Xiaoning Zhao

发表

Enhanced anti-tumor activity and reduced toxicity by combination andrographolide and bleomycin in ascitic tumor-bearing mice.

Ziren Su, X. Lai, J. Y. Zhan, 2016, European journal of pharmacology.

AMG 580: A Novel Small Molecule Phosphodiesterase 10A (PDE10A) Positron Emission Tomography Tracer

N. Chen, E. Hu, R. Kunz, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Discovery of Potent and Selective PI3Kγ Inhibitors.

N. Walker, U. Schindler, J. Powers, 2020, Journal of medicinal chemistry.

Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.

K. Pattabiraman, Zhulun Wang, C. Quéva, 2014, Journal of medicinal chemistry.

High throughput screening for orphan and liganded GPCRs.

J. Reagan, R. Schwandner, Xiaoning Zhao, 2008, Combinatorial chemistry & high throughput screening.

Design, Synthesis, and Structure-Activity Relationship Optimization of Pyrazolopyrimidine Amide Inhibitors of Phosphoinositide 3-Kinase γ (PI3Kγ).

N. Walker, U. Schindler, J. Powers, 2021, Journal of medicinal chemistry.

Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction.

Y. Wang, J. Canon, J. Oliner, 2014, Journal of medicinal chemistry.

Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A).

E. Hu, S. Chmait, J. Treanor, 2014, ACS medicinal chemistry letters.

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.

Y. Wang, J. Canon, M. Peterson, 2014, Journal of medicinal chemistry.

Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.

J. Canon, J. Oliner, Xin Huang, 2014, Journal of medicinal chemistry.

Rational design and binding mode duality of MDM2-p53 inhibitors.

Xin Huang, Paul Shaffer, Steve Schneider, 2013, Journal of medicinal chemistry.

Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.

J. Canon, J. Oliner, Xin Huang, 2014, Journal of medicinal chemistry.

Discovery of Potent and Selective 7-Azaindole Isoindolinone-Based PI3Kγ Inhibitors.

N. Walker, U. Schindler, J. Powers, 2020, ACS medicinal chemistry letters.

MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways

C. Su, J. Canon, J. Oliner, 2014, Oncotarget.

Apo2L/TRAIL and the death receptor 5 agonist antibody AMG 655 cooperate to promote receptor clustering and antitumor activity.

T. Bush, Tzu-Hsuan Huang, D. Branstetter, 2014, Cancer cell.

Structure-based design of novel inhibitors of the MDM2-p53 interaction.

J. Canon, J. Oliner, Min Jiang, 2012, Journal of medicinal chemistry.

A Homogeneous Enzyme Fragment Complementation-Based β-Arrestin Translocation Assay for High-Throughput Screening of G-Protein-Coupled Receptors

K. Olson, T. Wehrman, Xiaoning Zhao, 2008, Journal of biomolecular screening.

Strategy for the identification of GPR23/LPA4 receptor agonists and inverse agonists.

Shu-Chen Lu, W. Gu, Xiaoning Zhao, 2010, Assay and drug development technologies.

Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A).

E. Hu, R. Kunz, N. Chen, 2014, Journal of medicinal chemistry.

Abstract 4561: Preclinical characterization of GLS-010 (AB122): A fully humanized clinical-stage anti-PD-1 antibody

Yong Zheng, Xiaoning Zhao, Kai Chen, 2018, Clinical Research (Excluding Clinical Trials).

Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction.

Xin Huang, Paul Shaffer, Daqing Sun, 2014, ACS medicinal chemistry letters.

Discovery and Characterization of a Potent and Selective Inhibitor for Human Phosphoinositide‐3‐kinase γ

J. Powers, Lixia Jin, Xiaoning Zhao, 2020, The FASEB Journal.

An evaluation of the anti-tumor efficacy of oleanolic acid-loaded PEGylated liposomes

Dawei Gao, Jing Zhou, Xiaoning Zhao, 2013, Nanotechnology.

Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.

E. Hu, R. Kunz, N. Chen, 2014, Bioorganic & medicinal chemistry.

Discovery of selective biaryl ethers as PDE10A inhibitors: improvement in potency and mitigation of Pgp-mediated efflux.

E. Hu, Shannon Rumfelt, N. Chen, 2012, Bioorganic & medicinal chemistry letters.

Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors.

N. Walker, N. Sträter, J. Powers, 2021, Journal of medicinal chemistry.

Octreotide acetate-templated self-assembly Pt nanoparticles and their anti-tumor efficacy

Dawei Gao, Xuwu Zhang, Zhiwei Liu, 2015 .

Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.

K. Pattabiraman, Zhulun Wang, C. Quéva, 2014, Journal of medicinal chemistry.

258 AB308 is an anti-TIGIT antibody that enhances immune activation and anti-tumor immunity alone and in combination with other I-O therapeutic agents

F. Soriano, Xiaoning Zhao, Ada Chen, 2021, Journal for ImmunoTherapy of Cancer.

AMG 580: A Novel Small Molecule Phosphodiesterase 10A (PDE10A) Positron Emission Tomography Tracer

N. Chen, E. Hu, R. Kunz, 2015, The Journal of Pharmacology and Experimental Therapeutics.

E. Hu, R. Kunz, N. Chen, 2014, Journal of medicinal chemistry.