K. Harada

发表

Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter

Hitoshi Shimano, Takashi Matsuzaka, Yoko Iizuka, 2001, Molecular and Cellular Biology.

Induction of sustained expression of proto-oncogene c-fms by platelet-derived growth factor, epidermal growth factor, and basic fibroblast growth factor, and its suppression by interferon-gamma and macrophage colony-stimulating factor in human aortic medial smooth muscle cells.

Y. Yazaki, S. Ishibashi, T. Inaba, 1995, The Journal of clinical investigation.

Regulation of low density lipoprotein receptor activity in Chinese hamster ovary cells transfected with the c‐fms gene

Y. Yazaki, H. Shimano, N. Yamada, 1994, FEBS letters.

Effects of human recombinant macrophage colony-stimulating factor on the secretion of lipoprotein lipase from macrophages.

Y. Yazaki, H. Shimano, S. Ishibashi, 1991, Arteriosclerosis and thrombosis : a journal of vascular biology.

Effects of platelet-derived growth factor on the synthesis of lipoprotein lipase in human monocyte-derived macrophages.

Y. Yazaki, H. Shimano, Y. Akanuma, 1995, Arteriosclerosis, thrombosis, and vascular biology.

Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase.

Y. Yazaki, S. Ishibashi, T. Inaba, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice.

S. Perrey, Y. Yazaki, N. Yahagi, 1999, Journal of lipid research.

Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia.

D. Illingworth, N. Yahagi, R. Nagai, 2000, Journal of lipid research.

High Mobility Group Protein-B1 Interacts with Sterol Regulatory Element-binding Proteins to Enhance Their DNA Binding*

T. Kadowaki, H. Shimano, N. Yahagi, 2005, Journal of Biological Chemistry.

Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.

M. Katsuki, Y. Yazaki, H. Shimano, 1995, The Journal of clinical investigation.

Role of the Low Density Lipoprotein (LDL) Receptor Pathway in the Metabolism of Chylomicron Remnants

S. Perrey, Y. Yazaki, S. Ishibashi, 1996, The Journal of Biological Chemistry.

Effect of tumor necrosis factor/cachectin on the activity of the low density lipoprotein receptor on human skin fibroblasts.

H. Shimano, M. Kawakami, S. Ishibashi, 1990, Biochemical and biophysical research communications.

Resistance to high-fat diet-induced obesity and altered expression of adipose-specific genes in HSL-deficient mice.

F. Kraemer, S. Ishibashi, W. Shen, 2003, American journal of physiology. Endocrinology and metabolism.

Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases.

H. Shimano, N. Yahagi, N. Yamada, 2002, Diabetes.

Apoptotic cell death in atherosclerotic plaques of hyperlipidemic knockout mice.

Y. Yazaki, N. Yahagi, S. Ishibashi, 1997, Atherosclerosis.

Cholesteryl ester transfer protein deficiency caused by a nonsense mutation detected in the patient's macrophage mRNA.

Y. Yazaki, H. Shimano, T. Teramoto, 1993, Biochemical and biophysical research communications.

Expression of platelet-derived growth factor beta receptor on human monocyte-derived macrophages and effects of platelet-derived growth factor BB dimer on the cellular function.

Y. Yazaki, H. Shimano, Y. Watanabe, 1993, The Journal of biological chemistry.

Plasma lipid abnormalities and risk factors for coronary artery disease in Japanese subjects with diabetes mellitus and glucose intolerance.

Y. Akanuma, T. Murase, H. Yoshinaga, 1994, Diabetes research and clinical practice.

Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia.

M. Katsuki, Y. Yazaki, H. Shimano, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Resistance to high fat diet-induced obesity associated with altered expression of adipose specific genes in hormone-sensitive lipase deficient mice Authors

F. Kraemer, S. Ishibashi, W. Shen, 2003 .

Establishment of enzyme-linked immunosorbent assays for lipoprotein lipase with newly developed antibodies.

