Xiaohu Deng

发表

Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation

A. Bittner, Jiejun Wu, T. Rao, 2014, Proceedings of the National Academy of Sciences.

Practical Synthesis of a Cathepsin S Inhibitor

Xiaohu Deng, N. Mani, T. LiangJimmy, 2013 .

Boron trifluoride etherate-assisted ring opening of ethylene oxide by a chiral organolithium: enantioselective synthesis of (R)-N-Boc-2-(2-hydroxyethyl)pyrrolidine

Xiaohu Deng, N. Mani, 2005 .

Reactivity-Controlled Regioselectivity: A Regiospecific Synthesis of 1,2-Disubstituted Benzimidazoles

Xiaohu Deng, N. Mani, 2010 .

Allyl-Assisted, Cu(I)-Catalyzed Azide-Alkyne Cycloaddition/Allylation Reaction: Assembly of the [1,2,3]Triazolo-4,5,6,7-tetrahydropyridine Core Structure.

C. Dvorak, B. Savall, J. Liang, 2015, The Journal of organic chemistry.

Protecting-group-free synthesis of a dual CCK1/CCK2 receptor antagonist.

Xiaohu Deng, N. Mani, H. Venkatesan, 2011, Organic & biomolecular chemistry.

Identification of Structural Motifs Critical for Epstein-Barr Virus-Induced Molecule 2 Function and Homology Modeling of the Ligand Docking Site

T. Lovenberg, Jiejun Wu, Xia V. Yang, 2012, Molecular Pharmacology.

Fluoro analogs of bioactive oxy-sterols: Synthesis of an EBI2 agonist with enhanced metabolic stability.

Jiejun Wu, Changlu Liu, C. Kuei, 2016, Bioorganic & medicinal chemistry letters.

From Lab Formulation Development to CTM Manufacturing of KO-947 Injectable Drug Products: a Case Study and Lessons Learned

Hongbing Wu, P. Ren, Xiaohu Deng, 2021, AAPS PharmSciTech.

Base-mediated reaction of hydrazones and nitroolefins with a reversed regioselectivity: a novel synthesis of 1,3,4-trisubstituted pyrazoles.

Xiaohu Deng, N. Mani, 2008, Organic letters.

Regioselective synthesis of 1,3,5-tri- and 1,3,4,5-tetrasubstituted pyrazoles from N-arylhydrazones and nitroolefins.

Xiaohu Deng, N. Mani, 2008, The Journal of organic chemistry.

Regioselective Synthesis of 4‐Nitro‐ or 4‐Chloro‐Tetrasubstituted Pyrazoles from Hydrazones and β‐Halo‐β‐nitrostyrenes

Xiaohu Deng, N. Mani, T. LiangJimmy, 2014 .

Convergent Synthesis of a 5HT7/5HT2 Dual Antagonist

Xiaohu Deng, N. Mani, T. LiangJimmy, 2011 .

An efficient route to 4-aryl-5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine.

Xiaohu Deng, N. Mani, 2006, Organic letters.

Stereoselective synthesis of Z-α-aryl-α,β-unsaturated esters

Xiaohu Deng, N. Mani, T. K. Jones, 2006 .

A facile, environmentally benign sulfonamide synthesis in water

Xiaohu Deng, N. Mani, Xiaohu Deng, 2006 .

CuI-catalyzed amination of arylhalides with guanidines or amidines: a facile synthesis of 1-H-2-substituted benzimidazoles.

Xiaohu Deng, N. Mani, Heather M. McAllister, 2009, The Journal of organic chemistry.

Hindered Biaryl Bond Construction and Subsequent Diastereomeric Crystallization to Produce an Atropisomeric Covalent KRASG12C Inhibitor ARS-2102

P. Ren, Xiaohu Deng, Lian-Sheng Li, 2022, Organic Process Research & Development.

Reaction of N-monosubstituted hydrazones with nitroolefins: a novel regioselective pyrazole synthesis.

Xiaohu Deng, N. Mani, 2006, Organic letters.

Regioselective Synthesis of 4‐Nitro‐ or 4‐Chloro‐Tetrasubstituted Pyrazoles from Hydrazones and β‐Halo‐β‐nitrostyrenes.

J. Liang, Xiaohu Deng, N. Mani, 2014 .

A Practical Synthesis of Enantiopure 7-Alkoxy-4-aryl-tetrahydroisoquinoline, a Dual Serotonin Reuptake Inhibitor/Histamine H3 Antagonist

C. Schubert, J. Liang, Xiaohu Deng, 2007 .

Selective Metalation of Functionalized Quinazolines to Enable Discovery and Advancement of Covalent KRAS Inhibitors

P. Ren, J. Liang, Xiaohu Deng, 2022, Organic Process Research & Development.

Direct, metal-free amination of heterocyclic amides/ureas with NH-heterocycles and N-substituted anilines in POCl3.

Ivana Brdar, Xiaohu Deng, N. Mani, 2011, The Journal of organic chemistry.

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

P. Zarrinkar, K. Yu, D. Brehmer, 2018, Cell.

A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate.

C. Dvorak, N. Carruthers, A. Bhattacharya, 2018, Journal of medicinal chemistry.

Identification and optimization of anthranilic sulfonamides as novel, selective cholecystokinin-2 receptor antagonists.

M. Rosen, C. Woods, M. Hack, 2006, Journal of medicinal chemistry.

Development of a Recycling Process for an Industrial-Scale Production of Tipifarnib

Lu Wang, Pingda Ren, Xiaohu Deng, 2021, Organic Process Research & Development.

Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase.

Cheryl A. Grice, L. Karlsson, A. Fourie, 2013, Bioorganic & medicinal chemistry letters.

Solid Form Selection and Process Development of KO-947 Drug Substances

Tao Wu, Bo Mei, Linrong Zhu, 2021 .

A Practical Synthesis of Regioisomeric 6- and 7-Methoxytetrahydro-3-benzazepines

Xiaohu Deng, N. Mani, T. LiangJimmy, 2010 .

Identification of Structural Motifs Critical for Epstein-Barr Virus-Induced Molecule 2 Function and Homology Modeling of the Ligand Docking Site

T. Lovenberg, Jiejun Wu, Xia V. Yang, 2012, Molecular Pharmacology.

Fluoro analogs of bioactive oxy-sterols: Synthesis of an EBI2 agonist with enhanced metabolic stability.

Jiejun Wu, Changlu Liu, Victory Joseph, 2016, Bioorganic & medicinal chemistry letters.