Olivier René

发表

Syntheses of [3H2]T0901317 and a labeled structural isomer, and characterization of the dispersed labeled compounds via 19F NMR

Adam R. Johnson, P. Lockey, H. Wong, 2014 .

Late steps of ribosome assembly in E. coli are sensitive to a severe heat stress but are assisted by the HSP70 chaperone machine†

J. Alix, Olivier René, 2010, Nucleic acids research.

Efficient syntheses of 2-fluoroalkylbenzimidazoles and -benzothiazoles

Steven R. Magnuson, B. Fauber, Olivier René, 2013 .

A reversed sulfonamide series of selective RORc inverse agonists.

Bohdan Waszkowycz, Emanuela Gancia, Peter Lockey, 2014, Bioorganic & medicinal chemistry letters.

Palladium-Catalyzed Ring Expansion of Spirocyclopropanes to Form Caprolactams and Azepanes.

A. Gobbi, B. Fauber, Olivier René, 2015, The Journal of organic chemistry.

Evaluation of Electron‐Deficient Phosphine Ligands for Direct Arylation of Heterocycles

Olivier René, K. Fagnou, 2010 .

Advances in Palladium-Catalyzed Carbon-Carbon Bond Formation Via Functionalization of Carbon-Hydrogen Bonds

Olivier René, 2010 .

Room-temperature direct arylation of polyfluorinated arenes under biphasic conditions.

Olivier René, K. Fagnou, 2010, Organic letters.

Domino palladium-catalyzed Heck-intermolecular direct arylation reactions.

Olivier René, David Lapointe, K. Fagnou, 2009, Organic letters.

Syntheses of 4-, 5-, 6-, and 7-substituted tryptamine derivatives and the use of a bromine atom as a protecting group

B. Fauber, Olivier René, 2014 .

Palladium-catalyzed α-arylation of sultams with aryl and heteroaryl iodides.

B. Fauber, Olivier René, Sushant Malhotra, 2014, Organic letters.

Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) inverse agonist.

Adam R. Johnson, P. Lockey, W. Ouyang, 2015, Journal of medicinal chemistry.

Mechanism and regioselectivity of the cycloaddition of thiones derived from Meldrum's acid, malonates, or other dicarbonyls.

Olivier René, Y. Dory, C. Spino, 2008, The Journal of organic chemistry.

Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties.

Adam R. Johnson, A. Barnard, H. Wong, 2016, Bioorganic & medicinal chemistry letters.

Experimental and Computational Studies of the Diastereoselective Alkylations of 3-Substituted γ-Sultams.

B. Fauber, Olivier René, Kyle Clagg, 2015, The Journal of organic chemistry.

Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.

Peter Lockey, Maxine Norman, Adam R. Johnson, 2015, ACS medicinal chemistry letters.

Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.

Adam R. Johnson, P. Lockey, W. Ouyang, 2013, Bioorganic & medicinal chemistry letters.

Identification of tertiary sulfonamides as RORc inverse agonists.

Adam R. Johnson, P. Lockey, H. Wong, 2014, Bioorganic & medicinal chemistry letters.

Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists.

Adam R. Johnson, P. Lockey, W. Ouyang, 2014, Bioorganic & medicinal chemistry letters.

Identification of tertiary sulfonamides as RORc inverse agonists.

Adam R. Johnson, P. Lockey, H. Wong, 2014, Bioorganic & medicinal chemistry letters.