C. O’Kane

发表

MMP expression and abnormal lung permeability are important determinants of outcome in IPF

D. Thickett, A. Richter, S. McKeown, 2009, European Respiratory Journal.

Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers.

J. Backman, D. Thickett, M. Matthay, 2009, American journal of respiratory and critical care medicine.

Human Airway Epithelial Cells via a p38 Matrix Metalloproteinase-1 Secretion from Mycobacterium tuberculosis Up-Regulates

J. Friedland, J. Boyle, P. Elkington, 2013 .

MAPK Switch Human Airway Epithelial Cells via a p 38 Matrix Metalloproteinase-1 Secretion from UpRegulates Mycobacterium tuberculosis

J. Friedland, J. Boyle, P. Elkington, 2005 .

Mycobacterium tuberculosis Up-Regulates Matrix Metalloproteinase-1 Secretion from Human Airway Epithelial Cells via a p38 MAPK Switch1

J. Friedland, J. Boyle, L. D. Lopez-Pascua, 2005, The Journal of Immunology.

Hyperoxaemia and hypoxaemia are associated with harm in patients with ARDS

D. McAuley, P. Young, C. O’Kane, 2021, BMC Pulmonary Medicine.

Macrophages Survival of Mycobacteria within Secretion Occurs in Tuberculosis and Limits Monocyte-Dependent Fibroblast CXCL 8

J. Friedland, J. Boyle, P. Elkington, 2007 .

Precision‐cut lung slices: A powerful ex vivo model to investigate respiratory infectious diseases

G. Schroeder, C. O’Kane, Gunnar N. Schroeder, 2021, Molecular microbiology.

Simvastatin for patients with acute respiratory distress syndrome: long-term outcomes and cost-effectiveness from a randomised controlled trial

J. Laffey, D. McAuley, C. Hulme, 2017, Critical Care.

Emerging pharmacological therapies for ARDS: COVID-19 and beyond

J. Laffey, B. McNicholas, D. McAuley, 2020, Intensive Care Medicine.

Transcriptional Mechanisms Regulating Alveolar Epithelial Cell-specific CCL5 Secretion in Pulmonary Tuberculosis*

Jasim Uddin, J. Uddin, J. Friedland, 2004, Journal of Biological Chemistry.

STAT3, p38 MAPK, and NF-kappaB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis.

Michael D. Jones, G. Stamp, R. Gilman, 2010, American journal of respiratory cell and molecular biology.

Mycobacterium tuberculosis, but not vaccine BCG, specifically upregulates matrix metalloproteinase-1.

J. Friedland, J. Boyle, D. Edwards, 2005, American journal of respiratory and critical care medicine.

Repair of acute respiratory distress syndrome by stromal cell administration (REALIST) trial: A phase 1 trial

G. Perkins, J. Laffey, M. Shankar-Hari, 2021, EClinicalMedicine.

Secreted Extracellular Cyclophilin A is a Novel Mediator of Ventilator Induced Lung Injury.

D. McAuley, M. Takata, M. Malešević, 2021, American journal of respiratory and critical care medicine.

Corticosteroids in acute respiratory distress syndrome: a step forward, but more evidence is needed.

D. McAuley, K. Reddy, C. O’Kane, 2020, The Lancet. Respiratory medicine.

A stepwise approach to justify phase III randomized clinical trials and enhance the likelihood of a positive result

M. Griffiths, D. McAuley, C. O’Kane, 2010, Critical care medicine.

SMAD inhibition attenuates epithelial to mesenchymal transition by primary keratinocytes in vitro

C. Denton, D. McAuley, A. Kissenpfennig, 2014, Experimental dermatology.

Repair of acute respiratory distress syndrome by stromal cell administration (REALIST): a structured study protocol for an open-label dose-escalation phase 1 trial followed by a randomised, triple-blind, allocation concealed, placebo-controlled phase 2 trial

