L. Tu

发表

Macrophage Migration Inhibitory Factor (MIF) Inhibition in a Murine Model of Bleomycin-Induced Pulmonary Fibrosis

M. Humbert, C. Nicco, F. Batteux, 2018, International journal of molecular sciences.

Leptin signalling system as a target for pulmonary arterial hypertension therapy

M. Humbert, E. Fadel, C. Guignabert, 2015, European Respiratory Journal.

Role of Nerve Growth Factor in Development and Persistence of Experimental Pulmonary Hypertension.

M. Humbert, R. Marthan, B. Girerd, 2015, American journal of respiratory and critical care medicine.

Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension.

M. Humbert, P. Postmus, E. Fadel, 2012, American journal of respiratory and critical care medicine.

Angiomatoid fibrous histiocytoma of the pulmonary artery: a multidisciplinary discussion

P. Dartevelle, M. Ghigna, P. Dorfmuller, 2014, Histopathology.

Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22α‐targeted overexpression of the serotonin transporter

M. Humbert, E. Fadel, S. Eddahibi, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Lineage Tracing Reveals the Dynamic Contribution of Pericytes to the Blood Vessel Remodeling in Pulmonary Hypertension

M. Humbert, E. Fadel, L. Savale, 2020, Arteriosclerosis, thrombosis, and vascular biology.

Neutralization of CXCL12 attenuates established pulmonary hypertension in rats.

M. Humbert, J. Galzi, N. Frossard, 2019, Cardiovascular research.

Lysophospholipids, Lysophosphatidic Acids and Monoacylglycerols: New Therapeutic Targets in Cardiovascular Diseases?

M. Humbert, S. Azhar, C. Guignabert, 2021 .

Additive Protective Effects of Sacubitril/Valsartan and Bosentan on Vascular Remodeling in Experimental Pulmonary Hypertension.

M. Humbert, L. Savale, Marie-Camille Chaumais, 2020, Cardiovascular research.

Immune Dysregulation and Endothelial Dysfunction in Pulmonary Arterial Hypertension: A Complex Interplay

M. Humbert, F. Perros, D. Montani, 2014, Circulation.

A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents.

M. Humbert, E. Fadel, S. Eddahibi, 2012, American journal of respiratory and critical care medicine.

Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension.

M. Humbert, E. Fadel, S. Eddahibi, 2011, American journal of respiratory cell and molecular biology.

Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension

M. Goumans, P. Koolwijk, H. Bogaard, 2018, Cardiovascular research.

Role of endothelium-derived CC chemokine ligand 2 in idiopathic pulmonary arterial hypertension.

M. Humbert, E. Fadel, S. Eddahibi, 2007, American journal of respiratory and critical care medicine.

The Thousand Faces of Leptin in the Lung.

M. Humbert, E. Jutant, C. Guignabert, 2020, Chest.

Serum and pulmonary uric acid in pulmonary arterial hypertension

M. Humbert, E. Fadel, V. Cottin, 2021, European Respiratory Journal.

Endothelial cell dysfunction: a major player in SARS-CoV-2 infection (COVID-19)?

M. Humbert, L. Savale, D. Montani, 2020, European Respiratory Journal.

Driving Role of Interleukin‐2–Related Regulatory CD4+ T Cell Deficiency in the Development of Lung Fibrosis and Vascular Remodeling in a Mouse Model of Systemic Sclerosis

Y. Allanore, J. Avouac, C. Auffray, 2022 .

Pathogenesis of pulmonary arterial hypertension: lessons from cancer

M. Humbert, D. Montani, A. Seferian, 2013, European Respiratory Review.

Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10

M. Humbert, P. Perret, A. Bikfalvi, 2021, Cardiovascular research.

Dasatinib increases endothelial permeability leading to pleural effusion

M. Humbert, E. Jutant, D. Montani, 2017, European Respiratory Journal.

Regulatory T Cell Dysfunction in Idiopathic, Heritable and Connective Tissue-Associated Pulmonary Arterial Hypertension.

M. Humbert, O. Sitbon, Y. Allanore, 2016, Chest.

Peter A Complex Interplay Immune Dysregulation and Endothelial Dysfunction in Pulmonary Arterial Hypertension

M. Humbert, F. Perros, D. Montani, 2014 .

Leptin and regulatory T-lymphocytes in idiopathic pulmonary arterial hypertension

M. Humbert, E. Fadel, S. Eddahibi, 2012, European Respiratory Journal.

Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension. Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage.

