J. Baggott

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13C enrichment of carbons 2 and 8 of purine by folate-dependent reactions after [13C]formate and [2-13C]glycine dosing in adult humans.

G. Gorman, J. Baggott, T. Tamura, 2007, Metabolism: clinical and experimental.

Measurement of Erythrocyte Methotrexate Polyglutamate Levels: Ready for Clinical Use in Rheumatoid Arthritis?

D. Arnett, S. L. Bridges, M. Danila, 2010, Current rheumatology reports.

Homocysteine levels in patients with rheumatoid arthritis treated with low‐dose methotrexate

P. Ueland, H. Refsum, S. Morgan, 1991, Clinical pharmacology and therapeutics.

Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs.

S. Morgan, J. Baggott, W. Vaughn, 1992, The Biochemical journal.

Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease prevention.

G. Alarcón, S. Morgan, J. Baggott, 1998, The Journal of rheumatology.

Effect of methotrexate therapy on bone mineral density and body composition in rat adjuvant arthritis.

Dung-Tsa Chen, Dung-Tsa Chen, S. Morgan, 2004, The Journal of rheumatology.

Regulatory Role of Oxidized and Reduced Pteroylpolyglutamates

I. Eto, J. Baggott, C. Krumdieck, 1992, Annals of the New York Academy of Sciences.

Folate supplementation during methotrexate therapy for rheumatoid arthritis.

S. Morgan, J. Baggott, 2010, Clinical and experimental rheumatology.

Bioactivity of orally administered unnatural isomers, [6R]-5-formyltetrahydrofolate and [6S]-5,10-methenyltetrahydrofolate, in humans.

J. Baggott, T. Tamura, 1999, Biochimica et biophysica acta.

Effects of folate deficiency and supplementation on methylnitrosourea-induced rat mammary tumors.

I. Eto, M. Juliana, C. Grubbs, 1992, Journal of the National Cancer Institute.

Folate status of rheumatoid arthritis patients receiving long-term, low-dose methotrexate therapy.

S. Morgan, J. Baggott, M. Altz-Smith, 1987, Arthritis and rheumatism.

Effect of miso (Japanese soybean paste) and NaCl on DMBA-induced rat mammary tumors.

M. Juliana, C. Grubbs, J. M. Hardin, 1990, Nutrition and cancer.

Folate-Dependent Purine Nucleotide Biosynthesis in Humans.

J. Baggott, T. Tamura, 2015, Advances in nutrition.

Phenotypes and circadian rhythm in utilization of formate in purine nucleotide biosynthesis de novo in adult humans.

S. Morgan, G. Gorman, J. Baggott, 2011, Life sciences.

13C-enrichment at carbons 8 and 2 of uric acid after 13C-labeled folate dose in man.

S. Morgan, G. Gorman, J. Baggott, 2007, Biochemical and biophysical research communications.

Urinary adenosine and aminoimidazolecarboxamide excretion in methotrexate-treated patients with psoriasis.

J. Linden, S. Morgan, J. Baggott, 1999, Archives of dermatology.

Iron compounds catalyze the oxidation of 10-formyl-5,6,7,8 tetrahydrofolic acid to 10-formyl-7,8 dihydrofolic acid.

I. Eto, J. Baggott, G. Johanning, 1998, Journal of inorganic biochemistry.

Hydrolysis of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate at pH 2.5 to 4.5.

J. Baggott, 2000, Biochemistry.

The effect of methotrexate and 7-hydroxymethotrexate on rat adjuvant arthritis and on urinary aminoimidazole carboxamide excretion.

S. Morgan, W. Koopman, J. Baggott, 1998, Arthritis and rheumatism.

Homocysteine, Iron and Cardiovascular Disease: A Hypothesis

J. Baggott, T. Tamura, 2015, Nutrients.

Iron-dependent formation of homocysteine from methionine and other thioethers

J. Baggott, T. Tamura, 2007, European Journal of Clinical Nutrition.

Combined oral cyclosporin and methotrexate therapy in patients with rheumatoid arthritis elevates methotrexate levels and reduces 7-hydroxymethotrexate levels when compared with methotrexate alone.

R. Fox, S. Morgan, J. Baggott, 2003, Rheumatology.

Folate supplementation and methotrexate.

