D. Fambrough

发表

Expression of avian Ca2+-ATPase in cultured mouse myogenic cells

Z. Kaprielian, N. Karin, D. Fambrough, 1989, Molecular and cellular biology.

From growth cone to synapse: the life history of the RP3 motor neuron.

M. Bate, C. Goodman, H. Sink, 1993, Development.

Molecular Biology of Membrane Transport Disorders

S. Schultz, A. Brown, M. Welsh, 1996, Springer US.

Movement of Ca(2+)-ATPase molecules within the sarcoplasmic/endoplasmic reticulum in skeletal muscle.

Z. Kaprielian, P. Kessler, D. Fambrough, 1996, Journal of cell science.

Expression of avian Ca2+-ATPase in cultured mouse myogenic cells

Z. Kaprielian, N. Karin, D. Fambrough, 1989 .

Calf and Pea Histone IV II. THE COMPLETE AMINO ACID SEQUENCE OF CALF THYMUS HISTONE IV; PRESENCE OF ε-N-ACETYLLYSINE

Emil L. Smith, J. Bonner, R. Delange, 1969 .

Acetylcholine Receptors : Distribution and extrajunctional density in rat diaphragm after denervation correlated with acetylcholine sensitivity

H. C. Hartzell, D. Fambrough, H. Hartzell, 1972 .

Ouabain-sensitive (Na+ + K+)-ATPase activity expressed in mouse L cells by transfection with DNA encoding the alpha-subunit of an avian sodium pump.

K. Takeyasu, M. Tamkun, D. Fambrough, 1988, The Journal of biological chemistry.

Chick myotendinous antigen. II. A novel extracellular glycoprotein complex consisting of large disulfide-linked subunits

M. Chiquet, D. Fambrough, 1984, The Journal of cell biology.

[96] Isolation and characterization of chromosomal nucleoproteins

H. Ohlenbusch, J. Widholm, J. Bonner, 1968 .

Metabolism of Cell Surface Receptors

D. Fambrough, J. Gardner, 1982 .

Acetylcholine receptors. Revised estimates of extrajunctional receptor density in denervated rat diaphragm.

D. Fambrough, 1974 .

Pre-translational regulation of the (Na+ + K+)-ATPase in response to demand for ion transport in cultured chicken skeletal muscle.

D. Fambrough, J. Taormino, 1990, The Journal of biological chemistry.

Regulation of the sodium pump in excitable cells.

K. Takeyasu, M. Tamkun, B. Wolitzky, 1987, Kidney international. Supplement.

Stability of Na(+)-K(+)-ATPase alpha-subunit isoforms in evolution.

K. Takeyasu, V. Lemas, D. Fambrough, 1990, The American journal of physiology.

The (Na+ + K+)-ATPase of chick sensory neurons. Studies on biosynthesis and intracellular transport.

M. Tamkun, D. Fambrough, 1986, The Journal of biological chemistry.

Regulation of the (Na+ + K+)-ATPase in cultured chick skeletal muscle. Modulation of expression by the demand for ion transport.

B. Wolitzky, D. Fambrough, 1986, The Journal of biological chemistry.

Aspects of Receptor Systems Possibly Relevant to Neuron-Glial Interactions and Multiple Sclerosis

D. Fambrough, 1982 .

Denervation: Cholinergic Receptors of Skeletal Muscle

D. Fambrough, 1981 .

Some Observations on Denervation Supersensitivity in Skeletal Muscle

D. Linden, D. Fambrough, J. Gardner, 1979 .

Are muscle fibers denervated in myotonic dystrophy?

D. Drachman, D. Fambrough, 1976, Archives of neurology.

Electrical properties of normal and dysgenib mouse skeletal muscle in culture

D. Fambrough, J. Powell, Douglas M. Fambrough, 1973, Journal of cellular physiology.

The alternative carboxyl termini of avian cardiac and brain sarcoplasmic reticulum/endoplasmic reticulum Ca(2+)-ATPases are on opposite sides of the membrane.

P. Kessler, D. Fambrough, A. Campbell, 1992, The Journal of biological chemistry.

Multiple forms of (Na+ + K+)-ATPase in the chicken. Selective detection of the major nerve, skeletal muscle, and kidney form by a monoclonal antibody.

