A. Naldini

I. Filippi, G. Cirino, A. Pucci, 2006, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

The thrombin peptide, TP508, enhances cytokine release and activates signaling events

C. Baldari, S. R. Paccani, F. Carraro, 2004, Peptides.

Inhibition of interleukin‐12 expression by α‐thrombin in human peripheral blood mononuclear cells: a potential mechanism for modulating Th1/Th2 responses

L. Aarden, A. Pucci, F. Carraro, 2003, British journal of pharmacology.

Investigating the Benefit of Combined Androgen Modulation and Hypofractionation in Prostate Cancer

A. Tesei, A. Sarnelli, C. Arienti, 2020, International journal of molecular sciences.

Thrombin receptor expression and responsiveness of human monocytic cells to thrombin is linked to interferon‐induced cellular differentiation

L. Sower, A. Naldini, D. Carney, 1998, Journal of cellular physiology.

Studies on tumor necrosis factor (TNF)--I. Pharmacokinetics of human recombinant TNF in rabbits and monkeys after intravenous administration.

G. Pessina, A. Naldini, E. Maioli, 1987, General pharmacology.

Interleukin 2 inhibits in vitro granulocyte-macrophage colony formation.

Z. Ballas, G. Klimpel, A. Naldini, 1987, Journal of immunology.

Transforming growth factor-Plasma levels of immunosuppressive mediators during cardiopulmonary bypass

E. Luzzi, P. Giomarelli, A. Naldini, 2014 .

Hypoxia enhances the antiviral activity of interferons.

F. Carraro, A. Naldini, W. R. Fleischmann, 1993, Journal of interferon research.

Role of the Hedgehog Pathway and CAXII in Controlling Melanoma Cell Migration and Invasion in Hypoxia

I. Filippi, A. Falsini, F. Carraro, 2022, Cancers.

Alanine kinetics in humans during low-intensity exercise.

R. Wolfe, F. Carraro, A. Naldini, 1994, Medicine and science in sports and exercise.

Neuroglobin in Breast Cancer Cells: Effect of Hypoxia and Oxidative Stress on Protein Level, Localization, and Anti-Apoptotic Function

P. Ascenzi, M. Marino, C. Verde, 2016, PloS one.

Effects of hypoxia on the antiproliferative activity of human interferons.

F. Carraro, A. Naldini, V. Bocci, 1995, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Thrombin enhancement of interleukin-1 expression in mononuclear cells: involvement of proteinase-activated receptor-1.

A. Pucci, F. Carraro, A. Naldini, 2002, Cytokine.

Regulation of angiogenesis by Th1- and Th2-type cytokines.

A. Pucci, F. Carraro, A. Naldini, 2003, Current pharmaceutical design.

The lymphatic route--III. Pharmacokinetics of human natural interferon-beta injected with albumin as a retarder in rabbits.

M. Muscettola, A. Naldini, V. Bocci, 1986, General pharmacology.

The lymphatic route--II. Pharmacokinetics of human recombinant interferon-alpha 2 injected with albumin as a retarder in rabbits.

G. Segre, M. Muscettola, A. Naldini, 1986, General pharmacology.

Thrombin regulates the expression of proangiogenic cytokines via proteolytic activation of protease-activated receptor-1.

A. Pucci, F. Carraro, A. Naldini, 2000, General pharmacology.

Thrombin enhances T cell proliferative responses and cytokine production.

G. Klimpel, A. Naldini, D. Carney, 1993, Cellular immunology.

Mouse dendritic cells in the steady state: Hypoxia, autophagy, and stem cell factor

T. Colombo, I. Filippi, A. Santoni, 2022, Cell Biochemistry and Function.

Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia Cells

F. Manetti, M. Taddei, M. Ruat, 2016, PloS one.

In vitro cytokine production and T-cell proliferation in patients undergoing cardiopulmonary by-pass.

P. Giomarelli, A. Naldini, E. Borrelli, 1995, Cytokine.

Thrombin‐mediated IL‐10 up‐regulation involves protease‐activated receptor (PAR)‐1 expression in human mononuclear leukocytes

A. Pucci, F. Carraro, A. Naldini, 2005, Journal of leukocyte biology.

Interferon levels in human pulmonary tumors are lower than plasma levels.

