N. Mani

发表

Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation

A. Bittner, Jiejun Wu, T. Rao, 2014, Proceedings of the National Academy of Sciences.

First, Second, and Third Generation Scalable Syntheses of Two Potent H3 Antagonists

N. Mani, F. Villani, D. Pippel, 2011 .

A scalable synthesis of a histamine H3 receptor antagonist.

J. A. Jablonowski, N. Mani, T. K. Jones, 2004, The Journal of organic chemistry.

Practical Synthesis of a Cathepsin S Inhibitor

Xiaohu Deng, N. Mani, T. LiangJimmy, 2013 .

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.

Cheryl A. Grice, P. Desai, R. Thurmond, 2010, Bioorganic & medicinal chemistry letters.

Oxysterols direct B-cell migration through EBI2

L. Karlsson, T. Lovenberg, Jiejun Wu, 2011, Nature.

Boron trifluoride etherate-assisted ring opening of ethylene oxide by a chiral organolithium: enantioselective synthesis of (R)-N-Boc-2-(2-hydroxyethyl)pyrrolidine

Xiaohu Deng, N. Mani, 2005 .

Reactivity-Controlled Regioselectivity: A Regiospecific Synthesis of 1,2-Disubstituted Benzimidazoles

Xiaohu Deng, N. Mani, 2010 .

Allyl-Assisted, Cu(I)-Catalyzed Azide-Alkyne Cycloaddition/Allylation Reaction: Assembly of the [1,2,3]Triazolo-4,5,6,7-tetrahydropyridine Core Structure.

C. Dvorak, B. Savall, J. Liang, 2015, The Journal of organic chemistry.

Regioselective Electrophilic Fluorination of Rationally Designed Imidazole Derivatives.

N. Mani, Klaus Albertshofer, 2016, The Journal of organic chemistry.

Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate.

P. Bonaventure, Kiev S. Ly, T. Lovenberg, 2015, Journal of medicinal chemistry.

Protecting-group-free synthesis of a dual CCK1/CCK2 receptor antagonist.

Xiaohu Deng, N. Mani, H. Venkatesan, 2011, Organic & biomolecular chemistry.

Identification of Structural Motifs Critical for Epstein-Barr Virus-Induced Molecule 2 Function and Homology Modeling of the Ligand Docking Site

T. Lovenberg, Jiejun Wu, Xia V. Yang, 2012, Molecular Pharmacology.

Discovery of a potent, orally active, nonsteroidal androgen receptor agonist: 4-ethyl-1,2,3,4-tetrahydro-6- (trifluoromethyl)-8-pyridono[5,6-g]- quinoline (LG121071).

L. Hamann, N. Mani, T. K. Jones, 1999, Journal of medicinal chemistry.

Gram-Scale Synthesis of a β-Secretase 1 (BACE 1) Inhibitor

N. Mani, B. Allison, 2017, ACS omega.

Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793.

P. Bonaventure, C. Dvorak, T. Lovenberg, 2020, ACS medicinal chemistry letters.

Fluoro analogs of bioactive oxy-sterols: Synthesis of an EBI2 agonist with enhanced metabolic stability.

Jiejun Wu, Changlu Liu, C. Kuei, 2016, Bioorganic & medicinal chemistry letters.

The synthesis of 2-amino-4(3H)-quinazolinones and related heterocycles via a mild electrocyclization of aryl guanidines

N. Mani, B. Allison, Zachary S. Sales, 2018 .

SYNTHESIS OF A NOVEL BIS-GLUCO-CROWN ETHER DERIVATIVE

P. P. Kanakamma, V. Nair, N. Mani, 1995 .

Base-mediated reaction of hydrazones and nitroolefins with a reversed regioselectivity: a novel synthesis of 1,3,4-trisubstituted pyrazoles.

Xiaohu Deng, N. Mani, 2008, Organic letters.

Regioselective synthesis of 1,3,5-tri- and 1,3,4,5-tetrasubstituted pyrazoles from N-arylhydrazones and nitroolefins.

Xiaohu Deng, N. Mani, 2008, The Journal of organic chemistry.

