F. Lanza

发表

Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.

R. Tiedt, R. Skoda, M. Freund, 2007, Blood.

Targeting Platelet GPIb&bgr; Reduces Platelet Adhesion, GPIb Signaling and Thrombin Generation and Prevents Arterial Thrombosis

C. Gachet, A. Eckly, B. Hechler, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Pharmacological Blockade of Glycoprotein VI Promotes Thrombus Disaggregation in the Absence of Thrombin

S. Susen, A. Rauch, C. Gachet, 2020, Arteriosclerosis, thrombosis, and vascular biology.

Myosin IIA is critical for organelle distribution and F-actin organization in megakaryocytes and platelets.

C. Gachet, A. Eckly, C. Léon, 2014, Blood.

Identification of Thrombin Receptors in Rat Brain Capillary Endothelial Cells

K. Bartha, V. Ádám-Vizi, F. Lanza, 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Antibody cross‐linking of human CD9 and the high‐affinity immunoglobulin E receptor stimulates secretion from transfected rat basophilic leukaemia cells

A. Higginbottom, P. Monk, D. Azorsa, 2000, Immunology.

Tetraspanin CD9 is associated with very late-acting integrins in human vascular smooth muscle cells and modulates collagen matrix reorganization.

A. Scherberich, D. Azorsa, A Scherberich, 1998, Arteriosclerosis, thrombosis, and vascular biology.

FAK-mediated Inhibition of Vascular Smooth Muscle Cell Migration by the Tetraspanin CD9

A. Scherberich, G. Giannone, K. Takeda, 2002, Thrombosis and Haemostasis.

Biosynthesis and intracellular post-translational processing of normal and mutant platelet glycoprotein GPIb-IX

J. Salamero, S. Chasserot-Golaz, J. Cazenave, 2001 .

Signaling Role for Phospholipase Cγ2 in Platelet Glycoprotein Ibα Calcium Flux and Cytoskeletal Reorganization

M. Freund, J. Cazenave, C. Gachet, 2003, Journal of Biological Chemistry.

Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency.

S. Jackson, S. Sturgeon, C. Wright, 2006, Blood.

MRS2500 [2-Iodo-N6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate], a Potent, Selective, and Stable Antagonist of the Platelet P2Y1 Receptor with Strong Antithrombotic Activity in Mice

K. Jacobson, J. Cazenave, C. Gachet, 2006, Journal of Pharmacology and Experimental Therapeutics.

Mechanisms underlying FeCl3‐induced arterial thrombosis

M. Freund, J. Cazenave, C. Gachet, 2011, Journal of thrombosis and haemostasis : JTH.

Decreased Thrombotic Tendency in Mouse Models of the Bernard-Soulier Syndrome

T. David, M. Freund, C. Gachet, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Spectrum of the Mutations in Bernard–Soulier Syndrome

A. Pastore, P. Noris, R. Favier, 2014, Human mutation.

Willebrand factor interaction von - Cytoskeletal regulation of the platelet glycoprotein Ib/V/IX

D. Dunstan, S. Jackson, S. Cranmer, 2013 .

and aggregation Platelet glycoprotein V binds to collagen and participates in platelet adhesion

B. Nieswandt, M. Freund, J. Cazenave, 2013 .

The platelet glycoprotein GPIbβ intracellular domain participates in von Willebrand factor induced‐filopodia formation independently of the Ser 166 phosphorylation site

T. David, C. Gachet, A. Eckly, 2009, Journal of thrombosis and haemostasis : JTH.

Identification of five novel 14‐3‐3 isoforms interacting with the GPIb–IX complex in platelets

C. Gachet, F. Lanza, N. Receveur, 2009, Journal of thrombosis and haemostasis : JTH.

Synthesis of GPIbβ with novel transmembrane and cytoplasmic sequences in a Bernard–Soulier patient resulting in GPIb‐defective signaling in CHO cells

T. David, C. Gachet, C. Vinciguerra, 2006, Journal of thrombosis and haemostasis : JTH.

Biosynthesis of platelet glycoprotein V expressed as a single subunit or in association with GPIb-IX.