G. Perkins, J. Laffey, M. Shankar-Hari, 2022, Trials.

High MMP-9 activity characterises pleural tuberculosis correlating with granuloma formation

R. Gilman, J. Friedland, M. Tovar, 2009, European Respiratory Journal.

Prevention of post-operative complications by using a HMG-CoA reductase inhibitor in patients undergoing one-lung ventilation for non-cardiac surgery: study protocol for a randomised controlled trial

G. Perkins, D. McAuley, A. Agus, 2018, Trials.

Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial

Matthew A. Wiles, Manisha, Christopher M. Horvat, 2021, Intensive Care Medicine.

Effect of Simvastatin on Physiological and Biological Outcomes in Patients Undergoing Esophagectomy: A Randomized Placebo-Controlled Trial

J. Backman, D. McAuley, C. Calfee, 2014, Annals of surgery.

Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: a prospective analysis

D. McAuley, C. O’Kane, Andrew J. Boyle, 2015, Critical Care.

Evolution of the Inflammatory and Fibroproliferative Responses during Resolution and Repair after Ventilator-induced Lung Injury in the Rat

J. Laffey, D. O’Toole, D. McAuley, 2011, Anesthesiology.

A randomized clinical trial of hydroxymethylglutaryl- coenzyme a reductase inhibition for acute lung injury (The HARP Study).

D. McAuley, J. Elborn, T. Craig, 2011, American journal of respiratory and critical care medicine.

Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials.

K. Delucchi, M. Matthay, D. McAuley, 2020, The Lancet. Respiratory medicine.

Innate Lymphoid Cells Are the Predominant Source of IL-17A during the Early Pathogenesis of Acute Respiratory Distress Syndrome.

D. McAuley, A. Kissenpfennig, D. Fitzgerald, 2016, American journal of respiratory and critical care medicine.

Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation

D. Thickett, R. Vandivier, M. Matthay, 2016, Thorax.

ASpirin as a Treatment for Acute Respiratory Distress Syndrome – a multi-centre, randomised, double-blind, placebo-controlled trial (STAR): study protocol

D. McAuley, R. Verghis, C. O’Kane, 2018 .

Emerging drugs for treating the acute respiratory distress syndrome

D. McAuley, C. O’Kane, T. Shaw, 2019, Expert opinion on emerging drugs.

A functional variant of elafin with improved anti-inflammatory activity for pulmonary inflammation.

D. McAuley, T. Moreau, M. Zani, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

Proteolytic cleavage of elafin by 20S proteasome may contribute to inflammation in acute lung injury

D. McAuley, T. Craig, A. Kerrin, 2012, Thorax.

Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management

D. McAuley, C. O’Kane, E. Gorman, 2022, The Lancet.

Mesenchymal stromal cell extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS

K. Delucchi, D. McAuley, C. Calfee, 2020, European Respiratory Journal.

Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer

E. K. Cunningham, D. McAuley, A. Kissenpfennig, 2017, American journal of respiratory and critical care medicine.

Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis

D. Brazil, D. McAuley, D. Simpson, 2022, Thorax.

Baseline plasma IL-18 may predict simvastatin treatment response in patients with ARDS: a secondary analysis of the HARP-2 randomised clinical trial

M. Shankar-Hari, I. Bradbury, D. McAuley, 2022, Critical Care.

Benefits of statins in the critically ill: promising but not proven.

D. McAuley, C. O’Kane, P. McGuigan, 2011, Critical care medicine.

Potential Mechanisms by which Statins Modulate the Development of Acute Lung Injury

D. McAuley, T. Craig, C. O’Kane, 2007 .

Respiratory Support in the Time of COVID-19.

D. McAuley, A. Nichol, C. O’Kane, 2022, JAMA.

A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung

D. McAuley, J. Elborn, F. Lundy, 2015, Thorax.

Does MMP-12 play a role in human lung fibrosis?

