H. Hirota

发表

Cross-talk between bone morphogenetic protein 2 and leukemia inhibitory factor through ERK 1/2 and Smad1 in protection against doxorubicin-induced injury of cardiomyocytes.

M. Hori, I. Kawase, M. Izumi, 2006, Journal of molecular and cellular cardiology.

Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes.

Y. Fujio, T. Kishimoto, K. Yamauchi-Takihara, 1997, The Journal of clinical investigation.

Activation of Phosphatidylinositol 3-Kinase through Glycoprotein 130 Induces Protein Kinase B and p70 S6 Kinase Phosphorylation in Cardiac Myocytes*

Y. Fujio, T. Kishimoto, H. Matsui, 1998, The Journal of Biological Chemistry.

Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors

T. Martin, N. Udagawa, N. Takahashi, 1995, The Journal of experimental medicine.

Antiarrhythmic effects of eicosapentaenoic acid during myocardial infarction--enhanced cardiac microsomal (Ca(2+)-Mg2+)-ATPase activity.

S. Otsuji, K. Itoh, H. Hirota, 1994, Japanese circulation journal.

Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.

T. Kishimoto, K. Yoshida, T. Taga, 1995, Proceedings of the National Academy of Sciences of the United States of America.

AMP-Activated Protein Kinase Protects Cardiomyocytes against Hypoxic Injury through Attenuation of Endoplasmic Reticulum Stress

M. Hori, I. Kawase, M. Masaki, 2005, Molecular and Cellular Biology.

Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from Hypoxia/Reoxygenation-Induced Oxidative Stress Through the Upregulation of Manganese Superoxide Dismutase

Y. Fujio, T. Kishimoto, S. Negoro, 2001, Circulation.

gp130 signaling pathways: Recent advances and implications for cardiovascular disease.

T. Kishimoto, K. Yoshida, T. Taga, 1996, Trends in cardiovascular medicine.

Bcl-xl reduces doxorubicin-induced myocardial damage but fails to control cardiac gene downregulation.

Y. Fujio, S. Negoro, Y. Nakaoka, 2002, Cardiovascular research.

Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma

H. Kiyama, T. Kishimoto, T. Taga, 1996, The Journal of experimental medicine.

STATs in the Cardiovascular System

K. Chien, H. Hirota, H. Yasukawa, 2003 .

SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene.

I. Komuro, T. Hirano, N. Mochizuki, 2010, Journal of molecular and cellular cardiology.

Scaffolding / Docking Protein Gab 1 With Tyrosine Phosphatase SHP 2 in Cardiomyocytes Activation of gp 130 Transduces Hypertrophic Signal Through Interaction of

T. Hirano, I. Kawase, Y. Fujio, 2003 .

Activation of gp 130 Transduces Hypertrophic Signal Through Interaction of Scaffolding / Docking Protein Gab 1 With Tyrosine Phosphatase SHP 2 in Cardiomyocytes

T. Hirano, I. Kawase, Y. Fujio, 2003 .

Activation of gp130 Transduces Hypertrophic Signal Through Interaction of Scaffolding/Docking Protein Gab1 With Tyrosine Phosphatase SHP2 in Cardiomyocytes

T. Hirano, I. Kawase, Y. Fujio, 2003, Circulation research.

A Novel Role for Cytokine Signaling in Cardiac Remodeling

Y. Fujio, Y. Nakaoka, M. Izumi, 2003 .

Leukemia inhibitory factor induces a hypertrophic response mediated by gp130 in murine cardiac myocytes.

Y. Fujio, H. Matsui, K. Yamauchi-Takihara, 1996, Research communications in molecular pathology and pharmacology.

Protects Cardiomyocytes From Ischemia-Reperfusion Injury

I. Kawase, M. Kitakaze, Y. Nakaoka, 2005 .

Smad 1 Protects Cardiomyocytes From Ischemia-Reperfusion Injury

I. Kawase, M. Kitakaze, Y. Nakaoka, 2005 .

Aldosterone augments endothelin‐1‐induced cardiac myocyte hypertrophy with the reinforcement of the JNK pathway

I. Kawase, Y. Fujio, S. Negoro, 2002, FEBS letters.

The Interleukin-6 Family of Cytokines and their Receptors in Patients with Congestive Heart Failure

M. Izumi, K. Yamauchi-Takihara, H. Hirota, 2003 .

Carbacyclin induces carnitine palmitoyltransferase-1 in cardiomyocytes via peroxisome proliferator-activated receptor (PPAR) delta independent of the IP receptor signaling pathway.

