C. Squire

发表

Engineering a Lys-Asn isopeptide bond into an immunoglobulin-like protein domain enhances its stability

E. Baker, P. Young, H. Kwon, 2017, Scientific Reports.

Crystal Structures of Three Classes of Non-Steroidal Anti-Inflammatory Drugs in Complex with Aldo-Keto Reductase 1C3

Andrew P. Turnbull, A. Turnbull, J. Flanagan, 2012, PloS one.

Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily.

E. Baker, S. Panjikar, M. Brimble, 2016, Angewandte Chemie.

Total chemical synthesis of an Orf virus protein, ORFV002, an inhibitor of the master gene regulator NF‐κB

E. Baker, S. Kent, M. Brimble, 2014, Biopolymers.

Crystal and NMR Structures of a Peptidomimetic β-Turn That Provides Facile Synthesis of 13-Membered Cyclic Tetrapeptides.

A. Cameron, P. Edwards, E. Harjes, 2017, Chemistry, an Asian journal.

Preparation of truncated orf virus entry fusion complex proteins by chemical synthesis

E. Baker, M. Brimble, P. Harris, 2014, Journal of peptide science : an official publication of the European Peptide Society.

The high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkages

C. Squire, G. Clark, P. Pytel, 2012, Nucleic acids research.

Bioinspired Total Synthesis and Stereochemical Revision of the Fungal Metabolite Pestalospirane B.

M. Brimble, J. Sperry, C. Squire, 2017, Organic letters.

Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed.

J. Smaill, J. Flanagan, M. McKeage, 2015, Journal of structural biology.

Structures of m-iodo Hoechst-DNA complexes in crystals with reduced solvent content: implications for minor groove binder drug design.

C. Squire, L. Baker, G. Clark, 2000, Nucleic acids research.

Structures of the dimerization domains of the Escherichia coli disulfide-bond isomerase enzymes DsbC and DsbG.

C. Squire, P. Metcalf, S. Yeh, 2007, Acta crystallographica. Section D, Biological crystallography.

Defining the Potassium Binding Region in an Apple Terpene Synthase*

E. Baker, W. Laing, S. Green, 2009, Journal of Biological Chemistry.

The 1.65 Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition.

J. Smaill, A. Patterson, Y. Yosaatmadja, 2015, Acta crystallographica. Section D, Biological crystallography.

Structures and kinetics of Thermotoga maritima MetY reveal new insights into the predominant sulfurylation enzyme of bacterial methionine biosynthesis

W. Patrick, M. Selmer, C. Squire, 2021, The Journal of biological chemistry.

MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance.

I. Leung, C. Squire, Ivanhoe K. H. Leung, 2019, Drug discovery today.

A Convenient New Route to 4-Substituted Benzo[de][3,6]Phenanthrolin-6(6H)-Ones: Important Intermediates in the Synthesis of Ring-A Analogues of the Cytotoxic Marine Alkaloid Ascididemin

D. Appleton, B. Copp, R. P. Hansen, 1999 .

Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases.

W. Denny, E. Baker, A. M. Thompson, 2008, Bioorganic & medicinal chemistry letters.

Chemical synthesis of γ‐secretase activating protein using pseudoglutamines as ligation sites

M. Brimble, P. Young, P. Harris, 2015, Biopolymers.

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

W. Denny, N. Helsby, B. Baguley, 2021, Oncology and Therapy.

Structure of the first parallel DNA quadruplex-drug complex.

S. Neidle, C. Squire, G. Clark, 2003, Journal of the American Chemical Society.

Elongation of the Poly-γ-glutamate Tail of F420 Requires Both Domains of the F420:γ-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis*

H. Baker, E. Baker, G. Bashiri, 2016, The Journal of Biological Chemistry.

Crystal Structures of F420-dependent Glucose-6-phosphate Dehydrogenase FGD1 Involved in the Activation of the Anti-tuberculosis Drug Candidate PA-824 Reveal the Basis of Coenzyme and Substrate Binding*

E. Baker, G. Bashiri, N. Moreland, 2008, Journal of Biological Chemistry.

Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system.

E. Baker, G. Bashiri, N. Moreland, 2007, Protein expression and purification.

Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1).

B. Palmer, J. Jamie, J. Flanagan, 2013, Bioorganic & medicinal chemistry.

Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes

W. Patrick, Valerie W. C. Soo, Y. Yosaatmadja, 2016, The Journal of Biological Chemistry.

Investigations of the key macrolactamisation step in the synthesis of cyclic tetrapeptide pseudoxylallemycin A.

M. Brimble, A. Cameron, P. Harris, 2019, Organic & biomolecular chemistry.

Trapping HIV-1 Reverse Transcriptase Before and After Translocation on DNA*

A. D. Clark, S. Tuske, S. Sarafianos, 2003, The Journal of Biological Chemistry.

Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation.

