D. Browning

发表

Cysteine Redox Sensor in PKGIa Enables Oxidant-Induced Activation

J. P. Brennan, P. Eaton, E. Schröder, 2007, Science.

Autocrine regulation of interleukin-8 production in human monocytes.

W. Diehl, R. Ye, D. Browning, 2000, American journal of physiology. Lung cellular and molecular physiology.

Gamma-glutamyl transpeptidase has a role in the persistent colonization of the avian gut by Campylobacter jejuni.

I. Barnes, M. Bagnall, G. Manning, 2007, Microbial pathogenesis.

The Synthetic Peptide Trp-Lys-Tyr-Met-Val-d-Met Is a Potent Chemotactic Agonist for Mouse Formyl Peptide Receptor1

Ji Ming Wang, R. Ye, Rong L He, 2000, The Journal of Immunology.

Peptide Receptor Chemotactic Agonist for Mouse Formyl Trp-Lys-Tyr-Met-Val-d-Met Is a Potent The Synthetic Peptide and

Ji Ming Wang, R. Ye, Rong L He, 2000 .

Mutation of protein kinase C phosphorylation site S1076 on alpha-subunits affects BK(Ca) channel activity in HEK-293 cells.

Richard E. White, S. Barman, D. Fulton, 2009, American journal of physiology. Lung cellular and molecular physiology.

IFN-γ Upregulates Survivin and Ifi202 Expression to Induce Survival and Proliferation of Tumor-Specific T Cells

Xiaoling Hu, V. Ganapathy, D. Choubey, 2010, PloS one.

NF-kappaB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells.

N. Mukaida, R. Ye, M. Wang, 1999, Blood.

Gene transcription through activation of G-protein-coupled chemoattractant receptors.

E. Prossnitz, V. Kravchenko, R. Ye, 1996, Gene expression.

Sildenafil normalizes bowel transit in preclinical models of constipation

Yali Hou, Nagendra Singh, D. Browning, 2017, PloS one.

Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKA.

J. Niu, S. Orlov, N. Dulin, 2003, Cellular signalling.

Cell Type- and Developmental Stage-specific Activation of NF-κB by fMet-Leu-Phe in Myeloid Cells*

E. Prossnitz, R. Ye, Z. Pan, 1997, The Journal of Biological Chemistry.

Bradykinin stimulates NF-kappaB activation and interleukin 1beta gene expression in cultured human fibroblasts.

E. Prossnitz, R. Ye, Z. Pan, 1996, The Journal of clinical investigation.

Bradykinin Stimulates NF- (cid:107) B Activation and Interleukin 1 (cid:98) Gene Expression in Cultured Human Fibroblasts

E. Prossnitz, R. Ye, Z. Pan, 1996 .

Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells.

C. López-Otín, M. Balbín, S. Lamas, 2002, Molecular pharmacology.

Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase.

N. Dulin, N. Sandbo, S. Taurin, 2006, The Journal of biological chemistry.

Comparative analysis of chemotaxis in Dictyostelium using a radial bioassay method: protein tyrosine kinase activity is required for chemotaxis to folate but not to cAMP.

D. O’Day, D. Browning, T. The, 1995, Cellular signalling.

Myeloid-Derived Suppress or Cells Produce IL-10 to Elicit DNMT 3 b-Dependent IRF 8 Silencing to Promote Colitis-Associated Colon Tumorigenesis Graphical

P. Buckhaults, Dafeng Yang, Kebin Liu, 2018 .

Expression in Mononuclear Cells B Activation Is Required for C5a-Induced Interleukin-8 Gene κ NF-

N. Mukaida, R. Ye, D. Browning, 2013 .

IFN Regulatory Factor 8 Mediates Apoptosis in Nonhemopoietic Tumor Cells via Regulation of Fas Expression

B. Korchin, D. Lev, V. Ganapathy, 2007, The Journal of Immunology.

Inhibition of Colon Cancer Cell Growth by Phosphodiesterase Inhibitors Is Independent of cGMP Signaling

K. Vega, D. Browning, Rui Wang, 2022, The Journal of Pharmacology and Experimental Therapeutics.

An anti-tumor role for cGMP-dependent protein kinase.

