P. Kasperkiewicz

发表

Extended substrate specificity and first potent irreversible inhibitor/activity‐based probe design for Zika virus NS2B‐NS3 protease

R. Hilgenfeld, Linlin Zhang, M. Dra̧g, 2017, Antiviral research.

Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis

M. Bogyo, C. Craik, C. Lentz, 2016, ACS infectious diseases.

Recent advances and concepts in substrate specificity determination of proteases using tailored libraries of fluorogenic substrates with unnatural amino acids

M. Dra̧g, M. Poręba, Wioletta Rut, 2015, Biological chemistry.

Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4

G. Salvesen, D. Kirchhofer, M. Dra̧g, 2015, PloS one.

Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates

G. Salvesen, M. Dra̧g, M. Poręba, 2014, Cell Death and Differentiation.

Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease

B. Schmidt, C. Morissette, S. Vanner, 2019, Scientific Reports.

Effects of curcumin based PDT on the viability and the organization of actin in melanotic (A375) and amelanotic melanoma (C32)- in vitro studies.

J. Kulbacka, J. Saczko, Krzysztof Kotowski, 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families

L. Kaczmarek, G. Salvesen, D. Turk, 2017, Scientific Reports.

Current and prospective applications of non-proteinogenic amino acids in profiling of proteases substrate specificity

P. Kasperkiewicz, M. Drąg, Anna Gajda, 2012, Biological chemistry.

Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling

G. Salvesen, C. Winterbourn, M. Poręba, 2014, Proceedings of the National Academy of Sciences.

SUMO-mediated regulation of NLRP3 modulates inflammasome activity

E. Alnemri, T. Fernandes-Alnemri, T. Tenev, 2018, Nature Communications.

Simple phosphonic inhibitors of human neutrophil elastase.

M. Sieńczyk, J. Oleksyszyn, J. Wietrzyk, 2011, Bioorganic & medicinal chemistry letters.

High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils

M. Varjosalo, T. Wirth, J. Laitinen, 2020, Biological Procedures Online.

Tissue-ABPP enables high-resolution confocal fluorescence imaging of serine hydrolase activity in cryosections – Application to glioma brain unveils activity hotspots originating from tumor-associated neutrophils

M. Varjosalo, T. Wirth, J. Laitinen, 2019, bioRxiv.

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc04303a

G. Salvesen, D. Turk, K. Vuori, 2018, Chemical science.

Substrate Specificity and Possible Heterologous Targets of Phytaspase, a Plant Cell Death Protease*

M. Serebryakova, M. Poręba, N. Chichkova, 2015, The Journal of Biological Chemistry.

NETosis Occurs Independently of Neutrophil Serine Proteases.

G. Salvesen, S. Snipas, T. Janiszewski, 2020, The Journal of biological chemistry.

Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes

G. Salvesen, M. Poręba, S. Snipas, 2018, Scientific Reports.

The elastase-PK101 structure: mechanism of an ultrasensitive activity-based probe revealed.

B. C. Lechtenberg, H. Robinson, S. Riedl, 2015, ACS chemical biology.

The Cytoprotective Role of Antioxidants in Mammalian Cells Under Rapidly Varying UV Conditions During Stratospheric Balloon Campaign

J. Kulbacka, D. Przystupski, W. Bartosik, 2019, Front. Pharmacol..

The cytoprotective role of antioxidants in mammalian cells under rapidly varying temperature, pressure and UV conditions during stratospheric balloon campaign

J. Kulbacka, D. Przystupski, W. Bartosik, 2019, bioRxiv.

Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes

G. Salvesen, M. Poręba, S. Snipas, 2018, Scientific Reports.

Mechanism and specificity of the human paracaspase MALT1

G. Salvesen, M. Poręba, S. Snipas, 2012, The Biochemical journal.

Small Molecule Active Site Directed Tools for Studying Human Caspases.

G. Salvesen, M. Poręba, Wioletta Rut, 2015, Chemical reviews.

Positional scanning substrate combinatorial library (PS-SCL) approach to define caspase substrate specificity.

M. Poręba, P. Kasperkiewicz, A. Szalek, 2014, Methods in molecular biology.

Screening Combinatorial Peptide Libraries in Protease Inhibitor Drug Discovery

M. Poręba, Wioletta Rut, P. Kasperkiewicz, 2018 .

Emerging challenges in the design of selective substrates, inhibitors and activity‐based probes for indistinguishable proteases

M. Poręba, Katarzyna Groborz, P. Kasperkiewicz, 2017, The FEBS journal.

Peptidyl Activity-Based Probes for Imaging Serine Proteases

P. Kasperkiewicz, Paulina Kasperkiewicz, 2021, Frontiers in Chemistry.

Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils.

G. Salvesen, P. Kasperkiewicz, M. Drąg, 2017, Journal of the American Chemical Society.

Nanosecond pulsed electric field suppresses growth and reduces multi-drug resistance effect in pancreatic cancer

J. Kulbacka, J. Saczko, M. Tarek, 2023, Scientific Reports.

An alternative for proteinase K-heat-sensitive protease from fungus Onygena corvina for biotechnology: cloning, engineering, expression, characterization and special application for protein sequencing

P. Skowron, P. Kasperkiewicz, R. Brodzik, 2020, Microbial Cell Factories.

Fluorescent Activity-Based Probe To Image and Inhibit Factor XIa Activity in Human Plasma

J. Huntington, Sylwia Modrzycka, P. Kasperkiewicz, 2023, Journal of medicinal chemistry.

Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes.

G. Salvesen, D. Turk, B. Turk, 2016, Cell chemical biology.

Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples.

M. Poręba, S. Snipas, Wioletta Rut, 2018, Journal of medicinal chemistry.

Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes

G. Salvesen, J. Kulbacka, J. Saczko, 2019, The Journal of Biological Chemistry.

Detection of Active Granzyme A in NK92 Cells with Fluorescent Activity-Based Probe

G. Salvesen, P. Bird, D. Kaiserman, 2019, bioRxiv.

Leveraging peptide substrate libraries to design inhibitors of bacterial Lon protease

M. Bogyo, Brett M. Babin, T. Janiszewski, 2019, bioRxiv.

Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.

Katarzyna Groborz, P. Kasperkiewicz, M. Drąg, 2019, Biochimie.

High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils

M. Varjosalo, T. Wirth, J. Laitinen, 2020, Biological Procedures Online.

SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme.

H. Ovaa, C. Lima, M. Békés, 2015, The Biochemical journal.