C. Witt

发表

Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin.

Leena Peltonen, Siegfried Labeit, Bjarne Udd, 2002, American journal of human genetics.

Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients.

A. Girbes, C. Ottenheijm, M. Paul, 2015, American journal of respiratory and critical care medicine.

Deletion in the Z‐line region of the titin gene in a baby hamster kidney cell line, BHK‐21‐Bi

H. Jockusch, S. Labeit, C. Witt, 1997, FEBS letters.

Induction of MuRF1 is essential for TNF-alpha-induced loss of muscle function in mice.

G. Schuler, S. Gielen, A. Linke, 2008, Journal of molecular biology.

Variable titin-based stiffness adjustment in heart disease.

M. LeWinter, H. Granzier, S. Bell, 2003, Circulation.

Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development

C. Gregorio, A. McElhinny, S. Labeit, 2004, Journal of Cell Science.

Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin‐free skeletal muscle

C. Ottenheijm, H. Granzier, P. Vangheluwe, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Selective Diaphragm Muscle Weakness After Contractile Inactivity During Thoracic Surgery

C. Ottenheijm, H. Granzier, M. Paul, 2011, Annals of surgery.

Induction of Ankrd1 in Dilated Cardiomyopathy Correlates with the Heart Failure Progression

J. Čelutkienė, K. Brohm, S. Labeit, 2015, BioMed research international.

Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility.

U. Wisløff, G. Schuler, R. Hambrecht, 2007, Cardiovascular research.

Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms.

S. Lecker, M. Willis, L. Carrier, 2010, Cardiovascular research.

Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice

H. Granzier, S. Labeit, C. Witt, 2010, Journal of biomedicine & biotechnology.

MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance.

H. Granzier, S. Labeit, A. Moriscot, 2010, Journal of structural biology.

Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.

V. Rybin, Keiji Tanaka, S. Witt, 2008, Journal of molecular biology.

Normal cardiac contraction in mice lacking the proline-alanine rich region and C1 domain of cardiac myosin binding protein C.

S. Harris, C. Witt, S. V. van Dijk, 2015, Journal of molecular and cellular cardiology.

Hypercontractile Properties of Cardiac Muscle Fibers in a Knock-in Mouse Model of Cardiac Myosin-binding Protein-C*

M. Davies, W. Linke, B. Gerull, 2001, The Journal of Biological Chemistry.

Response to the letter of Drs. Mikhailov and Torrado

S. Witt, S. Labeit, C. Witt, 2006, Journal of Muscle Research & Cell Motility.

Molecular tools for the study of titin's differential expression.

C. Gregorio, H. Granzier, F. Fougerousse, 2000, Advances in experimental medicine and biology.

Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity.

C. Gregorio, H. Granzier, F. Fougerousse, 2000, Circulation Research.

Nebulin Alters Cross-bridge Cycling Kinetics and Increases Thin Filament Activation

C. Ottenheijm, H. Granzier, S. Ford, 2009, The Journal of Biological Chemistry.

Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency.

C. Ottenheijm, A. Beggs, H. Granzier, 2009, Human molecular genetics.

Expression of distinct classes of titin isoforms in striated and smooth muscles by alternative splicing, and their conserved interaction with filamins.

Dietmar Labeit, Siegfried Labeit, Henk Granzier, 2006, Journal of molecular biology.

Nebulin regulates thin filament length, contractility, and Z‐disk structure in vivo

Yiming Wu, Dietmar Labeit, Siegfried Labeit, 2006, The EMBO journal.

The complete mouse nebulin gene sequence and the identification of cardiac nebulin.

Christian C Witt, Siegfried Labeit, C. Gregorio, 2003, Journal of molecular biology.

The Complete Gene Sequence of Titin, Expression of an Unusual ≈700-kDa Titin Isoform, and Its Interaction With Obscurin Identify a Novel Z-Line to I-Band Linking System

Dietmar Labeit, Siegfried Labeit, M. Bang, 2001 .

I-Band Titin in Cardiac Muscle Is a Three-Element Molecular Spring and Is Critical for Maintaining Thin Filament Structure

Wolfgang A. Linke, Siegfried Labeit, Mathias Gautel, 1999, The Journal of cell biology.

The titin cDNA sequence and partial genomic sequences: insights into the molecular genetics, cell biology and physiology of the titin filament system.