R. Martindale, V. Ganapathy, Yali Hou, 2006, Cancer letters.

A role for cyclic-GMP dependent protein kinase in anoikis.

Yali Hou, W. Dostmann, D. Browning, 2006, Cellular signalling.

Activation of cGMP-dependent Protein Kinase by Protein Kinase C*

N. Dulin, Yali Hou, R. Ye, 2003, The Journal of Biological Chemistry.

Identification of Tetratricopeptide Repeat 1 as an Adaptor Protein That Interacts with Heterotrimeric G Proteins and the Small GTPase Ras

R. Ye, C. Marty, D. Browning, 2003, Molecular and Cellular Biology.

Constitutive Activation of NF-κB and Secretion of Interleukin-8 Induced by the G Protein-coupled Receptor of Kaposi's Sarcoma-associated Herpesvirus Involve Gα13 and RhoA*

T. Voyno-Yasenetskaya, P. Xie, R. Ye, 2001, The Journal of Biological Chemistry.

Activation of NF-κB by Bradykinin through a Gαq- and Gβγ-dependent Pathway That Involves Phosphoinositide 3-Kinase and Akt*

Nigel Mackman, Richard D. Ye, Ping Xie, 2000, The Journal of Biological Chemistry.

Activation of p38 Mitogen-activated Protein Kinase by Lipopolysaccharide in Human Neutrophils Requires Nitric Oxide-dependent cGMP Accumulation*

R. Ye, D. Browning, Nancy D. Windes, 1999, The Journal of Biological Chemistry.

Cyclic AMP-independent Activation of Protein Kinase A by Vasoactive Peptides*

J. Niu, T. Voyno-Yasenetskaya, N. Dulin, 2001, The Journal of Biological Chemistry.

Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis

P. Buckhaults, Dafeng Yang, Kebin Liu, 2018, Cell reports.

GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon.

G. Cresci, N. Lambert, J. Mellinger, 2009, Cancer research.

Clinical utility of plecanatide in the treatment of chronic idiopathic constipation

D. Browning, Sarah K. Sharman, B. Islam, 2018, International journal of general medicine.

PKG inhibits TCF signaling in colon cancer cells by blocking β-catenin expression and activating FOXO4

V. Ganapathy, M. Thangaraju, N. Dulin, 2010, Oncogene.

cGMP-dependent protein kinases as potential targets for colon cancer prevention and treatment.

D. Browning, Rui Wang, In‐Kiu Kwon, 2010, Future medicinal chemistry.

p50 suppresses cytotoxic T lymphocyte effector function to regulate tumor immune escape and response to immunotherapy

D. Munn, Dafeng Yang, Kebin Liu, 2020, Journal for ImmunoTherapy of Cancer.

IFNγ Induces DNA Methylation–Silenced GPR109A Expression via pSTAT1/p300 and H3K18 Acetylation in Colon Cancer

J. Lee, Y. Bhutia, V. Ganapathy, 2015, Cancer Immunology Research.

IFN g InducesDNAMethylation – SilencedGPR 109 A Expression via pSTAT 1 / p 300 and H 3 K 18 Acetylation in Colon Cancer

J. Lee, Y. Bhutia, V. Ganapathy, 2015 .

Phosphorylation of β-Catenin by Cyclic AMP-dependent Protein Kinase*

N. Dulin, N. Sandbo, S. Taurin, 2006, Journal of Biological Chemistry.

An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis

D. Munn, T. McGaha, R. Kolhe, 2016, Oncogenesis.

Protein kinase G as a therapeutic target for the treatment of metastatic colorectal cancer

D. Browning, 2008, Expert opinion on therapeutic targets.

Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells.

