A. Trifilieff

发表

Lung MRI for experimental drug research.

Yannick Crémillieux, N. Beckmann, B. Tigani, 2007, European journal of radiology.

PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect.

P. Whittaker, A. Trifilieff, A. Bench, 2003, British journal of pharmacology.

PPAR‐α and ‐γ but not ‐δ agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF‐κB‐independent effect

P. Whittaker, A. Trifilieff, A. Bench, 2003 .

The Preclinical Pharmacology of Indacaterol

S. Charlton, A. Trifilieff, R. A. Fairhurst, 2014 .

Pharmacological profile of PKF242‐484 and PKF241‐466, novel dual inhibitors of TNF‐α converting enzyme and matrix metalloproteinases, in models of airway inflammation

C. Walker, G. Kottirsch, U. Neumann, 2002, British journal of pharmacology.

Effects of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in a model of intestinal reperfusion injury in mice.

M. Teixeira, M. Andrade, D. G. Souza, 2007, European journal of pharmacology.

Activation of the Fas receptor on lung eosinophils leads to apoptosis and the resolution of eosinophilic inflammation of the airways.

C. Bertrand, A. Coyle, G. Anderson, 1995, The Journal of clinical investigation.

The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.

J. Fozard, B. Faller, D. Wyss, 2010, Journal of medicinal chemistry.

Effect of adenosine A2A receptor activation in murine models of respiratory disorders.

Christopher S. Stevenson, C. Stevenson, S. Ferretti, 2006, American journal of physiology. Lung cellular and molecular physiology.

Mast cell involvement in the adenosine mediated airway hyper‐reactivity in a murine model of ovalbumin‐induced lung inflammation

D. Wyss, A. Trifilieff, O. Bonneau, 2005, British journal of pharmacology.

Long Receptor Residence Time of C26 Contributes to Super Agonist Activity at the Human β2 Adrenoceptor

S. Charlton, A. Sattikar, D. Sykes, 2016, Molecular Pharmacology.

PPAR-a and -c but not -d agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-jB- independent effect

Paul, A. Trifilieff, M. Hanley, 2003 .

Bombesin Receptor Subtypes: Characterization and Solubilization

J. Gies, A. Trifilieff, E. Haddad, 1993 .

Inducible Nitric Oxide Synthase Inhibitors Suppress Airway Inflammation in Mice Through Down-Regulation of Chemokine Expression

C. Bertrand, F. Mentz, B. Dugas, 2000, The Journal of Immunology.

Kinins and respiratory tract diseases.

J. Gies, A. Trifilieff, A. Da Silva, 1993, The European respiratory journal.

ExpressionThrough Down-Regulation of Chemokine Suppress Airway Inflammation in Mice Inducible Nitric Oxide Synthase Inhibitors

C. Bertrand, F. Mentz, B. Dugas, 2000 .

IL-17, Produced by Lymphocytes and Neutrophils, Is Necessary for Lipopolysaccharide-Induced Airway Neutrophilia: IL-15 as a Possible Trigger

S. Ferretti, Carol E. Jones, A. Trifilieff, 2003, The Journal of Immunology.

A pharmacogenetic study of ADRB2 polymorphisms and indacaterol response in COPD patients

S. Lewitzky, R. Yelensky, E. Leroy, 2011, The Pharmacogenomics Journal.

Structural requirements for neuropeptide Y in mast cell and G protein activation.

J. Gies, M. Mousli, J. Pelton, 1995, European journal of pharmacology.

Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea‐pig trachea

J. Gies, L. Daeffler, A. Trifilieff, 1995, British journal of pharmacology.

Comparative action of new highly potent bradykinin receptor antagonists in the guinea-pig trachea.

J. Gies, Y. Amrani, A. Trifilieff, 1993, European journal of pharmacology.

Sphingosine-1-Phosphate-Induced Airway Hyper-Reactivity in Rodents Is Mediated by the Sphingosine-1-Phosphate Type 3 Receptor

J. Fozard, A. Trifilieff, 2012, Journal of Pharmacology and Experimental Therapeutics.

Inhibition of Th1- and Th2-Mediated Airway Inflammation by the Sphingosine 1-Phosphate Receptor Agonist FTY720

D. Kemeny, V. Brinkmann, C. Walker, 2003, The Journal of Immunology.

1-Phosphate Receptor Agonist FTY 720 Inflammation by the Sphingosine Inhibition of Th 1-and Th 2-Mediated Airway and

D. Kemeny, V. Brinkmann, C. Walker, 2003 .

Involvement of CCR3-Reactive Chemokines in Eosinophil Survival

G. Anderson, A. Trifilieff, K. Shinagawa, 2003, International Archives of Allergy and Immunology.

Synergistic effect of formoterol and mometasone in a mouse model of allergic lung inflammation

D. Wyss, A. Trifilieff, O. Bonneau, 2007, British journal of pharmacology.

Endothelin receptor antagonists inhibit antigen-induced lung inflammation in mice.

