Patrick M Sexton

发表

Ruben Abagyan, Arthur Christopoulos, John Simms, 2009, Methods in molecular biology.

Novel Allosteric Modulators of G Protein-coupled Receptors*

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2015, The Journal of Biological Chemistry.

Bridging the gap: bitopic ligands of G-protein-coupled receptors.

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2013, Trends in pharmacological sciences.

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands*

Arthur Christopoulos, Patrick M Sexton, Michael W Parker, 2007, Journal of Biological Chemistry.

Molecular Determinants of Allosteric Modulation at the M1 Muscarinic Acetylcholine Receptor*

Arthur Christopoulos, Patrick M Sexton, Laura López, 2014, The Journal of Biological Chemistry.

Towards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho)physiological bias.

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2015, Trends in pharmacological sciences.

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

Arthur Christopoulos, Laurence J Miller, Patrick M Sexton, 2013, Proceedings of the National Academy of Sciences.

Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping

Ruben Abagyan, Laurence J Miller, Patrick M Sexton, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Allosteric modulation of G protein-coupled receptors.

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2007, Annual review of pharmacology and toxicology.

A Novel Mechanism of G Protein-coupled Receptor Functional Selectivity

Arthur Christopoulos, Nathan E Hall, Patrick M Sexton, 2008, Journal of Biological Chemistry.

Functional Importance of a Structurally Distinct Homodimeric Complex of the Family B G Protein-Coupled Secretin Receptor

Ruben Abagyan, Arthur Christopoulos, Laurence J Miller, 2009, Molecular Pharmacology.

4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.

Arthur Christopoulos, Patrick M Sexton, Ben Capuano, 2016, Journal of Medicinal Chemistry.

The receptor activity modifying protein family of G protein coupled receptor accessory proteins.

Patrick M Sexton, Debbie L Hay, P. Sexton, 2004, Seminars in cell & developmental biology.

Constitutive Formation of Oligomeric Complexes between Family B G Protein-Coupled Vasoactive Intestinal Polypeptide and Secretin Receptors

Laurence J Miller, Patrick M Sexton, P. Sexton, 2006, Molecular Pharmacology.

Identification of Orthosteric and Allosteric Site Mutations in M2 Muscarinic Acetylcholine Receptors That Contribute to Ligand-selective Signaling Bias*

Arthur Christopoulos, Nathan E Hall, Patrick M Sexton, 2010, The Journal of Biological Chemistry.

A kinetic view of GPCR allostery and biased agonism.

Arthur Christopoulos, Patrick M Sexton, Robert G Parton, 2017, Nature chemical biology.

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor

Ruben Abagyan, Arthur Christopoulos, Irina Kufareva, 2016, Cell Research.

Molecular Basis of Secretin Docking to Its Intact Receptor Using Multiple Photolabile Probes Distributed throughout the Pharmacophore*

Ruben Abagyan, Laurence J Miller, Patrick M Sexton, 2011, The Journal of Biological Chemistry.

Structure-function studies of muscarinic acetylcholine receptors.

Arthur Christopoulos, Patrick M Sexton, John Simms, 2012, Handbook of experimental pharmacology.

Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs.

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2009, Molecular interventions.

Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes.

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2009, Journal of medicinal chemistry.

Refinement of Glucagon-like Peptide 1 Docking to Its Intact Receptor Using Mid-region Photolabile Probes and Molecular Modeling*

Ruben Abagyan, Laurence J Miller, Patrick M Sexton, 2011, The Journal of Biological Chemistry.

RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function.

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2008, Pharmacology & therapeutics.

Comparative genotypic and phenotypic analysis of human peripheral blood monocytes and surrogate monocyte-like cell lines commonly used in metabolic disease research

Christopher J Langmead, Patrick M Sexton, C. Langmead, 2018, PloS one.

The role of kinetic context in apparent biased agonism at GPCRs

Arthur Christopoulos, Patrick M Sexton, Jonathan A Javitch, 2016, Nature Communications.

Photoaffinity scanning in the mapping of the peptide receptor interface of class II G protein—coupled receptors

Patrick M Sexton, P. Sexton, V I Pham, 2004, Journal of peptide science : an official publication of the European Peptide Society.

Endogenous Allosteric Modulators of G Protein–Coupled Receptors

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2015, The Journal of Pharmacology and Experimental Therapeutics.