L. Knerr

发表

Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents.

A. Plowright, O. Engkvist, A. Gill, 2014, Angewandte Chemie.

Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia.

K. Hansson, O. Fjellström, D. Gustafsson, 2014, Bioorganic & medicinal chemistry letters.

Stapled Vasoactive Intestinal Peptide (VIP) Derivatives Improve VPAC2 Agonism and Glucose-Dependent Insulin Secretion.

A. Gill, Cl Priest, F. Giordanetto, 2013, ACS medicinal chemistry letters.

Therapeutic Potential of Foldamers: From Chemical Biology Tools To Drug Candidates?

R. Gopalakrishnan, E. Valeur, W. Drury, 2016, Journal of medicinal chemistry.

Fluorine-Directed Glycosylation Enables the Stereocontrolled Synthesis of Selective SGLT2 Inhibitors for Type II Diabetes.

Laurent Knerr, Johan Wernevik, Ryan Gilmour, 2018, Chemistry.

Iridium‐Catalyzed Asymmetric Hydrogenation of N ‐Alkyl α‐Aryl Furan‐Containing Imines: an Efficient Route to Unnatural N ‐Alkyl Arylalanines and Related Derivatives.

Magnus J. Johansson, S. Marsden, Rachel Munday, 2018, Advanced Synthesis & Catalysis.

Direct Synthesis of N-Alkyl Arylglycines by Organocatalytic Asymmetric Transfer Hydrogenation of N-Alkyl Aryl Imino Esters.

Magnus J. Johansson, S. Marsden, L. Knerr, 2017, Organic letters.

Design of Selective sPLA2-X Inhibitor (-)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1H-indol-1-yl]pyridine-2-yl}propanoic Acid.

Tomas Åkerud, N. Selmi, E. Hurt-Camejo, 2018, ACS medicinal chemistry letters.

2,6-Quinolinyl derivatives as potent VLA-4 antagonists.

A. Gassama, S. Routier, G. Guillaumet, 2007, Bioorganic & medicinal chemistry letters.

O-Glycosyl trichloroacetimidates bearing Fmoc as temporary hydroxy protecting group: a new access to solid-phase oligosaccharide synthesis.

R. Schmidt, L. Knerr, M. Grathwohl, 2000, Organic letters.

Synthesis of Diverse α-Fluoroalkoxyaryl Derivatives and Their Use for the Generation of Fluorinated Macrocycles.

L. Knerr, A. Dahlén, Thomas J. Cogswell, 2018, Chemistry.

Exploring physicochemical space via a bioisostere of the trifluoromethyl and ethyl groups (BITE): attenuating lipophilicity in fluorinated analogues of Gilenya® for multiple sclerosis.

G. Kehr, L. Knerr, R. Gilmour, 2018, Chemical communications.

Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor.

A. Åstrand, A. Wallberg, N. Selmi, 2013, Bioorganic & medicinal chemistry letters.

Design of a Small Molecule That Stimulates VEGFA Informed from an Expanded Encyclopedia of RNA Fold-Small Molecule Interactions

Hafeez S Haniff, M. Disney, Malin Lemurell, 2019 .

Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists.

Andrew M. White, A. Plowright, D. Craik, 2022, Journal of medicinal chemistry.

Imidazopyridines as VLA-4 integrin antagonists.

A. Ratcliffe, L. Knerr, Benjamin G. Perry, 2008, Bioorganic & medicinal chemistry letters.

Targeted delivery for regenerative medicines: an untapped opportunity for drug conjugates.

E. Valeur, Malin Lemurell, L. Knerr, 2017, Drug discovery today.

Solid‐Phase Synthesis of a Branched Hexasaccharide Related to Lacto‐N‐Hexaose

R. Schmidt, L. Knerr, 2000 .

New synthetic pathway to diverse 2-substituted quinolines based on a multicomponent reaction: solution-phase and solid-phase applications.

P. Pasau, L. Knerr, Thierry Demaude, 2004, Journal of combinatorial chemistry.

Preferential phosphorylation at the primary alcohol of non-protected thymidine or carbohydrates

X. Pannecoucke, L. Knerr, G. Schmitt, 1996 .

Target-Directed Approaches for Screening Small Molecules against RNA Targets

Hafeez S Haniff, Laurent Knerr, Jonathan L Chen, 2020, SLAS discovery : advancing life sciences R & D.