Regioselective Synthesis of 4‐Nitro‐ or 4‐Chloro‐Tetrasubstituted Pyrazoles from Hydrazones and β‐Halo‐β‐nitrostyrenes

Xiaohu Deng, N. Mani, T. LiangJimmy, 2014 .

Convergent Synthesis of a 5HT7/5HT2 Dual Antagonist

Xiaohu Deng, N. Mani, T. LiangJimmy, 2011 .

Syntheses based on cyclohexadienes. Part 2. Convenient synthesis of 6-alkylsalicylates, 6-alkyl-2,4-dihydroxybenzoate, and 2,5-dialkylresorcinols

N. Mani, C. Kanakam, H. Ramanathan, 1989 .

An efficient route to 4-aryl-5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine.

Xiaohu Deng, N. Mani, 2006, Organic letters.

Stereoselective synthesis of Z-α-aryl-α,β-unsaturated esters

Xiaohu Deng, N. Mani, T. K. Jones, 2006 .

Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator.

Arjan van Oeveren, Mehrnouch Motamedi, Neelakandha S Mani, 2006, Journal of medicinal chemistry.

High-Yielding Syntheses of 1-Piperidin-4-yl Butyro- and Valerolactams through a Tandem Reductive Amination−Lactamization (Reductive Lactamization)

N. Mani, Christopher M. Mapes and, 2007 .

Scale-Up Synthesis of a TRPV1 Antagonist Featuring a Facile Thiazolo[5,4-d]pyrimidine Formation

N. Mani, Jing Liu, A. Lebsack, 2011 .

A facile, environmentally benign sulfonamide synthesis in water

Xiaohu Deng, N. Mani, Xiaohu Deng, 2006 .

CuI-catalyzed amination of arylhalides with guanidines or amidines: a facile synthesis of 1-H-2-substituted benzimidazoles.

Xiaohu Deng, N. Mani, Heather M. McAllister, 2009, The Journal of organic chemistry.

Reaction of N-monosubstituted hydrazones with nitroolefins: a novel regioselective pyrazole synthesis.

Xiaohu Deng, N. Mani, 2006, Organic letters.

Regioselective Synthesis of 4‐Nitro‐ or 4‐Chloro‐Tetrasubstituted Pyrazoles from Hydrazones and β‐Halo‐β‐nitrostyrenes.

J. Liang, Xiaohu Deng, N. Mani, 2014 .

Porphyrazines and Norphthalocyanines Bearing Nitrogen Donor Pockets: Metal Sensor Properties.

David J. Williams, A. Barrett, B. Hoffman, 1998, The Journal of organic chemistry.

A Practical Synthesis of Enantiopure 7-Alkoxy-4-aryl-tetrahydroisoquinoline, a Dual Serotonin Reuptake Inhibitor/Histamine H3 Antagonist

C. Schubert, J. Liang, Xiaohu Deng, 2007 .

Selective Metalation of Functionalized Quinazolines to Enable Discovery and Advancement of Covalent KRAS Inhibitors

P. Ren, J. Liang, Xiaohu Deng, 2022, Organic Process Research & Development.

Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: synthesis and preliminary SAR analysis.

John J. M. Wiener, Cheryl A. Grice, M. Hack, 2007, Bioorganic & medicinal chemistry letters.

An efficient intramolecular 1,3-dipolar cycloaddition involving 2-(1,2-dichlorovinyloxy)aryldiazomethanes: a one-pot synthesis of benzofuropyrazoles from salicylaldehydes.

N. Mani, Zachary S. Sales, 2009, The Journal of organic chemistry.

Synthesis of a dextrophane prototype: a novel cavity molecule

A. Barrett, N. Mani, 1987 .

A Concise Synthesis of (+)-Cerulenin from a Chiral Oxiranyllithium.

C. Townsend, N. Mani, 1997, The Journal of organic chemistry.

Synthesis of 4-arylpiperidines from 1-benzyl-4-piperidone: application of the Shapiro reaction and alkenylsilane cross-coupling.

N. Mani, C. Morrill, 2007, Organic letters.

Addition of Grignard Reagents to Quinolinium Salts: Evidence for a Unique Redox Reaction between a 1,4- and a 1,2-Dihydroquinoline.

