Alexei Brooun

Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain expos

Wei Liu, Huichun Zhu, Dac Dinh, 2014, Journal of medicinal chemistry.

Acquired resistance to crizotinib from a mutation in CD74-ROS1.

Mari Mino-Kenudson, Ryohei Katayama, Sidra Mahmood, 2013, The New England journal of medicine.

Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure‐based drug design

Wei Liu, Ping Chen, Simon Bergqvist, 2014, Protein science : a publication of the Protein Society.

Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant

Huichun Zhu, Benjamin J. Burke, John Charles Kath, 2014 .

Structural and Biophysical Characterization of the EphB4·EphrinB2 Protein-Protein Interaction and Receptor Specificity*

Manfred Auer, Peter Kuhn, Gye Won Han, 2006, Journal of Biological Chemistry.

Identification of Cys255 in HIF‐1α as a novel site for development of covalent inhibitors of HIF‐1α/ARNT PasB domain protein–protein interaction

Ping Chen, Simon Bergqvist, Kevin K-C Liu, 2012, Protein science : a publication of the Protein Society.

An Archaeal Aerotaxis Transducer Combines Subunit I Core Structures of Eukaryotic Cytochrome c Oxidase and Eubacterial Methyl-Accepting Chemotaxis Proteins

M. Alam, T. Freitas, A. Brooun, 1998, Journal of bacteriology.

Crystal Structure of Nonstructural Protein 10 from the Severe Acute Respiratory Syndrome Coronavirus Reveals a Novel Fold with Two Zinc-Binding Motifs

Kin Moy, Raymond C. Stevens, Peter Kuhn, 2006, Journal of Virology.

A Dose-Response Study of Antibiotic Resistance inPseudomonas aeruginosa Biofilms

A. Brooun, K. Lewis, Kim Lewis, 2000, Antimicrobial Agents and Chemotherapy.