Xiangdong Wu

发表

Role of insulin-induced reactive oxygen species in the insulin signaling pathway.

Xiangdong Wu, H. Motoshima, B. Goldstein, 2005, Antioxidants & redox signaling.

Adiponectin Suppression of High-Glucose–Induced Reactive Oxygen Species in Vascular Endothelial Cells

H. Motoshima, B. Goldstein, Shi-qiong Xu, 2006, Diabetes.

Insulin-Stimulated Reactive Oxygen Species and Insulin Signal Transduction

B. Goldstein, K. Mahadev, Xiangdong Wu, 2007 .

Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets.

B. Goldstein, K. Mahadev, Xiangdong Wu, 2005, Diabetes.

Protein-tyrosine phosphatase activity in human adipocytes is strongly correlated with insulin-stimulated glucose uptake and is a target of insulin-induced oxidative inhibition.

B. Goldstein, S. Jabbour, K. Mahadev, 2003, Metabolism: clinical and experimental.

Use of an anaerobic environment to preserve the endogenous activity of protein‐tyrosine phosphatases isolated from intact cells

B. Goldstein, S. Jabbour, K. Mahadev, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Suppression of Hepatic FLOT1 (Flotillin-1) by Type 2 Diabetes Mellitus Impairs the Disposal of Remnant Lipoproteins via Syndecan-1

Keyang Chen, K. Williams, P. Cheung, 2018, Arteriosclerosis, thrombosis, and vascular biology.

An oxide transport chain essential for balanced insulin signaling

Keyang Chen, K. Williams, Xiangdong Wu, 2018, bioRxiv.

Decreased secretion of adiponectin through its intracellular accumulation in adipose tissue during tobacco smoke exposure

K. Williams, Yan Chen, V. Werth, 2015, Nutrition & Metabolism.

The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H₂0₂ and plays an integral role in insulin signal transduction

H. Motoshima, J. Lambeth, B. Goldstein, 2022 .

Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells.

B. Goldstein, A. Eckhart, K. Mahadev, 2008, Cardiovascular research.

Adiponectin suppresses IκB kinase activation induced by tumor necrosis factor-α or high glucose in endothelial cells: role of cAMP and AMP kinase signaling

B. Goldstein, Shi-qiong Xu, K. Mahadev, 2007 .

Adiponectin Protects Against Angiotensin II or Tumor Necrosis Factor &agr;–Induced Endothelial Cell Monolayer Hyperpermeability: Role of cAMP/PKA Signaling

B. Goldstein, Shi-qiong Xu, K. Mahadev, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Comment on: Hattori et al. (2007) Globular Adiponectin Activates Nuclear Factor-κB and Activating Protein-1 and Enhances Angiotensin II–Induced Proliferation in Cardiac Fibroblasts: Diabetes 56:804–808

Xinliang Ma, B. Goldstein, K. Mahadev, 2007, Diabetes.

Integration of multiple downstream signals determines the net effect of insulin on MAP kinase vs. PI 3'-kinase activation: potential role of insulin-stimulated H(2)O(2).

H. Motoshima, B. Goldstein, K. Mahadev, 2004, Cellular signalling.

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).

P. McNamara, S. Joseph, B. Laffitte, 2017, Journal of medicinal chemistry.

Chicken optineurin suppresses MDA5-mediated interferon β production

Jing Xiao, Huansheng Wu, N. Jiang, 2020, Poultry science.

IMMUNOLOGY, HEALTH AND DISEASE

Jing Xiao, Huansheng Wu, N. Jiang, 2020 .

Adiponectin suppresses IkappaB kinase activation induced by tumor necrosis factor-alpha or high glucose in endothelial cells: role of cAMP and AMP kinase signaling.

B. Goldstein, Shi-qiong Xu, K. Mahadev, 2007, American journal of physiology. Endocrinology and metabolism.

Hyperglycemia potentiates H2O2 production in adipocytes and enhances insulin signal transduction: Potential role for oxidative inhibition of thiol-sensitive protein-tyrosine phosphatases

H. Motoshima, B. Goldstein, K. Mahadev, 2005 .

The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H2O2 and Plays an Integral Role in Insulin Signal Transduction

H. Motoshima, J. Lambeth, B. Goldstein, 2004, Molecular and Cellular Biology.

Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone.

H. Motoshima, B. Goldstein, M. Sinha, 2002, The Journal of clinical endocrinology and metabolism.

Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL.

H. Motoshima, B. Goldstein, K. Mahadev, 2004, Biochemical and biophysical research communications.

Hydrogen Peroxide Generated during Cellular Insulin Stimulation Is Integral to Activation of the Distal Insulin Signaling Cascade in 3T3-L1 Adipocytes*

Xiangdong Wu, B. Goldstein, K. Mahadev, 2001, The Journal of Biological Chemistry.

Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes.

H. Motoshima, B. Goldstein, K. Mahadev, 2003, Diabetes.

Imbalanced insulin action in chronic over nutrition: Clinical harm, molecular mechanisms, and a way forward.

K. Williams, Xiangdong Wu, K. Williams, 2016, Atherosclerosis.

NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness

K. Williams, Xiangdong Wu, K. Williams, 2012, Arteriosclerosis, thrombosis, and vascular biology.

The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia

Keyang Chen, K. Williams, Xiangdong Wu, 2012, Current opinion in lipidology.

An oxide transport chain essential for balanced insulin action.

Keyang Chen, K. Williams, Xiangdong Wu, 2020, Atherosclerosis.

Type 2 diabetes in mice induces hepatic overexpression of sulfatase 2, a novel factor that suppresses uptake of remnant lipoproteins

Keyang Chen, G. Boden, L. Schaffer, 2010, Hepatology.

LncRNA H19 mediates BMP9-induced angiogenesis in mesenchymal stem cells by promoting the p53-Notch1 angiogenic signaling axis

J. Liao, Xiangdong Wu, Wei Huang, 2022, Genes & diseases.

Single ethanol binge causes severe liver injury in mice fed Western diet

B. Xue, Hang Shi, Liqing Yu, 2023, Hepatology communications.

Insulin Action Is Facilitated by Insulin-Stimulated Reactive Oxygen Species With Multiple Potential Signaling Targets

Xiangdong Wu, Barry J. Goldstein, Mahadev Kalyankar, 2005 .