P. Giomarelli, F. Carraro, A. Naldini, 1990, Journal of biological regulators and homeostatic agents.

Colorectal administration of human interferon-α

F. Corradeschi, A. Naldini, V. Bocci, 1985 .

Pharmacokinetics of human lymphoblastoid interferon in rabbits.

G. Pessina, G. Lunghetti, M. Muscettola, 1985, General pharmacology.

Analysis of protease‐activated receptor‐1 and ‐2 in human scar formation

D. Massi, M. Paglierani, M. Santucci, 2007, The Journal of pathology.

Heparin Coating of Extracorporeal Circuits Inhibits Cytokine Release from Mononuclear Cells during Cardiac Operations

B. Biagioli, P. Giomarelli, A. Naldini, 2000, The International journal of artificial organs.

Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines.

M. Trincavelli, C. Martini, C. Brullo, 2008, Journal of medicinal chemistry.

2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors.

E. Dreassi, I. Filippi, S. Schenone, 2010, European journal of medicinal chemistry.

New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation.

P. Fossa, C. Brullo, S. Schenone, 2004, Bioorganic & medicinal chemistry letters.

Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation.

M. Modugno, P. Fossa, C. Tintori, 2006, Journal of medicinal chemistry.

Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study.

M. Radi, C. Tintori, F. Musumeci, 2011, Journal of medicinal chemistry.

Protease‐activated receptor‐2 downregulation is associated to vitiligo lesions

D. Massi, I. Filippi, A. Pacini, 2009, Pigment cell & melanoma research.

Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma.

M. Hollenberg, D. Massi, A. Franchi, 2005, Human pathology.

The lymphatic route. IV. Pharmacokinetics of human recombinant interferon α2 and natural interferon β administered intradermally in rabbits

M. Muscettola, A. Naldini, V. Bocci, 1986 .

Hypoxia influences the cellular cross-talk of human dermal fibroblasts. A proteomic approach.

R. Tiozzo, P. Sommer, D. Quaglino, 2007, Biochimica et biophysica acta.

GM-CSF Inhibits c-Kit and SCF Expression by Bone Marrow-Derived Dendritic Cells

I. Filippi, A. Santoni, U. Tarantino, 2017, Front. Immunol..

Identification of thrombin-like activity in ovarian cancer associated ascites and modulation of multiple cytokine networks

P. Allavena, R. Giavazzi, F. Carraro, 2011, Thrombosis and Haemostasis.

p66SHC Promotes Apoptosis and Antagonizes Mitogenic Signaling in T Cells

P. Pelicci, C. Baldari, L. Patrussi, 2004, Molecular and Cellular Biology.

High-pressure oxygen rewires glucose metabolism of patient-derived glioblastoma cells and fuels inflammasome response.

A. Tesei, D. Bartolini, A. Sarnelli, 2021, Cancer letters.

The effects of autologous platelet gel on inflammatory cytokine response in human peripheral blood mononuclear cells

M. Fimiani, F. Carraro, A. Naldini, 2008, Platelets.

The Shc protein RAI promotes an adaptive cell survival program in hypoxic neuroblastoma cells

I. Filippi, C. Aldinucci, F. Carraro, 2018, Journal of cellular physiology.

Plasma levels of immunosuppressive mediators during cardiopulmonary bypass

E. Luzzi, P. Giomarelli, A. Naldini, 1996, Mediators of inflammation.

Different Adaptive Responses to Hypoxia in Normal and Multiple Myeloma Endothelial Cells

I. Filippi, A. Vacca, R. Ria, 2018, Cellular Physiology and Biochemistry.

Cutting Edge: IL-1β Mediates the Proangiogenic Activity of Osteopontin-Activated Human Monocytes1

D. Ribatti, B. Nico, M. Presta, 2006, The Journal of Immunology.

Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migration

I. Filippi, F. Carraro, A. Naldini, 2018, Journal of cellular physiology.

A Ribonuclease Protection Assay-based Approach for Analysis of Angiogenic Gene Expression in Archival Tissues

D. Massi, A. Franchi, M. Santucci, 2007, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

Short‐Term Hypoxia Enhances the Migratory Capability of Dendritic Cell Through HIF‐1α and PI3K/Akt Pathway

I. Filippi, S. Sozzani, C. Aldinucci, 2014, Journal of cellular physiology.

Identification of a functional role for the protease-activated receptor-1 in hypoxic breast cancer cells.

I. Filippi, R. Giavazzi, F. Carraro, 2009, European journal of cancer.

Role of inflammatory mediators in angiogenesis.