Y. Yazaki, H. Shimano, Y. Watanabe, 1994, Journal of lipid research.

Skipping of exon 14 and possible instability of both the mRNA and the resultant truncated protein underlie a common cholesteryl ester transfer protein deficiency in Japan.

Y. Yazaki, S. Ishibashi, T. Teramoto, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene*

H. Shimano, N. Yahagi, N. Yamada, 2000, The Journal of Biological Chemistry.

Overexpression of low density lipoprotein receptor on Chinese hamster ovary cells generates foam cells.

Y. Yazaki, H. Shimano, S. Ishibashi, 1991, Arteriosclerosis and thrombosis : a journal of vascular biology.

Severe Hypercholesterolemia, Hypertriglyceridemia, and Atherosclerosis in Mice Lacking Both Leptin and the Low Density Lipoprotein Receptor*

S. Perrey, H. Sone, H. Shimano, 2001, The Journal of Biological Chemistry.

Overexpression of human lipoprotein lipase protects diabetic transgenic mice from diabetic hypertriglyceridemia and hypercholesterolemia.

S. Perrey, Y. Yazaki, S. Ishibashi, 1995, Arteriosclerosis, thrombosis, and vascular biology.

Role of Macrophage Colony‐Stimulating Factor in the Initial Process of Atherosclerosis

Y. Yazaki, Y. Watanabe, T. Inaba, 1994 .

Dextran sulfate, a competitive inhibitor for scavenger receptor, prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.

H. Shimano, Y. Watanabe, M. Shiomi, 1994, Atherosclerosis.

Macrophage colony-stimulating factor regulates both activities of neutral and acidic cholesteryl ester hydrolases in human monocyte-derived macrophages.

Y. Yazaki, H. Shimano, T. Inaba, 1993, The Journal of clinical investigation.

Macrophage colony stimulating factor prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.

H. Shimano, Y. Watanabe, M. Shiomi, 1992, Atherosclerosis.

Role of Monocyte Colony-Stimulating Factor in Foam Cell Generation

Y. Yazaki, H. Shimano, N. Yamada, 1992, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Oxidation-labile subfraction of human plasma low density lipoprotein isolated by ion-exchange chromatography.

Yazaki, Y. Yazaki, H. Shimano, 1991, Journal of lipid research.

Absence of ACAT-1 Attenuates Atherosclerosis but Causes Dry Eye and Cutaneous Xanthomatosis in Mice with Congenital Hyperlipidemia*

S. Perrey, H. Shimano, N. Yahagi, 2000, The Journal of Biological Chemistry.

Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.

H. Shimano, Y. Watanabe, N. Yamada, 1992, The Journal of clinical investigation.

Overexpression of Apolipoprotein E Prevents Development of Diabetic Hyperlipidemia in Transgenic Mice

Y. Yazaki, H. Shimano, N. Yamada, 1995, Diabetes.

Embryonic Lethality and Defective Neural Tube Closure in Mice Lacking Squalene Synthase*

S. Perrey, Y. Yazaki, N. Yahagi, 1999, The Journal of Biological Chemistry.

HMG-CoA Reductase Deficiency in Mice 1 Early embryonic lethality caused by targeted disruption of the HMG-CoA reductase gene

H. Shimano, N. Yahagi, N. Yamada, 2003 .

Elimination of Cholesterol Ester from Macrophage Foam Cells by Adenovirus-mediated Gene Transfer of Hormone-sensitive Lipase*

K. Tsukamoto, H. Shimano, N. Yahagi, 2002, The Journal of Biological Chemistry.

Human monocyte colony-stimulating factor enhances the clearance of lipoproteins containing apolipoprotein B-100 via both low density lipoprotein receptor-dependent and -independent pathways in rabbits.

H. Shimano, S. Ishibashi, F. Takaku, 1990, The Journal of biological chemistry.

Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E. Accelerated clearance of lipoproteins containing apolipoprotein B.