J. Cazenave, F. Lanza, M. Baas, 2004, European journal of biochemistry.

Interaction between Platelet Glycoprotein Ibα and Filamin-1 Is Essential for Glycoprotein Ib/IX Receptor Anchorage at High Shear*

S. Jackson, S. Cranmer, F. Lanza, 2002, The Journal of Biological Chemistry.

Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation.

B. Nieswandt, M. Freund, C. Gachet, 2001, Blood.

Cytoskeletal regulation of the platelet glycoprotein Ib/V/IX-von willebrand factor interaction.

D. Dunstan, S. Jackson, S. Cranmer, 2000, Blood.

Profiling of the Tetraspanin Web of Human Colon Cancer Cells *S

J. Emile, C. Boucheix, M. Billard, 2006, Molecular & Cellular Proteomics.

Thrombin receptor-mediated increase of two matrix metalloproteinases, MMP-1 and MMP-3, in human endothelial cells.

C. Orvain, C. Klein-Soyer, J. Cazenave, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Evaluation of soluble glycoprotein V as a marker of venous thromboembolism

J. Cazenave, C. Gachet, T. Kirchgesner, 2011, Thrombosis and Haemostasis.

Bernard-Soulier syndrome (Hemorrhagiparous thrombocytic dystrophy)

F. Lanza, 2006, Orphanet journal of rare diseases.

A study of platelet activation in atrial fibrillation and the effects of antithrombotic therapy.

G. Lip, A. Blann, J. Cazenave, 2002, European heart journal.

Integrin-Alpha IIb Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to RANKL

B. Ludewig, Mélanie Chypre, H. Yagita, 2016, PloS one.

Hemostasis Imbalance in Experimental Hypertension

J. Michel, L. Louedec, R. Vranckx, 2002, Molecular medicine.

The tubulin code in platelet biogenesis.

A. Eckly, F. Lanza, C. Strassel, 2022, Seminars in cell & developmental biology.

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene.

M. Bryckaert, W. Vainchenker, N. Debili, 2014, Blood.

On the Way to in vitro Platelet Production

C. Gachet, F. Lanza, C. Strassel, 2018, Front. Med..

On the way to in vitro platelet production.

C. Gachet, F. Lanza, C. Strassel, 2018, Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine.

Haemorrhagic and thrombotic diatheses in mouse models with thrombocytosis

C. Denis, R. Skoda, M. Freund, 2014, Thrombosis and Haemostasis.

Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype.

S. Coughlin, T. Diacovo, D. Bainton, 1999, Blood.

Transgenic Animals in Primary Hemostasis and Thrombosis

C. Gachet, C. Léon, B. Hechler, 2004 .

Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRγ deficiency. Commentary

S. Jackson, S. Sturgeon, M. Kahn, 2006 .

Normal filopodia extension in VASP-deficient platelets upon activation by adhesive matrices or soluble agonists

C. Gachet, Sandra Eliautou, F. Lanza, 2009, Thrombosis and Haemostasis.

Renin‐angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells

C. Gachet, J. Freund, F. Lanza, 2021, Stem cells.

Importance of Platelet Phospholipase Cγ2 Signaling in Arterial Thrombosis as a Function of Lesion Severity

J. Cazenave, C. Gachet, B. Hechler, 2005, Arteriosclerosis, thrombosis, and vascular biology.

in vivo Diverging signaling events control the pathway of GPVI down-regulation

S. Watson, B. Nieswandt, Takashi Saito, 2011 .

Diverging signaling events control the pathway of GPVI down-regulation in vivo.

