A. Addlagatta

发表

Ultrahigh-resolution structure of a BPTI mutant.

J Otlewski, S. Krzywda, M. Jaskólski, 2001, Acta crystallographica. Section D, Biological crystallography.

Paradoxical role of C1561T glutamate carboxypeptidase II (GCPII) genetic polymorphism in altering disease susceptibility.

V. Kutala, S. Naushad, R. Digumarti, 2012, Gene.

Synthesis of new chromeno-annulated cis-fused pyrano[3,4-c]pyran derivatives via domino Knoevenagel–hetero-Diels–Alder reactions and their biological evaluation towards antiproliferative activity

A. Venkatesham, K. Nagaiah, B. Sridhar, 2012 .

Structural characterization of the protein cce_0567 from Cyanothece 51142, a metalloprotein associated with nitrogen fixation in the DUF683 family.

G. W. Buchko, H. Robinson, A. Addlagatta, 2009, Biochimica et biophysica acta.

Discovery, Structural and Biochemical Studies of a rare Glu/Asp Specific M1 Class Aminopeptidase from Legionella pneumophila.

A. Addlagatta, R. Gumpena, A. K. Marapaka, 2018, International journal of biological macromolecules.

Unraveling structural insights of ribokinase from Leishmania donovani.

I. Qureshi, D. Vasudevan, A. Addlagatta, 2019, International journal of biological macromolecules.

Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases

C. Tarnus, E. Salomon, I. Florent, 2018, Molecules.

Crystal and molecular structure of bis(N-methylpiperidine betaine) hydroiodide

M. Jaskólski, M. Szafran, A. Addlagatta, 2004 .

Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression

Jun O. Liu, B. Matthews, A. Addlagatta, 2006, Proceedings of the National Academy of Sciences.

Discovery of a New Genetic Variant of Methionine Aminopeptidase from Streptococci with Possible Post-Translational Modifications: Biochemical and Structural Characterization

A. Addlagatta, R. Reddi, C. Kishor, 2013, PloS one.

Synthesis of new cis-fused tetrahydrochromeno[4,3-b]quinolines and their antiproliferative activity studies against MDA-MB-231 and MCF-7 breast cancer cell lines.

A. Venkatesham, K. Nagaiah, B. Sridhar, 2010, Bioorganic & medicinal chemistry letters.

Design and synthesis of biaryl aryl stilbenes/ethylenes as antimicrotubule agents.

N. Jain, B. Sreedhar, A. Addlagatta, 2013, European journal of medicinal chemistry.

Discovery of Tröger's base analogues as selective inhibitors against human breast cancer cell line: design, synthesis and cytotoxic evaluation.

A. Addlagatta, Manjula Alla, B. R. Manda, 2014, European journal of medicinal chemistry.

Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines.

A. Addlagatta, Manjula Alla, Vittal Rao Bommena, 2010, European journal of medicinal chemistry.

First Stereoselective Total Synthesis and Biological Evaluation of Amphidinin B and Its Analogues

J. Yadav, B. Reddy, C. Reddy, 2011 .

Serine 124 completes the Tyr, Lys and Ser triad responsible for the catalysis of human type 1 3beta-hydroxysteroid dehydrogenase.

W. Duax, A. Addlagatta, S. Carloni, 2004, Journal of molecular endocrinology.

Structure/function aspects of human 3β-hydroxysteroid dehydrogenase

W. Duax, B. Kacsoh, A. Addlagatta, 2004, Molecular and Cellular Endocrinology.

Catalyst-free efficient synthesis of polyhydroquinolines using polyethylene glycol as a solvent and evaluation of their cytotoxicity

B. Das, A. Addlagatta, S. Nagendra, 2014, Medicinal Chemistry Research.

Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents.

N. Jain, B. Sreedhar, A. Addlagatta, 2011, Journal of medicinal chemistry.

Synthesis, cytotoxic, and DNA binding studies of novel fluorinated condensed pyrano pyrazoles

V. Kanakaiah, J. Rani, A. Addlagatta, 2012, Medicinal Chemistry Research.

Microwave-Assisted Palladium Mediated Efficient Synthesis of Pyrazolo[3,4-b]pyridines, Pyrazolo[3,4-b]quinolines, Pyrazolo[1,5-a]pyrimidines and Pyrazolo[1,5-a]quinazolines.