K. Ozato, V. Ganapathy, M. Thangaraju, 2007, Cancer research.

Sodium-Coupled Transport of the Short Chain Fatty Acid Butyrate by SLC5A8 and Its Relevance to Colon Cancer

G. Cresci, J. Mellinger, V. Ganapathy, 2008, Journal of Gastrointestinal Surgery.

Upregulation of the EGFR/MEK1/MAPK1/2 signaling axis as a mechanism of resistance to antiestrogen-induced BimEL dependent apoptosis in ER+ breast cancer cells

John R. Barrett, M. Thangaraju, M. McGee-Lawrence, 2022, International journal of oncology.

Sildenafil Suppresses Inflammation-Driven Colorectal Cancer in Mice

R. Kolhe, Yali Hou, F. Berger, 2017, Cancer Prevention Research.

cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium.

F. Hofmann, Yali Hou, Nagendra Singh, 2017, The American journal of pathology.

Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa.

F. Hofmann, V. Ganapathy, M. Thangaraju, 2012, American journal of physiology. Gastrointestinal and liver physiology.

IFN Regulatory Factor 8 Mediates Apoptosis in Nonhemopoietic Tumor Cells via Regulation of Fas Expression

B. Korchin, D. Lev, V. Ganapathy, 2007, The Journal of Immunology.

A role for macroautophagy in protection against 4-hydroxytamoxifen–induced cell death and the development of antiestrogen resistance

Sylvia B. Smith, D. Browning, Jennifer Duplantier, 2008, Molecular Cancer Therapeutics.

Differential Roles of the NPXXY Motif in Formyl Peptide Receptor Signaling1

R. Ye, D. Browning, Rong L. He, 2001, The Journal of Immunology.

SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer.

V. Ganapathy, S. Ramachandran, M. Thangaraju, 2011, Cancer research.

Type 2 cGMP-dependent protein kinase regulates homeostasis by blocking c-Jun N-terminal kinase in the colon epithelium

F. Hofmann, R. Wang, D. Browning, 2013, Cell Death and Differentiation.

Curcumin inhibits PhIP induced cytotoxicity in breast epithelial cells through multiple molecular targets.

M. Thangaraju, Satoru Takahashi, W. Bollag, 2015, Cancer letters.

The Campylobacter jejuni Response Regulator and Cyclic-Di-GMP Binding CbrR Is a Novel Regulator of Flagellar Motility

Vincent T. Lee, C. Waters, V. Lee, 2021, Microorganisms.

proliferation and differentiation in the colonic mucosa Type 2 cGMP-dependent protein kinase regulates

F. Hofmann, V. Ganapathy, M. Thangaraju, 2012 .

Type 2 cGMP-Dependent Protein Kinase Regulates Proliferation and Differentiation in the 5 Colonic Mucosa 6 7 8 ( Running title : PKG 2 regulates colon homeostasis ) 9 10 11

F. Hofmann, V. Ganapathy, M. Thangaraju, 2012 .

Constitutive activation of NF-kappa B and secretion of interleukin-8 induced by the G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus involve G alpha(13) and RhoA.

T. Voyno-Yasenetskaya, P. Xie, M. Yang, 2001, The Journal of biological chemistry.

Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation.

M. Nagarkatti, P. Nagarkatti, Anne B. Hofseth, 2007, Cancer research.

Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation

G. Zhu, Kebin Liu, Nagendra Singh, 2019, Cell Discovery.

Carbidopa, a drug in use for management of Parkinson disease inhibits T cell activation and autoimmunity

A. Mellor, H. Lemos, Lei Huang, 2017, PloS one.

Molecular and Cellular Pathobiology SIRT 1 Is Essential for Oncogenic Signaling by Estrogen / Estrogen Receptor a in Breast Cancer

V. Ganapathy, S. Ramachandran, M. Thangaraju, 2011 .

Activation of NF-kappa B by bradykinin through a Galpha(q)- and Gbeta gamma-dependent pathway that involves phosphoinositide 3-kinase and Akt.