C. Bertrand, A. Coyle, A. Trifilieff, 1997, American journal of respiratory and critical care medicine.

Phosphoinositide 3-kinase γ: a key modulator in inflammation and allergy

P. Finan, E. Hirsch, F. Altruda, 2001 .

High-affinity receptors for bombesin-like peptides in normal guinea pig lung membranes.

J. Gies, A. Trifilieff, Y. Landry, 1991, Life sciences.

Bradykinin-induced contraction of human peripheral airways mediated by both bradykinin B2 and thromboxane prostanoid receptors.

J. Gies, A. Trifilieff, 1995, American journal of respiratory and critical care medicine.

Indacaterol: A new once-daily long-acting β2-adrenoceptor agonist (LABA)

M. Higgins, J. Beier, A. Trifilieff, 2010 .

Long-Term Protective and Antigen-Specific Effect of Heat-Killed Mycobacterium vaccae in a Murine Model of Allergic Pulmonary Inflammation

G. Rook, C. Walker, A. Trifilieff, 2002, The Journal of Immunology.

Inflammationin a Murine Model of Allergic Pulmonary Mycobacterium vaccae Effect of Heat-Killed Long-Term Protective and Antigen-Specific

G. Rook, C. Walker, A. Trifilieff, 2002 .

Bradykinin-induced contraction of guinea pig lung in vitro

J. Gies, M. Mousli, A. Trifilieff, 1994, Naunyn-Schmiedeberg's Archives of Pharmacology.

Bradykinin binding sites in healthy and carcinomatous human lung

J. Gies, A. Trifilieff, P. Dumont, 1994, British journal of pharmacology.

Involvement of B2 receptors in the bradykinin‐induced relaxation of guinea‐pig isolated trachea

Y. Amrani, A. Trifilieff, Y. Landry, 1995, British journal of pharmacology.

In Vitro and in Vivo Pharmacological Characterization of 5-[ ( R )-2-( 5 , 6-Diethyl-indan-2-ylamino )-1-hydroxyethyl ]-8-hydroxy-1 H-quinolin-2one ( Indacaterol ) , a Novel Inhaled 2 Adrenoceptor Agonist with a 24h Duration of Action

J. Fozard, C. Battram, B. Cuenoud, 2006 .

Fas‐induced death of a murine pulmonary epithelial cell line: modulation by inflammatory cytokines

C. Bertrand, A. Coyle, A. Trifilieff, 1999, Fundamental & clinical pharmacology.

Differential DNA synthesis in response to activation of protease-activated receptors on cultured guinea-pig tracheal smooth muscle cells

M. Ferretti, S. Ferretti, R. Corteling, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

Abrogation of lung inflammation in sensitized Stat6‐deficient mice is dependent on the allergen inhalation procedure

R. Corteling, A. Trifilieff, C. Owen, 2000, British journal of pharmacology.

The Design of the Indacaterol Molecule

S. Charlton, A. Trifilieff, R. A. Fairhurst, 2014 .

Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.

J. Fozard, T. Keller, David Beer, 2012, Journal of medicinal chemistry.

Endothelin Receptor Antagonists Inhibit Anti en-induced Lung Inflammation in Mice 9 9

C. Bertrand, A. Trifilieff, S. Tsuyuki, 1997 .

Effect of Hoe 140, a new B2 noncompetitive antagonist, on guinea pig tracheal bradykinin receptors.

J. Gies, A. Trifilieff, Y. Landry, 1992, The Journal of pharmacology and experimental therapeutics.

Essential role of phosphoinositide 3‐kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation

P. Finan, J. Westwick, E. Hirsch, 2009, Immunology.

Co-solubilization of bradykinin B2 receptors and angiotensin-converting enzyme from guinea pig lung membranes.

J. Gies, M. Mousli, A. Trifilieff, 1994, Biochimica et biophysica acta.

Evidence for two high-affinity bradykinin binding sites in the guinea-pig lung.

J. Gies, A. Trifilieff, Y. Landry, 1991, European journal of pharmacology.

Gender comparison in a murine model of allergen-driven airway inflammation and the response to budesonide treatment

R. Corteling, A. Trifilieff, 2004, BMC pharmacology.

Association of guinea pig lung bombesin receptors with pertussis toxin-sensitive guanine nucleotide binding proteins.

J. Gies, A. Trifilieff, D. Scherrer, 1994, European journal of pharmacology.

Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy.

P. Finan, E. Hirsch, M. Wymann, 2003, Biochemical Society transactions.

Activation of the lung S1P1 receptor reduces allergen‐induced plasma leakage in mice

N. Frossard, N. Beckmann, C. Gérard, 2009, British journal of pharmacology.

Running Title : Super Agonism at the β 2 Adrenoceptor

S. Charlton, A. Trifilieff, R. A. Fairhurst, 2017 .

Title : Long Receptor Residence Time of C 26 Contributes to Super Agonist Activity at the Human β 2 Adrenoceptor

S. Charlton, A. Sattikar, D. Sykes, 2016 .

Role of sphingosine-1-phosphate (S1P) and the S1P2 receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips

J. Fozard, A. Trifilieff, F. Baur, 2009, Naunyn-Schmiedeberg's Archives of Pharmacology.

Pharmacological profile of a novel phosphodiesterase 4 inhibitor, 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridin-6-yl)-benzoic acid (NVP-ABE171), a 1,7-naphthyridine derivative, with anti-inflammatory activities.