S. Gogoi, A. Addlagatta, V. Saddanapu, 2015 .

Microwave-assisted palladium mediated efficient synthesis of pyrazolo[3,4-b]pyridines, pyrazolo[3,4-b]quinolines, pyrazolo[1,5-a]pyrimidines and pyrazolo[1,5-a]quinazolines

S. Gogoi, A. Addlagatta, V. Saddanapu, 2014 .

Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents.

A. Kamal, S. Pushpavalli, A. Addlagatta, 2012, European journal of medicinal chemistry.

Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.

Thokhir Basha Shaik, A. Kamal, S. Ramakrishna, 2012, Bioorganic & medicinal chemistry.

Discovery of α,β‐ and α,γ‐Diamino Acid Scaffolds for the Inhibition of M1 Family Aminopeptidases

A. Addlagatta, C. Kishor, R. Gumpena, 2011, ChemMedChem.

Discovery of alpha, beta- and alpha, gamma-Diamino Acid Scaffolds for the Inhibition of M1 Family Aminopeptidases

A. Addlagatta, C. Kishor, R. Gumpena, 2010 .

Catalyst-free efficient synthesis of polyhydroquinolines using polyethylene glycol as a solvent and evaluation of their cytotoxicity

B. Das, A. Addlagatta, Humani Paidepala, 2013, Medicinal Chemistry Research.

Design and synthesis of pyrazole-oxindole conjugates targeting tubulin polymerization as new anticancer agents.

N. Jain, A. Kamal, R. Mishra, 2015, European journal of medicinal chemistry.

3‐Substituted 2‐Phenylimidazo[2,1‐b]benzothiazoles: Synthesis, Anticancer Activity, and Inhibition of Tubulin Polymerization

A. Kamal, M. J. Ramaiah, S. Pushpavalli, 2012, ChemMedChem.

Iodine-catalyzed condensation of isatin with indoles: a facile synthesis of di(indolyl)indolin-2-ones and evaluation of their cytotoxicity.

B. V. Subba Reddy, A. Addlagatta, N. Rajeswari, 2012, Bioorganic & medicinal chemistry letters.

Synthesis, cytotoxicity and hDHFR inhibition studies of 2H-pyrido[1,2-a]pyrimidin-2-ones

A. Addlagatta, Manjula Alla, C. Kishor, 2013 .

Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases.

Jun O. Liu, B. Matthews, A. Addlagatta, 2006, Angewandte Chemie.

Synthesis, cytotoxic, and DNA binding studies of novel fluorinated condensed pyrano pyrazoles

V. Kanakaiah, J. Rani, A. Addlagatta, 2013, Medicinal Chemistry Research.

Design, Synthesis and Mechanistic Studies of Novel Isatin-Pyrazole Hydrazone Conjugates as Selective and Potent Bacterial MetAP Inhibitors

K. Kavanagh, Shailja Singh, M. Abid, 2022, Antibiotics.

Synthesis of new cis-fused tetrahydrochromeno[4,3-b]quinolines and their antiproliferative activity studies against MDA-MB-231 and MCF-7 breast cancer cell lines.

A. Venkatesham, K. Nagaiah, B. Sridhar, 2010, Bioorganic & medicinal chemistry letters.

Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site

B. Matthews, L. Gay, A. Addlagatta, 2006, Proceedings of the National Academy of Sciences.

Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases.

S. McGowan, A. Addlagatta, R. Reddi, 2015, Journal of medicinal chemistry.

Identification, biochemical and structural evaluation of species-specific inhibitors against type I methionine aminopeptidases.

Jun O. Liu, A. Addlagatta, D. Ma, 2013, Journal of medicinal chemistry.

4,4-Diphenyl-2,5-cyclohexadienone: four polymorphs and nineteen crystallographically independent molecular conformations.

F. Allen, J. Howard, Raju Mondal, 2002, Angewandte Chemie.

Structural basis for the unusual specificity of Escherichia coli aminopeptidase N.

