J. E. Semple

发表

Novel and general method for the preparation of peptidyl argininals

R. Nutt, S. Tamura, W. Ripka, 1996 .

Rational design and synthesis of a novel, selective class of thrombin inhibitors: P1-argininal derivatives incorporating P3P4 quaternary lactam dipeptide surrogates

R. Nutt, S. Tamura, W. Ripka, 1997 .

Guanylpiperidine peptidomimetics: potent and selective bis-cation inhibitors of factor Xa.

R. Nutt, S. Tamura, J. Ho, 2000, Bioorganic & medicinal chemistry letters.

Atom-Economical Synthesis of the N(10)−C(17) Fragment of Cyclotheonamides via a Novel Passerini Reaction−Deprotection−Acyl Migration Strategy1

J. E. Semple, Timothy D. Owens and, J. Semple, 2001 .

New Synthetic Technology for Efficient Construction of α-Hydroxy-β-amino Amides via the Passerini Reaction1

Andrew Nguyen, J. E. Semple, O. Levy, 2000 .

Novel, potent and selective chimeric FXa inhibitors featuring hydrophobic P1-ketoamide moieties.

D. Siev, J. E. Semple, N. K. Minami, 2000, Bioorganic & medicinal chemistry letters.

Guanylpiperidine Peptidomimetics: Potent and Selective Bis‐Cation Inhibitors of Factor Xa.

J. E. Semple, 2000 .

Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties.

R. Nutt, S. Tamura, A. Tulinsky, 1996, Journal of medicinal chemistry.

Thiazolides as novel antiviral agents. 1. Inhibition of hepatitis B virus replication.

Raman Sharma, N. Berry, G. Edwards, 2011, Journal of medicinal chemistry.

Thiazolides as novel antiviral agents. 2. Inhibition of hepatitis C virus replication.

Raman Sharma, N. Berry, G. Edwards, 2011, Journal of medicinal chemistry.

Total synthesis and revised structural assignment of (+)-furanomycin

M. Joullié, Pengxin Wang, J. E. Semple, 1980 .

Total synthesis of (+)-furanomycin and stereoisomers

M. Joullié, Pengxin Wang, J. E. Semple, 1980 .

Novel protocol for the solid-phase synthesis of peptidyl and peptidomimetic P1-argininal derivatives

D. Siev, J. E. Semple, John A. Gaudette, 1999 .

Open Research Second-generation nitazoxanide derivatives: thiazolides are eﬀective inhibitors of the inﬂuenza A virus

Jean-François, N. Berry, P. O’Neill, 2022 .

Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bicyclic arginine surrogates.

J. Cui, S. Kemp, D. Siev, 2002, Bioorganic & medicinal chemistry letters.

Synthetic studies of fungal metabolites: ascofuranone and colletochlorin D

M. Joullié, J. E. Semple, Anne A. Guthrie, 1982 .

Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates

R. Nutt, S. Tamura, M. Lim-Wilby, 1997 .

Rational design, synthesis, and serine protease inhibitory activity of a novel P1-argininal derivative featuring a conformationally constrained P2–P3 bicyclic lactam moiety

S. Tamura, W. Ripka, J. E. Semple, 1997 .

Design and Synthesis of a Novel Class of Thrombin Inhibitors Incorporating Heterocyclic Dipeptide Surrogates.

R. Nutt, S. Tamura, W. Ripka, 1997 .

Investigation of the S3 site of thrombin: design, synthesis and biological activity of 4-substituted 3-amino-2-pyridones incorporating P1-argininals.

R. Nutt, S. Tamura, J. E. Semple, 1999, Bioorganic & medicinal chemistry letters.

Potent and selective thrombin inhibitors incorporating the constrained arginine mimic l-3-piperidyl(N-guanidino)alanine at P1.