S. Watson, B. Nieswandt, Takashi Saito, 2007, Blood.

The P2Y1 receptor plays an essential role in the platelet shape change induced by collagen when TxA2 formation is prevented

P. Ohlmann, J. Cazenave, C. Gachet, 2004, Journal of thrombosis and haemostasis : JTH.

CD9, a tetraspan transmembrane protein, renders cells susceptible to canine distemper virus

V. ter meulen, F. Lottspeich, D. Azorsa, 1997, Journal of virology.

J virus . renders cells susceptible to canine distemper CD 9 , a tetraspan transmembrane protein

F. Lottspeich, D. Azorsa, V. Meulen, 1996 .

Integrin &agr;6&bgr;1 Is the Main Receptor for Vascular Laminins and Plays a Role in Platelet Adhesion, Activation, and Arterial Thrombosis

C. Denis, B. Nieswandt, C. Gachet, 2013, Circulation.

Blocking platelet aggregation inhibits thromboxane A2 formation by low dose agonists but does not inhibit phosphorylation and activation of cytosolic phospholipase A2.

R. Carroll, F. Lanza, B. Steiner, 1997, Thrombosis research.

Immature myeloid dendritic cells capture and remove activated platelets from preformed aggregates

C. Gachet, D. Hanau, A. Eckly, 2010, Journal of thrombosis and haemostasis : JTH.

Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis.

M. Freund, C. Gachet, A. Eckly, 2019, Blood advances.

Soluble Platelet Glycoprotein V Is a Marker of Thrombosis in Patients With Ischemic Stroke

M. Giroud, J. Cazenave, V. Wolff, 2005, Stroke.

Imaging thrombosis with 99mTc-labeled RAM.1-antibody in vivo.

A. Ouadi, C. Gachet, Patrice Marchand, 2018, Nuclear medicine and biology.

The thienopyridine PCR 4099 selectively inhibits ADP-induced platelet aggregation and fibrinogen binding without modifying the membrane glycoprotein IIb-IIIa complex in rat and in man.

J. Maffrand, J. Cazenave, C. Gachet, 1990, Biochemical pharmacology.

Human platelet glycoprotein VI function is antagonized by monoclonal antibody‐derived Fab fragments

L. A. Feeney, J. Villeval, C. Gachet, 2003, Journal of thrombosis and haemostasis : JTH.

A Leu7Pro mutation in the signal peptide of platelet glycoprotein (GP)IX in a case of Bernard–Soulier syndrome abolishes surface expression of the GPIb–V–IX complex

J. Cazenave, F. Lanza, M. Baas, 2002, British journal of haematology.

Shear rate gradients promote a bi-phasic thrombus formation on weak adhesive proteins, such as fibrinogen in a VWF-dependent manner.

C. Denis, C. Gachet, M. Panteleev, 2019, Haematologica.

Fibrillar cellular fibronectin supports efficient platelet aggregation and procoagulant activity

B. Nieswandt, C. Gachet, C. Dubois, 2015, Thrombosis and Haemostasis.

A PLCγ2‐independent platelet collagen aggregation requiring functional association of GPVI and integrin α2β1

B. Nieswandt, M. Freund, C. Gachet, 2003 .

Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation.

M. Freund, J. Cazenave, C. Gachet, 2009, Blood.

Aryl hydrocarbon receptor-dependent enrichment of a megakaryocytic precursor with a high potential to produce proplatelets.

K. Tarte, I. Bièche, C. Gachet, 2016, Blood.

High prevalence of the natural Asn89Asp mutation in the GP1BB gene associated with Bernard–Soulier syndrome in French patients from the genetic isolate of Reunion Island

Renhao Li, C. Gachet, M. Jacquemont, 2020, British journal of haematology.

Studies of mice lacking the GPIb‐V‐IX complex question the role of this receptor in atherosclerosis

C. Gachet, B. Hechler, F. Lanza, 2009, Journal of thrombosis and haemostasis : JTH.

β-arrestin-1 participates in thrombosis and regulates integrin αIIbβ3 signalling without affecting P2Y receptors desensitisation and function

P. Ohlmann, C. Gachet, P. Ohlmann, 2012, Thrombosis and Haemostasis.

Microparticles are new biomarkers of septic shock-induced disseminated intravascular coagulopathy

P. Asfar, J. Freyssinet, F. Meziani, 2013, Intensive Care Medicine.

Fast clearance of platelets in a commonly used mouse model for GPIbα is impeded by an anti‐GPIbβ antibody derivative

Renhao Li, W. Bergmeier, F. Lanza, 2022, Journal of thrombosis and haemostasis : JTH.