B. Matthews, L. Gay, A. Addlagatta, 2008, Biochemistry.

The influence of halide anions on the molecular structure of bis( N-methylpiperidine betaine) monocation with short hydrogen bond

M. Jaskólski, M. Szafran, A. Addlagatta, 2005 .

Crystal structure and vibrational spectrum of N-methylpiperidine betaine hexafluorosilicate

M. Jaskólski, M. Szafran, A. Addlagatta, 2001 .

Highly functionalized tetrahydropyridines are cytotoxic and selective inhibitors of human puromycin sensitive aminopeptidase.

A. Addlagatta, Manjula Alla, A. K. Marapaka, 2015, European journal of medicinal chemistry.

Structural basis for the functional differences between type I and type II human methionine aminopeptidases.

Jun O. Liu, B. Matthews, A. Addlagatta, 2005, Biochemistry.

Synthesis of tetrazole–isoxazoline hybrids as a new class of tubulin polymerization inhibitors

A. Kamal, M. J. Ramaiah, S. Pushpavalli, 2012 .

Synthesis and mechanistic studies of diketo acids and their bioisosteres as potential antibacterial agents.

M. M. Rizvi, C. Daniliuc, K. Kavanagh, 2019, European journal of medicinal chemistry.

Pancreatic α-amylase inhibition and free radical scavenging activity of substituted pyranochromenone derivatives

A. Tiwari, B. Sridhar, J. Ashok Kumar, 2014, Medicinal Chemistry Research.

Synthesis and structure-activity relationships of pyridinyl-1H-1,2,3-triazolyldihydroisoxazoles as potent inhibitors of tubulin polymerization.

D. Srikanth, A. Addlagatta, K. Rajkumar, 2015, European journal of medicinal chemistry.

Human Naa50 Protein Displays Broad Substrate Specificity for Amino-terminal Acetylation

A. Addlagatta, R. Reddi, Prabhakar Sripadi, 2016, The Journal of Biological Chemistry.

Discovery of natural product ovalicin sensitive type 1 methionine aminopeptidases: molecular and structural basis.

A. Addlagatta, T. Arya, A. K. Marapaka, 2019, The Biochemical journal.

Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase

B. Matthews, A. Addlagatta, 2006, Protein science : a publication of the Protein Society.

Synthesis and Biological Evaluation of Imidazopyridine–Oxindole Conjugates as Microtubule‐Targeting Agents

A. Kamal, A. Nagabhushana, K. Ramakrishna, 2013, ChemMedChem.

Structure/Function Relationships Responsible for Coenzyme Specificity and the Isomerase Activity of Human Type 1 3β-Hydroxysteroid Dehydrogenase/Isomerase*

W. Duax, R. R. Fuller, William L Duax, 2003, Journal of Biological Chemistry.

Inhibition of Xanthine oxidase by 1-O-methyl chrysophanol, a hydroxyanthraquinone isolated from Amycolatopsis thermoflava ICTA 103

U. R. Batchu, Joshna Rani Surapaneni, P. Shetty, 2023, bioRxiv.

Association of glutamate carboxypeptidase II (GCPII) haplotypes with breast and prostate cancer risk.

V. Kutala, S. Naushad, R. Digumarti, 2013, Gene.

Three-dimensional structure of homodimeric cholesterol esterase-ligand complex at 1.4 A resolution.

V. Pletnev, Z. Wawrzak, W. Duax, 2003, Acta crystallographica. Section D, Biological crystallography.

Rational proteomics I. Fingerprint identification and cofactor specificity in the short‐chain oxidoreductase (SCOR) enzyme family

Jeremy Bruenn, V. Pletnev, C. Weeks, 2003, Proteins.

Methionine aminopeptidases with short sequence inserts within the catalytic domain are differentially inhibited: Structural and biochemical studies of three proteins from Vibrio spp.

