C. Huselton

发表

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

J. Grippo, A. Lovey, A. Levin, 1992, Nature.

Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis.

Robert Steffan, Anna Wilhelmsson, T. Bonn, 2008, Journal of medicinal chemistry.

A road less travelled: Normal phase microbore liquid chromatography—mass spectrometry using direct liquid introduction

D. Liberato, W. Garland, C. Huselton, 1991 .

Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized Sprague–Dawley rats

D. Deecher, C. Huselton, Xiaohong Chen, 2006, Brain Research.

Constitutive variability in the pharmacokinetics of the natural retinoid, all-trans-retinoic acid, and its modulation by ketoconazole.

M. Kris, R. Warrell, J. Rigas, 1993, Journal of the National Cancer Institute.

SAM-531, N,N-dimethyl-3-{[3-(1-naphthylsulfonyl)-1H-indazol-5-yl]oxy} propan-1-amine, a novel serotonin-6 receptor antagonist with preclinical pro-cognitive efficacy

T. Comery, A. Robichaud, M. Pangalos, 2010, Alzheimer's & Dementia.

Development of an early biomarker for the ovarian liability of selective estrogen receptor modulators in rats

F. Azam, R. Winneker, V. Chennathukuzhi, 2008, The Journal of Steroid Biochemistry and Molecular Biology.

Quantification of retinyl-β-glucuronides in rat urine by reversed-phase high-performance liquid chromatography with ultraviolet detection

S. Li, C. Huselton, A. Barua, 1996 .

Quantification of endogenous retinoic acid in human plasma by liquid chromatography/mass spectrometry

D. Liberato, W. Garland, C. Huselton, 1990 .

Further modification on phenyl acetic acid based quinolines as liver X receptor modulators.

Farooq Azam, Anna Wilhelmsson, James Jetter, 2007, Bioorganic & medicinal chemistry.

Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis.

Christopher Miller, Farooq Azam, Anna Wilhelmsson, 2006, Journal of medicinal chemistry.

The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists.

M. Day, T. Comery, S. Grauer, 2010, Journal of medicinal chemistry.

5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists.

T. Comery, A. Robichaud, Z. Hughes, 2010, Journal of medicinal chemistry.

Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).

R. Winneker, E. Melenski, Jeff Cohen, 2008, Journal of medicinal chemistry.

Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles.

A. Robichaud, R. Winneker, E. Koury, 2009, Bioorganic & medicinal chemistry.

3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists.

Robert Steffan, Anna Wilhelmsson, P. Nambi, 2010, Bioorganic & medicinal chemistry letters.

Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.

B. Harrison, C. Beyer, G. Stack, 2009, Journal of medicinal chemistry.

Ability of melanins to protect against the radiolysis of thymine and thymidine.

C. Huselton, B. Pilas, H. Hill, 1987, Pigment cell research.

A potentially new metabolic pathway: ethyl esterification of acitretin.

C. Huselton, R. Chou, R. Wyss, 1992, Xenobiotica; the fate of foreign compounds in biological systems.

Quantification of acitretin in human plasma by microbore liquid chromatography-negative chemical ionization mass spectrometry.

D. Liberato, W. Garland, C. Huselton, 1991, Journal of chromatography.

Synthesis of Novel Glucuronide Conjugates of Retinoid Carboxylic Acids

C. Huselton, A. Barua, J. Olson, 1996 .

Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors.

K. Burroughs, D. Deecher, P. Mahaney, 2009, Bioorganic & medicinal chemistry letters.

Transplantation, growth, and regression of mouse melanoma xenografts in neonatal marsupials.

B. Fadem, C. Huselton, H. Hill, 1988, Cancer investigation.

A single dose pharmacokinetic study of 13-cis retinoic acid (Isotretinoin, Ro 04-3780) in the pregnant New Zealand rabbit using intravenous infusion

D. Liberato, C. Huselton, E. Stahl, 1996 .

Discovery of WAY-260022, a Potent and Selective Inhibitor of the Norepinephrine Transporter.

K. Burroughs, D. Deecher, P. Mahaney, 2010, ACS medicinal chemistry letters.

The Metabotropic Glutamate Receptor 7 Allosteric Modulator AMN082: A Monoaminergic Agent in Disguise?

J. Dwyer, L. Di, A. Randall, 2011, Journal of Pharmacology and Experimental Therapeutics.

SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models.

Fei Ye, Kim Arndt, Judy Lucas, 2005, Cancer research.

A newly discovered xenobiotic metabolic pathway: ethyl ester formation.

C. Huselton, R. Chou, R. Wyss, 1991, Life sciences.

Novel progesterone receptor modulators: 4-aryl-phenylsulfonamides.

R. Winneker, E. Melenski, C. Huselton, 2012, Bioorganic & medicinal chemistry letters.

1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists.

Anna Wilhelmsson, P. Nambi, R. Bernotas, 2010, Bioorganic & medicinal chemistry letters.

5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists.

T. Comery, Radka Graf, A. Robichaud, 2010, Journal of Medicinal Chemistry.

Clinical pharmacology of oral all-trans retinoic acid in patients with acute promyelocytic leukemia.

R. Warrell, W. Garland, S. Frankel, 1992, Cancer research.

Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents.

Eric I. Rossman, L. Di, B. Larsen, 2009, Bioorganic & medicinal chemistry letters.

Discovery of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134)13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation.

Eric I. Rossman, A. Alimardanov, L. Di, 2009, Journal of medicinal chemistry.

A New Pathway for Vitamin A

C. Kratzeisen, J. Grippo, A. Lovey, 1992 .

Micro liquid chromatography-mass spectrometry with direct liquid introduction used for separation and quantitation of all-trans- and 13-cis-retinoic acids and their 4-oxo metabolites in human plasma.

B. Lausecker, C. Huselton, U. Ranalder, 1993, Journal of chromatography.

Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists.

Anna Wilhelmsson, James Jetter, P. Nambi, 2010, Bioorganic & medicinal chemistry letters.

Selective Kv1.5 blockers: development of (R)-1-(methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a potential treatment for atrial arrhythmia.

S. Gardell, R. Magolda, E. Trybulski, 2009, Journal of medicinal chemistry.

WAY-163909, a 5-HT2C agonist, enhances the preclinical potency of current antipsychotics

T. Comery, K. Marquis, S. Grauer, 2009, Psychopharmacology.

Patients with Acute Promyelocytic Leukemia Retinoic Acid in trans Clinical Pharmacology of Oral All-Updated Version

R. Warrell, W. Garland, C. Huselton, 2006 .

Melanin photosensitizes ultraviolet light (uvc) dna damage in pigmented cells

J. O’Neill, C. Huselton, H. Hill, 1990, Environmental and molecular mutagenesis.