Youyan Zhang

发表

A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activity1

W. K. Wilson, K. Houck, K. Borchert, 2006, Journal of Lipid Research.

Coadministration of a Liver X Receptor Agonist and a Peroxisome Proliferator Activator Receptor-α Agonist in Mice: Effects of Nuclear Receptor Interplay on High-Density Lipoprotein and Triglyceride Metabolism in Vivo

S. Karathanasis, P. Eacho, R. Schmidt, 2004, Journal of Pharmacology and Experimental Therapeutics.

A Natural Product Ligand of the Oxysterol Receptor, Liver X Receptor

K. Houck, K. Borchert, K. Bramlett, 2003, Journal of Pharmacology and Experimental Therapeutics.

Liver X receptor and retinoic X receptor mediated ABCA1 regulation and cholesterol efflux in macrophage cells-messenger RNA measured by branched DNA technology.

K. Bramlett, P. Eacho, R. Schmidt, 2002, Molecular genetics and metabolism.

Mouse PDX Trial Suggests Synergy of Concurrent Inhibition of RAF and EGFR in Colorectal Cancer with BRAF or KRAS Mutations

P. Iversen, G. Plowman, Y. Webster, 2017, Clinical Cancer Research.

An apolipoprotein A-I mimetic dose-dependently increases the formation of prebeta1 HDL in human plasma.

W. Alborn, A. Murphy, Youyan Zhang, 2008, Journal of lipid research.

Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization.

D. Peake, Tiruneh K. Hailemariam, M. Kuo, 2007, Biochimica et biophysica acta.

Niacin stimulates adiponectin secretion through the GPR109A receptor.

S. Offermanns, R. Judd, E. Plaisance, 2009, American journal of physiology. Endocrinology and metabolism.

Enlargement of High Density Lipoprotein in Mice via Liver X Receptor Activation Requires Apolipoprotein E and Is Abolished by Cholesteryl Ester Transfer Protein Expression*

W. Quan, P. Eacho, R. Schmidt, 2003, Journal of Biological Chemistry.

A novel splicing variant of proprotein convertase subtilisin/kexin type 9.

Y. Qian, E. Su, Xiaohong Yu, 2008, DNA and cell biology.

Secreted PCSK 9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis

Y. Qian, D. Moller, Xiliang Wang, 2007 .

Phospholipid Transfer Protein Is Regulated by Liver X Receptors in Vivo *

P. Eacho, R. Schmidt, Xian-cheng Jiang, 2002, The Journal of Biological Chemistry.

The Acyl CoenzymeA:Monoacylglycerol Acyltransferase 3 (MGAT3) Gene is a Pseudogene in Mice but Encodes a Functional Enzyme in Rats

Y. Qian, J. Calley, S. Li, 2011, Lipids.

Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A.

E. Su, T. Large, P. Eacho, 2005, Biochemical and biophysical research communications.

Reducing Plasma Membrane Sphingomyelin Increases Insulin Sensitivity

D. Peake, M. Kuo, Xian-cheng Jiang, 2011, Molecular and Cellular Biology.

Design, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors.

G. Stephenson, R. Schmidt, S. Sweetana, 2012, Bioorganic & medicinal chemistry letters.

The CDK4/6 Inhibitor LY2835219 Overcomes Vemurafenib Resistance Resulting from MAPK Reactivation and Cyclin D1 Upregulation

T. Burke, R. Beckmann, Sheng-Bin Peng, 2013, Molecular Cancer Therapeutics.

Identification of Druggable Cancer Driver Genes Amplified across TCGA Datasets

T. Doman, R. Higgs, Xiwen Ma, 2014, PloS one.

Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.

P. Hipskind, D. Clawson, D. Manglicmot, 2015, Journal of medicinal chemistry.

Abstract 1259: Preclinical characterization of LY3537982, a novel, highly selective and potent KRAS-G12C inhibitor

M. J. Chalmers, D. Manglicmot, Sheng-Bin Peng, 2021, Experimental and Molecular Therapeutics.

Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120.

Shih-Hsun Chen, S. Wong, G. Plowman, 2016, Cancer discovery.

LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer

Xiu-juan Yuan, J. Manro, Sheng-Bin Peng, 2016, Oncotarget.

Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.

Xiwen Ma, Shih-Hsun Chen, G. Plowman, 2015, Cancer cell.

Inhibition of RAF Isoforms and Active Dimers by LY 3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers Graphical

Xiwen Ma, Shih-Hsun Chen, G. Plowman, 2015 .

Antidiabetic Action of a Liver X Receptor Agonist Mediated By Inhibition of Hepatic Gluconeogenesis*

A. R. Miller, G. Etgen, C. Broderick, 2003, The Journal of Biological Chemistry.

Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis Published, JLR Papers in Press, April 20, 2007.

Y. Qian, D. Moller, Xiliang Wang, 2007, Journal of Lipid Research.

Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure

S. Karathanasis, R. Schmidt, Youyan Zhang, 2011, Journal of Lipid Research.

A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes

S. Paul, K. Bales, R. Demattos, 2004, Journal of neurochemistry.

KRASG12C-independent feedback activation of wild-type RAS constrains KRASG12C inhibitor efficacy

Fengqin Gao, S. Kopetz, A. Sorokin, 2022, Cell reports.

RAF inhibitor LY3009120 sensitizes RAS or BRAF mutant cancer to CDK4/6 inhibition by abemaciclib via superior inhibition of phospho-RB and suppression of cyclin D1

T. Burke, R. Beckmann, J. Manro, 2018, Oncogene.

Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors.

R. Schmidt, S. Sweetana, Youyan Zhang, 2012, Bioorganic & medicinal chemistry letters.

Reducing Plasma Membrane Sphingomyelin Increases Insulin Sensitivity

D. Peake, M. Kuo, Zhiqiang Li, 2011, Molecular and Cellular Biology.