G. Alarcón, S. Morgan, W. Koopman, 1993, Annals of the rheumatic diseases.

Long-term treatment of the MRL/lpr mouse with methotrexate and 10-deazaaminopterin

R. Gay, S. Gay, S. Morgan, 2005, Agents and Actions.

The energy cost of adjuvant-induced arthritis in rats.

S. Morgan, J. Baggott, Jodelle R Carlee, 2003, Arthritis and rheumatism.

The form of folate affects the mechanisms of methotrexate resistance in Enterococcus hirae [corrected].

A. Antony, J. Baggott, T. Tamura, 1997, Microbiology.

5,10-methenyltetrahydrofolate cyclohydrolase, rat liver and chemically catalysed formation of 5-formyltetrahydrofolate.

R. Mackenzie, J. Baggott, 2003, The Biochemical journal.

Oxidation of 10-formyltetrahydrofolate to 10-formyldihydrofolate by complex IV of rat mitochondria.

P. Brookes, J. Baggott, 2002, Biochemistry.

Cofactor role for 10-formyldihydrofolic acid.

I. Eto, S. Morgan, C. W. Prince, 1995, The Biochemical journal.

5-aminoimidazole-4-carboxamide ribotide (AICAR) and its metabolites: metabolic and cytotoxic effects and accumulation during methotrexate treatment☆

J. Baggott, T. Ha, 1994 .

Folate conjugase activity in the plasma and tumors of breast-cancer patients.

C. Butterworth, J. Baggott, C. Krumdieck, 1987, The American journal of clinical nutrition.

Methotrexate and sulfasalazine combination therapy: is it worth the risk?

G. Alarcón, S. Morgan, J. Baggott, 1993, Arthritis and rheumatism.

Leucovorin versus folic acid in the treatment of methotrexate toxicity: comment on the article by Shiroky et al.

G. Alarcón, S. Morgan, W. Koopman, 1994, Arthritis and rheumatism.

Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism.

S. Morgan, J. Baggott, 2007, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

High-dosage vitamin E supplementation and all-cause mortality.

J. Baggott, 2005, Annals of internal medicine.

Evidence for the hypothesis that 10-formyldihydrofolate is the in vivo substrate for aminoimidazolecarboxamide ribotide transformylase

J. Baggott, T. Tamura, 2010, Experimental biology and medicine.

Evidence for two phenotypes in the metabolism of methotrexate to 7-hydroxymethotrexate in patients with rheumatoid arthritis.

S. L. Bridges, S. Morgan, J. Baggott, 2005, Arthritis and rheumatism.

trans-alpha, beta-Diformamido-beta-(5'-phosphoribosylamino)acrylamide: a possible new intermediate in de novo purine biosynthesis.

J. Baggott, C. Krumdieck, 1979, Biochemistry.

Supplementation with Folic Acid during Methotrexate Therapy for Rheumatoid Arthritis: A Double-Blind, Placebo-Controlled Trial

G. Alarcón, S. Morgan, W. Koopman, 1994, Annals of Internal Medicine.

Genetic Variants Associated with Methotrexate Efficacy and Toxicity in Early Rheumatoid Arthritis: Results from the Treatment of Early Aggressive Rheumatoid Arthritis Trial

D. Arnett, S. L. Bridges, L. Moreland, 2013, The Pharmacogenomics Journal.

The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis.

G. Alarcón, S. Morgan, J. Baggott, 1990, Arthritis and rheumatism.

Methotrexate in Rheumatoid Arthritis

G. Alarcón, S. Morgan, J. Baggott, 1997, BioDrugs.

10-Formyl-dihydrofolic acid is bioactive in human leukemia cells.

J. Baggott, G. Johanning, 1999, The Journal of nutrition.

The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis.

L. Moreland, R. Desmond, S. Morgan, 2009, Journal of medicinal food.

Folylpoly-gamma-glutamates as cosubstrates of 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase.

C L Krumdieck, J. Baggott, J E Baggott, 1979, Biochemistry.

Bioactivity of [ 6 R ]-5-formyltetrahydrofolate , an unnatural isomer , in humans and Enterococcus hirae , and cytochrome c oxidation of 10-formyltetrahydrofolate to 10-formyldihydrofolate

J. Baggott, C. B. Robinson, K. Johnston, 2022 .

The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis.

G. Alarcón, Jeannette Y Lee, R. Oster, 2004, Arthritis and rheumatism.

Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide.

