Haopeng Sun

发表

STING, a promising target for small molecular immune modulator: A review.

Wenyuan Liu, F. Feng, Yijun Liu, 2020, European journal of medicinal chemistry.

Docking Study and Three-Dimensional Quantitative Structure- Activity Relationship （3D-QSAR） Analyses and Novel Molecular Design of a Series of 4-Aminoquinazolines as Inhibitors of Aurora B Kinase

Yadong Chen, Haopeng Sun, J. Zhu, 2011 .

Indenoisoquinoline derivatives as topoisomerase I inhibitors that suppress angiogenesis by affecting the HIF signaling pathway.

F. Liu, Yong Yang, Q. You, 2013, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Discovery of novel inhibitors disrupting HIF-1α/von Hippel–Lindau interaction through shape-based screening and cascade docking

Yuan Sun, Hai‐tao Yu, Haopeng Sun, 2016, PeerJ.

Affinity-Based Fluorescence Polarization Assay for High-Throughput Screening of Prolyl Hydroxylase 2 Inhibitors.

Q. You, Haopeng Sun, Xiaojin Zhang, 2015, ACS medicinal chemistry letters.

Structure‐Based Pharmacophore Modeling from Multicomplex: a Comprehensive Pharmacophore Generation of Protein Kinase CK2 and Virtual Screening Based on it for Novel Inhibitors

Q. You, Haopeng Sun, J. Zhu, 2011, Molecular informatics.

Novel protein–protein interaction inhibitor of Nrf2–Keap1 discovered by structure-based virtual screening

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2014 .

Target the human Alanine/Serine/Cysteine Transporter 2(ASCT2): Achievement and future for novel cancer therapy.

F. Feng, Haopeng Sun, Wei Qu, 2020, Pharmacological research.

Identification of novel JMJD2A inhibitor scaffold using shape and electrostatic similarity search combined with docking method and MM-GBSA approach

Fang Liu, Q. You, Dongdong Li, 2015 .

Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016)

F. Feng, Kai Gu, Haopeng Sun, 2017, Expert opinion on therapeutic patents.

The recent progress of isoxazole in medicinal chemistry.

Haopeng Sun, Jie Zhu, Hongzhi Lin, 2018, Bioorganic & medicinal chemistry.

Studies on gambogic acid (IV): Exploring structure-activity relationship with IκB kinase-beta (IKKβ).

Q. You, Q. Guo, L. Qiang, 2012, European journal of medicinal chemistry.

Synthesis and evaluation of novel aza-caged Garcinia xanthones.

Q. You, Q. Guo, Zhengyu Jiang, 2012, Organic & biomolecular chemistry.

The Development of Pharmacophore Modeling: Generation and Recent Applications in Drug Discovery.

Xin Lu, Hongyu Yang, Wei Qu, 2018, Current pharmaceutical design.

Expansion of the scaffold diversity for the development of highly selective butyrylcholinesterase (BChE) inhibitors: Discovery of new hits through the pharmacophore model generation, virtual screening and molecular dynamics simulation.

Q. Guo, Wenyuan Liu, F. Feng, 2019, Bioorganic chemistry.

Identification, Design and Bio-Evaluation of Novel Hsp90 Inhibitors by Ligand-Based Virtual Screening

Q. You, Meng-Chen Lu, Shengmiao Zhang, 2013, PloS one.

Overview of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1): Functions, regulation, and structural insights of inhibitors.

Q. Guo, F. Feng, Yijun Liu, 2021, Chemico-biological interactions.

3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.

M. Zhang, R. Hu, Q. You, 2013, Journal of medicinal chemistry.

Reasonably activating Nrf2: A long-term, effective and controllable strategy for neurodegenerative diseases.

Ying Chen, Q. Guo, Wenyuan Liu, 2019, European journal of medicinal chemistry.

Key Role of Nf-κ B in the Cellular Pharmacokinetics of Adriamycin in MCF-7/Adr Cells: The Potential Mechanism for Synergy with 20(S)-Ginsenoside Rh2

Haopeng Sun, Jingwei Zhang, 2012 .