R. Hersperger, D. Wyss, C. Walker, 2002, The Journal of pharmacology and experimental therapeutics.

Pharmacological Characterization of Indacaterol, a Novel Once Daily Inhaled β2 Adrenoceptor Agonist, on Small Airways in Human and Rat Precision-Cut Lung Slices

A. Nicholson, P. Barnes, R. Sturton, 2008, Journal of Pharmacology and Experimental Therapeutics.

The ion channel transient receptor potential melastatin-2 does not play a role in inflammatory mouse models of chronic obstructive pulmonary diseases

D. Wyss, A. Trifilieff, L. Hardaker, 2012, Respiratory Research.

Airway inflammation: chemokine‐induced neutrophilia and the class I phosphoinositide 3‐kinases

P. Finan, J. Westwick, B. Vanhaesebroeck, 2005, European journal of immunology.

Phosphoinositide 3-Kinase γ Is an Essential Amplifier of Mast Cell Function

P. Finan, E. Hirsch, M. Wymann, 2002 .

In vivo models of lung neutrophil activation. Comparison of mice and hamsters

D. Wyss, R. Corteling, A. Trifilieff, 2002, BMC pharmacology.

The Th2 Cell Cytokines IL-4 and IL-13 Regulate Found in Inflammatory Zone 1/Resistin-Like Molecule α Gene Expression by a STAT6 and CCAAT/Enhancer-Binding Protein-Dependent Mechanism

A. Stütz, A. Trifilieff, M. Woisetschläger, 2003, The Journal of Immunology.

Effect of indacaterol, a novel long-acting β2-agonist, on isolated human bronchi

E. Naline, C. Advenier, M. Molimard, 2007, European Respiratory Journal.

CGH2466, a combined adenosine receptor antagonist, p38 mitogen‐activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti‐inflammatory activities

T. Keller, David Beer, P. Gedeck, 2005, British journal of pharmacology.

Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).

T. Keller, David Beer, N. Press, 2015, Journal of medicinal chemistry.

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function.

P. Finan, E. Hirsch, M. Wymann, 2002, Immunity.

In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling.

A. Trifilieff, Y. Fujitani, 2003, American journal of respiratory and critical care medicine.

Allergen-induced lung inflammation in actively sensitized mice assessed with MR imaging.

N. Frossard, N. Beckmann, F. Blé, 2008, Radiology.

IL‐5 deficiency abolishes aspects of airway remodelling in a murine model of lung inflammation

C. Bertrand, M. Kopf, A. Trifilieff, 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Time course of inflammatory and remodeling events in a murine model of asthma: effect of steroid treatment.

C. Bertrand, A. El-Hashim, A. Trifilieff, 2000, American journal of physiology. Lung cellular and molecular physiology.

An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol.

J. Fozard, B. Cuenoud, S. Charlton, 2012, Bioorganic & medicinal chemistry letters.

In Vitro and in Vivo Pharmacological Characterization of 5-[(R)-2-(5,6-Diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one (Indacaterol), a Novel Inhaled β2 Adrenoceptor Agonist with a 24-h Duration of Action

J. Fozard, C. Battram, B. Cuenoud, 2006, Journal of Pharmacology and Experimental Therapeutics.

The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist.

J. Fozard, S. Charlton, M. Gosling, 2014, Bioorganic & medicinal chemistry letters.

Heterogeneity of guinea-pig lung muscarinic receptors revealed by [3H]4-DAMP-binding.

J. Gies, A. Trifilieff, Y. Landry, 1993, Pulmonary pharmacology.

The Influence of Receptor Kinetics on the Onset and Duration of Action and the Therapeutic Index of NVA237 and Tiotropium

M. Dowling, S. Charlton, D. Sykes, 2012, Journal of Pharmacology and Experimental Therapeutics.

Comparing the cardiovascular therapeutic indices of glycopyrronium and tiotropium in an integrated rat pharmacokinetic, pharmacodynamic and safety model.

S. Charlton, D. Sykes, Kenny J. Watson, 2015, Toxicology and applied pharmacology.

The Influence of Receptor Kinetics on the Onset and Duration of Action and the Therapeutic Index of NVA237 and Tiotropium

M. Dowling, S. Charlton, D. Sykes, 2012, Journal of Pharmacology and Experimental Therapeutics.

Essential role of phosphoinositide 3‐kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation

P. Finan, J. Westwick, E. Hirsch, 2009, Immunology.