D. Fambrough, E. Bayne, 1983, The Journal of biological chemistry.

Extracellular matrix organization in developing muscle: correlation with acetylcholine receptor aggregates

M. Anderson, D. Fambrough, E. Bayne, 1984, The Journal of cell biology.

Skeletal Muscle

D. Fambrough, D. W. Pumplin, Lanny Shulman, 2019, Basic Physiology for Anaesthetists.

26 amino acids of an extracellular domain of the Na,K-ATPase alpha-subunit are sufficient for assembly with the Na,K-ATPase beta-subunit.

K. Takeyasu, D. Fambrough, M. V. Lemas, 1994, The Journal of biological chemistry.

Structure of a Gene for a Lysosomal Membrane Glycoprotein (LEPlOO) HOUSEKEEPING GENE

D. Fambrough, 2001 .

Acetylcholine Receptors

H. C. Hartzell, D. Fambrough, Douglas M. Fambrough, 1972, The Journal of general physiology.

Identification and molecular-genetic characterization of a LAMP/CD68-like protein from Caenorhabditis elegans.

A. Fire, M. Kostich, D. Fambrough, 2000, Journal of cell science.

Acetylcholinesterase of human erythrocytes and neuromuscular junctions: homologies revealed by monoclonal antibodies.

A. Engel, T. Rosenberry, D. Fambrough, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Diverse Signaling Pathways Activated by Growth Factor Receptors Induce Broadly Overlapping, Rather Than Independent, Sets of Genes

Andrius Kazlauskas, Eric S Lander, Kimberly McClure, 1999, Cell.

Proteins of excitable membranes.

B. Hille, D. Fambrough, 1987, Society of General Physiologists series.

Expression of hybrid (Na+ + K+)-ATPase molecules after transfection of mouse Ltk-cells with DNA encoding the beta-subunit of an avian brain sodium pump.

K. Takeyasu, M. Tamkun, D. Fambrough, 1987, The Journal of biological chemistry.

The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c.

C. Hatem, N. Gough, D. Fambrough, 1995, DNA and cell biology.

Fibronectin expression during myogenesis

D. Fambrough, J. Gardner, 1983, The Journal of cell biology.

Immunocytochemical and quantitative studies of Na+,K+-ATPase distribution in the developing chick cochlea

Mark E. Schneider, D. Cotanche, F. Matschinsky, 1987, Hearing Research.

Aggregates of acetylcholine receptors are associated with plaques of a basal lamina heparan sulfate proteoglycan on the surface of skeletal muscle fibers

M. Anderson, D. Fambrough, 1983, The Journal of cell biology.

Chapter 8 Differential Subunit and Isoform Expression Involved in Regulation of Sodium Pump in Skeletal Muscle

K. Takeyasu, M. Tamkun, B. Wolitzky, 1989 .

The sodium pump becomes a family

D. Fambrough, 1988, Trends in Neurosciences.

Nucleotide sequences of avian cardiac and brain SR/ER Ca(2+)-ATPases and functional comparisons with fast twitch Ca(2+)-ATPase. Calcium affinities and inhibitor effects.

P. Kessler, Y. Sagara, G. Inesi, 1991, Journal of Biological Chemistry.

Molecular characterization and expression of the (Na+ + K+)‐ATPase alpha‐subunit in Drosophila melanogaster.

K. Takeyasu, R. Lebovitz, D. Fambrough, 1989, The EMBO journal.

Different Steady State Subcellular Distributions of the Three Splice Variants of Lysosome-associated Membrane Protein LAMP-2 Are Determined Largely by the COOH-terminal Amino Acid Residue

N. Gough, D. Fambrough, 1997, The Journal of cell biology.

Ultrastructural and electrophysiological correlates of cell coupling and cytoplasmic fusion during myogenesis in vitro.

J. Rash, D. Fambrough, J E Rash, 1973, Developmental biology.

Molecular forms of chicken embryo acetylcholinesterase in vitro and in vivo. Isolation and characterization.

D. Fambrough, R. Rotundo, 1979, The Journal of biological chemistry.

Structure of a gene for a lysosomal membrane glycoprotein (LEP100). Housekeeping gene with unexpected exon organization.