Key Role of Nuclear Factor-κB in the Cellular Pharmacokinetics of Adriamycin in MCF-7/Adr Cells: The Potential Mechanism for Synergy with 20(S)-Ginsenoside Rh2

Guangji Wang, Haopeng Sun, Jingwei Zhang, 2012, Drug Metabolism and Disposition.

Small molecular Nrf2 inhibitors as chemosensitizers for cancer therapy.

Wenyuan Liu, F. Feng, Y. Qiao, 2020, Future medicinal chemistry.

Insight into the Intermolecular Recognition Mechanism between Keap1 and IKKβ Combining Homology Modelling, Protein-Protein Docking, Molecular Dynamics Simulations and Virtual Alanine Mutation

Q. You, Zhengyu Jiang, Haopeng Sun, 2013, PloS one.

Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection.

Wenyuan Liu, F. Feng, Shuaishuai Xing, 2021, Journal of medicinal chemistry.

Hybrids of the Benzofuran Core from Natural Products and the 2,4‐Dihydroxy‐5‐isopropylbenzene Fragment as Potent Hsp90 Inhibitors: Design, Synthesis and Bioevaluation

Q. You, Haopeng Sun, Xiaoli Xu, 2014, Molecular informatics.

Discovery and Bioevaluation of Novel Pyrazolopyrimidine Analogs as Competitive Hsp90 Inhibitors Through Shape‐Based Similarity Screening

Q. You, Haopeng Sun, Xiaoli Xu, 2014, Molecular informatics.

Identification of 4-aminoquinoline core for the design of new cholinesterase inhibitors

Yuqiong Pei, Wei Li, Yaoyao Bian, 2016, PeerJ.

Structure-Activity and Structure-Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2015, Journal of medicinal chemistry.

Garcinia xanthones as orally active antitumor agents.

S. Zeng, Q. You, Q. Guo, 2013, Journal of medicinal chemistry.

Novel approach to stereoselective synthesis of (E)/(Z)-(N-acyl-oxazolidinone)-eneglycinates

Q. You, Yanyan Zhang, Haopeng Sun, 2015, Research on Chemical Intermediates.

PROTACs suppression of GSK-3β, a crucial kinase in neurodegenerative diseases.

F. Feng, Xin Liu, Haopeng Sun, 2020, European journal of medicinal chemistry.

N-Benzyl Benzamide Derivatives as Selective Sub-Nanomolar Butyrylcholinesterase Inhibitors for Possible Treatment in Advanced Alzheimer's Disease.

W. Li, Wenyuan Liu, F. Feng, 2022, Journal of medicinal chemistry.

Discovery of Resorcinol-Based Polycyclic Structures as Tyrosinase Inhibitors for Treatment of Parkinson's Disease.

Shuaishuai Xing, Haopeng Sun, Ning Zhang, 2021, ACS chemical neuroscience.

Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer's Disease Drug Discovery.

F. Feng, Haopeng Sun, Wei Qu, 2018, ACS medicinal chemistry letters.

Chemical Constituents of the Seed Cake of Camellia oleifera and Their Antioxidant and Antimelanogenic Activities

Wenyuan Liu, F. Feng, M. Abe, 2018, Chemistry & biodiversity.

Synthesis and evaluation of 4-(2-hydroxypropyl)piperazin-1-yl) derivatives as Hsp90 inhibitors.

Q. You, Haopeng Sun, Xiaoli Xu, 2016, Bioorganic & medicinal chemistry.

Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease.

Wenyuan Liu, F. Feng, Y. Qiao, 2022, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of aromatic tertiary amine derivatives as selective butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease.

Wenyuan Liu, F. Feng, Yijun Liu, 2022, European journal of medicinal chemistry.

Therapeutic Agents in Alzheimer's Disease Through a Multi-targetdirected Ligands Strategy: Recent Progress Based on Tacrine Core.

Kai Gu, Haopeng Sun, Jie Zhu, 2017, Current topics in medicinal chemistry.

Current Development of ROS-Modulating Agents as Novel Antitumor Therapy.

Q. You, Jinlei Bian, Haopeng Sun, 2017, Current cancer drug targets.

Novel Dual-Site-Binding Neuraminidase Inhibitor from Virtual Screening by Pharmacophore and Molecular Dynamics Methods

Q. You, Zhengyu Jiang, Haopeng Sun, 2012 .

Discovery and biological evaluation of a novel highly potent selective butyrylcholinsterase inhibitor.