J. Baggott, W. Vaughn, J E Baggott, 1986, The Biochemical journal.

Effects of tenidap on superoxide-generating enzymes. Non-competitive inhibition of xanthine oxidase.

W. Blackburn, W. Chatham, J. Baggott, 1995, Biochemical pharmacology.

Mass spectrometric method for detecting carbon 13 enrichment introduced by folate coenzymes in uric acid.

G. Gorman, J. Baggott, T. Tamura, 2003, Analytical biochemistry.

Inhibition of human serine proteases by SPAAT, the C-terminal 44-residue peptide from alpha1-antitrypsin.

E. J. Miller, J. Baggott, M. Niemann, 1997, Biochimica et biophysica acta.

Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis

T. Beasley, G. Alarcón, S. L. Bridges, 2006, Annals of the rheumatic diseases.

Re-evaluation of the metabolism of oral doses of racemic carbon-6 isomers of formyltetrahydrofolate in human subjects

J. Baggott, T. Tamura, H. Baker, 2001, British Journal of Nutrition.

Metabolism of 10-formyldihydrofolate in humans.

J. Baggott, T. Tamura, 2001, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Polyglutamyl folate coenzymes and inhibitors of chicken liver glycinamide ribotide transformylase.

J. Baggott, V. Chan, 1982, Biochimica et biophysica acta.

13C-Enrichment of Urinary Uric Acid after l-[Ring-2-13C]Histidine Dose in Adult Humans

J. Baggott, T. Tamura, 2015, Nutrients.

Medical foods: products for the management of chronic diseases.

S. Morgan, J. Baggott, 2006, Nutrition reviews.

The importance of inhibition of a catabolic pathway of methotrexate metabolism in its efficacy for rheumatoid arthritis.

S. Morgan, J. Baggott, 2019, Medical hypotheses.

Meta-analysis of cancer risk in folic acid supplementation trials.

R. Oster, J. Baggott, T. Tamura, 2012, Cancer epidemiology.

Antifolates in rheumatoid arthritis: a hypothetical mechanism of action.

G. Alarcón, S. Morgan, W. Koopman, 1993, Clinical and Experimental Rheumatology.

MTX affects inflammation and tissue destruction differently in the rat AA model.

G. Alarcón, R. Gay, W. Bernreuter, 2001, The Journal of rheumatology.

Folic acid and folinic acid supplementation during low-dose methotrexate therapy for rheumatoid arthritis: comment on the article by van Ede et al.

G. Alarcón, S. Morgan, W. Koopman, 2002, Arthritis and rheumatism.

Folic acid supplementation and methotrexate efficacy: comment on articles by Schiff, Emery et al, and others.

G. Alarcón, S. Morgan, J. Baggott, 2000, Arthritis and rheumatism.

Binding of SPAAT, the 44‐residue C‐terminal peptide of α1‐antitrypsin, to proteins of the extracellular matrix

E. J. Miller, J. Baggott, M. Niemann, 1997, Journal of cellular biochemistry.

Methotrexate therapy in rheumatoid arthritis patients diminishes lectin-induced mononuclear cell proliferation

J. Hardin, W. Koopman, J. Baggott, 2005, Rheumatology International.

Methotrexate catabolism to 7-hydroxymethotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplementation.

S. Morgan, J. Baggott, 2009, Arthritis and rheumatism.

Effect of folic acid supplementation on the efficacy of methotrexate treatment in rheumatoid arthritis: comment on the article by Khanna et al.

G. Alarcón, S. Morgan, J. Baggott, 2006, Arthritis and rheumatism.

Folic acid supplements are good (not bad) for rheumatoid arthritis patients treated with low-dose methotrexate.

S. Morgan, J. Baggott, 2008, American Journal of Clinical Nutrition.

Differences in methotrexate and 7-hydroxymethotrexate inhibition of folate-dependent enzymes of purine nucleotide biosynthesis.

S. Morgan, J. Baggott, W. Vaughn, 1994, The Biochemical journal.

Measurement of Erythrocyte Methotrexate Polyglutamate Levels: Ready for Clinical Use in Rheumatoid Arthritis?

M. Danila, J. Baggott, E. Brown, 2010, Current rheumatology reports.

In vitro formation of homocysteine in whole blood in the presence of anticoagulants.

J. Baggott, T. Tamura, 2008, Clinical chemistry.