C. Lepre

发表

Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide

M. Murcko, P. Caron, C. Rice, 1996, Cell.

Practical aspects of NMR-based fragment screening.

Christopher A Lepre, C. Lepre, 2011, Methods in enzymology.

Theory and applications of NMR-based screening in pharmaceutical research.

Jeffrey W. Peng, Christopher A Lepre, Jonathan M Moore, 2004, Chemical reviews.

Application of NMR screening in drug discovery.

Xiaoling Xie, Jasna Fejzo, C. Lepre, 2003, Current topics in medicinal chemistry.

Practical applications of time-averaged restrained molecular dynamics to ligand-receptor systems: FK506 bound to the Q50R,A95H,K98I triple mutant of FKBP-13

D. Pearlman, J. Moore, D. Livingston, 1996, Journal of biomolecular NMR.

Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism.

C. Koth, L. Swenson, E. ter Haar, 2010, Structure.

Dynamic NMR studies of ligand‐receptor interactions: Design and analysis of a rapidly exchanging complex of FKBP‐12/FK506 with a 24 kDa calcineurin fragment

M. Su, J. Peng, J. Thomson, 1996, Protein science : a publication of the Protein Society.

Interaction of Platinum Antitumor Compounds with DNA

S. Lippard, C. Lepre, 1990 .

Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors.

E. ter Haar, J. Coll, R. Rijnbrand, 2016, Journal of medicinal chemistry.

Drug Design: NMR in fragment-based drug discovery

P. Connolly, C. Lepre, Jonathan M. Moore, 2010 .

Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor.

C. Koth, J. Lippke, P. Connolly, 2010, Biochemistry.

High-resolution solution structure of reduced French bean plastocyanin and comparison with the crystal structure of poplar plastocyanin.

D. Case, G. Gippert, P. Wright, 1991, Journal of molecular biology.

Synthesis and 1H NMR spectroscopic characterization of trans-[Pt(NH3)2[d(ApGpGpCpCpT)-N7-A(1),N7-G(3)]].

S. Lippard, S. Lippard, C. Lepre, 1987, Biochemistry.

Platinum-195 NMR kinetic and mechanistic studies of cis- and trans-diamminedichloroplatinum(II) binding to DNA

Christopher A. Lepre, Stephen J. Lippard, S. Lippard, 1990 .

The SHAPES strategy: an NMR-based approach for lead generation in drug discovery.

Ajay, G. Bemis, M. Murcko, 1999, Chemistry & biology.

Directional electron transfer in ruthenium-modified horse heart cytochrome c

S. S. Isied, C. Lepre, R. Bechtold, 1986, Nature.

195Pt NMR Kinetic and Mechanistic Studies of cis- and trans-Diamminedichloroplatinum(II) Binding to DNA.

S. Lippard, C. Lepre, D. Bancroft, 1990 .

Synthesis and characterization of trans-[Pt(NH3)2Cl2] adducts of d(CCTCGAGTCTCC).d(GGAGACTCGAGG).

S. Lippard, C. Costello, C. Lepre, 1990, Biochemistry.

Nitrogen-15 NMR relaxation studies of the FK506 binding protein: Backbone dynamics of the uncomplexed receptor

J. Fulghum, S. P. Chambers, Jyawei Cheng, 1993 .

15N NMR relaxation studies of the FK506 binding protein: backbone dynamics of the uncomplexed receptor.

J. Fulghum, J. Moore, S. P. Chambers, 1993, Biochemistry.

Crystal Structure of the P38α-MAPKAP Kinase 2 Heterodimer*

C. Lepre, Xun Liu, E. T. Haar, 2007, Journal of Biological Chemistry.

Microdrop screening: A rapid method to optimize solvent conditions for NMR spectroscopy of proteins

J M Moore, C A Lepre, C. Lepre, 1998, Journal of biomolecular NMR.

Solution structure of FK506 bound to the R42K, H87V double mutant of FKBP-12.

D. Pearlman, J. Moore, D. Livingston, 1994, Biochemistry.

15N NMR relaxation studies of the FK506 binding protein: dynamic effects of ligand binding and implications for calcineurin recognition.

J. Moore, C. Lepre, J. W. Cheng, 1994, Biochemistry.

Library design for NMR-based screening.

C. Lepre, C A. Lepre, 2001, Drug discovery today.

Solution structure of FK506 bound to FKBP‐12

J. Thomson, C. Lepre, Jonathan M. Moore, 1992, FEBS letters.

Dynamics of a receptor-bound ligand by heteronuclear NMR: FK506 bound to FKBP-12

Jyawei Cheng, C. Lepre, Jonathan M. Moore, 1993 .

Fragment-based drug discovery using the SHAPES method

C. Lepre, Christopher Lepre, 2007, Expert opinion on drug discovery.

Leveraging structural approaches: applications of NMR-based screening and X-ray crystallography for inhibitor design.

Jeffrey W. Peng, Xiaoling Xie, M. Jacobs, 2004, Journal of synchrotron radiation.

Nuclear magnetic resonance-based approaches for lead generation in drug discovery.

J. Peng, J. Moore, N. Abdul-Manan, 2001, Methods in enzymology.

Fragment-Based NMR Screening in Lead Discovery

C. Lepre, Jonathan M. Moore, 2007 .

Theory and Applications of NMR‐Based Screening in Pharmaceutical Research

Jeffrey W. Peng, Christopher A. Lepre, C. Lepre, 2004 .

Applications of SHAPES screening in drug discovery.

Jeffrey W. Peng, Xiaoling Xie, J. Pocas, 2002, Combinatorial chemistry & high throughput screening.

Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism.

C. Koth, L. Swenson, E. ter Haar, 2010, Structure.

1H resonance assignments and secondary structure of the carbon monoxide complex of soybean leghemoglobin determined by homonuclear two-dimensional and three-dimensional NMR spectroscopy.

P. Wright, D. Morikis, C. Lepre, 1994, European journal of biochemistry.