Wenyuan Liu, F. Feng, Shuaishuai Xing, 2020, Journal of medicinal chemistry.

A highly effective and stable butyrylcholinesterase inhibitor with multi-faceted neuroprotection and cognition improvement.

Ying Chen, Wenyuan Liu, F. Feng, 2022, European journal of medicinal chemistry.

Synthesis and bio-evaluation of a novel selective butyrylcholinesterase inhibitor discovered through structure-based virtual screening.

Wenyuan Liu, F. Feng, Shuaishuai Xing, 2020, International journal of biological macromolecules.

CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells

Q. You, Meng-Chen Lu, Haopeng Sun, 2016, Scientific Reports.

Synthesis, cytotoxicity and topoisomerase II inhibitory activity of lomefloxacin derivatives.

Q. You, Haopeng Sun, Yuan Sun, 2013, Bioorganic & medicinal chemistry letters.

Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: introduction of an additional carboxyl group at the C-2 position of quinoline.

Q. You, J. Zhuang, Dongdong Li, 2015, European journal of medicinal chemistry.

A Mild and Direct C(sp3)-S Cross-Coupling of Oxindoles with Thiols: Synthesis of Unsymmetrical 3-Thiooxindoles.

Wenyuan Liu, F. Feng, Haopeng Sun, 2019, The Journal of organic chemistry.

Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease.

F. Feng, Haopeng Sun, Wei Qu, 2018, European journal of medicinal chemistry.

Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors.

Jing Xu, Q. You, Qian Yang, 2013, Bioorganic & medicinal chemistry.

Design of Small Molecule Autophagy Modulators: A Promising Druggable Strategy.

Xin Lu, Qi Li, Feng Feng, 2017, Journal of medicinal chemistry.

2-Diphenylphosphinoyl-acetyl as a remote directing group for the highly stereoselective synthesis of β-glycosides

Huiyong Sun, Biao Yu, Haopeng Sun, 2021, Chinese Journal of Chemistry.

A facile and efficient [4 + 2] annulation reaction of sulfur ylides: access to N-fused benzimidazoles

Wenyuan Liu, F. Feng, Haopeng Sun, 2019, Organic Chemistry Frontiers.

Alkylsulfonamide-containing quinazoline derivatives as potent and orally bioavailable PI3Ks inhibitors.

Yifan Feng, Haopeng Sun, San-qi Zhang, 2019, Bioorganic & medicinal chemistry.

Novel BuChE-IDO1 inhibitors from sertaconazole: Virtual screening, chemical optimization and molecular modeling studies.

Yijun Liu, Xin Lu, Haopeng Sun, 2020, Bioorganic & medicinal chemistry letters.

Discovery of potent glycogen synthase kinase 3/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer's disease.

Wenyuan Liu, F. Feng, Haopeng Sun, 2020, Bioorganic & medicinal chemistry.

Structure and therapeutic uses of butyrylcholinesterase: Application in detoxification, Alzheimer's disease, and fat metabolism

Wenyuan Liu, F. Feng, Shuaishuai Xing, 2020, Medicinal research reviews.

Discovery of a Selective 6-Hydroxy-1, 4-Diazepan-2-one Containing Butyrylcholinesterase Inhibitor by Virtual Screening and MM-GBSA Rescoring

Xin Lu, Haopeng Sun, K. H. Hong, 2020, Dose-response : a publication of International Hormesis Society.

Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening.

Yao Chen, Wei Li, Zong-liang Liu, 2015, Bioorganic & medicinal chemistry letters.

Palladium(II)-Catalyzed C-H Bond Activation/C-C Coupling/Intramolecular Tsuji-Trost Reaction Cascade: Facile Access to 2H-Pyranonaphthoquinones.

Q. You, Jinlei Bian, Haopeng Sun, 2015, Organic letters.

NbCl5 mediated biomimetic cascade reaction: efficient and scalable one-pot synthesis of dunnione and nor-β-lapachone

Q. You, Jinlei Bian, Haopeng Sun, 2015 .

Synthesis and bioevaluation of a series of α-pyrone derivatives as potent activators of Nrf2/ARE pathway (part I).