Retinoic acid receptor‐α regulates synthetic events in human platelets: comment

C. Gachet, F. Lanza, H. Salle, 2018, Journal of thrombosis and haemostasis : JTH.

Lentiviral gene rescue of a Bernard–Soulier mouse model to study platelet glycoprotein Ibβ function

M. Freund, C. Gachet, A. Dubart-Kupperschmitt, 2016, Journal of thrombosis and haemostasis : JTH.

Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance

Wei Zhang, C. Casari, Renhao Li, 2020, Haematologica.

Sustained elevated amounts of circulating procoagulant membrane microparticles and soluble GPV after acute myocardial infarction in diabetes mellitus

J. Freyssinet, O. Morel, J. Cazenave, 2004, Thrombosis and Haemostasis.

MRS2500, a potent, selective and stable antagonist of the P2Y1 receptor, with strong antithrombotic activity in mice

K. Jacobson, C. Gachet, E. Roh, 2005 .

Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions.

D. Azorsa, C. Boucheix, M. Billard, 1999, The Biochemical journal.

Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry.

A. van Dorsselaer, D. Loew, R. Arcone, 2000, Biochemistry.

Pharmacological Inhibition of the ADP-GP IIb/IIIa-Fibrinogen Pathway of Platelet Aggregation

J. Cazenave, C. Gachet, F. Lanza, 1991 .

CDX2 regulates ACE expression in blood development and leukemia cells.

M. Negroni, C. Gachet, L. Vallat, 2021, Blood advances.

Use of tandem Biacore-mass spectrometry to identify platelet membrane targets of novel monoclonal antibodies.

J. Cazenave, C. Gachet, P. Ohlmann, 2009, Analytical biochemistry.

Potentiation by adrenaline of human platelet activation and the inhibition by the alpha-adrenergic antagonist nicergoline of platelet adhesion, secretion and aggregation

J. Cazenave, F. Lanza, J. Kretz, 1986, Agents and Actions.

Selective tetraspan–integrin complexes (CD81/α4β1, CD151/α3β1, CD151/α6β1) under conditions disrupting tetraspan interactions

D. Azorsa, C. Boucheix, M. Billard, 1999 .

Arterial thrombosis: relevance of a model with two levels of severity assessed by histologic, ultrastructural and functional characterization

C. Denis, M. Freund, C. Gachet, 2010, Journal of thrombosis and haemostasis : JTH.

Activation of the fibrinogen binding site on platelets isolated from a patient with the Strasbourg I variant of Glanzmann's thrombasthenia.

L. Jennings, J. Cazenave, F. Lanza, 1994, Blood.

Measurement of GPV Released by Activated Platelets Using a Sensitive Immunocapture ELISA – Its Use to Follow Platelet Storage in Transfusion

D. Azorsa, G. Folléa, C. Ravanat, 1999, Thrombosis and Haemostasis.

Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage.

A. van Dorsselaer, D. Azorsa, D. Loew, 1997, Blood.

Inhibition of adhesive and signaling functions of the platelet GPIb‐V‐IX complex by a cell penetrating GPIbα peptide

T. David, P. Ohlmann, C. Gachet, 2006, Journal of thrombosis and haemostasis : JTH.

Integrin α 6 β 1 Is the Main Receptor for Vascular Laminins and Plays a Role in Platelet Adhesion, Activation, and Arterial Thrombosis

C. Denis, B. Nieswandt, C. Gachet, 2013 .

Broader expression of the mouse platelet factor 4‐cre transgene beyond the megakaryocyte lineage

C. Gachet, J. Freund, A. Eckly, 2015, Journal of thrombosis and haemostasis : JTH.

Epinephrine potentiates human platelet activation but is not an aggregating agent.