A. Zot, D. Fambrough, 1990, The Journal of biological chemistry.

Negative transcriptional regulation of the chicken Na+/K(+)-ATPase alpha 1-subunit gene.

K. Takeyasu, S. Nettikadan, D. Fambrough, 1996, Biochimica et biophysica acta.

Chick myotendinous antigen. I. A monoclonal antibody as a marker for tendon and muscle morphogenesis

M. Chiquet, D. Fambrough, 1984, The Journal of cell biology.

Synthesis, insertion into the plasma membrane, and turnover of alpha- bungarotoxin receptors in chick sympathetic neurons

S. Carbonetto, D. Fambrough, 1979, The Journal of cell biology.

Acetylcholine receptor degradation measured by density labeling: Effects of cholinergic ligands and evidence against recycling

D. Fambrough, J. Gardner, 1979, Cell.

Newly synthesized acetylcholine receptors are located in the Golgi apparatus

P. Devreotes, D. Fambrough, 1978, The Journal of cell biology.

Kinetics of biosynthesis of acetylcholine receptor and subsequent incorporation into plasma membrane of cultured chick skeletal muscle

P. Devreotes, D. Fambrough, J. Gardner, 1977, Cell.

Acetylcholine receptor turnover in membranes of developing muscle fibers

P. Devreotes, D. Fambrough, 1975, The Journal of cell biology.

Calf and pea histone IV. I. Amino acid compositions and the identical COOH-terminal 19-residue sequence.

E. L. Smith, J. Bonner, R. Delange, 1968, The Journal of biological chemistry.

Identification of a Ca 2 +-ATPase in cerebellar Purkinje cells

D. Fambrough, 2015 .

Differential distribution of the alternative forms of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase, SERCA2b and SERCA2a, in the avian brain

F. Wuytack, D. Fambrough, A. Campbell, 1993, Brain Research.

Identification of a Ca2+-ATPase in cerebellar Purkinje cells.

Z. Kaprielian, D. Fambrough, A. Campbell, 1989, Brain research. Molecular brain research.

Biosynthesis and degradation of acetylcholine receptors in rat skeletal muscles. Effects of electrical stimulation

D. Linden, D. Fambrough, Douglas M. Fambrough, 1979, Neuroscience.

Turnover of acetylcholine receptors in skeletal muscle.

P. Devreotes, P N Devreotes, D M Fambrough, 1976, Cold Spring Harbor symposia on quantitative biology.

Control of acetylcholine receptors in skeletal muscle.

D M Fambrough, D. Fambrough, 1979, Physiological reviews.

Expression of the Avian Na,K-ATPase Subunits in Dictyostelium discoideum

D. Fambrough, X. Zhou, 1999, The Journal of Membrane Biology.

Subunit Interactions in the Na,K-ATPase Explored with the Yeast Two-hybrid System*

D. Fambrough, L. Huynh, T. Colonna, 1997, The Journal of Biological Chemistry.

Analysis of subunit assembly of the Na-K-ATPase.

K. Takeyasu, D. Fambrough, M. Emerick, 1994, The American journal of physiology.

Assembly of the extracellular domain of the Na,K-ATPase beta subunit with the alpha subunit. Analysis of beta subunit chimeras and carboxyl-terminal deletions.

D. Fambrough, M. Hamrick, K. J. Renaud, 1993, The Journal of biological chemistry.

Cytoplasmic and transmembrane domain deletions of Na,K-ATPase beta-subunit. Effects on subunit assembly and intracellular transport.

D. Fambrough, K. J. Renaud, E. Inman, 1991, The Journal of biological chemistry.

Cation Transport ATPases

G. Inesi, D. Fambrough, 1996 .

Neuromuscular Junction in Myasthenia Gravis: Decreased Acetylcholine Receptors

D. Drachman, D M Fambrough, D B Drachman, 1973, Science.

The Biology of Isolated Chromatin

Ru-chih C. Huang, J. Bonner, D. Fambrough, 1968, Science.