R. Hu, Q. You, Q. Guo, 2013, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel carboline-cinnamic acid hybrids as multifunctional agents for treatment of Alzheimer's disease.

Wenyuan Liu, F. Feng, Haopeng Sun, 2020, Bioorganic chemistry.

Convenient Method of Synthesizing Aryloxyalkyl Esters from Phenolic Esters Using Halogenated Alcohols

F. Feng, Haopeng Sun, Wei Qu, 2018, Molecules.

Novel naphtho[2,1-d]oxazole-4,5-diones as NQO1 substrates with improved aqueous solubility: Design, synthesis, and in vivo antitumor evaluation.

Jinlei Bian, Tingting Yang, Jing Gu, 2016, Bioorganic & medicinal chemistry.

2-Substituted 3-methylnaphtho[1,2-b]furan-4,5-diones as novel L-shaped ortho-quinone substrates for NAD(P)H:quinone oxidoreductase (NQO1).

Q. You, Jinlei Bian, Haopeng Sun, 2014, European journal of medicinal chemistry.

A convenient cyclopropanation process of oxindoles via bromoethylsulfonium salt

Wenyuan Liu, F. Feng, Haopeng Sun, 2018, Tetrahedron.

Total synthesis of aldehyde-containing Garcinia natural products isomorellin and gaudichaudione A

Q. You, Nianguang Li, Xiaojian Wang, 2011 .

Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry.

F. Feng, Yijun Liu, Xin Lu, 2020, European journal of medicinal chemistry.

Microwave-assisted transition-metal-free intramolecular Ullmann-type O-arylation in water for the synthesis of xanthones and azaxanthones

Li Yang, Q. You, Haopeng Sun, 2014 .

Design, synthesis and evaluation of novel bivalent β-carboline derivatives as multifunctional agents for the treatment of Alzheimer's disease.

Weijiang Zhang, Wenyuan Liu, F. Feng, 2018, Bioorganic & medicinal chemistry.

More than a Leaving Group: N-Phenyltrifluoroacetimidate as a Remote Directing Group for Highly α-Selective 1,2-cis Glycosylation.

W. Li, Wei Liu, Huiyong Sun, 2022, Angewandte Chemie.

Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease.

Haopeng Sun, Yao Chen, Hongyu Yang, 2017, European journal of medicinal chemistry.

Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms.

Feng Feng, Xueyang Jiang, Haopeng Sun, 2019, Journal of medicinal chemistry.

Bioactivity-based analysis and chemical characterization of hypoglycemic and antioxidant components from Artemisia argyi.

Wei Li, K. Koike, F. Feng, 2019, Bioorganic chemistry.

Lewis acid mediated highly regioselective intramolecular cyclization for the synthesis of β-lapachone

Q. You, Jinlei Bian, Haopeng Sun, 2014 .

Synthesis and activity of miconazole derivatives as dual BChE/IDO1 inhibitors for the treatment of Alzheimer's disease.

Wenyuan Liu, F. Feng, Yijun Liu, 2021, Future medicinal chemistry.

Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease.

F. Feng, Yaoyao Bian, Xin Lu, 2018, Bioorganic & medicinal chemistry.

Anti-angiogenic and anticancer effects of baicalein derivatives based on transgenic zebrafish model.

Q. Guo, Wenyuan Liu, F. Feng, 2018, Bioorganic & medicinal chemistry.

Studies on Chemical Structure Modification and StructureActivity Relationship of Derivatives of Gambogic Acid at C(39)

Q. You, Q. Guo, Haopeng Sun, 2012, Chemistry & biodiversity.

Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors

Haopeng Sun, Yuan Sun, Chen Kang, 2018, PeerJ.

Synthesis and antibacterial evaluation of a novel series of 10-hydroxyl ketolide derivatives.

Ying Sun, Q. You, Haopeng Sun, 2013, Bioorganic & medicinal chemistry letters.

Novel natural-product-like caged xanthones with improved druglike properties and in vivo antitumor potency.

