R. Lueoend

发表

Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides.

Jean-Michel Rondeau, Laura Jacobson, M. Staufenbiel, 2012, Journal of medicinal chemistry.

Assessment of the active-site requirements of 5-aminolevulinic acid dehydratase: evaluation of substrate and product analogs as competitive inhibitors

R. Lueoend, R. Neier, Joseph T. Walker, 1992 .

α-Nitro keto hydrazone and keto imine dianions. Synthetic equivalents for the nitroalkene d3 synthon

S. Denmark, R. Lueoend, J. A. Sternberg, 1988 .

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid β-peptides.

M. Staufenbiel, J. Rondeau, S. Desrayaud, 2013, Bioorganic & medicinal chemistry letters.

Cyclometalated Compounds of Platinum(II) with Two Different C,N‐Aromatic Ligands.

C. Deuschel-Cornioley, A. V. Zelewsky, R. Lueoend, 1989 .

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

M. Staufenbiel, G. Laue, D. Shimshek, 2015, Molecular Neurodegeneration.

Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease.

G. Laue, J. Rondeau, L. Jacobson, 2021, Journal of medicinal chemistry.

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

M. Staufenbiel, G. Laue, D. Shimshek, 2015, Molecular Neurodegeneration.

Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360.

Mathias Frederiksen, Philipp Holzer, M. Staufenbiel, 2021, Journal of medicinal chemistry.

THE BACE INHIBITOR NB-360 HAS EXCELLENT BRAIN PENETRATION AND EFFICACY ON AMYLOID-B LOAD IN ANIMAL MODELS

M. Staufenbiel, G. Laue, D. Shimshek, 2014, Alzheimer's & Dementia.

Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors.

Mathias Frederiksen, Philipp Holzer, M. Staufenbiel, 2018, Bioorganic & medicinal chemistry letters.

Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase.

G. Thoma, D. Bednarczyk, C. Beerli, 2023, Journal of medicinal chemistry.