E. Baker, C. Squire, J. Dickson, 2005, Structure.

Poxviral Ankyrin Proteins

A. Mercer, C. Squire, Michael H. Herbert, 2015, Viruses.

Structure of AKR1C3 with 3-phenoxybenzoic acid bound.

J. Flanagan, Y. Yosaatmadja, C. Squire, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

TAS-120 cancer target binding; defining reactivity and revealing the first FGFR1 irreversible structure.

J. Smaill, M. Middleditch, A. Patterson, 2019 .

TAS‐120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure

J. Smaill, M. Middleditch, A. Patterson, 2019, ChemMedChem.

2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors.

Yong Xu, J. Smaill, Xiaoyun Lu, 2017, European journal of medicinal chemistry.

Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery.

E. Baker, Zhening Zhang, T. Caradoc-Davies, 2009, Journal of molecular biology.

Identification of MRP2 as a targetable factor limiting oxaliplatin accumulation and response in gastrointestinal cancer

T. Nakanishi, I. Tamai, M. McKeage, 2019, Scientific Reports.

Rotational Freedom, Steric Hindrance, and Protein Dynamics Explain BLU554 Selectivity for the Hinge Cysteine of FGFR4.

J. Smaill, Xiaoyun Lu, M. Middleditch, 2019, ACS medicinal chemistry letters.

Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis.

E. Baker, C. Squire, N. Koon, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).

E. Baker, Clyde A. Smith, C. Squire, 2006, Acta crystallographica. Section D, Biological crystallography.

Efficient Synthesis of (S)-1-(5-Fluoropyrimidin-2-yl)ethylamine Using an ω-Transaminase Biocatalyst in a Two-Phase System

Oliver May, Daniel Mink, Christopher John Squire, 2013 .

Use of ω-Transaminase Enzyme Chemistry in the Synthesis of a JAK2 Kinase Inhibitor

Christopher John Squire, David J. Klauber, Kevin William Leslie, 2013 .

High-resolution crystal structure of plant carboxylesterase AeCXE1, from Actinidia eriantha, and its complex with a high-affinity inhibitor paraoxon.

Edward N Baker, J. Oakeshott, R. Russell, 2007, Biochemistry.

Amino-acid substitutions at the domain interface affect substrate and allosteric inhibitor binding in α-isopropylmalate synthase from Mycobacterium tuberculosis.

E. Parker, C. Squire, Frances H A Huisman, 2013, Biochemical and biophysical research communications.

Removal of the C-terminal regulatory domain of α-isopropylmalate synthase disrupts functional substrate binding.

H. Baker, E. Baker, E. Parker, 2012, Biochemistry.

Activation Domain-dependent Degradation of Somatic Wee1 Kinase*

Valerie Cavett, Trey K. Sato, N. Ayad, 2009, The Journal of Biological Chemistry.

In Vitro Studies with Methylproamine

J. White, P. Lobachevsky, C. Squire, 2004, Cancer Research.

Designer DNA-binding drugs: the crystal structure of a meta-hydroxy analogue of Hoechst 33258 bound to d(CGCGAATTCGCG)2.

S. Neidle, C. Squire, W. Leupin, 1996, Nucleic acids research.

Autocatalytically generated Thr-Gln ester bond cross-links stabilize the repetitive Ig-domain shaft of a bacterial cell surface adhesin

E. Baker, P. Young, H. Kwon, 2013, Proceedings of the National Academy of Sciences.

Crystal Structure of LeuA from Mycobacterium tuberculosis

E. Baker, C. Squire, N. Koon, 2004 .

Self-generated covalent cross-links in the cell-surface adhesins of Gram-positive bacteria.

E. Baker, P. Young, C. Squire, 2015, Biochemical Society transactions.

Structure and function of GlmU from Mycobacterium tuberculosis.

E. Baker, E. M. Bulloch, R. D. Bunker, 2009, Acta crystallographica. Section D, Biological crystallography.

Identification of MRP2 as a targetable factor limiting oxaliplatin accumulation and response in gastrointestinal cancer

T. Nakanishi, I. Tamai, M. McKeage, 2019, Scientific Reports.

Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases.

W. Denny, E. Lunney, E. Baker, 2008, European journal of medicinal chemistry.

Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed.

J. Smaill, J. Flanagan, M. McKeage, 2015, Journal of structural biology.

Structure of AKR1C3 with 3-phenoxybenzoic acid bound.

J. Flanagan, Y. Yosaatmadja, C. Squire, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

1.85 angstrom structure of EGFR kinase domain with gefitinib

Y. Yosaatmadja, C. Squire, 2014 .

Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) from Mycobacterium tuberculosis.

E. Baker, N. Paterson, G. Bashiri, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.