Q. You, Jinlei Bian, Haopeng Sun, 2015, Bioorganic & medicinal chemistry letters.

Synthesis and Evaluation of Gambogic Acid Derivatives as Antitumor Agents. Part III

Q. You, Q. Guo, Cheng Jiang, 2013, Chemistry & biodiversity.

Studies on Chemical‐Structure Modification and StructureActivity Relationship of Gambogic Acid Derivatives at Carbon(34)

Q. You, Q. Guo, Haopeng Sun, 2012, Chemistry & biodiversity.

Design and evaluation of Nrf2 activators with 1,3,4-oxa/thiadiazole core as neuro-protective agents against oxidative stress in PC-12 cells.

Wenyuan Liu, F. Feng, Y. Qiao, 2019, Bioorganic & medicinal chemistry letters.

The Design and Optimization of Monomeric Multitarget Peptides for the Treatment of Multifactorial Diseases.

Yuqiong Pei, Yaoyao Bian, Haopeng Sun, 2022, Journal of medicinal chemistry.

Therapeutic strategies of glioblastoma (GBM): The current advances in the molecular targets and bioactive small molecule compounds

Hui Liu, Wenyuan Liu, F. Feng, 2021, Acta pharmaceutica Sinica. B.

CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors.

Haopeng Sun, Kui Du, Chunlei Wu, 2019, European journal of medicinal chemistry.

p62/SQSTM1, a Central but Unexploited Target: Advances in its Physiological/Pathogenic Functions and Small Molecular Modulators.

Ying Chen, Wenyuan Liu, F. Feng, 2020, Journal of medicinal chemistry.

Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening.

Hao-Ze Huang, Fang Liu, Xiao-Li Xu, 2014, European journal of medicinal chemistry.

Strategies for Structural Modification of Small Molecules to Improve Blood-Brain Barrier Penetration: A Recent Perspective.

Wei Li, Qi Li, Shuaishuai Xing, 2021, Journal of medicinal chemistry.

Overview of AKR1C3: Inhibitor Achievements and Disease Insights.

Q. Guo, Wenyuan Liu, F. Feng, 2020, Journal of medicinal chemistry.

The Development and Design Strategy of Leucine-Rich Repeat Kinase 2 Inhibitors: Promising Therapeutic Agents for Parkinson's Disease.

Wenyuan Liu, F. Feng, Shuaishuai Xing, 2023, Journal of medicinal chemistry.

A novel anti-alpha-fetoprotein single-chain variable fragment displays anti-tumor effects in HepG2 cells as a single agent or in combination with paclitaxel

Xiangdong Gao, Haopeng Sun, Xiaonan Ji, 2016, Tumor Biology.

Rational design and biological evaluation of a new class of thiazolopyridyl tetrahydroacridines as cholinesterase and GSK-3 dual inhibitors for Alzheimer's disease.

Wenyuan Liu, F. Feng, Chang Liu, 2020, European journal of medicinal chemistry.

Small molecule modulators targeting protein kinase CK1 and CK2.

Q. Guo, Wenyuan Liu, F. Feng, 2019, European journal of medicinal chemistry.

Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010-2020).

Yuqiong Pei, Yaoyao Bian, Haopeng Sun, 2021, European journal of medicinal chemistry.

Pharmacophore Modeling and in Silico Screening Studies to Design Potential KDR Kinase Inhibitors

Yadong Chen, Q. You, Li‐Ping Sun, 2011 .

Discovery and Design of Tricyclic Scaffolds as Protein Kinase CK2 (CK2) Inhibitors through a Combination of Shape-Based Virtual Screening and Structure-Based Molecular Modification

Fang Liu, Xiaoli Xu, Xiaowen Wu, 2013, J. Chem. Inf. Model..

Discovery of 2-(cyclopropanecarboxamido)-N-(5-((1-(4-fluorobenzyl)piperidin-4-yl)methoxy)pyridin-3-yl)isonicotinamide as a potent dual AChE/GSK3β inhibitor for the treatment of Alzheimer's disease: Significantly increasing the level of acetylcholine in the brain without affecting that in intestine.

Wenyuan Liu, F. Feng, T. Lin, 2021, European journal of medicinal chemistry.

Discovery of new acetylcholinesterase and butyrylcholinesterase inhibitors through structure-based virtual screening

Yuqiong Pei, R. Tan, Wei Li, 2017 .

Pharmacophore‐Based Drug Design and Biological Evaluation of Novel ABCB1 Inhibitors

Hui Peng, Q. You, Haopeng Sun, 2013, Chemical biology & drug design.