G. Perkins, D. Thickett, D. McAuley, 2008, American journal of respiratory cell and molecular biology.

Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome

G. Perkins, D. Thickett, D. McAuley, 2009, Critical care medicine.

Where next for cell-based therapy in ARDS

D. McAuley, C. O’Kane, Andrew J. Boyle, 2018, Thorax.

Novel anti-tumor necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury

M. Hind, M. Griffiths, E. Chilvers, 2018 .

Innate Lymphoid Cells are the Predominant Source of Interleukin-17A During the Early Pathogenesis of Acute Respiratory Distress Syndrome

D. McAuley, A. Kissenpfennig, D. Fitzgerald, 2015 .

Matrix metalloproteinases in acute lung injury: mediators of injury and drivers of repair

D. McAuley, C. O’Kane, A. Davey, 2011, European Respiratory Journal.

Hypercapnic acidosis induces mitochondrial dysfunction and impairs the ability of mesenchymal stem cells to promote distal lung epithelial repair

D. McAuley, L. McClements, C. O’Kane, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo

P. Carmeliet, D. McAuley, B. Ghesquière, 2019, American journal of respiratory and critical care medicine.

Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury

K. Dib, D. McAuley, H. Herwald, 2013, BMC Pulmonary Medicine.

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS

M. Matthay, D. McAuley, A. Kissenpfennig, 2016, Stem cells.

A potential role for keratinocyte growth factor and clarithromycin in the treatment of paraquat overdose.

D. McAuley, C. O’Kane, B. Mullan, 2010, QJM : monthly journal of the Association of Physicians.

S59 The Role of Lymphocytes in Acute Lung Injury

T. Craig, R. Ingram, D. McAuley, 2012, Thorax.

Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia

G. Perkins, T. Walsh, D. McAuley, 2014, Thorax.

T3 Mitochondrial transfer is an important mechanism by which Mesenchymal Stromal Cells (MSC) facilitate macrophage phagocytosis in the in vitro and in vivo models of Acute Respiratory Distress Syndrome (ARDS)

D. McAuley, C. O’Kane, A. Krasnodembskaya, 2015 .

Statins and sepsis: potential benefit but more unanswered questions.

G. Perkins, D. McAuley, C. O’Kane, 2013, American journal of respiratory and critical care medicine.

Results Of The HARP Study: A Randomized Double Blind Phase II Trial Of 80mg Simvastatin In Acute Lung Injury

D. McAuley, J. Elborn, T. Craig, 2010, ATS 2010.

Matrix metalloproteinases: a potential role in the pathogensis of ARDS

D. McAuley, J. Frank, C. O’Kane, 2004 .

MSC extracellular vesicles modulate human macrophages in ARDS towards anti-inflammatory phenotype via transfer of miRNA181-a and PTEN-pSTAT5-SOCS1 signalling

D. Brazil, C. O’Kane, A. Krasnodembskaya, 2021, Mechanisms of lung injury and repair.

Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration in COVID-19 (REALIST-COVID-19): A structured summary of a study protocol for a randomised, controlled trial

G. Perkins, J. Laffey, M. Shankar-Hari, 2020, Trials.

Keratinocyte growth factor in acute lung injury--a work in progress.

D. Thickett, D. McAuley, C. O’Kane, 2009, Critical care medicine.

Elevated ferritin is associated with systemic inflammation, inflammasome activation and mortality in Acute Respiratory Distress Syndrome (ARDS)

M. Shankar-Hari, P. Mehta, D. McAuley, 2022, Acute critical care.

Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome.

K. Borensztajn, D. McAuley, L. Holsinger, 2022, American journal of respiratory and critical care medicine.

Aspirin as a Treatment for Acute Respiratory Distress Syndrome: a randomised placebo controlled clinical trial.

D. McAuley, R. Verghis, C. O’Kane, 2021, Chest.

Response.