W. Linke, C. Gregorio, G. Stier, 1999, Reviews of physiology, biochemistry and pharmacology.

A survey of the primary structure and the interspecies conservation of I-band titin's elastic elements in vertebrates.

A. Pastore, H. Jockusch, S. Millevoi, 1998, Journal of structural biology.

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system.

T Centner, M. Bang, C. Gregorio, 2001, Circulation research.

Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity.

T Centner, W Hell, C. Gregorio, 2000, Circulation research.

Titin (TTN) Gene

H. Granzier, S. Labeit, C. Witt, 2005 .

MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination.

Christian C Witt, Stephanie H Witt, Siegfried Labeit, 2005, Journal of molecular biology.

The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules.

Christian C Witt, Dietmar Labeit, Siegfried Labeit, 2003, Journal of molecular biology.

Calcium-dependent molecular spring elements in the giant protein titin

Yiming Wu, Dietmar Labeit, Siegfried Labeit, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Conditional Expression of Mutant M-line Titins Results in Cardiomyopathy with Altered Sarcomere Structure*

Christian C Witt, Siegfried Labeit, Joachim Herz, 2003, The Journal of Biological Chemistry.

Adaptations in titin's spring elements in normal and cardiomyopathic hearts.

Yiming Wu, Dietmar Labeit, Siegfried Labeit, 2003, Advances in experimental medicine and biology.

Changes in Titin Isoform Expression in Pacing-Induced Cardiac Failure Give Rise to Increased Passive Muscle Stiffness

Yiming Wu, Christian C Witt, Siegfried Labeit, 2002, Circulation.

Titin-actin interaction in mouse myocardium: passive tension modulation and its regulation by calcium/S100A1.

H. Granzier, M. Berri, M. Kellermayer, 2001, Biophysical journal.

THE STUDY OF TITIN'S DIFFERENTIAL EXPRESSION

C. Gregorio, F. Fougerousse, H. Granzier, 2000 .

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

Thomas W. Mühleisen, N. Wray, D. Rujescu, 2017, Translational Psychiatry.

Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.

K. Pelin, M. Bang, C. Gregorio, 2001, Journal of molecular biology.

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling.

Yiming Wu, Christian C Witt, Stephanie H Witt, 2004, Journal of molecular biology.

Genomic organization of M line titin and its tissue-specific expression in two distinct isoforms.

B. Kolmerer, S. Labeit, C. Witt, 1996, Journal of molecular biology.

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.

C. Ottenheijm, A. Aiba, K. Nakao, 2010, The Journal of clinical investigation.

Altered Titin Expression, Myocardial Stiffness, and Left Ventricular Function in Patients With Dilated Cardiomyopathy

Yiming Wu, Christian C. Witt, Siegfried Labeit, 2004, Circulation.

Longitudinal transcriptome-wide gene expression analysis of sleep deprivation treatment shows involvement of circadian genes and immune pathways

M. Rietschel, A. Meyer-Lindenberg, B. Müller-Myhsok, 2019, bioRxiv.

Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2

Christian C Witt, Stephanie H Witt, Stefanie Lerche, 2007, The EMBO journal.

Dimerization of the cardiac ankyrin protein CARP: Implications for MARP titin-based signaling

Christian C. Witt, Stephanie H. Witt, Dietmar Labeit, 2006, Journal of Muscle Research & Cell Motility.

Small‐molecule‐mediated chemical knock‐down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure

V. Beneš, Joe D. Lewis, P. Sehr, 2019, Journal of cachexia, sarcopenia and muscle.

In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype

M. Jubeau, N. Gretz, P. Cozzone, 2013, Neuromuscular Disorders.

Comparison of gene expression profiles in the blood, hippocampus and prefrontal cortex of rats

M. Rietschel, A. Hansson, S. Witt, 2013, In Silico Pharmacology.

Investigation of manic and euthymic episodes identifies state- and trait-specific gene expression and STAB1 as a new candidate gene for bipolar disorder

S. Cichon, M. Rietschel, M. Nöthen, 2014, Translational Psychiatry.

Comparison of gene expression profiles in the blood, hippocampus and prefrontal cortex of rats

M. Rietschel, A. Hansson, S. Witt, 2013, In Silico Pharmacology.

Titin expression in human articular cartilage and cultured chondrocytes: a novel component in articular cartilage biomechanical sensing?

S. Milz, S. Witt, H. Scharf, 2008, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.