CDK 8 as a therapeutic target for cancers and recent developments in discovery of CDK 8 inhibitors

Haopeng Sun, Chunlei Wu, Runpu Shen, 2018 .

Therapeutic potential of phosphodiesterase inhibitors for cognitive amelioration in Alzheimer's disease.

Haopeng Sun, Runpu Shen, Mei-Yang Xi, 2022, European journal of medicinal chemistry.

Peptide-based and small synthetic molecule inhibitors on PD-1/PD-L1 pathway: A new choice for immunotherapy?

F. Feng, Zongliang Liu, Haopeng Sun, 2019, European journal of medicinal chemistry.

Recent Advances in the Discovery of HIF-1α-p300/CBP Inhibitors as Anti-Cancer Agents.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2016, Mini reviews in medicinal chemistry.

Therapeutic potential of targeting kynurenine pathway in neurodegenerative diseases.

Haopeng Sun, Runpu Shen, Mei-Yang Xi, 2023, European journal of medicinal chemistry.

Novel IKKβ inhibitors discovery based on the co-crystal structure by using binding-conformation-based and ligand-based method.

Q. You, Zhengyu Jiang, Haopeng Sun, 2013, European journal of medicinal chemistry.

Combination of pharmacophore model development and binding mode analyses: identification of ligand features essential for IκB kinase-beta (IKKβ) inhibitors and virtual screening based on it.

Yuan Zhang, Q. You, Haopeng Sun, 2011, European journal of medicinal chemistry.

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2015, Journal of medicinal chemistry.

Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1).

Q. You, Jinlei Bian, Haopeng Sun, 2015, Bioorganic & medicinal chemistry letters.

Discovery of Novel Aldo-Keto Reductase 1C3 Inhibitors as Chemotherapeutic Potentiators for Cancer Drug Resistance.

Q. Guo, Wenyuan Liu, F. Feng, 2022, ACS medicinal chemistry letters.

Synthesis and Bioevaluation of Gambogic Acid Derivatives as Antitumor Agents

Q. You, Lei Zhang, Haopeng Sun, 2012 .

Targeted degradation of anaplastic lymphoma kinase by gold nanoparticle-based multi-headed proteolysis targeting chimeras.

Wenyuan Liu, F. Feng, Fu-Rong Yang, 2020, Colloids and surfaces. B, Biointerfaces.

Regulation of beta‐amyloid for the treatment of Alzheimer's disease: Research progress of therapeutic strategies and bioactive compounds

F. Feng, Lei Wang, Yijun Liu, 2023, Medicinal research reviews.

Computational design of binder as the LC3-p62 protein-protein interaction.

Wenyuan Liu, F. Feng, Haopeng Sun, 2021, Bioorganic chemistry.

Small molecule KDM4s inhibitors as anti-cancer agents

F. Feng, Q. Hu, Kai Gu, 2018, Journal of enzyme inhibition and medicinal chemistry.

Design, synthesis, biological evaluation, and molecular modeling studies of quinoline-ferulic acid hybrids as cholinesterase inhibitors.

Q. Guo, Wenyuan Liu, F. Feng, 2019, Bioorganic chemistry.

Design, synthesis, in vitro and in vivo evaluation of tacrine–cinnamic acid hybrids as multi-target acetyl- and butyrylcholinesterase inhibitors against Alzheimer's disease

Yuqiong Pei, R. Tan, Yaoyao Bian, 2017 .

Discovery of new scaffolds from approved drugs as acetylcholinesterase inhibitors

Wei Li, Zongliang Liu, Haopeng Sun, 2015 .

Discovery, molecular dynamic simulation and biological evaluation of structurally diverse cholinesterase inhibitors with new scaffold through shape-based pharmacophore virtual screening.

Wenyuan Liu, F. Feng, Xin Lu, 2019, Bioorganic chemistry.

Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer’s Diseases

Zhongwei Huang, Yan Guo, Zongliang Liu, 2020, Molecules.

Small molecule PROTACs in targeted therapy: An emerging strategy to induce protein degradation.

Bin Chen, Haopeng Sun, Kui Du, 2019, European journal of medicinal chemistry.

Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2014, Journal of medicinal chemistry.