C. O’Kane, P. Toner, Daniel McAuley, 2022, Chest.

Mesenchymal stromal cells for acute respiratory distress syndrome (ARDS), sepsis, and COVID-19 infection: optimizing the therapeutic potential

D. McAuley, J. Millar, C. O’Kane, 2020, Expert review of respiratory medicine.

Simvastatin in the acute respiratory distress syndrome.

G. Perkins, J. Laffey, D. McAuley, 2014, The New England journal of medicine.

Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study

M. Shankar-Hari, S. Cutler, D. Brealey, 2020, The Lancet Respiratory Medicine.

Subphenotypes in critical care: translation into clinical practice.

A. Gordon, D. McAuley, C. Calfee, 2020, The Lancet. Respiratory medicine.

Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial.

Matthew A. Wiles, Nerissa C. Brown, Christopher M. Horvat, 2022, JAMA.

Targeting Siglecs with a sialic acid–decorated nanoparticle abrogates inflammation

J. F. Burrows, J. Johnston, D. McAuley, 2015, Science Translational Medicine.

Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury.

A. Edwards, M. Matthay, D. McAuley, 2014, American journal of respiratory and critical care medicine.

Transfer of mitochondria through msc-derived extracellular vesicles improves alveolar-capillary barrier integrity and alleviate mitochondrial dysfunction in acute respiratory distress syndrome (ards)

D. McAuley, C. O’Kane, A. Krasnodembskaya, 2020 .

American Thoracic Society Meeting 2016.: Mitochondrial Transfer Via Tunnelling Nanotubes (TNT) Is a Novel Mechanism by Which Mesenchymal Stromal Cells Enhance Macrophage Phagocytosis in In Vivo Models of Acute Lung Injury

M. Matthay, D. McAuley, C. O’Kane, 2016 .

in Acute Respiratory Distress Syndrome Th17 Cells β α Unexpected Role for Adaptive

D. Sheppard, M. Matthay, D. McAuley, 2017 .

Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome

D. Sheppard, M. Matthay, D. McAuley, 2015, The Journal of Immunology.

Title Unexpected role for adaptive αβTh 17 cells in acute respiratory distress syndrome

D. Sheppard, M. Matthay, D. McAuley, 2015 .

Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung.

T. S. Wilkinson, T. Walsh, K. Dhaliwal, 2012, Chest.

Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial.

J. Laffey, M. Shankar-Hari, K. Delucchi, 2018, The Lancet. Respiratory medicine.

Defining phenotypes and treatment effect heterogeneity to inform acute respiratory distress syndrome and sepsis trials: secondary analyses of three RCTs

J. Laffey, M. Shankar-Hari, K. Delucchi, 2021, Efficacy and Mechanism Evaluation.

Heterogeneity of treatment effect by baseline risk of mortality in critically ill patients: re-analysis of three recent sepsis and ARDS randomised controlled trials

M. Shankar-Hari, A. Gordon, S. Santhakumaran, 2019, Critical Care.

Consistent Ards Endotypes Are Identified Using Minimal Data From A United Kingdom Clinical Trial

J. Laffey, M. Shankar-Hari, M. Matthay, 2017 .

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction (HARP-2) trial: study protocol for a randomized controlled trial

G. Perkins, J. Laffey, G. Crealey, 2012, Trials.

Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction – a randomised placebo-controlled trial (KARE): study protocol

M. Matthay, D. McAuley, C. O’Kane, 2013, Trials.

Mesenchymal Stromal Cells: an Antimicrobial and Host-Directed Therapy for Complex Infectious Diseases

M. Maeurer, Alimuddin Zumla, C. O’Kane, 2021, Clinical microbiology reviews.

Reducing mortality and morbidity in patients with severe COVID-19 disease by advancing ongoing trials of Mesenchymal Stromal (stem) Cell (MSC) therapy — Achieving global consensus and visibility for cellular host-directed therapies