R. Nutt, A. Tulinsky, E. Dempsey, 1996, Journal of medicinal chemistry.

Facile Access to Novel 1,4-Dihydroxynapththalene-2,3-dicarboximides and Heterofused Analogs

J. E. Semple, W. M. Murray, 1996 .

Concise total synthesis of the prolyl endopeptidase inhibitor eurystatin A via a novel Passerini reaction–deprotection–acyl migration strategy

R. Nutt, J. E. Semple, T. D. Owens, 2001 .

Recent Drug Discovery against Cryptosporidium

G. Gargala, A. Stachulski, J. E. Semple, 2011 .

Asymmetric synthesis of novel quaternary α-Hydroxy-δ-lactam dipeptide surrogates

J. E. Semple, N. K. Minami, J. Reiner, 1999 .

Novel, potent non-covalent thrombin inhibitors incorporating p(3)-lactam scaffolds.

J. Ho, J. E. Semple, T. Gibson, 2002, Bioorganic & medicinal chemistry letters.

Novel benzo-fused lactam scaffolds as factor Xa inhibitors.

S. Tamura, J. E. Semple, E. Goldman, 1999, Bioorganic & medicinal chemistry letters.

A Practical and Efficient Synthetic Route to Dihydropipercide and Pipercide1

J. E. Semple, Lloyd W. Rotherham and, 1998 .

Total synthesis of (+)-furanomycin and stereoisomers

M. Joullié, Pengxin Wang, J. E. Semple, 1980 .

Alkoxide-catalyzed ring-opening of a novel homosaccharin derivative: synthesis of potent, selective P3-lactam thrombin inhibitors containing P4-o-alkoxycarbonylbenzylsulfonamide residues.

J. E. Semple, T. D. Owens, 1998, Bioorganic & medicinal chemistry letters.

A CONCISE SYNTHESIS OF PELLITORINE

J. E. Semple, 1995 .

Total syntheses of fungal metabolites and functionalized furanones

M. Joullié, J. E. Semple, Kau-Ming Chen, 1985 .

Large-scale synthesis of α-amino acid-N-carboxyanhydrides

Kevin N Sill, B. Sullivan, J. E. Semple, 2017 .

Synthesis of functionalized tetrahydrofurans

M. Joullié, J. E. Semple, A. E. Guthrie, 1981 .

Synthesis of muscarine analogues: Approaches to fuhctionalized tetrahydrofurans

M. Joullié, Pengxin Wang, J. E. Semple, 1978 .

Synthetic route to P 1 -argininals suitable for radiolabeling studies

R. Nutt, S. Tamura, D. Rowley, 2002 .

Synthesis and Characterization of Micelle-Forming PEG-Poly(Amino Acid) Copolymers with Iron-Hydroxamate Cross-Linkable Blocks for Encapsulation and Release of Hydrophobic Drugs.

Kevin N Sill, B. Sullivan, J. E. Semple, 2017, Biomacromolecules.

Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus.

N. Berry, P. O’Neill, M. Santoro, 2018, Future medicinal chemistry.

New Synthetic Technology for Efficient Construction of α‐Hydroxy‐β‐amino Amides via the Passerini Reaction.

J. E. Semple, O. Levy, T. D. Owens, 2001 .

Synthesis and biological activity of P2–P4 azapeptidomimetic P1-argininal and P1-ketoargininamide derivatives: a novel class of serine protease inhibitors

D. Rowley, W. Ripka, J. E. Semple, 1997 .

Imaging the delivery of drug-loaded, iron-stabilized micelles.

Kevin N Sill, G. Martinez, B. Sullivan, 2017, Nanomedicine : nanotechnology, biology, and medicine.

Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.

A. Tulinsky, K. Håkansson, R. Arni, 1998, Biochemistry.

Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties.

R. Nutt, S. Tamura, A. Tulinsky, 1996, Journal of medicinal chemistry.

Stabilized Polymer Micelles for the Development of IT-147, an Epothilone D Drug-Loaded Formulation

Kevin N Sill, B. Sullivan, J. E. Semple, 2016, Journal of drug delivery.

IT-143, A Polymer Micelle Nanoparticle, Widens Therapeutic Window of Daunorubicin

Kevin N Sill, B. Sullivan, J. E. Semple, 2016 .

Asymmetric synthesis of novel quaternary alpha-hydroxy-delta-lactam dipeptide surrogates.

J. E. Semple, N. K. Minami, J. Reiner, 1999, Bioorganic & medicinal chemistry letters.