M. Paul, W. Timens, H. Bogaard, 2016, American journal of respiratory and critical care medicine.

CHAPTER 5 Delayed microvascular shear adaptation in Pulmonary Arterial Hypertension : role of Platelet Endothelial Cell Adhesion Molecul-1 cleavage

M. Paul, W. Timens, G. Amerongen, 2016 .

Transgenic Mice Overexpressing the 5-Hydroxytryptamine Transporter Gene in Smooth Muscle Develop Pulmonary Hypertension Integrative

M. Hamon, S. Eddahibi, D. Rodman, 2006 .

Transgenic Mice Overexpressing the 5-Hydroxytryptamine Transporter Gene in Smooth Muscle Develop Pulmonary Hypertension

M. Hamon, S. Eddahibi, D. Rodman, 2006, Circulation research.

Altered TGFβ/SMAD Signaling in Human and Rat Models of Pulmonary Hypertension: An Old Target Needs Attention

M. Goumans, T. Sanada, H. Bogaard, 2021, Cells.

The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient

M. Goumans, K. Wiesmeijer, H. Bogaard, 2020, Cells.

Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

A. van Rossum, J. Paton, M. L. Handoko, 2017, JACC. Basic to translational science.

Prevention of progression of pulmonary hypertension by the Nur77 agonist 6-mercaptopurine: role of BMP signalling

M. Goumans, P. ten Dijke, C. D. de Vries, 2019, European Respiratory Journal.

Increased Pericyte Coverage Mediated by Endothelial Derived FGF-2 and IL-6 is a Source of Smooth Muscle-Like Cells in Pulmonary Hypertension Running title: Ricard et al.; Pericytes in pulmonary arterial hypertension

M. Humbert, E. Fadel, D. Montani, 2014 .

Pulmonary hemodynamic responses to inhaled NO in chronic heart failure depend on PDE5 G(-1142)T polymorphism

P. Lesault, J. Dubois-Randé, S. Eddahibi, 2011, Pulmonary circulation.

Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice

S. Eddahibi, L. Savale, S. Adnot, 2009, Respiratory research.

Platelet‐Derived Growth Factor Receptor Type α Activation Drives Pulmonary Vascular Remodeling Via Progenitor Cell Proliferation and Induces Pulmonary Hypertension

M. Humbert, R. Harvey, F. Soubrier, 2022, Journal of the American Heart Association.

Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension

B. Bruckner, M. Blackburn, H. Eltzschig, 2018, Front. Physiol..

Connexin-43 is a promising target for pulmonary hypertension due to hypoxaemic lung disease

R. Marthan, P. Berger, C. Guignabert, 2019, European Respiratory Journal.

RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling.

M. Humbert, E. Fadel, S. Eddahibi, 2009, American journal of respiratory and critical care medicine.

Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension

Y. Allanore, J. Avouac, I. Konstantinova, 2017, Annals of the rheumatic diseases.

Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models

S. Dillon, C. Nicco, F. Batteux, 2022, Arthritis Research & Therapy.

ALPN-101 (Acazicolcept) a Dual ICOS/CD28 Antagonist, Demonstrates Efficacy in Systemic Sclerosis Preclinical Mouse Models

S. Dillon, C. Nicco, F. Batteux, 2021 .

Therapeutic effect of pirfenidone in the sugen/hypoxia rat model of severe pulmonary hypertension

M. Humbert, L. Savale, M. Ghigna, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Role for interleukin-6 in COPD-related pulmonary hypertension.

B. Housset, S. Eddahibi, L. Savale, 2009, Chest.

T-cell costimulation blockade is effective in experimental digestive and lung tissue fibrosis

C. Nicco, F. Batteux, Y. Allanore, 2018, Arthritis Research & Therapy.

Role of Stromelysin 2 (Matrix Metalloproteinase 10) as a Novel Mediator of Vascular Remodeling Underlying Pulmonary Hypertension Associated With Systemic Sclerosis

R. Resnick, M. Humbert, E. Hachulla, 2017, Arthritis & rheumatology.

Purinergic Dysfunction in Pulmonary Arterial Hypertension

C. Guignabert, D. Merkus, L. Tu, 2020, Journal of the American Heart Association.

Regression of flow-induced pulmonary arterial vasculopathy after flow correction in piglets.