FLUIDITY OF THE SURFACE OF CULTURED MUSCLE FIBERS

M. Edidin, D. Fambrough, Michael Edidin, 1973, The Journal of cell biology.

Neuronal Recognition

D. Fambrough, Douglas M. Fambrough, 1976, Current Topics in Neurobiology.

The immunoglobulin μ chains of membrane-bound and secreted IgM molecules differ in their C-terminal segments

L. Hood, M. Kehry, C. Sibley, 1980, Cell.

Structure of LEP100, a glycoprotein that shuttles between lysosomes and the plasma membrane, deduced from the nucleotide sequence of the encoding cDNA

K. Takeyasu, D. Fambrough, N. Siegel, 1988, The Journal of cell biology.

Characterization of a plasma membrane glycoprotein common to myoblasts, skeletal muscle satellite cells, and glia.

M. Chiquet, D. Fambrough, E. Wakshull, 1983, Developmental biology.

Acetylcholine Sensitivity of Muscle Fiber Membranes: Mechanism of Regulation by Motoneurons

D. Fambrough, 1970, Science.

Maintenance State of the Art Report

D. A. Brown, J. W. Griffin, B. Droz, 1982 .

Membrane permeability : 100 years since Ernest Overton

D. Deamer, A. Kleinzeller, D. Fambrough, 1999 .

Lysosomal membrane dynamics: structure and interorganellar movement of a major lysosomal membrane glycoprotein

J. Lippincott-Schwartz, D. Fambrough, 1986, The Journal of cell biology.

Quantitative analysis of dicer substrate oligonucleotides in mouse liver by ultra-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.

D. Fambrough, B. Brown, S. Basu, 2012, Assay and drug development technologies.

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

Matthew Tudor, Rudolf Jaenisch, Eric Lander, 2001, Nature Genetics.

An endogenous MDCK lysosomal membrane glycoprotein is targeted basolaterally before delivery to lysosomes

I. Nabi, A. Le Bivic, E. Rodriguez-Boulan, 1991, The Journal of cell biology.

Negative transcriptional regulation of the chicken Na+/K+-ATPase α1-subunit gene

K. Takeyasu, S. Nettikadan, D. Fambrough, 1996 .

A mutation of the drosophila sodium pump α subunit gene results in bang-sensitive paralysis

J. Palka, Yuanyi Feng, D. Fambrough, 1994, Neuron.

Chapter 3 Structural Requirements for Subunit Assembly of the Na, K-ATPase

K. Takeyasu, D. Fambrough, M. V. Lemas, 1994 .

Subunit Interactions in the Sodium Pump a

M. Kostich, J. Rawn, D. Fambrough, 1997, Annals of the New York Academy of Sciences.

Expression of fast and slow isoforms of the Ca2+-ATPase in developing chick skeletal muscle.

Z. Kaprielian, D. Fambrough, 1987, Developmental biology.

Expression of Ca2(+)-ATPase isoforms in denervated, regenerating, and dystrophic chicken skeletal muscle.

Z. Kaprielian, E. Bandman, D. Fambrough, 1991, Developmental biology.

Nonequivalence of alpha-bungarotoxin receptors and acetylcholine receptors in chick sympathetic neurons.

K. J. Muller, S. Carbonetto, D. Fambrough, 1978, Proceedings of the National Academy of Sciences of the United States of America.

J. Bonner, D. Fambrough, 1966, Biochemistry.

Sequence homology and role of cysteine in plant and animal arginine-rich histones.

J. Bonner, D. Fambrough, 1968, The Journal of biological chemistry.

The life history of acetylcholine receptors.

P. Devreotes, D. Fambrough, J. Gardner, 1979, Progress in brain research.

Calf and pea histone IV. 3. Complete amino acid sequence of pea seedling histone IV; comparison with the homologous calf thymus histone.

E. L. Smith, J. Bonner, R. Delange, 1969, The Journal of biological chemistry.

Sequence analysis of DNA encoding an avian Na+, K+-ATPase β2-subunit

D. Fambrough, M. V. Lemas, 1993 .

Development of acetylcholine sensitivity during myogenesis.

