Yoon, C. Dinarello, Soohyun Kim, 2005 .

IL-38 regulates intestinal stem cell homeostasis by inducing WNT signaling and beneficial IL-1β secretion

E. Eisenmesser, J. Redzic, C. Dinarello, 2023, bioRxiv.

Effect of advanced glycation end products on endotoxin-induced TNF-alpha, IL-1beta and IL-8 in human peripheral blood mononuclear cells.

C. Dinarello, T. Niwa, M. Pischetsrieder, 2004, Clinical nephrology.

Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue

D. Seals, G. Cavalli, C. Tack, 2018, The Journal of Biological Chemistry.

Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1β and by the induction of endogenous IL-1Ra

L. Joosten, M. Netea, C. Dinarello, 2015, Annals of the rheumatic diseases.

Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

T. Pitts, W. Messersmith, S. Atif, 2023, Cancer research communications.

Specific Inhibition of Histone Deacetylase 8 Reduces Gene Expression and Production of Proinflammatory Cytokines in Vitro and in Vivo*

A. Abbate, C. Dinarello, G. Fossati, 2014, The Journal of Biological Chemistry.

IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism.

M. Netea, S. Girardin, E. Abraham, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Alpha1-antitrypsin impacts innate host–pathogen interactions with Candida albicans by stimulating fungal filamentation

L. Joosten, M. Netea, M. Gresnigt, 2024, Virulence.

An antibody to IL-1 receptor 7 protects mice from LPS-induced tissue and systemic inflammation

T. Azam, Suzhao Li, Jesús Amo-Aparicio, 2024, Frontiers in immunology.

Interleukin-18 Binding Protein (IL-18BP): A Long Journey From Discovery to Clinical Application

T. Azam, C. A. Dinarello, Soohyun Kim, 2024, Immune network.