E. Fadel, S. Eddahibi, P. Hervé, 2009, The Journal of thoracic and cardiovascular surgery.

An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension

M. Humbert, M. Yanagisawa, C. Guignabert, 2021, Nature Communications.

Right lung ischemia induces contralateral pulmonary vasculopathy in an animal model.

E. Fadel, S. Eddahibi, P. Hervé, 2012, The Journal of thoracic and cardiovascular surgery.

Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension

M. Humbert, L. Savale, C. Guignabert, 2019, Circulation research.

Mineralocorticoid Receptor Antagonism by Finerenone Attenuates Established Pulmonary Hypertension in Rats

M. Humbert, S. Viengchareun, P. Kolkhof, 2022, Hypertension.

Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα

E. Boersma, I. Kema, I. Reiss, 2022, Scientific Reports.

Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension

E. Boersma, I. Reiss, D. Duncker, 2020, Journal of clinical medicine.

Response by Guignabert et al to Letter Regarding Article, "Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension".

M. Humbert, C. Guignabert, S. Bailly, 2019, Circulation research.

The Therapeutic Potential Of The Renin-Angiotensin-Aldosteron System In Idiopathic Pulmonary Arterial Hypertension

M. Humbert, P. Postmus, E. Fadel, 2012, ATS 2012.

Increased renin-angiotensin-aldosteron system activity in lungs of patients with idiopathic pulmonary arterial hypertension

M. Humbert, E. Fadel, S. Eddahibi, 2011 .

Leptin receptor deficiency restores immune function of regulatory T lymphocytes and inhibits hypoxia-induced pulmonary hypertension

M. Humbert, C. Guignabert, Nicolas Ricard, 2014 .

6-mercaptopurine, an agonist of Nur77, reduces progression of pulmonary hypertension by enhancing BMP signalling.

M. Goumans, A. Noordegraaf, P. ten Dijke, 2019, The European respiratory journal.

New molecular targets of pulmonary vascular remodeling in pulmonary arterial hypertension: importance of endothelial communication.

M. Humbert, B. Girerd, D. Montani, 2015, Chest.

CD74-Dependent Interleukin-6 And Monocyte Chemoattractant Protein-1 Secretion By Pulmonary Endothelial Cells In Idiopathic Pulmonary Hypertension

M. Humbert, E. Fadel, S. Eddahibi, 2012, Asian Test Symposium.

Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT and is associated with pulmonary hypertension.

E. V. D. van de Kamp, K. van der Heiden, M. Brandt, 2022, American journal of physiology. Heart and circulatory physiology.

Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary arterial hypertension by serum proteome analysis

M. Humbert, J. Cracowski, L. Rice, 2022, Annals of the Rheumatic Diseases.

Emerging molecular targets for anti-proliferative strategies in pulmonary arterial hypertension.

C. Guignabert, L. Tu, 2013, Handbook of experimental pharmacology.

Different tryptophan-kynurenine metabolism profiles in human pulmonary arterial hypertension and animal models of pulmonary hypertension

I. Kema, D. Duncker, A. V. D. Bosch, 2020 .

Therapeutic potential of melatonin and melatonergic drugs on K18‐hACE2 mice infected with SARS‐CoV‐2

E. Cecon, R. Jockers, M. Ghigna, 2021, Journal of pineal research.

[New insights in the pathogenesis of pulmonary arterial hypertension].

M. Humbert, L. Savale, C. Guignabert, 2019, Revue des maladies respiratoires.

Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension.

M. Humbert, E. Jutant, G. Simonneau, 2016, The Journal of clinical investigation.

Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension

M. Humbert, E. Fadel, E. Jutant, 2018, The Journal of clinical investigation.

Increased Pericyte Coverage Mediated by Endothelial-Derived Fibroblast Growth Factor-2 and Interleukin-6 Is a Source of Smooth Muscle–Like Cells in Pulmonary Hypertension

M. Humbert, E. Fadel, D. Montani, 2014, Circulation.

Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension

M. Goumans, M. Humbert, A. Casali, 2017, Circulation.

Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents.

