K. Ohashi

发表

Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter

Hitoshi Shimano, Takashi Matsuzaka, Yoko Iizuka, 2001, Molecular and Cellular Biology.

Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase.

Y. Yazaki, S. Ishibashi, T. Inaba, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice.

S. Perrey, Y. Yazaki, N. Yahagi, 1999, Journal of lipid research.

Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia.

D. Illingworth, N. Yahagi, R. Nagai, 2000, Journal of lipid research.

High Mobility Group Protein-B1 Interacts with Sterol Regulatory Element-binding Proteins to Enhance Their DNA Binding*

T. Kadowaki, H. Shimano, N. Yahagi, 2005, Journal of Biological Chemistry.

Role of the Low Density Lipoprotein (LDL) Receptor Pathway in the Metabolism of Chylomicron Remnants

S. Perrey, Y. Yazaki, S. Ishibashi, 1996, The Journal of Biological Chemistry.

SREBP-1-independent regulation of lipogenic gene expression in adipocytes Published, JLR Papers in Press, April 24, 2007.

T. Kadowaki, H. Shimano, N. Yahagi, 2007, Journal of Lipid Research.

Myeloid HMG-CoA (3-Hydroxy-3-Methylglutaryl-Coenzyme A) Reductase Determines Atherosclerosis by Modulating Migration of Macrophages

M. Hayakawa, S. Tominaga, Hiroko Hayakawa, 2018, Arteriosclerosis, thrombosis, and vascular biology.

Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice.

H. Sone, H. Shimano, N. Yahagi, 2004, Diabetes.

Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver Published, JLR Papers in Press, June 1, 2006.

T. Kadowaki, K. Tsukamoto, H. Shimano, 2006, Journal of Lipid Research.

Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases.

H. Shimano, N. Yahagi, N. Yamada, 2002, Diabetes.

Apoptotic cell death in atherosclerotic plaques of hyperlipidemic knockout mice.

Y. Yazaki, N. Yahagi, S. Ishibashi, 1997, Atherosclerosis.

FEEL-1 and FEEL-2 Are Endocytic Receptors for Advanced Glycation End Products*

H. Shimano, N. Yahagi, R. Nagai, 2003, The Journal of Biological Chemistry.

A truncated species of apolipoprotein B (B-38.7) in a patient with homozygous hypobetalipoproteinemia associated with diabetes mellitus.

Y. Yazaki, S. Ishibashi, N. Yamada, 1998, Arteriosclerosis, thrombosis, and vascular biology.

Mutations in Japanese subjects with primary hyperlipidemia--results from the Research Committee of the Ministry of Health and Welfare of Japan since 1996--.

S. Yamashita, Y. Matsuzawa, T. Kita, 2004, Journal of atherosclerosis and thrombosis.

Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene*

H. Shimano, N. Yahagi, N. Yamada, 2000, The Journal of Biological Chemistry.

Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.

H. Sone, H. Shimano, N. Yahagi, 2015, Biochemical and biophysical research communications.

Severe Hypercholesterolemia, Hypertriglyceridemia, and Atherosclerosis in Mice Lacking Both Leptin and the Low Density Lipoprotein Receptor*

S. Perrey, H. Sone, H. Shimano, 2001, The Journal of Biological Chemistry.

Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice.

Y. Izumida, T. Kadowaki, H. Shimano, 2009, Biochemical and biophysical research communications.

Absence of ACAT-1 Attenuates Atherosclerosis but Causes Dry Eye and Cutaneous Xanthomatosis in Mice with Congenital Hyperlipidemia*

S. Perrey, H. Shimano, N. Yahagi, 2000, The Journal of Biological Chemistry.

Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene.

Y. Izumida, T. Kadowaki, N. Yahagi, 2013, Journal of atherosclerosis and thrombosis.

Embryonic Lethality and Defective Neural Tube Closure in Mice Lacking Squalene Synthase*

S. Perrey, Y. Yazaki, N. Yahagi, 1999, The Journal of Biological Chemistry.

Identification of a Novel Member of the Carboxylesterase Family That Hydrolyzes Triacylglycerol

T. Kadowaki, K. Tsukamoto, H. Shimano, 2006, Diabetes.

HMG-CoA Reductase Deficiency in Mice 1 Early embryonic lethality caused by targeted disruption of the HMG-CoA reductase gene

H. Shimano, N. Yahagi, N. Yamada, 2003 .

Elimination of Cholesterol Ester from Macrophage Foam Cells by Adenovirus-mediated Gene Transfer of Hormone-sensitive Lipase*

K. Tsukamoto, H. Shimano, N. Yahagi, 2002, The Journal of Biological Chemistry.

Polyunsaturated Fatty Acids Selectively Suppress Sterol Regulatory Element-binding Protein-1 through Proteolytic Processing and Autoloop Regulatory Circuit*

K. Kataoka, Y. Izumida, T. Kadowaki, 2010, The Journal of Biological Chemistry.

In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression.

