Sonnet S. Davis

发表

Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis.

A. Ramanathan, J. Campisi, F. Alimirah, 2019, JCI insight.

High-Throughput Liquid Chromatography–Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II

K. Gunasekaran, S. Poda, G. Astarita, 2020, International journal of molecular sciences.

Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease

Nicholas E. Propson, R. Maciuca, K. Scearce-Levie, 2022, Science Translational Medicine.

Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.

Dong Eun Kim, A. Ramanathan, J. Campisi, 2021, Cell metabolism.

Association of caffeine and related analytes with resistance to Parkinson disease among LRRK2 mutation carriers

R. Maciuca, A. Ascherio, G. Astarita, 2020, Neurology.

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

Katrina W. Lexa, B. Boeve, H. Rosen, 2021, Cell.

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

Steve Lianoglou, T. Sandmann, S. Poda, 2019, Neuron.

JNK modifies neuronal metabolism to promote proteostasis and longevity

S. Ghaemmaghami, A. Ramanathan, G. Juhász, 2019, Aging cell.

Metformin extends the lifespan of iMSUD mice by rescuing physiologic dysfunction and modulating mechanisms of mTORC1 activation

Chen-Yu Liao, B. Kennedy, A. Ramanathan, 2020 .

Fibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock-in mouse model

Julie A. Harris, Jennifer D. Whitesell, K. Scearce-Levie, 2021, bioRxiv.

Measurement of Metabolite Changes in Senescent Cells by Mass Spectrometry.

A. Ramanathan, Christopher D Wiley, Sonnet S. Davis, 2018, Methods in molecular biology.

LRRK2 Kinase Activity Regulates Parkinson’s Disease-Relevant Lipids at the Lysosome

Nicholas E. Propson, Michelle L. Reyzer, R. Maciuca, 2022, bioRxiv.

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.

M. Velarde, A. Ramanathan, E. Verdin, 2016, Cell metabolism.

Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

T. Sandmann, L. Przybyla, G. Astarita, 2020, Nature Neuroscience.

Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila.

Subhash D. Katewa, Rachel B. Brem, A. Ramanathan, 2016, Cell metabolism.

Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

T. Sandmann, L. Przybyla, G. Astarita, 2020, Nature Neuroscience.

Characterization of Fluid Biomarkers Reveals Lysosome Dysfunction and Neurodegeneration in Neuronopathic MPS II Patients

K. Scearce-Levie, G. Astarita, M. Troyer, 2020, International journal of molecular sciences.

Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice

Adam P. Silverman, Jennifer A. Getz, Michelle L. Reyzer, 2020, Science Translational Medicine.

A novel AhR ligand, 2AI, protects the retina from environmental stress

A. Ramanathan, G. Perdew, J. Neves, 2016, Scientific Reports.

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

Nicholas E. Propson, K. Scearce-Levie, Steve Lianoglou, 2023, Nature Neuroscience.

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

Julie A. Harris, Jennifer D. Whitesell, K. Scearce-Levie, 2022, Molecular neurodegeneration.

Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.

Dylan J. Sorensen, Rachel B. Brem, T. Oron, 2016, Cell reports.

DNL310 normalizes primary storage substrates and biomarkers of lysosomal dysfunction in neuronopathic MPS II: 2-year interim analysis of a phase 1/2 study

A. Bakardjiev, M. Troyer, Akhil Bhalla, 2023, Molecular Genetics and Metabolism.

Rescue of FTLD-associated TDP-43 pathology and neurodegeneration by peripheral AAV-mediated expression of brain-penetrant progranulin

T. Sandmann, M. Simon, C. Haass, 2023, bioRxiv.

DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress Response

R. Maciuca, K. Scearce-Levie, Y. Ran, 2023, bioRxiv.

DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress Response

R. Maciuca, K. Scearce-Levie, Y. Ran, 2024, bioRxiv.

Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist

J. Ulrich, Carla M. Yuede, Sonnet S. Davis, 2023, Neuron.

Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration

T. Sandmann, D. Edbauer, Sarah L. DeVos, 2024, Science Translational Medicine.

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

T. Ulas, Bettina van Lengerich, M. Brendel, 2024, bioRxiv.

DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

M. Larhammar, P. C. Haddick, Joseph W. Lewcock, 2024, eLife.

Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

Nicholas E. Propson, T. Sandmann, Joseph W. Lewcock, 2024, Cell.