N. Hay, N. Mackman, P. Xie, 2000, The Journal of biological chemistry.

Expression of cyclic guanosine monophosphate‐dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis

V. Ganapathy, N. Dulin, Kebin Liu, 2008, Cancer.

Targeting Lymphotoxin β Receptor with Tumor-Specific T Lymphocytes for Tumor Regression

Dafeng Yang, Kebin Liu, S. Abrams, 2007, Clinical Cancer Research.

Bradykinin Stimulates NFk B Activation and Interleukin 1 b Gene Expression in Cultured Human Fibroblasts

E. Prossnitz, R. Ye, Z. Pan, 2013 .

Functional Analysis of Type 1α cGMP-dependent Protein Kinase Using Green Fluorescent Fusion Proteins*

R. Ye, C. Marty, D. Browning, 2001, The Journal of Biological Chemistry.

Nitric Oxide Activation of p38 Mitogen-activated Protein Kinase in 293T Fibroblasts Requires cGMP-dependent Protein Kinase*

R. Ye, D. Browning, Caroline Marty, 2000, The Journal of Biological Chemistry.

Guanylate cyclase and cyclic GMP-dependent protein kinase regulate agrin signaling at the developing neuromuscular junction.

D. Browning, E. Godfrey, R. Schwarte, 2007, Developmental biology.

Activation of the small GTPase Rac1 by cGMP-dependent protein kinase.

Yali Hou, R. Ye, D. Browning, 2004, Cellular signalling.

Activation of the Mitogen Activated Protein Kinase Extracellular Signal-Regulated Kinase 1 and 2 by the Nitric Oxide – cGMP – cGMP-Dependent Protein Kinase Axis Regulates the Expression of Matrix Metalloproteinase 13 in Vascular Endothelial Cells

C. López-Otín, M. Balbín, S. Lamas, 2002 .

Concanavalin A and wheat germ agglutinin binding glycoproteins associated with cell fusion and zygote differentiation in Dictyostelium discoideum: effects of calcium ions and tunicamycin on glycoprotein profiles.

D. O’Day, D. Browning, 1991, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Zygote giant cell differentiation in Dictyostelium discoideum: biochemical markers of specific stages of sexual development.

D. O’Day, D. Browning, K. E. Lewis, 1992, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Signal transduction during cannibalistic sexual phagocytosis: calcium is not the trigger but GTP-binding protein function is essential.

D. O’Day, D. Browning, K. E. Lewis, 1994, Cellular signalling.

8 – Signal Transduction during Phagocytosis

D. O’Day, D. Browning, K. E. Lewis, 1993 .

The regulation of GTP-binding proteins during fertilization and zygote differentiation in Dictyostelium discoideum.

D. O’Day, D. Browning, G. Proteau, 1993, Experimental cell research.

γ-Glutamyl transpeptidase has a role in the persistent colonization of the avian gut by Campylobacter jejuni

M. Bagnall, G. Manning, If H. A. Barnes, 2007 .

Cyclic 3′,5′‐guanosine monophosphate‐dependent protein kinase inhibits colon cancer cell adaptation to hypoxia

T. Baudino, M. Thangaraju, Kebin Liu, 2011, Cancer.

Erratum: Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells (Molecular Pharmacology (2002) 62 (927-935))

C. López-Otín, M. Balbín, S. Lamas, 2002 .

Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation

G. Zhu, Kebin Liu, Nagendra Singh, 2019, Cell Discovery.

Cyclic-GMP–Elevating Agents Suppress Polyposis in ApcMin Mice by Targeting the Preneoplastic Epithelium

Yali Hou, F. Berger, Nagendra Singh, 2018, Cancer Prevention Research.