M. Katsuki, Y. Yazaki, H. Shimano, 1992, The Journal of clinical investigation.

The LDL receptor is the major pathway for beta-VLDL uptake by mouse peritoneal macrophages.

S. Perrey, N. Yahagi, S. Ishibashi, 2001, Atherosclerosis.

Apoptosis in Atherosclerosis: Induction of Apoptosis by Oxidized Low Density Lipoprotein and Oxysterols

N. Yamada, S. Ishibashi, K. Harada, 2000 .

Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.

Y. Yazaki, H. Shimano, S. Ishibashi, 1998, The Journal of clinical investigation.

Effects of apo E deficiency on plasma lipid levels in mice lacking APOBEC-1.

Y. Yazaki, S. Ishibashi, N. Yamada, 1997, Biochemical and biophysical research communications.

Hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis.

F. Kraemer, S. Ishibashi, W. Shen, 2004, Molecular endocrinology.

Monocyte colony-stimulating factor enhances uptake and degradation of acetylated low density lipoproteins and cholesterol esterification in human monocyte-derived macrophages.

H. Shimano, S. Ishibashi, F. Takaku, 1990, The Journal of biological chemistry.

Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase

Y. Yazaki, N. Yamada, S. Ishibashi, 1996 .

Clinical Features Associated With the Homozygous Trp64Arg Mutation of the β3-Adrenergic Receptor

Y. Yazaki, S. Ishibashi, N. Yamada, 1998 .

Clinical features associated with the homozygous Trp64Arg mutation of the beta3-adrenergic receptor: no evidence for its association with obesity in Japanese.

Y. Yazaki, S. Ishibashi, N. Yamada, 1998, Arteriosclerosis, thrombosis, and vascular biology.

Transgenic Mouse and Gene Therapy

H. Shimano, S. Ishibashi, N. Yamada, 1996, Diabetes.

High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding.

T. Kadowaki, H. Shimano, N. Yahagi, 2005, The Journal of biological chemistry.

Overexpression of human lipoprotein lipase enhances uptake of lipoproteins containing apolipoprotein B-100 in transfected cells.

H. Shimano, Y. Watanabe, T. Inaba, 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

Elevated serum and urinary thrombomodulin levels in patients with non-insulin-dependent diabetes mellitus.

Y. Yazaki, H. Shimano, M. Kawakami, 1994, Clinica chimica acta; international journal of clinical chemistry.

Asialoglycoprotein Receptor Deficiency in Mice Lacking the Major Receptor Subunit

H. Shimano, N. Yahagi, N. Yamada, 2001, The Journal of Biological Chemistry.

Detection of three separate DNA polymorphisms in the human lipoprotein lipase gene by gene amplification and restriction endonuclease digestion.

Y. Yazaki, H. Shimano, T. Murase, 1992, Journal of lipid research.

Effect of macrophage colony-stimulating factor on the development of diabetes mellitus in BB rats.

Y. Yazaki, H. Shimano, S. Kawazu, 1993, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Mutational analysis of the "regulatory module" of hormone-sensitive lipase.

F. Kraemer, W. Shen, Jining Wang, 2005, Biochemistry.

p53 Involvement in the Pathogenesis of Fatty Liver Disease*

T. Kadowaki, H. Shimano, N. Yahagi, 2004, Journal of Biological Chemistry.

Absence of Sterol Regulatory Element-binding Protein-1 (SREBP-1) Ameliorates Fatty Livers but Not Obesity or Insulin Resistance inLep ob /Lep ob Mice*

H. Shimano, N. Yahagi, N. Yamada, 2002, The Journal of Biological Chemistry.

Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes DOI 10.1194/jlr.M100417-JLR200

Hitoshi Shimano, Takashi Matsuzaka, Yoko Iizuka, 2002, Journal of Lipid Research.

Thiazolidinedione- and tumor necrosis factor alpha-induced downregulation of peroxisome proliferator-activated receptor gamma mRNA in differentiated 3T3-L1 adipocytes.

