Adam K. Hedger

发表

Detecting chromatin interactions along and between sister chromatids with SisterC

J. Dekker, J. Watts, Marlies E Oomen, 2020, bioRxiv.

Detecting chromatin interactions between and along sister chromatids with SisterC

J. Dekker, J. Watts, Marlies E Oomen, 2020, Nature Methods.

SisterC: A novel 3C-technique to detect chromatin interactions between and along sister chromatids

J. Dekker, J. Watts, Marlies E Oomen, 2020 .

Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state

C. Schiffer, H. Matsuo, J. Watts, 2022, bioRxiv.

Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance.

C. Schiffer, Akbar Ali, Adam K. Hedger, 2022, Journal of molecular biology.

Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance

C. Schiffer, E. Chan, Akbar Ali, 2021, bioRxiv.

Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.

C. Schiffer, C. Petropoulos, Wei Huang, 2021, Journal of medicinal chemistry.

Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors

C. Schiffer, Akbar Ali, Adam K. Hedger, 2020, mBio.

Progress toward an amplifiable metabolic label for DNA: conversion of 4-thiothymidine (4sT) to 5-methyl-2′-deoxycytidine and synthesis of a 4sT phosphorodiamidate prodrug

N. Rhind, J. Dekker, J. Watts, 2018, Canadian Journal of Chemistry.

Next generation APOBEC3 inhibitors: Optimally designed for potency and nuclease stability

Nese Kurt-Yilmaz, Adam K. Hedger, W. Myint, 2024, bioRxiv.