J. Cazenave, D. Hanau, F. Lanza, 1988, The American journal of physiology.

Cyclic nucleotide phosphodiesterase inhibitors prevent aggregation of human platelets by raising cyclic AMP and reducing cytoplasmic free calcium mobilization.

J. Cazenave, F. Lanza, A. Beretz, 1987, Thrombosis research.

A 13 base pair deletion in the GPIbβ gene in a second unrelated Bernard–Soulier family due to slipped mispairing between direct repeats

I. Juhan-vague, M. Alessi, F. Lanza, 2004, Journal of thrombosis and haemostasis : JTH.

Plasma glycoprotein V levels in the general population: Normal distribution, associated parameters and implications for clinical studies

J. Cazenave, C. Gachet, V. Wolff, 2006, Thrombosis and Haemostasis.

with megakaryocyte-restricted MYH9 inactivation Abnormal megakaryocyte morphology and proplatelet formation in mice

M. Freund, J. Cazenave, A. Eckly, 2013 .

Circulating procoagulant microparticles and soluble GPV in myocardial infarction treated by primary percutaneous transluminal coronary angioplasty. A possible role for GPIIb‐IIIa antagonists

J. Freyssinet, O. Morel, A. Tedgui, 2004, Journal of thrombosis and haemostasis : JTH.

A revised model of platelet aggregation.

P Mangin, I S Harper, M Freund, 2000, The Journal of clinical investigation.

Analysis of 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia

P. Nurden, P. Noris, R. Favier, 2014, Haematologica.

Hirudin and heparin enable efficient megakaryocyte differentiation of mouse bone marrow progenitors.

J. Cazenave, C. Gachet, A. Eckly, 2012, Experimental cell research.

Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation.

C. Gachet, A. Eckly, C. Léon, 2016, Blood.

Megakaryocytes use in vivo podosome‐like structures working collectively to penetrate the endothelial barrier of bone marrow sinusoids

H. de la Salle, C. Gachet, D. Michel, 2020, Journal of thrombosis and haemostasis : JTH.

The von Willebrand Factor-Glycoprotein Ib/V/IX Interaction Induces Actin Polymerization and Cytoskeletal Reorganization in Rolling Platelets and Glycoprotein Ib/V/IX-transfected Cells*

S. Jackson, W. Nesbitt, S. Cranmer, 1999, The Journal of Biological Chemistry.

Microtubule plus-end tracking Adenopolyposis Coli negatively regulates proplatelet formation

M. Freund, C. Gachet, A. Eckly, 2018, Scientific Reports.

Glycoprotein (GP) Ib-IX-transfected Cells Roll on a von Willebrand Factor Matrix under Flow

S. Jackson, B. Cooke, S. Cranmer, 1999, The Journal of Biological Chemistry.

Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor

David S. Paul, Yan Xu, Renhao Li, 2016, Nature Communications.

Reconstitution of the platelet glycoprotein Ib-IX complex in phospholipid bilayer Nanodiscs.

X. Mo, Renhao Li, Angel M. Paredes, 2011, Biochemistry.

Thrombin interaction with a recombinant N-terminal extracellular domain of the thrombin receptor in an acellular system.

J. Cazenave, M. Bouton, M. Jandrot-Perrus, 1995, The Biochemical journal.

The contribution of mouse models to the understanding of constitutional thrombocytopenia

C. Gachet, C. Léon, F. Lanza, 2016, Haematologica.

Contribution of mouse models in constitutional thrombocytopenia

C. Gachet, C. Léon, F. Lanza, 2015 .

A novel platelet-type von Willebrand disease mutation (GP1BA p.Met255Ile) associated with type 2B “Malmö/New York” von Willebrand disease

Renhao Li, C. Gachet, É. Fressinaud, 2016, Thrombosis and Haemostasis.

Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice

J. Cazenave, C. Gachet, A. Eckly, 2010, Journal of thrombosis and haemostasis : JTH.

Transcriptome analysis of the effect of AHR on productive and unproductive pathways of in vitro megakaryocytopoiesis

H. de la Salle, C. Gachet, F. Lanza, 2021, bioRxiv.

Dual role of IL-21 in megakaryopoiesis and platelet homeostasis

H. de la Salle, M. Freund, C. Gachet, 2017, Haematologica.

Biogenesis of the demarcation membrane system (DMS) in megakaryocytes.

W. Geerts, C. Gachet, A. Eckly, 2014, Blood.

Deletion of human GP 1 BB and SEPT 5 is associated with Bernard-Soulier syndrome , platelet secretion defect , polymicrogyria , and develop-mental delay

P. Nurden, J. Oldenburg, I. Hainmann, 2018 .

Co-localization of CD9 and GPIIb-IIIa (·IIb ·3 integrin) on activated platelet pseudopods and ·-granule membranes

D. Azorsa, F. Lanza, J. Cazenave, 1997, The Histochemical Journal.

Mutations in the most divergent α-tubulin isotype, α8-tubulin, cause defective platelet biogenesis.

C. Férec, C. Gachet, C. Janke, 2021, Journal of Thrombosis and Haemostasis.

Blood platelet formation at a glance

A. Eckly, C. Léon, F. Lanza, 2020, Journal of Cell Science.

Platelet activation revealed by reduced serotonin content in various left ventricular hypertrophic states.

J. Cazenave, C. Gachet, F. Lanza, 1992, Acta cardiologica.

The αIIbβ3 integrin and GPIb-V-IX complex identify distinct stages in the maturation of CD34+cord blood cells to megakaryocytes

J. Cazenave, M. Leboeuf, G. Uzan, 2000 .

Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome

M. Freund, J. Cazenave, C. Gachet, 2009, Haematologica.

TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology

A. Munnich, R. Scharfmann, M. Polak, 2018, EMBO molecular medicine.

Time-Dependent Decay of mRNA and Ribosomal RNA during Platelet Aging and Its Correlation with Translation Activity

H. de la Salle, C. Gachet, A. Eckly, 2016, PloS one.

Increased Platelet Glycoprotein V Levels in Patients with Coronary and Peripheral Atherosclerosis

G. Lip, A. Blann, P. Galajda, 2001, Thrombosis and Haemostasis.

α of platelet glycoprotein Ib binding site within the cytoplasmic tail ζ Identification of a novel 14-3-3

T. David, J. Cazenave, C. Gachet, 2013 .

Identification of a novel 14-3-3zeta binding site within the cytoplasmic tail of platelet glycoprotein Ibalpha.

T. David, J. Cazenave, C. Gachet, 2004, Blood.

Role of the intracellular domains of GPIb in controlling the adhesive properties of the platelet GPIb/V/IX complex.

J. Cazenave, S. Jackson, S. Cranmer, 2003, Blood.

A Novel Monoclonal Antibody against the Extracellular Domain of GPIbβ Modulates vWF Mediated Platelet Adhesion

M. Freund, E. Rubinstein, C. Ravanat, 2001, Thrombosis and Haemostasis.

Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation

C. Gachet, A. Eckly, C. Léon, 2020, Haematologica.

Parallel investigation of exocytosis kinetics and membrane fluidity changes in human platelets with the fluorescent probe, trimethylammonio-diphenylhexatriene.

