M. V. van Roosmalen

发表

Type I signal peptidases of Gram-positive bacteria.

Sierd Bron, Nick Geukens, J. Dubois, 2004, Biochimica et biophysica acta.

Detergent-independent in vitro activity of a truncated Bacillus signal peptidase.

S. Bron, J. V. van Dijl, G. Venemâ, 2001, Microbiology.

Intranasal Delivery of Influenza Subunit Vaccine Formulated with GEM Particles as an Adjuvant

W. Hinrichs, H. Frijlink, A. Huckriede, 2010, The AAPS Journal.

Mucosal vaccine delivery of antigens tightly bound to an adjuvant particle made from food-grade bacteria.

G. Robillard, O. Kuipers, J. Kok, 2006, Methods.

Development of lactococcal GEM-based pneumococcal vaccines.

K. Leenhouts, E. Nieuwenhuis, P. Hermans, 2007, Vaccine.

Gastro-intestinal delivery of influenza subunit vaccine formulation adjuvanted with Gram-positive enhancer matrix (GEM) particles.

W. Hinrichs, H. Frijlink, A. Huckriede, 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Lactococcus lactis GEM particles displaying pneumococcal antigens induce local and systemic immune responses following intranasal immunization.

G. Robillard, K. Leenhouts, P. Hermans, 2006, Vaccine.

Development of a multiplexed bead-based immunoassay for the simultaneous detection of antibodies to 17 pneumococcal proteins

A. van Belkum, M. Rahman, T. Mitchell, 2010, European Journal of Clinical Microbiology & Infectious Diseases.

A Truncated Soluble Bacillus Signal Peptidase Produced in Escherichia coli Is Subject to Self-Cleavage at Its Active Site

S. Bron, J. V. van Dijl, G. Venemâ, 2000, Journal of bacteriology.

A Novel PspA Protein Vaccine Intranasal Delivered by Bacterium-Like Particles Provides Broad Protection Against Pneumococcal Pneumonia in Mice

Yongge Wu, W. Kong, Chunlai Jiang, 2018, Immunological investigations.

Exploiting the peptidoglycan-binding motif, LysM, for medical and industrial applications

J. Kok, G. Buist, K. Leenhouts, 2014, Applied Microbiology and Biotechnology.

Lactococcus lactis as expression host for the biosynthetic incorporation of tryptophan analogues into recombinant proteins.

H. Permentier, K. Leenhouts, M. El Khattabi, 2008, The Biochemical journal.

Novel Surface Display System for Proteins on Non-Genetically Modified Gram-Positive Bacteria

G. Robillard, O. Kuipers, J. Kok, 2006, Applied and Environmental Microbiology.

Bacterium-like particles as multi-epitope delivery platform for Plasmodium berghei circumsporozoite protein induce complete protection against malaria in mice

G. van Gemert, R. Sauerwein, K. Leenhouts, 2012, Malaria Journal.

Influenza antigen-sparing by immune stimulation with Gram-positive enhancer matrix (GEM) particles.

W. Hinrichs, H. Frijlink, A. Huckriede, 2010, Vaccine.

SecDF of Bacillus subtilis, a Molecular Siamese Twin Required for the Efficient Secretion of Proteins*

S. Bron, J. V. van Dijl, W. Quax, 1998, The Journal of Biological Chemistry.

Functional analysis of the secretory precursor processing machinery of Bacillus subtilis: identification of a eubacterial homolog of archaeal and eukaryotic signal peptidases.

S. Bron, W. Schumann, J. V. van Dijl, 1998, Genes & development.

Bacterium-like particles supplemented with inactivated influenza antigen induce cross-protective influenza-specific antibody responses through intranasal administration.

B. Haijema, T. Meijerhof, K. Leenhouts, 2012, Vaccine.

Neonatal mucosal immunization with a non-living, non-genetically modified Lactococcus lactis vaccine carrier induces systemic and local Th1-type immunity and protects against lethal bacterial infection

W. Picking, K. Leenhouts, M. Pasetti, 2009, Mucosal Immunology.

Shigella IpaB and IpaD displayed on L. lactis bacterium-like particles induce protective immunity in adult and infant mice

W. Blackwelder, W. Picking, K. Leenhouts, 2015, Immunology and cell biology.

A Protective and Safe Intranasal RSV Vaccine Based on a Recombinant Prefusion-Like Form of the F Protein Bound to Bacterium-Like Particles

P. Rottier, C. D. de Haan, B. Haijema, 2013, PloS one.

Inactivated influenza vaccine adjuvanted with bacterium-like particles induce systemic and mucosal influenza A virus specific T-cell and B-cell responses after nasal administration in a TLR2 dependent fashion.

W. van Eden, B. Haijema, C. Keijzer, 2014, Vaccine.

Exploiting the peptidoglycan-binding motif, LysM, for medical and industrial applications

J. Kok, G. Buist, K. Leenhouts, 2014, Applied Microbiology and Biotechnology.

Local and Systemic Immunity Against RSV Induced by a Novel Intranasal Vaccine: A Randomised, Double- Blind, Placebo-Controlled Trial.

B. Haijema, C. Chiu, P. Openshaw, 2019, American journal of respiratory and critical care medicine.

Distinction between Major and Minor Bacillus Signal Peptidases Based on Phylogenetic and Structural Criteria*

J. Dubois, S. Bron, J. V. van Dijl, 2001, The Journal of Biological Chemistry.

Biophysical characterization of the type III secretion tip proteins and the tip proteins attached to bacterium-like particles.

S. Joshi, W. Picking, W. Picking, 2015, Journal of pharmaceutical sciences.

A Combined YopB and LcrV Subunit Vaccine Elicits Protective Immunity against Yersinia Infection in Adult and Infant Mice

C. Drachenberg, W. Picking, K. Leenhouts, 2019, The Journal of Immunology.

Biophysical Characterization of the Type III Secretion System Translocator Proteins and the Translocator Proteins Attached to Bacterium-Like Particles.

W. Picking, W. Picking, K. Leenhouts, 2015, Journal of Pharmacy and Science.

Monitoring lysin motif-ligand interactions via tryptophan analog fluorescence spectroscopy.

D. Petrović, K. Leenhouts, M. V. van Roosmalen, 2012, Analytical biochemistry.

Novel Surface Display System for Proteins on Non-Genetically Modified Gram-Positive Bacteria

G. Robillard, O. Kuipers, J. Kok, 2006, Applied and Environmental Microbiology.

Biophysical Characterization of the Type III Secretion System Translocator Proteins and the Translocator Proteins Attached to Bacterium-Like Particles.

W. Picking, W. Picking, K. Leenhouts, 2015, Journal of pharmaceutical sciences.