Kathryn J Wicht

发表

Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity.

T. Egan, Jill M Combrinck, Peter J. Smith, 2015, Bioorganic & medicinal chemistry.

The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance

E. Winzeler, K. Chibale, E. Istvan, 2021, Cell Chemical Biology.

Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites

R. F. Campbell, E. Winzeler, S. Meister, 2021, Scientific Reports.

Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.

K. Chibale, T. Egan, Dale Taylor, 2020, Journal of medicinal chemistry.

Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria.

D. Fidock, K. Wicht, S. Mok, 2020, Annual review of microbiology.

Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity

E. Winzeler, M. Bösche, K. Chibale, 2020, Cell chemical biology.

Structure and Drug Resistance of the Plasmodium falciparum Transporter PfCRT

Yong Zi Tan, P. Roepe, D. Fidock, 2019, Nature.

Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.

C. Eyermann, K. Chibale, Dale Taylor, 2018, Journal of medicinal chemistry.

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

D. Fidock, L. Ross, Satish K. Dhingra, 2018, Nature Communications.

Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.

K. Chibale, Dale Taylor, K. Wicht, 2018, Journal of medicinal chemistry.

Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches

T. Egan, Kathryn J Wicht, Kathryn J. Wicht, 2023, Scientific Reports.

Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum.

Philip Smith, T. Egan, Jill M Combrinck, 2016, Journal of medicinal chemistry.

Identification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity

T. Egan, D. Wright, Kathryn J Wicht, 2014, International journal for parasitology. Drugs and drug resistance.

Identi fi cation and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum

T. Egan, Jill M Combrinck, Peter J. Smith, 2016 .

Antimalarial drug discovery: progress and approaches

E. Winzeler, K. Chibale, D. Fidock, 2023, Nature Reviews Drug Discovery.

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance

M. Eppstein, P. Roepe, D. Fidock, 2022, PLoS pathogens.

Synthesis and antimalarial testing of neocryptolepine analogues: addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines.

T. Egan, K. Wicht, M. Kaiser, 2013, European journal of medicinal chemistry.

Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.

K. Chibale, T. Egan, C. Masimirembwa, 2015, Bioorganic & medicinal chemistry.

Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity.

Vipan Kumar, J. Gut, P. Rosenthal, 2014, European journal of medicinal chemistry.

Identification and Deconvolution of Cross-Resistance Signals from Antimalarial Compounds Using Multidrug-Resistant Plasmodium falciparum Strains

E. Bilsland, T. Egan, D. V. van Schalkwyk, 2014, Antimicrobial Agents and Chemotherapy.