J. Cazenave, J. Kuhry, F. Lanza, 1987, Biochimica et biophysica acta.

Role of the Leucine-Rich Domain of Platelet GPIbα in Correct Post-translational Processing – The Nancy I Bernard-Soulier Mutation Expressed on CHO Cells

M. Briquel, S. Jackson, S. Cranmer, 2000, Thrombosis and Haemostasis.

Studies of Alpha2-Adrenergic Receptors of Intact and Functional Washed Human Platelets by Binding of 3H-Dihydroergocryptine and 3H-Yohimbine-Correlation of 3H-Yohimbine Binding with the Potentiation by Adrenaline of ADP-Induced Aggregation

F. Lanza, J. Cazenave, 1985, Thrombosis and Haemostasis.

Platelet functions, α 2-adrenergic receptors and cytoplasmic free calcium are normal in the myotonic dystrophy of Steinert

J. Cazenave, J. Warter, C. Tranchant, 1987, Journal of the Neurological Sciences.

Glycoprotein V : the unsolved GPV puzzle

C. Ravanat, F. Lanza, S. Moog, 2022, Platelets.

Increased plasma levels of soluble platelet glycoprotein V in patients with acute myocardial infarction

J. Mossard, B. Aleil, F. Lanza, 2003, Journal of thrombosis and haemostasis : JTH.

GPV Is a Marker of In Vivo Platelet Activation – Study in a Rat Thrombosis Model

D. Azorsa, M. Freund, C. Ravanat, 2000, Thrombosis and Haemostasis.

Differential regulation of the platelet GPIb‐IX complex by anti‐GPIbβ antibodies

B. Nieswandt, Renhao Li, H. Deckmyn, 2021, Journal of thrombosis and haemostasis : JTH.

A novel missense mutation in a leucine‐rich repeat of GPIbα in a Bernard‐Soulier variant reduces shear‐dependent adherence on von Willebrand factor

M. Bryckaert, P. Nurden, F. Adam, 2019, British journal of haematology.

Normal ADP-Induced Aggregation and Absence of Dissociation of the Membrane GP IIb-IIIa Complex of Intact Rat Platelets Pretreated with EDTA

C. Gachet, P. Ohlmann, D. Hanau, 1991, Thrombosis and Haemostasis.

A general approach to the generation of monoclonal antibodies against members of the tetraspanin superfamily using recombinant GST fusion proteins.

D. Azorsa, F. Lanza, J. Cazenave, 1999, Journal of immunological methods.

Reassessment of in vivo thrombus formation in glycoprotein V deficient mice backcrossed on a C57Bl/6 strain

J. Cazenave, C. Gachet, B. Hechler, 2007, Journal of thrombosis and haemostasis : JTH.

CD9 participates in endothelial cell migration during in vitro wound repair.

D. Azorsa, F. Lanza, J. Cazenave, 2000, Arteriosclerosis, thrombosis, and vascular biology.

AHR:IKAROS Interaction Promotes Platelet Biogenesis in Response to SR1

P. Kastner, H. de la Salle, C. Gachet, 2021, Reports.

CD9 negatively regulates integrin αIIbβ3 activation and could thus prevent excessive platelet recruitment at sites of vascular injury

C. Gachet, C. Boucheix, F. Lanza, 2009, Journal of thrombosis and haemostasis : JTH.

PF4 inhibits thrombin-stimulated MMP-1 and MMP-3 metalloproteinase expression in human vascular endothelial cells.

C. Orvain, J. Cazenave, C. Ravanat, 1997, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.

Thrombin Cleavage Megakaryocyte-Specific Promoters and Demonstration of Functional Gene Cloning of Rat and Mouse Platelet Glycoprotein V: Identification of

D. Azorsa, D. Loew, J. Cazenave, 2013 .

Deletion of human GP1BB and SEPT5 is associated with Bernard-Soulier syndrome, platelet secretion defect, polymicrogyria, and developmental delay

P. Nurden, J. Oldenburg, I. Hainmann, 2011, Thrombosis and Haemostasis.

Characterization of megakaryocyte development in the native bone marrow environment.