A. Addlagatta, V. Pillalamarri, S. Bala, 2020, European journal of medicinal chemistry.

Anti-inflammatory and antioxidant activities of Gymnema Sylvestre extract rescue acute respiratory distress syndrome in rats via modulating the NF-κB/MAPK pathway

A. Addlagatta, J. Thota, A. Jangam, 2023, Inflammopharmacology.

Green Synthesis of Curcumin Capped Gold Nanoparticles and Evaluation of Their Cytotoxicity

R. Ummanni, K. Datta, B. Reddy, 2013 .

The unique functional role of the C-HS hydrogen bond in the substrate specificity and enzyme catalysis of type 1 methionine aminopeptidase.

D. Pal, K. Singarapu, A. Addlagatta, 2016, Molecular bioSystems.

Exo-selective intermolecular Diels–Alder reaction by PyrI4 and AbnU on non-natural substrates

D. Pal, A. Addlagatta, Manjula Alla, 2021, Communications Chemistry.

Glu121‐Lys319 salt bridge between catalytic and N‐terminal domains is pivotal for the activity and stability of Escherichia coli aminopeptidase N

N. Jain, A. Addlagatta, C. Kishor, 2012, Protein science : a publication of the Protein Society.

Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization

Yingjie Zhang, Chunhua Ma, P. Sijwali, 2021, Chinese Chemical Letters.

Rational genomics I: Antisense open reading frames and codon bias in short‐chain oxido reductase enzymes and the evolution of the genetic code

Robert Huether, Lukas Habegger, V. Pletnev, 2005, Proteins.

Determining Structure and Function of Steroid Dehydrogenase Enzymes by Sequence Analysis, Homology Modeling, and Rational Mutational Analysis

Robert Huether, Lukas Habegger, V. Pletnev, 2005, Annals of the New York Academy of Sciences.

Expression, Functional Characterization and X-ray Analysis of HosA, A Member of MarR Family of Transcription Regulator from Uropathogenic Escherichia coli

D. Ghosh, A. Ranjan, A. Addlagatta, 2016, The Protein Journal.

Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents

A. Addlagatta, R. Reddi, C. Kishor, 2014, The FEBS journal.

Identification of an SH3-binding motif in a new class of methionine aminopeptidases from Mycobacterium tuberculosis suggests a mode of interaction with the ribosome.

Jun O. Liu, B. Matthews, Michael L. Quillin, 2005, Biochemistry.

Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N

A. Addlagatta, R. Reddi, R. Gumpena, 2015, Protein science : a publication of the Protein Society.

Structural studies of Enterococcus faecalis methionine aminopeptidase and design of microbe specific 2,2′-bipyridine based inhibitors

A. Addlagatta, R. Reddi, C. Kishor, 2012 .

Development of 2-chloroquinoline based heterocyclic frameworks as dual inhibitors of SARS-CoV-2 MPro and PLPro

A. Addlagatta, S. S. Jadav, S. Are, 2023, International Journal of Biological Macromolecules.

A single amino acid difference between archaeal and human type 2 methionine aminopeptidases differentiates their affinity towards ovalicin.

A. Addlagatta, S. Bala, Bharati Reddi, 2022, Biochimica et biophysica acta. Proteins and proteomics.

Regioselectivity in inhibition of peptide deformylase from Haemophilus influenzae by 4- vs 5-azaindole hydroxamic acid derivatives: Biochemical, structural and antimicrobial studies.

R. Gundla, A. Addlagatta, C. Kishor, 2022, Bioorganic chemistry.

Discovery of a new class of type 1 methionine aminopeptidases that have relaxed substrate specificity.

A. Addlagatta, R. Reddi, R. Kashyap, 2019, International journal of biological macromolecules.

Bengamides display potent activity against drug-resistant Mycobacterium tuberculosis

V. Sintchenko, P. Rutledge, J. Triccas, 2019, Scientific Reports.

Design and synthesis of pyrazole-oxindole conjugates targeting tubulin polymerization as new anticancer agents.

N. Jain, A. Kamal, R. Mishra, 2015, European journal of medicinal chemistry.

Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.

Thokhir Basha Shaik, A. Kamal, S. Ramakrishna, 2012, Bioorganic & medicinal chemistry.

Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents.

B. Sreedhar, Nishant Jain, A. Addlagatta, 2011, Journal of medicinal chemistry.