F. Carraro, A. Naldini, 2005, Current drug targets. Inflammation and allergy.

CA-IX-Expressing Small Extracellular Vesicles (sEVs) Are Released by Melanoma Cells under Hypoxia and in the Blood of Advanced Melanoma Patients

A. Falsini, F. Carraro, A. Naldini, 2023, International journal of molecular sciences.

Inhibition of Bcr‐Abl Phosphorylation and Induction of Apoptosis by Pyrazolo[3,4‐d]pyrimidines in Human Leukemia Cells

C. Brullo, G. Maga, S. Schenone, 2007, ChemMedChem.

Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism.

D. Massi, M. Santucci, N. Marchionni, 2007, Basic & clinical pharmacology & toxicology.

The lymphatic route. 1) Albumin and hyaluronidase modify the normal distribution of interferon in lymph and plasma

M. Muscettola, G. Grasso, M. Muscettola, 1986, Experientia.

Interplay between Hypoxia and Extracellular Vesicles in Cancer and Inflammation

F. Carraro, A. Naldini, M. Criscuoli, 2021, Biology.

In vivo myelosuppression by combination interferon treatment: antagonism of MuIFN-gamma and MuIFN-beta myelosuppressive effects.

A. Naldini, W. R. Fleischmann, 1987, Journal of biological response modifiers.

Role of the hypoxic microenvironment in the antitumor activity of tyrosine kinase inhibitors.

I. Filippi, F. Carraro, A. Naldini, 2011, Current medicinal chemistry.

Inducible nitric oxide synthase activity correlates with lymphangiogenesis and vascular endothelial growth factor‐C expression in head and neck squamous cell carcinoma

L. Magnelli, E. Fanti, E. Masini, 2006, The Journal of pathology.

Protease-activated receptor-1 (PAR-1) promotes the motility of human melanomas and is associated to their metastatic phenotype

S. Bernasconi, R. Giavazzi, P. Oliva, 2009, Clinical & Experimental Metastasis.

The adaptor protein p66shc is a positive regulator in the angiogenic response induced by hypoxic T cells

D. Ribatti, P. Pelicci, C. Baldari, 2010, Journal of leukocyte biology.

Carbonic anhydrase XII expression is linked to suppression of Sonic hedgehog ligand expression in triple negative breast cancer cells.

I. Filippi, J. Pouysségur, J. Durivault, 2019, Biochemical and biophysical research communications.

PRO-ANGIOGENIC PROPERTIES OF ALTERNATIVELY ACTIVATED DENDRITIC CELLS.

S. Bernasconi, I. Filippi, S. Sozzani, 2005 .

Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK-3 activation and PD-1 expression

C. Baldari, C. Ulivieri, A. Taddei, 2023, bioRxiv.

3D QSAR Models Built on Structure‐Based Alignments of Abl Tyrosine Kinase Inhibitors

Fabrizio Manetti, Maurizio Botta, Silvia Schenone, 2009, ChemMedChem.

Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells.

P. Fossa, C. Brullo, S. Schenone, 2004, Journal of medicinal chemistry.

THROMBIN ENHANCES T CELL ACTIVATION

A. Naldini, D. Carney, V. Bocci, 1991 .

Downregulation of hypoxia-related responses by novel antitumor histone deacetylase inhibitors in MDAMB231 breast cancer cells.

I. Filippi, E. Cini, M. Rodriquez, 2012, Anti-cancer agents in medicinal chemistry.

Thrombin modulation of natural killer activity in human peripheral lymphocytes.

A. Naldini, D. Carney, 1996, Cellular Immunology.

Interleukin-1β regulates the migratory potential of MDAMB231 breast cancer cells through the hypoxia-inducible factor-1α.

I. Filippi, R. Giavazzi, M. Moschetta, 2010, European journal of cancer.

Recent Advances in Angiogenesis and Antiangiogenesis

E. Crivellato, D. Ribatti, R. Kerbel, 2018 .

The Shc protein RAI promotes an adaptive cell survival program in hypoxic neuroblastoma cells

I. Filippi, C. Aldinucci, F. Carraro, 2018, Journal of cellular physiology.

METABOLISM AND PHARMACOKINETICS OF BIOLOGICAL RESPONSE MODIFIERS (BRMS)

L. Paulesu, F. Carraro, A. Naldini, 1990 .