J. Cazenave, C. Gachet, A. Eckly, 2012, Methods in molecular biology.

Novel Function of Tenascin-C, a Matrix Protein Relevant to Atherosclerosis, in Platelet Recruitment and Activation Under Flow

C. Denis, C. Gachet, F. Lanza, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets.

M. Elvers, B. Nieswandt, C. Gachet, 2010, Blood.

Delayed-onset of procoagulant signalling revealed by kinetic analysis of COAT platelet formation

L. Alberio, C. Gachet, B. Hechler, 2017, Thrombosis and Haemostasis.

Platelets in cancer

C. Gachet, F. Lanza, P. Mangin, 2016, Onkologische Welt.

Platelets in cancer

C. Gachet, F. Lanza, P. Mangin, 2015, Hämostaseologie.

A PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1.

B. Nieswandt, M. Freund, C. Gachet, 2003, FEBS letters.

A unique microenvironment in the developing liver supports the expansion of megakaryocyte progenitors.

D. Sugiyama, C. Gachet, P. Simmons, 2017, Blood advances.

Functional properties of human platelets derived in vitro from CD34+ cells

M. Freund, C. Gachet, A. Eckly, 2020, Scientific Reports.

Thrombin Interaction With Platelet Membrane Glycoprotein Ib

F. Lanza, M. Bouton, M. Jandrot-Perrus, 1996, Seminars in thrombosis and hemostasis.

Identification of a novel 14-3-3zeta binding site within the cytoplasmic tail of platelet glycoprotein Ibalpha.

T. David, J. Cazenave, C. Gachet, 2004, Blood.

Marginal band microtubules are acetylated by αTAT1

S. Khochbin, T. Buchou, Ekaterina Bourova-Flin, 2020, Platelets.

Plasma levels of soluble platelet glycoprotein V are linked to fasting blood glucose in patients with type 2 diabetes

J. Cazenave, C. Gachet, M. Pinget, 2008, Thrombosis and Haemostasis.

A second report of platelet-type von Willebrand disease with a Gly233Ser mutation in the GPIBA gene

P. Nurden, A. Nurden, F. Lanza, 2007, Thrombosis and Haemostasis.

Shear rate gradients promote a bi-phasic thrombus formation on weak adhesive proteins, such as fibrinogen in a von Willebrand factor-dependent manner

C. Denis, C. Gachet, M. Panteleev, 2019, Haematologica.

Inhibition of platelet aggregation by abciximab but not by aspirin can be detected by a new point-of-care test, the hemostatus.

P. Nurden, A. Nurden, F. Forestier, 1999, Thrombosis research.

Bernard-Soulier syndrome (Hemorrhagiparous thrombocytic dystrophy)

F. Lanza, 2006 .

cDNA cloning and expression of platelet p24/CD9. Evidence for a new family of multiple membrane-spanning proteins.

J. Seyer, V. Fried, S. Coughlin, 1991, The Journal of biological chemistry.

Co-localization of CD9 and GPIIb-IIIa (alpha IIb beta 3 integrin) on activated platelet pseudopods and alpha-granule membranes.

D. Azorsa, F. Lanza, J. Cazenave, 1997, The Histochemical Journal.

A novel missense mutation shows that GPIbbeta has a dual role in controlling the processing and stability of the platelet GPIb-IX adhesion receptor.

P. Nurden, M. Alessi, H. Chambost, 2003, Biochemistry.

A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg----214Trp mutation.

J. Cazenave, A. Nurden, D. Fournier, 1992, The Journal of clinical investigation.

Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation.

C. Gachet, A. Eckly, C. Léon, 2016, Blood.

The contribution of mouse models to the understanding of constitutional thrombocytopenia

C. Gachet, C. Léon, F. Lanza, 2016, Haematologica.

Loss of α4A- and β1-tubulin leads to severe platelet spherocytosis and strongly impairs hemostasis in mice.

M. Freund, A. Eckly, Y. Knapp, 2022, Blood.

Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA.

M. Freund, J. Cazenave, C. Gachet, 2003, The Journal of biological chemistry.

Spectrum of the Mutations in Bernard–Soulier Syndrome

A. Pastore, P. Noris, R. Favier, 2014, Human mutation.

Biogenesis of the demarcation membrane system (DMS) in megakaryocytes.

C. Gachet, A. Eckly, C. Léon, 2014, Blood.