N. Mani, T. K. Jones, Peng Chen, 1999, The Journal of organic chemistry.

Synthesis and antitumor activity of an inhibitor of fatty acid synthase.

C. Townsend, F. Kuhajda, E. Pizer, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Chiral crown ethers incorporating D-glucose

P. P. Kanakamma, V. Nair, U. Maitra, 1995 .

Direct, metal-free amination of heterocyclic amides/ureas with NH-heterocycles and N-substituted anilines in POCl3.

Ivana Brdar, Xiaohu Deng, N. Mani, 2011, The Journal of organic chemistry.

Synthesis and antitumor activity of an inhibitor of fatty acid synthase

C. Townsend, F. Kuhajda, E. Pizer, 2000 .

Synthesis based on cyclohexadienes: Part 4. Novel synthesis of the 6-aryl-2,4-dimethoxybenzoates. Alternariol and methyl trimethylaltenusin

N. Mani, C. Kanakam, G. Rao, 1990 .

Convenient Preparation of Glycosyl Bromides

N. Mani, Puthuparambil P. Kanakamma, 1992 .

Synthesis of novel chiral macrocycles: crown ethers derived from D-glucose

N. Mani, Puthuparambil P. Kanakamma, 1994 .

Convenient Preparation of Glycosyl Bromides.

N. Mani, Puthuparambil P. Kanakamma, 1993 .

Synthesis of Novel Chiral Macrocycles: Crown Ethers Derived from D‐ Glucose.

N. Mani, Puthuparambil P. Kanakamma, 1994 .

A novel entry to xanthones by an intramolecular Diels-Alder reaction involving 2-(1,2-dichlorovinyloxy) aryl dienones

K. Otrubova, N. Mani, A. Fitzgerald, 2018, Tetrahedron.

Characterization of in Vivo Nitrate Reductase Activity in Triticum Vulgare Seedlings

N. Mani, B. Seshagiri, D. Kaladhar, 2009 .

Synthesis and characterisation of porphyrazinoctamine derivatives: X-ray crystallographic studies of [2,3,7,8,12,13,17,18-octakis(dibenzylamino)- porphyrazinato]magnesium(II) and {2,3,7,8,12,13,17,18-octakis[allyl(benzyl)amino]- porphyrazinato} nickel(II)

A. Barrett, B. Hoffman, S. Parkin, 1994 .

A step-economical route to fused 1,2,3-triazoles via an intramolecular 1,3-dipolar cycloaddition between a nitrile and an in situ generated aryldiazomethane.

N. Mani, A. Fitzgerald, 2014, The Journal of organic chemistry.

A Step‐Economical Route to Fused 1,2,3‐Triazoles via an Intramolecular 1,3‐Dipolar Cycloaddition Between a Nitrile and an in situ Generated Aryldiazomethane.

N. Mani, E. FitzgeraldAnne, 2015 .

Reactions between Weinreb amides and 2-magnesiated oxazoles: a simple and efficient preparation of 2-acyl oxazoles.

N. Mani, D. Pippel, C. M. Mapes, 2007, The Journal of organic chemistry.

Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development.

P. Bonaventure, Kiev S. Ly, T. Lovenberg, 2015, ACS Medicinal Chemistry Letters.

A Practical Synthesis of Regioisomeric 6- and 7-Methoxytetrahydro-3-benzazepines

Xiaohu Deng, N. Mani, T. LiangJimmy, 2010 .

Regioselective assembly of fused pyrazole-azepine heterocycles: Synthesis of the 5-HT7 antagonist 1-benzyl-3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine

C. Dvorak, N. Carruthers, N. Mani, 2021 .

Carboxylation reaction of a highly functionalized vinylic anion: a case of unexpected stability and reactivity

Sudipto Basu, N. Mani, J. Breitenbucher, 2010 .

Identification of Structural Motifs Critical for Epstein-Barr Virus-Induced Molecule 2 Function and Homology Modeling of the Ligand Docking Site

T. Lovenberg, Jiejun Wu, Xia V. Yang, 2012, Molecular Pharmacology.