D. J. Bennett

发表

Design, structure activity relationships and X-Ray co-crystallography of non-steroidal LXR agonists.

D. J. Bennett, E. Carswell, A. Cooke, 2008, Current medicinal chemistry.

Non-steroidal LXR agonists; an emerging therapeutic strategy for the treatment of atherosclerosis.

D. J. Bennett, A. Cooke, A. S. Edwards, 2006, Recent patents on cardiovascular drug discovery.

Liver X receptor agonists as a treatment for atherosclerosis

E. Moir, Peter C. Ray, D. J. Bennett, 2004 .

Discovery of a chemical probe for PRDM9

E. Guccione, C. Arrowsmith, M. Schapira, 2019, Nature Communications.

Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activity relationships.

A. Bom, D. Rees, G. Rosair, 2002, Journal of medicinal chemistry.

An update on non-steroidal liver X receptor agonists and their potential use in the treatment of atherosclerosis

L. Brown, D. J. Bennett, A. Cooke, 2006 .

Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds.

X. Fradera, Haiyan Xu, M. Bittinger, 2021, ACS medicinal chemistry letters.

Novel water soluble 2,6-dimethoxyphenyl ester derivatives with intravenous anaesthetic activity.

D. J. Bennett, A. Cooke, M. Maidment, 2003, Bioorganic & medicinal chemistry letters.

1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors: separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen pka.

X. Fradera, D. J. Bennett, P. Jones, 2011, Bioorganic & medicinal chemistry letters.

Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing.

Theodore A. Martinot, Yongxin Han, N. Solban, 2022, Journal of medicinal chemistry.

Discovery of MK‐8970: An Acetal Carbonate Prodrug of Raltegravir with Enhanced Colonic Absorption

Q. Dang, Jing Li, P. Coleman, 2015, ChemMedChem.

STimulator of INterferon Genes Agonism Accelerates Antitumor Activity in Poorly Immunogenic Tumors

J. Cumming, Sarah Javaid, A. Tse, 2021, Molecular Cancer Therapeutics.

Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1).

Patrick J. Curran, Mee Ra Heo, M. Augustin, 2020, ACS medicinal chemistry letters.

Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group.

W. Shipe, H. Su, J. Gesell, 2016, ACS medicinal chemistry letters.

Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV-1 Protease Inhibitors.

Tao Ji, William Morris, M Katharine Holloway, 2017, ACS medicinal chemistry letters.

Alpha(2) adrenoceptor agonists as potential analgesic agents. 1. (Imidazolylmethyl)oxazoles and -thiazoles.

R. E. Boyd, R. Raffa, A. Reitz, 1999, Journal of medicinal chemistry.

Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.

Theodore A. Martinot, Michael J. Ardolino, Xiao Wang, 2019, ACS medicinal chemistry letters.

Identification and in Vivo Evaluation of Liver X Receptor β-Selective Agonists for the Potential Treatment of Alzheimer's Disease.

K. K. Nanda, M. Rudd, J. Uslaner, 2016, Journal of medicinal chemistry.

N-aryl-N'-benzylpiperazines as potential antipsychotic agents.

M. Renzi, M. McDonnell, A. Reitz, 1995, Journal of medicinal chemistry.

Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.

Andrew M Haidle, Matthew L. Maddess, J. Cumming, 2022, Journal of medicinal chemistry.

A kinase-cGAS cascade to synthesize a therapeutic STING activator

Steven P. Miller, Paul N. Devine, Matthew L. Maddess, 2022, Nature.

A Selective Synthesis of 2,2-Difluorobicyclo[1.1.1]pentane Analogues: "BCP-F2".

Yongxin Han, D. J. Bennett, Xiaoshen Ma, 2019, Organic letters.

An orally available non-nucleotide STING agonist with antitumor activity

Andrew M Haidle, J. Cumming, I. Kariv, 2020, Science.

Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors.

Patrick J. Curran, Theodore A. Martinot, Yongxin Han, 2021, ACS medicinal chemistry letters.

A facile synthesis of N-benzylallylglycine

D. J. Bennett, N. Hamilton, 2000 .

4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important.

X. Fradera, J. Uitdehaag, D. J. Bennett, 2010, Bioorganic & medicinal chemistry letters.

2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors.

X. Fradera, Z. Rankovic, J. Uitdehaag, 2010, Bioorganic & medicinal chemistry letters.

Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors.

X. Fradera, Z. Rankovic, J. Uitdehaag, 2010, Bioorganic & medicinal chemistry letters.

X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.

Ross McGuire, Robert Wynands, Xavier Fradera, 2010, Journal of molecular biology.

Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors.

Yongxin Han, N. Solban, X. Fradera, 2020, ACS medicinal chemistry letters.

A New Arylpiperazine Antipsychotic (IV) with High D2/D3/5-HT1A/α 1A-Adrenergic Affinity and a Low Potential for Extrapyramidal Effects.

M. Renzi, R. Shank, A. Reitz, 1994 .

A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects.

M. Renzi, R. Shank, A. Reitz, 1994, Journal of medicinal chemistry.

Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.

Michael J. Ardolino, Karin M. Otte, M. Kennedy, 2021, Journal of medicinal chemistry.

Rapid Access to 2-Substituted Bicyclo[1.1.1]pentanes.

D. MacMillan, C. Yeung, Yufan Liang, 2023, Journal of the American Chemical Society.

Selective Synthesis of 1-Dialkylamino-2-alkylbicyclo-[1.1.1]pentanes.

Yongxin Han, D. J. Bennett, Xiaoshen Ma, 2020, Organic letters.

General access to cubanes as benzene bioisosteres

D. MacMillan, C. Yeung, D. J. Bennett, 2023, Nature.

Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.

Theodore A. Martinot, Michael J. Ardolino, Matthew L. Maddess, 2022, Journal of medicinal chemistry.

Enantiospecific enzyme-catalysed resolution of novel N,N-disubstituted α-amino acid phenolic ester derivatives using pig liver esterase

D. J. Bennett, A. Cooke, O. Epemolu, 2001 .

Design of Prodrugs to Enhance Colonic Absorption by Increasing Lipophilicity and Blocking Ionization

Q. Dang, P. Coleman, A. Templeton, 2014, Pharmaceuticals.

Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Michael E. Lassman, Jeffrey T. Kuethe, M. Struthers, 2015, ACS medicinal chemistry letters.

α-Amino Acid Phenolic Ester Derivatives: Novel Water-Soluble General Anesthetic Agents Which Allosterically Modulate GABAA Receptors

R. McGuire, J. A. Peters, J. Lambert, 2001 .