C. Cordon-Cardo, L. Zitvogel, S. El-Kafrawy, 2020, International Journal of Infectious Diseases.

A Porcine Ex Vivo Lung Perfusion Model To Investigate Bacterial Pathogenesis

D. McAuley, J. Bengoechea, C. O’Kane, 2019, mBio.

Simvastatin to reduce pulmonary dysfunction in patients with acute respiratory distress syndrome: the HARP-2 RCT

G. Perkins, J. Laffey, D. McAuley, 2018 .

More research is required to understand factors influencing antibiotic prescribing in complex conditions like suspected ventilator-associated pneumonia

G. Perkins, T. Walsh, A. Conway Morris, 2020, Annals of translational medicine.

Synergistic up-regulation of epithelial cell matrix metalloproteinase-9 secretion in tuberculosis.

J. Friedland, J. Boyle, L. D. Lopez-Pascua, 2007, American journal of respiratory cell and molecular biology.

Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database

Karen E. Williams, John C. Adams, Barrett T. Kitch, 2018, Critical Care.

Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial.

M. Grocott, M. Matthay, D. McAuley, 2017, The Lancet. Respiratory medicine.

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury

M. Hind, R. D. de Wildt, M. Griffiths, 2018, Thorax.

Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation

G. Perkins, T. Walsh, A. Conway Morris, 2019, The Lancet. Respiratory medicine.

Characterisation of eppin function: expression and activity in the lung

Maelíosa T. C. McCrudden, D. Timson, D. McAuley, 2017, European Respiratory Journal.

Respiratory Infections Cause the Release of Extracellular Vesicles: Implications in Exacerbation of Asthma/COPD

Christopher S. Stevenson, C. Stevenson, M. Belvisi, 2014, PloS one.

A randomized clinical trial of ascorbic acid in open abdominal aortic aneurysm repair

I. Young, D. McAuley, D. Harkin, 2015, Intensive Care Medicine Experimental.

Monocyte-Dependent Fibroblast CXCL8 Secretion Occurs in Tuberculosis and Limits Survival of Mycobacteria within Macrophages1

Paul T. Elkington, Joseph J. Boyle, J. Friedland, 2007, The Journal of Immunology.

Monocyte‐dependent oncostatin M and TNF‐α synergize to stimulate unopposed matrix metalloproteinase‐1/3 secretion from human lung fibroblasts in tuberculosis

J. Friedland, P. Elkington, C. O’Kane, 2008, European journal of immunology.

Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS

D. McAuley, A. Kissenpfennig, R. Verghis, 2017, Thorax.

Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial): A Multicentre, Randomised, Controlled Trial.

G. Perkins, J. Laffey, M. Shankar-Hari, 2023, American journal of respiratory and critical care medicine.

Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial.

Bethany S. Jones, Max C. Richardson, Louis I. Hamilton, 2022, JAMA.

Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management.

D. McAuley, C. O’Kane, E. Gorman, 2022, Lancet.

The paradox of matrix metalloproteinases in infectious disease

J. Friedland, P. Elkington, C. O’Kane, 2005, Clinical and experimental immunology.

Reply to Letter: "Effect of Simvastatin on Physiological and Biological Outcomes in Patients Undergoing Esophagectomy: A Randomized Placebo-controlled Trial".

D. McAuley, C. O’Kane, M. Shyamsundar, 2015, Annals of surgery.

Novel pulmonary biomarkers in the diagnosis of VAP

D. McAuley, Cecilia M O'Kane, C. O’Kane, 2010, Thorax.

Elevated Plasma Interleukin-18 Identifies High-Risk Acute Respiratory Distress Syndrome Patients not Distinguished by Prior Latent Class Analyses Using Traditional Inflammatory Cytokines: A Retrospective Analysis of Two Randomized Clinical Trials.

M. Matthay, C. Calfee, R. Baron, 2023, Critical care medicine.

Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials

M. Matthay, D. McAuley, J. Levitt, 2023, Critical Care.