J. Rash, D. Fambrough, Douglas M. Fambrough, 1971, Developmental biology.

Specificity of Nerve-Muscle Interactions

D. Fambrough, 1976 .

Electrophysiological properties of the membrane and acetylcholine receptor in developing rat and chick myotubes

D. Fambrough, A. K. Ritchie, 1975, The Journal of general physiology.

Acetylcholine Receptors: Number and Distribution at Neuromuscular Junctions in Rat Diaphragm

H. C. Hartzell, D. Fambrough, Douglas M. Fambrough, 1972, Science.

Acetylcholine Receptors

D. Fambrough, 1974, The Journal of general physiology.

Ionic properties of the acetylcholine receptor in cultured rat myotubes

D. Fambrough, A. K. Ritchie, Ritchie And Fambrough, 1975, The Journal of general physiology.

Acetycholine receptor production and incorporation into membranes of developing muscle fibers.

H. C. Hartzell, D. Fambrough, Douglas M. Fambrough, 1973, Developmental biology.

The cell surface metalloprotease/disintegrin Kuzbanian is required for axonal extension in Drosophila.

G. Rubin, C. Goodman, D. Pan, 1996, Proceedings of the National Academy of Sciences of the United States of America.

The Drosophila abrupt gene encodes a BTB-zinc finger regulatory protein that controls the specificity of neuromuscular connections.

C. Goodman, S. Crews, D. Fambrough, 1995, Genes & development.

The Drosophila Na,K-ATPase alpha-subunit gene: gene structure, promoter function and analysis of a cold-sensitive recessive-lethal mutation.

K. Takeyasu, D. Fambrough, Y. Feng, 1997, Genes and function.

Limited molecular heterogeneity of plant histones.

J. Bonner, D. Fambrough, 1969, Biochimica et biophysica acta.

Selective dissociation of pea bud nucleohistone.

J. Bonner, D. Fambrough, 1968, Biochimica et biophysica acta.

Apical plasma membrane mispolarization of NaK-ATPase in polycystic kidney disease epithelia is associated with aberrant expression of the beta2 isoform.

P. Wilson, O. Devuyst, S. Robinson, 2000, The American journal of pathology.

Aspects of Neural Ontogeny. A. F. W. Hughes. Logos Press, London; Academic Press, New York, 1968. xii + 249 pp., illus. $12.50

D. Fambrough, 1968, Science.

Cycling of the integral membrane glycoprotein, LEP100, between plasma membrane and lysosomes: Kinetic and morphological analysis

J. Lippincott-Schwartz, D. Fambrough, 1987, Cell.

Acetylcholinesterase‐immunoreactive axonal network in monkey visual cortex

G. Uhl, J. Hedreen, S. Bacon, 1984, The Journal of comparative neurology.

Synthesis, transport and fate of acetylcholinesterase in cultured chick embryo muscle cells

D. Fambrough, R. Rotundo, 1980, Cell.

Multiple mRNAs encode the avian lysosomal membrane protein LAMP-2, resulting in alternative transmembrane and cytoplasmic domains.

C. Hatem, N. Gough, D. Fambrough, 1995, Journal of cell science.

Genes that control neuromuscular specificity in Drosophila

C. Goodman, D. V. Vactor, H. Sink, 1993, Cell.

The Drosophila beaten path Gene Encodes a Novel Secreted Protein That Regulates Defasciculation at Motor Axon Choice Points

C. Goodman, D. Fambrough, 1996, Cell.

Secretion of acetylcholinesterase: Relation to acetylcholine receptor metabolism

D. Fambrough, R. Rotundo, 1980, Cell.

P-type ATPases in Caenorhabditis and Drosophila: Implications for Evolution of the P-type ATPase Subunit Families with Special Reference to the Na,K-ATPase and H,K-ATPase Subgroup

K. Takeyasu, J. C. Yasuhara, D. Fambrough, 2003, The Journal of Membrane Biology.

The pathway and targeting signal for delivery of the integral membrane glycoprotein LEP100 to lysosomes

J. Martinie, D. Fambrough, P. M. Mathews, 1992, The Journal of cell biology.

A mutation of the Drosophila sodium pump alpha subunit gene results in bang-sensitive paralysis.

J. Palka, D. Fambrough, Y. Feng, 1994, Neuron.

Ca(2+)-dependent and thapsigargin-inhibited phosphorylation of Na+,K(+)-ATPase catalytic domain following chimeric recombination with Ca(2+)-ATPase.