Targeting phosphodiesterase 4 as a therapeutic strategy for cognitive improvement.

Haopeng Sun, Runpu Shen, Guoqi Yu, 2022, Bioorganic chemistry.

Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis

Yang Pan, Zhengyu Jiang, Li-Li Xu, 2014, Journal of Computer-Aided Molecular Design.

Microwave-assisted copper- and palladium-catalyzed sonogashira-type coupling of aryl bromides and iodides with trimethylsilylacetylene

Q. You, H. Xiang, Haopeng Sun, 2016 .

Design, synthesis, biological evaluation and molecular modeling of N-isobutyl-N-((2-(p-tolyloxymethyl)thiazol-4yl)methyl)benzo[d][1,3] dioxole-5-carboxamides as selective butyrylcholinesterase inhibitors.

Haopeng Sun, Kui Du, Runpu Shen, 2022, Bioorganic & medicinal chemistry letters.

Nafamostat mesilate improves function recovery after stroke by inhibiting neuroinflammation in rats

Xin-Fu Zhou, Haopeng Sun, H. Liao, 2016, Brain, Behavior, and Immunity.

Discovery of NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with novel chemical scaffolds by shape-based virtual screening combined with cascade docking

Q. You, Jinlei Bian, Haopeng Sun, 2015 .

Discovery of novel covalent proteasome inhibitors through a combination of pharmacophore screening, covalent docking, and molecular dynamics simulations

Haopeng Sun, Xiaoxin Wu, Qidong You, 2014, Journal of Molecular Modeling.

Gamma secretase inhibitors: a patent review (2013 - 2015)

Kai Gu, Xin Lu, Haopeng Sun, 2017, Expert opinion on therapeutic patents.

Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease

Yuqiong Pei, R. Tan, Yaoyao Bian, 2017, Journal of enzyme inhibition and medicinal chemistry.

Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease

Yuqiong Pei, Yaoyao Bian, Haopeng Sun, 2018, Journal of enzyme inhibition and medicinal chemistry.

Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I).

Q. You, Qian Yang, Haopeng Sun, 2014, European journal of medicinal chemistry.

Discovery and identification of Cdc37-derived peptides targeting the Hsp90–Cdc37 protein–protein interaction

Lei Wang, Q. You, Zhengyu Jiang, 2015 .

Elucidating the Novel Mechanism of Ligustrazine in Preventing Postoperative Peritoneal Adhesion Formation

Yaoyao Bian, Haopeng Sun, Feiyan Chen, 2022, Oxidative medicine and cellular longevity.

Therapeutic potential of targeting SHP2 in human developmental disorders and cancers.

Haopeng Sun, Guofeng Wu, Runpu Shen, 2020, European journal of medicinal chemistry.

Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5.

Lei Wang, Q. You, Yi-Yue Xie, 2016, European journal of medicinal chemistry.

Effective Screening Strategy Using Ensembled Pharmacophore Models Combined with Cascade Docking: Application to p53-MDM2 Interaction Inhibitors

Fang Liu, Xiaoli Xu, Lei Wang, 2013, J. Chem. Inf. Model..

Synthesis and Anti‐tumor Evaluation of Novel C‐37 Modified Derivatives of Gambogic Acid

Q. You, Q. Guo, Haopeng Sun, 2012 .

A sensitive colorimetric strategy for monitoring cerebral β-amyloid peptides in AD based on dual-functionalized gold nanoplasmonic particles.

Yao-Wu Liu, Xiao‐xing Yin, Haopeng Sun, 2015, Chemical communications.

Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer.

Q. Guo, Wenyuan Liu, F. Feng, 2022, European journal of medicinal chemistry.

Predicting the potency of hERG K+ channel inhibition by combining 3D-QSAR pharmacophore and 2D-QSAR models

Yadong Chen, Haopeng Sun, Qidong You, 2012, Journal of Molecular Modeling.

Nafamostat Mesilate Improves Neurological Outcome and Axonal Regeneration after Stroke in Rats

Xin-Fu Zhou, Haopeng Sun, H. Liao, 2016, Molecular Neurobiology.

Characterization, quantitation, similarity evaluation and combination with Na+,K+-ATPase of cardiac glycosides from Streblus asper.

Wenyuan Liu, F. Feng, J. Manosroi, 2019, Bioorganic chemistry.

Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold.

Q. You, Haopeng Sun, Xiaoli Xu, 2014, Bioorganic & medicinal chemistry letters.

Design, synthesis, in vitro and in vivo evaluation of benzylpiperidine-linked 1,3-dimethylbenzimidazolinones as cholinesterase inhibitors against Alzheimer’s disease

Wenyuan Liu, F. Feng, Yan Guo, 2019, Journal of enzyme inhibition and medicinal chemistry.

Discovery of Potent and Wild-Type-Sparing Fourth-Generation EGFR Inhibitors for Treatment of Osimertinib-Resistance NSCLC.

Hao Shen, Haopeng Sun, Yibei Xiao, 2023, Journal of medicinal chemistry.

Discovery of thiazole salt AChE inhibitors and development of thiamine disulfide prodrugs targeting the central nervous system.

Wenyuan Liu, F. Feng, Jianguo Zuo, 2023, Bioorganic chemistry.

Recent advances in the structure-based and ligand-based design of IKKβ inhibitors as anti-inflammation and anti-cancer agents.

Q. You, Zhengyu Jiang, Haopeng Sun, 2014, Current Medicinal Chemistry.

Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016)

F. Feng, Kai Gu, Haopeng Sun, 2017, Expert opinion on therapeutic patents.

Betulinic acid acetate, an antiproliferative natural product, suppresses client proteins of heat shock protein pathways through a CDC37-binding mechanism

Q. You, Lei Wang, Haopeng Sun, 2016 .

Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment.

Q. Guo, Wenyuan Liu, F. Feng, 2023, Journal of medicinal chemistry.

Novel N-hydroxyfurylacrylamide-based histone deacetylase (HDAC) inhibitors with branched CAP group (Part 2).

Q. You, Haopeng Sun, H. Su, 2013, Bioorganic & medicinal chemistry.

Design, synthesis and evaluation of wound healing activity for β-sitosterols derivatives as potent Na+/K+-ATPase inhibitors.

Wenyuan Liu, F. Feng, Zijian Xie, 2019, Bioorganic chemistry.

Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease.

Lei Wang, Haopeng Sun, Hui Liu, 2023, ACS chemical neuroscience.

Discovery of tryptophan‐tetrahydroisoquinoline derivatives as multifunctional agents for treatment of Alzheimer's disease

Yijun Liu, Xin Lu, Nan Qin, 2022, Chinese journal of chemistry.

A Practical and High‐Affinity Fluorescent Probe for Butyrylcholinesterase: A Good Strategy for Binding Affinity Characterization

Lei Wang, Yueqing Li, Xin Lu, 2022, Chinese journal of chemistry.

Anti-angiogenic and anticancer effects of baicalein derivatives based on transgenic zebrafish model.

Q. Guo, Wenyuan Liu, F. Feng, 2018, Bioorganic & medicinal chemistry.

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2015, Journal of Medicinal Chemistry.

Discovery and optimization of new benzofuran derivatives against p53-independent malignant cancer cells through inhibition of HIF-1 pathway.

Q. You, Jia‐Lin Wang, Yi-Yue Xie, 2016, Bioorganic & medicinal chemistry letters.

Structure‐Based Pharmacophore Modeling from Multicomplex: a Comprehensive Pharmacophore Generation of Protein Kinase CK2 and Virtual Screening Based on it for Novel Inhibitors

Q. You, Haopeng Sun, J. Zhu, 2011, Molecular informatics.

Inhibition of Son of Sevenless Homologue 1 (SOS1): Promising therapeutic treatment for KRAS-mutant cancers.

Haopeng Sun, Yao Chen, Tingkai Chen, 2023, European journal of medicinal chemistry.

Medicinal prospects of targeting tyrosinase: A feature review.

Shuaishuai Xing, Haopeng Sun, Ying Chen, 2022, Current medicinal chemistry.

G9a - An Appealing Antineoplastic Target.

Q. You, Dongdong Li, Wei-lin Chen, 2017, Current cancer drug targets.

Triazoles in Medicinal Chemistry: Physicochemical Properties, Bioisosterism, and Application.

Shuaishuai Xing, Haopeng Sun, Yao Chen, 2024, Journal of medicinal chemistry.