F. Saccoccia

发表

Typical 2-Cys peroxiredoxins in human parasites: Several physiological roles for a potential chemotherapy target.

A. Miele, F. Angelucci, A. Bellelli, 2016, Molecular and biochemical parasitology.

Selenocysteine robustness versus cysteine versatility: a hypothesis on the evolution of the moonlighting behaviour of peroxiredoxins.

A. Miele, F. Angelucci, A. Bellelli, 2014, Biochemical Society transactions.

Switching between the alternative structures and functions of a 2-Cys peroxiredoxin, by site-directed mutagenesis.

A. Miele, M. Brunori, F. Angelucci, 2013, Journal of molecular biology.

Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production

S. Harper, N. Gennari, M. Andreini, 2017, PLoS neglected tropical diseases.

The crystal structure of archaeal serine hydroxymethyltransferase reveals idiosyncratic features likely required to withstand high temperatures

F. Angelucci, A. Ilari, S. Angelaccio, 2014, Proteins.

Evolution of the p53-MDM2 pathway

M. Grabherr, P. Jemth, Greta Hultqvist, 2017, BMC Evolutionary Biology.

Crystal structure of Plasmodium falciparum thioredoxin reductase, a validated drug target.

A. Miele, M. Brunori, F. Angelucci, 2012, Biochemical and biophysical research communications.

(+)-(R)- and (-)-(S)-Perhexiline maleate: Enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages.

S. Gemma, G. Campiani, O. Taglialatela‐Scafati, 2020, Bioorganic chemistry.

Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation.

L. Altucci, J. O’Sullivan, Simone Brogi, 2020, ACS medicinal chemistry letters.

Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability.

L. Altucci, Simone Brogi, S. Gemma, 2022, European journal of medicinal chemistry.

Thiazinoquinones as new promising multi-stage schistosomicidal compounds impacting Schistosoma mansoni and egg viability.

A. Pietrantoni, C. Fattorusso, M. Persico, 2019, ACS infectious diseases.

Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors

Simone Brogi, S. Gemma, G. Campiani, 2022, The Journal of biological chemistry.

Screening and phenotypical characterization of Schistosoma mansoni histone deacetylase 8 (SmHDAC8) inhibitors as multi-stage antischistosomal agents.

Simone Brogi, M. Brindisi, S. Gemma, 2020, ACS infectious diseases.

One ring (or two) to hold them all – on the structure and function of protein nanotubes

F. Angelucci, A. Bellelli, R. Ippoliti, 2015, The FEBS journal.

Investigating the Antiparasitic Potential of the Marine Sesquiterpene Avarone, Its Reduced Form Avarol, and the Novel Semisynthetic Thiazinoquinone Analogue Thiazoavarone

S. Parapini, C. Fattorusso, M. Persico, 2020, Marine drugs.

Thioredoxin Reductase and its Inhibitors

A. Miele, F. Angelucci, A. Bellelli, 2014, Current protein & peptide science.

Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design.

E. Novellino, A. Lavecchia, E. Scotti, 2008, Journal of medicinal chemistry.

Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation.

L. Altucci, Simone Brogi, M. Brindisi, 2020, European journal of medicinal chemistry.

Comparative metabolic profiling by 1H-NMR spectroscopy analysis reveals the adaptation of S. mansoni from its host to in vitro culture conditions: a pilot study with ex vivo and GSH-supplemented medium-cultured parasites

D. Cicero, F. Saccoccia, G. Ruberti, 2022, Parasitology Research.

Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production

N. Gennari, G. Paonessa, E. Nizi, 2018, Parasites & Vectors.

Drug effects on metabolic profiles of Schistosoma mansoni adult male parasites detected by 1H-NMR spectroscopy

A. Guidi, D. Cicero, F. Saccoccia, 2020, PLoS neglected tropical diseases.

Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors.

A. Prasse, L. Altucci, E. Bargagli, 2021, Journal of medicinal chemistry.

Moonlighting by different stressors: crystal structure of the chaperone species of a 2-Cys peroxiredoxin.

A. Miele, M. Brunori, F. Angelucci, 2012, Structure.

Evolution of the p53-MDM2 pathway

M. Grabherr, P. Jemth, F. Saccoccia, 2017, BMC Evolutionary Biology.

Mapping the Catalytic Cycle of Schistosoma mansoni Thioredoxin Glutathione Reductase by X-ray Crystallography*

A. Miele, M. Brunori, F. Angelucci, 2010, The Journal of Biological Chemistry.

On the mechanism and rate of gold incorporation into thiol-dependent flavoreductases.

A. Miele, M. Brunori, F. Angelucci, 2012, Journal of inorganic biochemistry.

Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production

N. Gennari, G. Paonessa, A. Guidi, 2018, Parasites & Vectors.

Evolution of the p53-MDM2 pathway

M. Grabherr, P. Jemth, F. Saccoccia, 2017, BMC Evolutionary Biology.

Switching between the alternative structures and functions of a 2-Cys peroxiredoxin, by site-directed mutagenesis.

A. Miele, R. Ippoliti, G. Boumis, 2013, Journal of Molecular Biology.

E. Novellino, A. Lavecchia, E. Scotti, 2008, Journal of medicinal chemistry.