M. Hori, Y. Fujio, K. Yamauchi-Takihara, 2007, Journal of molecular and cellular cardiology.

A case of hypereosinophilic syndrome presenting mid-ventricular obstruction

Y. Fujio, Y. Nakaoka, M. Izumi, 2002, Heart and Vessels.

Novel insertional mutation in the bone morphogenetic protein receptor type II associated with sporadic primary pulmonary hypertension.

M. Hori, I. Kawase, Y. Fujio, 2004, Circulation journal : official journal of the Japanese Circulation Society.

Roles of gp130 signaling pathways in cardiac myocytes: recent advances and implications for cardiovascular disease.

Y. Fujio, T. Kishimoto, T. Taga, 1996, Journal of cardiac failure.

Sildenafil as adjunct therapy to high-dose epoprostenol in a patient with pulmonary veno-occlusive disease.

K. Yamauchi-Takihara, M. Masaki, T. Kuroda, 2006, Heart, lung & circulation.

Specific cardiomyopathy caused by multisystemic lipid storage in Jordans' anomaly.

I. Kawase, Y. Nakaoka, S. Hasegawa, 2003, Internal medicine.

Effect of bosentan on plasma endothelin-1 concentration in patients with pulmonary arterial hypertension.

M. Hori, Y. Fujio, K. Yamauchi-Takihara, 2007, Circulation journal : official journal of the Japanese Circulation Society.

Physiological and pathological role of gp130, a common signal transducer for IL-6-family of cytokines

T. Kishimoto, T. Taga, H. Hirota, 1996 .

The effect on immunoglobulin glycosylation of altering in vivo production of immunoglobulin G

P. Delves, M. Chesnutt, D. Wofsy, 1999, Immunology.

Cardiac-specific Activation of Signal Transducer and Activator of Transcription 3 Promotes Vascular Formation in the Heart*

I. Kawase, M. Okabe, Y. Fujio, 2002, The Journal of Biological Chemistry.

Signal Transducer and Activator of Transcription 3 Is Required for Glycoprotein 130-mediated Induction of Vascular Endothelial Growth Factor in Cardiac Myocytes*

Y. Fujio, T. Kishimoto, S. Negoro, 2000, The Journal of Biological Chemistry.

Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130.

T. Kishimoto, K. Yoshida, T. Taga, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Interleukin ( IL )-6 Induc t ion o f Osteoclast Dif ferent iat

T. Martin, N. Udagawa, N. Takahashi, 2003 .

Interaction of Scaffolding Adaptor Protein Gab1 with Tyrosine Phosphatase SHP2 Negatively Regulates IGF-I-dependent Myogenic Differentiation via the ERK1/2 Signaling Pathway*

T. Hirano, M. Hori, N. Mochizuki, 2008, Journal of Biological Chemistry.

Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling.

T. Kodama, T. Hirano, K. Otsu, 2007, The Journal of clinical investigation.

Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes.

Y. Fujio, T. Kishimoto, H. Matsui, 1996, Circulation.

Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure

Y. Fujio, Y. Nakaoka, M. Izumi, 2004, Heart and Vessels.

Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress

J. Ross, K. Rajewsky, Yusu Gu, 1999, Cell.

Bone Morphogenetic Protein-2 Inhibits Serum Deprivation-induced Apoptosis of Neonatal Cardiac Myocytes through Activation of the Smad1 Pathway*

Y. Fujio, T. Kishimoto, S. Negoro, 2001, The Journal of Biological Chemistry.

Smad1 Protects Cardiomyocytes From Ischemia-Reperfusion Injury

I. Kawase, M. Kitakaze, Y. Nakaoka, 2005, Circulation.

Images in cardiovascular medicine. Specific cardiomyopathy caused by multisystemic lipid storage in Jordan's anomaly.

I. Kawase, Y. Fujio, Y. Nakaoka, 2002, Circulation.

Haplotype of thrombomodulin gene associated with plasma thrombomodulin level and deep vein thrombosis in the Japanese population.

Y. Kokubo, I. Kawase, T. Miyata, 2007, Thrombosis research.

Solitary right ventricle metastasis by renal cell carcinoma.

I. Kawase, Y. Tomita, N. Hosen, 2004, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

Highly purified eicosapentaenoic acid attenuates tissue damage in experimental myocardial infarction.

S. Otsuji, H. Hirota, N. Shibata, 1993, Japanese circulation journal.

Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from Hypoxia/Reoxygenation-Induced Oxidative Stress Through the Upregulation of Manganese Superoxide Dismutase

Y. Fujio, T. Kishimoto, S. Negoro, 2001, Circulation.