Masayuki Yamamoto, T. Kadowaki, H. Shimano, 2007, Biochemical and biophysical research communications.

The LDL receptor is the major pathway for beta-VLDL uptake by mouse peritoneal macrophages.

S. Perrey, N. Yahagi, S. Ishibashi, 2001, Atherosclerosis.

Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.

Y. Yazaki, H. Shimano, S. Ishibashi, 1998, The Journal of clinical investigation.

Effects of apo E deficiency on plasma lipid levels in mice lacking APOBEC-1.

Y. Yazaki, S. Ishibashi, N. Yamada, 1997, Biochemical and biophysical research communications.

Current Diagnosis and Management of Abetalipoproteinemia

K. Matsuki, S. Yokoyama, S. Ishibashi, 2021, Journal of atherosclerosis and thrombosis.

Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase

Y. Yazaki, N. Yamada, S. Ishibashi, 1996 .

Clinical Features Associated With the Homozygous Trp64Arg Mutation of the β3-Adrenergic Receptor

Y. Yazaki, S. Ishibashi, N. Yamada, 1998 .

Clinical features associated with the homozygous Trp64Arg mutation of the beta3-adrenergic receptor: no evidence for its association with obesity in Japanese.

Y. Yazaki, S. Ishibashi, N. Yamada, 1998, Arteriosclerosis, thrombosis, and vascular biology.

High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding.

T. Kadowaki, H. Shimano, N. Yahagi, 2005, The Journal of biological chemistry.

Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.

M. Fukayama, Y. Izumida, T. Kadowaki, 2011, Biochemical and biophysical research communications.

Asialoglycoprotein Receptor Deficiency in Mice Lacking the Major Receptor Subunit

H. Shimano, N. Yahagi, N. Yamada, 2001, The Journal of Biological Chemistry.

Improved Glycemic Control in a Diabetic Patient After Discontinuation of Allopurinol Administration

Y. Yazaki, S. Ishibashi, N. Yamada, 1998, Diabetes Care.

p53 Activation in Adipocytes of Obese Mice*

H. Shimano, N. Yahagi, N. Yamada, 2003, Journal of Biological Chemistry.

p53 Involvement in the Pathogenesis of Fatty Liver Disease*

T. Kadowaki, H. Shimano, N. Yahagi, 2004, Journal of Biological Chemistry.

Absence of Sterol Regulatory Element-binding Protein-1 (SREBP-1) Ameliorates Fatty Livers but Not Obesity or Insulin Resistance inLep ob /Lep ob Mice*

H. Shimano, N. Yahagi, N. Yamada, 2002, The Journal of Biological Chemistry.

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.

H. Sone, H. Shimano, N. Yahagi, 2003, Molecular endocrinology.

LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2

Makoto Kobayashi, Masayuki Yamamoto, H. Kaneko, 2015, Proceedings of the National Academy of Sciences.

Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes DOI 10.1194/jlr.M100417-JLR200

Hitoshi Shimano, Takashi Matsuzaka, Yoko Iizuka, 2002, Journal of Lipid Research.

Thiazolidinedione- and tumor necrosis factor alpha-induced downregulation of peroxisome proliferator-activated receptor gamma mRNA in differentiated 3T3-L1 adipocytes.

S. Perrey, N. Yahagi, S. Ishibashi, 2001, Metabolism: clinical and experimental.

Bcl‐2 protein inhibits oxysterol‐induced apoptosis through suppressing CPP32‐mediated pathway

Y. Yazaki, T. Miyashita, S. Ishibashi, 1997, FEBS letters.

Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.

Y. Furukawa, T. Kadowaki, N. Yahagi, 2009, Cell metabolism.

Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes*

H. Shimano, N. Yahagi, N. Yamada, 1999, The Journal of Biological Chemistry.

Scavenger Receptor Expressed by Endothelial Cells I (SREC-I) Mediates the Uptake of Acetylated Low Density Lipoproteins by Macrophages Stimulated with Lipopolysaccharide*

Hiroshi Suzuki, T. Kadowaki, H. Shimano, 2004, Journal of Biological Chemistry.

Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma.

M. Makuuchi, K. Hasegawa, T. Kadowaki, 2005, European journal of cancer.

G‐quadruplex‐forming nucleic acids interact with splicing factor 3B subunit 2 and suppress innate immune gene expression

K. Ueda, H. Seimiya, K. Ohashi, 2020, Genes to cells : devoted to molecular & cellular mechanisms.

A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids*

H. Shimano, N. Yahagi, R. Nagai, 1999, The Journal of Biological Chemistry.

Sterol Regulatory Element-binding Protein-1 Is Regulated by Glucose at the Transcriptional Level*

S. Perrey, H. Shimano, N. Yahagi, 2000, The Journal of Biological Chemistry.

A kindred of familial acromegaly without evidence for linkage to MEN-1 locus.

H. Shimano, N. Yahagi, N. Yamada, 2002, Endocrine journal.

Polyunsaturated Fatty Acids Suppress Sterol Regulatory Element-binding Protein 1c Promoter Activity by Inhibition of Liver X Receptor (LXR) Binding to LXR Response Elements*

H. Sone, H. Shimano, N. Yahagi, 2002, The Journal of Biological Chemistry.

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

Hitoshi Shimano, Mayumi Ishikawa, Takashi Matsuzaka, 2007, Nature Medicine.

Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.

H. Sone, H. Shimano, N. Yahagi, 2002, Journal of lipid research.

Absence of Hormone-sensitive Lipase Inhibits Obesity and Adipogenesis in Lepob/ob Mice*

H. Shimano, N. Yahagi, N. Yamada, 2004, Journal of Biological Chemistry.

LSD 1 / KDM 1 A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv 2

Masayuki Yamamoto, H. Kaneko, Miki Takeuchi, 2016 .

Troglitazone Inhibits Atherosclerosis in Apolipoprotein E–Knockout Mice: Pleiotropic Effects on CD36 Expression and HDL

S. Perrey, H. Shimano, N. Yahagi, 2001, Arteriosclerosis, thrombosis, and vascular biology.

Tetsuya Effects on CD 36 Expression and HDL Knockout Mice : Pleiotropic − Troglitazone Inhibits Atherosclerosis in Apolipoprotein

S. Perrey, H. Shimano, N. Yahagi, 2001 .

Early Embryonic Lethality Caused by Targeted Disruption of the 3-Hydroxy-3-methylglutaryl-CoA Reductase Gene*

H. Shimano, N. Yahagi, N. Yamada, 2003, Journal of Biological Chemistry.

Identification of Neutral Cholesterol Ester Hydrolase, a Key Enzyme Removing Cholesterol from Macrophages*

T. Kadowaki, N. Yahagi, R. Nagai, 2008, Journal of Biological Chemistry.

Nitro‐fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1‐Nrf2 system: a study using green fluorescent protein transgenic zebrafish

K. Kawakami, Makoto Kobayashi, Masayuki Yamamoto, 2011, Genes to cells : devoted to molecular & cellular mechanisms.

The Critical Role of Neutral Cholesterol Ester Hydrolase 1 in Cholesterol Removal From Human Macrophages

M. Fukayama, T. Kadowaki, R. Nagai, 2010, Circulation research.

Transcription factor PU.1 mediates induction of c-fms in vascular smooth muscle cells: a mechanism for phenotypic change to phagocytic cells

Y. Yazaki, S. Ishibashi, K. Ohashi, 1996, Molecular and cellular biology.

Induction of Macrophage Colony-stimulating Factor Receptor (c-fms) Expression in Vascular Medial Smooth Muscle Cells Treated with Heparin Binding Epidermal Growth Factor-like Growth Factor*

Y. Matsuzawa, Y. Yazaki, S. Ishibashi, 1996, The Journal of Biological Chemistry.

Liver-Specific Deletion of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Causes Hepatic Steatosis and Death

S. Ishibashi, Motohiro Sekiya, K. Ohashi, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Synergistic effects of transforming growth factor‐β on the expression of c‐fms, macrophage colony‐stimulating factor receptor gene, in vascular smooth muscle cells

Y. Yazaki, S. Ishibashi, T. Inaba, 1996, FEBS letters.