Discovery of AZD2716: A Novel Secreted Phospholipase A2 (sPLA2) Inhibitor for the Treatment of Coronary Artery Disease

N. Selmi, N. Dekker, E. Hurt-Camejo, 2016, ACS medicinal chemistry letters.

Stereocontrolled Synthesis of Tetrafluoropentanols: Multivicinal Fluorinated Alkane Units for Drug Discovery.

C. Daniliuc, K. Bergander, L. Knerr, 2019, Organic letters.

Solid‐Phase Synthesis of Lactose‐Containing Oligosaccharides

R. Schmidt, L. Knerr, F. Roussel, 2001 .

APPLICATION OF A RING CLOSING METATHESIS BASED LINKER TO THE SOLID PHASE SYNTHESIS OF OLIGOSACCHARIDES

R. Schmidt, L. Knerr, 1999 .

Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell.

Richard G. Lee, C. Ämmälä, E. Valeur, 2021, Journal of the American Chemical Society.

Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions

Hafeez S Haniff, Ilyas Yildirim, M. Disney, 2020, Nature Chemistry.

T-type calcium channels inhibitors: a patent review

Laurent Knerr, Fabrizio Giordanetto, A. Wallberg, 2011, Expert opinion on therapeutic patents.

The Conundrum of GSK3 Inhibitors: Is it the Dawn of a New Beginning?

R. Bhat, U. Andersson, L. Knerr, 2018, Journal of Alzheimer's disease : JAD.

Targeted delivery of antisense oligonucleotides to pancreatic β-cells

C. Ämmälä, B. Monia, E. Valeur, 2018, Science Advances.

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.

Philipp M. Cromm, A. Plowright, D. Craik, 2018, Journal of medicinal chemistry.

Discovery of N-(1-adamantyl)-2-(4-alkylpiperazin-1-yl)acetamide derivatives as T-type calcium channel (Cav3.2) inhibitors.

N. Selmi, F. Giordanetto, A. Llinàs, 2011, Bioorganic & medicinal chemistry letters.

Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2 Type X (sPLA2-X) Inhibitors.

Tomas Åkerud, N. Selmi, K. Hallberg, 2018, ACS Medicinal Chemistry Letters.

Discovery of a novel pyrazole series of group X secreted phospholipase A2 inhibitor (sPLA2X) via fragment based virtual screening.

Tomas Åkerud, K. Hallberg, Hongming Chen, 2014, Bioorganic & medicinal chemistry letters.

Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity

Nathaniel G. Martin, Robert D. M. Davies, P. Macfaul, 2013 .

Cover Feature: Fluorine-Directed Glycosylation Enables the Stereocontrolled Synthesis of Selective SGLT2 Inhibitors for Type II Diabetes (Chem. Eur. J. 12/2018)

G. Kehr, L. Knerr, R. Gilmour, 2018 .

Late-Stage Functionalization of Histidine in Unprotected Peptides.

Magnus J. Johansson, R. Gopalakrishnan, E. Valeur, 2019, Angewandte Chemie.

Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework.

Andrew M. White, A. Plowright, D. Craik, 2021, Journal of medicinal chemistry.

A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype.

Hafeez S Haniff, M. Disney, Malin Lemurell, 2021, Cell chemical biology.

Small molecules exploiting structural differences within microRNA-200 precursors family members reverse a type 2 diabetes phenotype

Hafeez S Haniff, M. Disney, Malin Lemurell, 2020, bioRxiv.

EFFICIENT SYNTHESIS OF HYDROPHILIC PHOSPHODIESTER DERIVATIVES OF LIPOPHILIC ALCOHOLS VIA THE GLYCOSYL HYDROGENPHOSPHONATE METHOD

X. Pannecoucke, L. Knerr, B. Luu, 1998 .

Late‐Stage Functionalization of Histidine in Unprotected Peptides

Magnus J. Johansson, R. Gopalakrishnan, E. Valeur, 2019, Angewandte Chemie.

Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents.

A. Plowright, O. Engkvist, A. Gill, 2014, Angewandte Chemie.

Novel, Acidic CCR2 Receptor Antagonists: From Hit to Lead

P. Higgins, J. Eckman, M. Gillard, 2007 .

IA-Lab: A MATLAB framework for efficient microscopy image analysis development, applied to quantifying intracellular transport of internalized peptide-drug conjugate

Yinhai Wang, Laurent Knerr, Adam M Corrigan, 2019, PloS one.