M. Humbert, E. Fadel, S. Eddahibi, 2009, The Journal of clinical investigation.

Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension

M. Humbert, P. Dartevelle, E. Fadel, 2009, European Respiratory Journal.

Preventing the Increase in Lysophosphatidic Acids: A New Therapeutic Target in Pulmonary Hypertension?

M. Humbert, V. Richard, S. Azhar, 2021, Metabolites.

Inhibition of Soluble Epoxide Hydrolase Does Not Promote or Aggravate Pulmonary Hypertension in Rats

M. Humbert, P. Mulder, C. Morisseau, 2023, Cells.

New targets for pulmonary arterial hypertension: going beyond the currently targeted three pathways

C. Guignabert, A. Huertas, L. Tu, 2017, Current opinion in pulmonary medicine.

Proinflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension. Role of the Macrophage Migration Inhibitory Factor/CD74 Complex.

M. Humbert, E. Fadel, D. Montani, 2015, American journal of respiratory and critical care medicine.

[Towards new targets for the treatment of pulmonary arterial hypertension : Importance of cell-cell communications].

M. Humbert, M. Ghigna, C. Guignabert, 2016, Biologie aujourd'hui.

A genome-wide association analysis identifies PDE1A|DNAJC10 locus on chromosome 2 associated with idiopathic pulmonary arterial hypertension in a Japanese population

M. Humbert, N. Kamatani, S. Kamitsuji, 2017, Oncotarget.

Pulmonary hypertension associated with neurofibromatosis type 2

M. Humbert, C. Guignabert, R. Thuillet, 2021, Pulmonary Circulation.

Driving Role of Interleukin‐2–Related Regulatory CD4+ T Cell Deficiency in the Development of Lung Fibrosis and Vascular Remodeling in a Mouse Model of Systemic Sclerosis

Y. Allanore, J. Avouac, C. Auffray, 2022, Arthritis & rheumatology.

AMPK activation by metformin protects against pulmonary hypertension in rats and relaxes isolated human pulmonary artery.

Y. Castier, A. Silverstein, D. Longrois, 2023, European journal of pharmacology.

Chronic Inflammation Within the Vascular Wall in Pulmonary Arterial Hypertension: More than a Spectator.

M. Humbert, C. Guignabert, A. Huertas, 2019, Cardiovascular research.

N-acetylcysteine improves established monocrotaline-induced pulmonary hypertension in rats

M. Humbert, F. Perros, G. Simonneau, 2014, Respiratory Research.

Bone Morphogenetic Protein-9 Controls Pulmonary Vascular Growth and Remodeling

R. Schermuly, P. Barbry, L. Savale, 2023, medRxiv.

Serum and Pulmonary Expression Profiles of the Activin Signaling System in Pulmonary Arterial Hypertension

M. Humbert, E. Fadel, P. De Groote, 2023, Circulation.

Phenotypic Diversity of Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension: Implications for Therapy.

M. Humbert, C. Guignabert, A. Huertas, 2021, Chest.

085 Attenuated hypoxic pulmonary hypertension in interleukin-6 knockout mice

S. Eddahibi, L. Savale, S. Adnot, 2007 .

BONE MORPHOGENETIC PROTEIN SIGNALING IN HERITABLE VERSUS IDIOPATHIC PULMONARY HYPERTENSION BMP signaling in Pulmonary Hypertension

M. Humbert, E. Fadel, R. Naeije, 2009 .

Cytokines as prognostic biomarkers in pulmonary arterial hypertension

M. Humbert, P. De Groote, X. Jaïs, 2022, European Respiratory Journal.

Design, Synthesis, and Biological Activity of New N-(Phenylmethyl)-benzoxazol-2-thiones as Macrophage Migration Inhibitory Factor (MIF) Antagonists: Efficacies in Experimental Pulmonary Hypertension.

M. Humbert, E. Fadel, G. Simonneau, 2018, Journal of medicinal chemistry.

Poster session 2

Hugo A. Katus, V. V. Miroshnikova, Paolo Dario, 2004, EP Europace.

Loss of cAbl Tyrosine Kinase in Pulmonary Arterial Hypertension Causes Dysfunction of Vascular Endothelial Cells.

M. Humbert, C. Guignabert, A. Huertas, 2022, American journal of respiratory cell and molecular biology.

Additive protective effects of sacubitril/valsartan and bosentan on vascular remodeling in experimental pulmonary hypertension

M. Humbert, L. Savale, C. Guignabert, 2020 .