K. Takeyasu, G. Inesi, D. Lewis, 1993, The Journal of biological chemistry.

Reduced acetylcholine receptors in myasthenia gravis.

D. Drachman, D. Fambrough, S. Satyamurti, 1973, Transactions of the American Neurological Association.

Growth Factor-specific Signaling Pathway Stimulation and Gene Expression Mediated by ErbB Receptors* 210

E. Lander, C. Huard, L. Cantley, 2001, The Journal of Biological Chemistry.

Utilization of the indirect lysosome targeting pathway by lysosome-associated membrane proteins (LAMPs) is influenced largely by the C-terminal residue of their GYXXphi targeting signals.

J. Bonifacino, N. Gough, O. Martínez-Augustin, 1999, Journal of cell science.

Monoclonal Antibodies to Skeletal Muscle Cell Surface

D. Fambrough, M. Anderson, E. Wakshull, 1982 .

RECEPTOR PROPERTIES OF DEVELOPING MUSCLE

H. C. Hartzell, J. Rash, D. Fambrough, 1974 .

( Na ÷ + K÷ )-ATPase Correlated of Intramembrane Particles in of Cultured Chick Myotubes with a Major Group Freeze-Fracture Replicas

Pumplin, D. Fambrough, W. David, 2003 .

[27] Biosynthesis and intracellular transport of acetylcholine receptors

D. Fambrough, 1983 .

(Na+ + K+)-ATPase correlated with a major group of intramembrane particles in freeze-fracture replicas of cultured chick myotubes

D. Fambrough, D. W. Pumplin, 1983, Journal of Cell Biology.

Mutation of a conserved proline residue in the beta-subunit ectodomain prevents Na(+)-K(+)-ATPase oligomerization.

K. Geering, F. Jaisser, P. Mathews, 1993, The American journal of physiology.

Assembly of Na,K-ATPase α-subunit isoforms with Na,K-ATPase β-subunit isoforms and H,K-ATPase β-subunit

K. Takeyasu, D. Fambrough, B. Kone, 1994 .

Studies on the Na+-K+ ATPase of skeletal muscle and nerve.

D. Fambrough, 1983, Cold Spring Harbor Symposia on Quantitative Biology.

Molecular dissection of functional domains of the E1E2-ATPase using sodium and calcium pump chimeric molecules.

K. Takeyasu, V. Lemas, D. Luckie, 1992, Biophysical journal.

Spliced cDNAs Encode the Chicken sarco / Endoplasmic Reticulum Slow Ca 2 +

P. Kessler, D. Fambrough, M. Campbell, 2015 .

Biosynthesis and turnover of nicotinic acetylcholine receptors

D. Fambrough, 1981 .

Assembly of Na,K-ATPase alpha-subunit isoforms with Na,K-ATPase beta-subunit isoforms and H,K-ATPase beta-subunit.

K. Takeyasu, D. Fambrough, B. Kone, 1994, The Journal of biological chemistry.

Chick myotendinous antigen. II. A novel extracellular glycoprotein complex consisting of large disulfide-linked subunits

M. Chiquet, M. Olsson, D. Fambrough, 1984, The Journal of cell biology.

Growth Factor-specific Signaling Pathway Stimulation and Gene Expression Mediated by ErbB Receptors* 210

E. Lander, C. Huard, L. Cantley, 2001, The Journal of Biological Chemistry.

Identification and molecular-genetic characterization of a LAMP/CD68-like protein from Caenorhabditis elegans.

A. Fire, M. Kostich, D. Fambrough, 2000, Journal of cell science.

Synthesis, insertion into the plasma membrane, and turnover of alpha- bungarotoxin receptors in chick sympathetic neurons

S. Carbonetto, D. Fambrough, 1979, The Journal of cell biology.

Synthesis of acetylcholine receptors by cultured chick myotubes and denervated mouse extensor digitorum longus muscles.

P. Devreotes, D. Fambrough, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Revised Estimates of Extrajunctional Receptor Density in Denervated Rat Diaphragm

D. Fambrough, 1974 .

Mutations in the Caenorhabditis elegans Na,K-ATPase alpha-subunit gene, eat-6, disrupt excitable cell function

S. Lockery, M. Davis, L. Avery, 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.