S. Perrey, N. Yahagi, S. Ishibashi, 2001, Metabolism: clinical and experimental.

Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes*

H. Shimano, N. Yahagi, N. Yamada, 1999, The Journal of Biological Chemistry.

The effect of apo E secretion on lipoprotein uptake in transfected cells.

Y. Yazaki, H. Shimano, Y. Shibasaki, 1991, Biochimica et biophysica acta.

A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids*

H. Shimano, N. Yahagi, R. Nagai, 1999, The Journal of Biological Chemistry.

Sterol Regulatory Element-binding Protein-1 Is Regulated by Glucose at the Transcriptional Level*

S. Perrey, H. Shimano, N. Yahagi, 2000, The Journal of Biological Chemistry.

A kindred of familial acromegaly without evidence for linkage to MEN-1 locus.

H. Shimano, N. Yahagi, N. Yamada, 2002, Endocrine journal.

Regulation of hormone-sensitive lipase in islets.

F. Kraemer, S. Michie, S. Ishibashi, 2007, Diabetes research and clinical practice.

Absence of Hormone-sensitive Lipase Inhibits Obesity and Adipogenesis in Lepob/ob Mice*

H. Shimano, N. Yahagi, N. Yamada, 2004, Journal of Biological Chemistry.

Troglitazone Inhibits Atherosclerosis in Apolipoprotein E–Knockout Mice: Pleiotropic Effects on CD36 Expression and HDL

S. Perrey, H. Shimano, N. Yahagi, 2001, Arteriosclerosis, thrombosis, and vascular biology.

Tetsuya Effects on CD 36 Expression and HDL Knockout Mice : Pleiotropic − Troglitazone Inhibits Atherosclerosis in Apolipoprotein

S. Perrey, H. Shimano, N. Yahagi, 2001 .

Early Embryonic Lethality Caused by Targeted Disruption of the 3-Hydroxy-3-methylglutaryl-CoA Reductase Gene*

H. Shimano, N. Yahagi, N. Yamada, 2003, Journal of Biological Chemistry.

Platelet-derived growth factor induces c-fms and scavenger receptor genes in vascular smooth muscle cells.

Y. Yazaki, H. Shimano, Y. Watanabe, 1992, The Journal of biological chemistry.

Cloning and structural analysis of the mouse apolipoprotein B mRNA editing protein gene.

Y. Yazaki, S. Ishibashi, N. Yamada, 1995, Biochemical and Biophysical Research Communications - BBRC.

Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice.

Y. Yazaki, H. Shimano, N. Yamada, 1994, The Journal of clinical investigation.

Transcription factor PU.1 mediates induction of c-fms in vascular smooth muscle cells: a mechanism for phenotypic change to phagocytic cells

Y. Yazaki, S. Ishibashi, K. Ohashi, 1996, Molecular and cellular biology.

Induction of Macrophage Colony-stimulating Factor Receptor (c-fms) Expression in Vascular Medial Smooth Muscle Cells Treated with Heparin Binding Epidermal Growth Factor-like Growth Factor*

Y. Matsuzawa, Y. Yazaki, S. Ishibashi, 1996, The Journal of Biological Chemistry.

The release of hepatic triglyceride lipase from rat monolayered hepatocytes in primary culture.

H. Shimano, Y. Akanuma, S. Ishibashi, 1990, Endocrinologia japonica.

Overexpression of human lipoprotein lipase increases hormone-sensitive lipase activity in adipose tissue of mice.

Y. Yazaki, S. Ishibashi, Y. Watanabe, 1995, Biochemical and biophysical research communications.

Synergistic effects of transforming growth factor‐β on the expression of c‐fms, macrophage colony‐stimulating factor receptor gene, in vascular smooth muscle cells

Y. Yazaki, S. Ishibashi, T. Inaba, 1996, FEBS letters.

Regulation of low density lipoprotein receptor activity in Chinese hamster ovary cells transfected with the c‐fms gene

Y. Yazaki, H. Shimano, N. Yamada, 1994, FEBS letters.