K. Mealey

发表

Evaluation of the biliary and brain distribution of technetium Tc 99m sestamibi in healthy dogs with the ABCB1 wildtype genotype before and after treatment with spinosad.

R. Tucker, J. Mattoon, C. Mackay, 2012, American journal of veterinary research.

Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and ABCB1 wild type dogs.

F. Nelson, D. Raunig, K. Schmidt, 2010, Journal of veterinary pharmacology and therapeutics.

Canine ABCB1 and macrocyclic lactones: heartworm prevention and pharmacogenetics.

K. Mealey, 2008, Veterinary parasitology.

Comparison of the hypothalamic^pituitary^adrenal axis in MDR1-1D and MDR1 wildtype dogs

K. Mealey, D. Waiting, Linda G. Martin, 2007 .

Adverse Drug Reactions in Herding-Breed Dogs: The Role of P-Glycoprotein *

K. Mealey, 2006 .

Therapeutic implications of the MDR-1 gene.

K. Mealey, 2004, Journal of veterinary pharmacology and therapeutics.

Pharmacogenetic and Metabolic Differences Between Dog Breeds: Their Impact on Canine Medicine and the Use of the Dog as a Preclinical Animal Model

Marilyn N. Martinez, E. Ostrander, K. Mealey, 2008, The AAPS Journal.

Fecal polymerase chain reaction with 16S ribosomal RNA primers can detect the presence of gastrointestinal Helicobacter in dogs.

T. Besser, G. Cantor, K. Mealey, 2002, Journal of veterinary internal medicine.

Respiratory Pharmacotherapeutics

K. Mealey, 2019, Pharmacotherapeutics for Veterinary Dispensing.

Comparative metabolism of mycophenolic acid by glucuronic acid and glucose conjugation in human, dog, and cat liver microsomes

K. Mealey, M. Court, J. E. Slovak, 2017, Journal of veterinary pharmacology and therapeutics.

Identification of canine cytochrome P‐450s (CYPs) metabolizing the tramadol (+)‐M1 and (+)‐M2 metabolites to the tramadol (+)‐M5 metabolite in dog liver microsomes

K. Mealey, M. Court, Tania E Perez Jimenez, 2018, Journal of veterinary pharmacology and therapeutics.

Population variability in animal health: Influence on dose-exposure-response relationships: Part I: Drug metabolism and transporter systems.

Marilyn N. Martinez, J. Fink-Gremmels, K. Mealey, 2018, Journal of veterinary pharmacology and therapeutics.

ABCG2 transporter: therapeutic and physiologic implications in veterinary species.

K. Mealey, 2012, Journal of veterinary pharmacology and therapeutics.

The genomic architecture of segmental duplications and associated copy number variants in dogs.

Thomas J. Nicholas, E. Eichler, Ze Cheng, 2008, Genome research.

Adverse drug reactions in veterinary patients associated with drug transporters.

K. Mealey, 2013, The Veterinary clinics of North America. Small animal practice.

Molecular genetic basis for fluoroquinolone-induced retinal degeneration in cats

C. Ramirez, K. Mealey, J. Gay, 2011, Pharmacogenetics and genomics.

Oral co-administration of fluconazole with tramadol markedly increases plasma and urine concentrations of tramadol and the O-desmethyltramadol metabolite (M1) in healthy dogs

B. Kukanich, H. Joo, K. Mealey, 2018, Veterinary Anaesthesia and Analgesia.

Oral Coadministration of Fluconazole with Tramadol Markedly Increases Plasma and Urine Concentrations of Tramadol and the O-Desmethyltramadol Metabolite in Healthy Dogs

B. Kukanich, H. Joo, K. Mealey, 2018, Drug Metabolism and Disposition.

Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine.

J. Akey, K. Mealey, M. Jabbes, 2008, Xenobiotica; the fate of foreign compounds in biological systems.

Effect of low doses of cosyntropin on serum cortisol concentrations in clinically normal dogs.

E. Behrend, D. Carpenter, K. Mealey, 2007, American journal of veterinary research.

Frequency of the mutant MDR1 allele associated with multidrug sensitivity in a sample of herding breed dogs living in Australia.

K. Munyard, K. Mealey, S. Bentjen, 2005, Veterinary parasitology.

Pharmacokinetics and haematological effects of a single intravenous dose of mitoxantrone in cats.

D. Alberts, K. Mealey, R. Meyers, 1995, Journal of veterinary pharmacology and therapeutics.

Excessive Cyclosporine-Associated Immunosuppression in a Dog Heterozygous for the MDR1 (ABCB1-1Δ) Mutation.

D. Boothe, K. Mealey, T. Archer, 2020, Journal of the American Animal Hospital Association.

Breed Differences and Pharmacogenetics

K. Mealey, 2019, Pharmacotherapeutics for Veterinary Dispensing.

Digoxin and mexiletine sensitivity in a Collie with the MDR1 mutation.

K. Mealey, R. Henik, S. Bentjen, 2006, Journal of veterinary internal medicine.

The Effect of the Canine ABCB1‐1Δ Mutation on Sedation after Intravenous Administration of Acepromazine

K. Mealey, M. Gieseg, J. P. Chambers, 2016, Journal of veterinary internal medicine.

Loperamide toxicity in a collie with the MDR1 mutation associated with ivermectin sensitivity.

L. Trepanier, K. Mealey, S. Bentjen, 2004, Journal of veterinary internal medicine.

Establishment of a cell line for assessing drugs as canine P‐glycoprotein substrates: proof of principle

N. S. Burke, K. Mealey, S. Dassanayake, 2017, Journal of veterinary pharmacology and therapeutics.

Vincristine-induced central neurotoxicity in a collie homozygous for the ABCB1Δ mutation.

J. Bryan, K. Mealey, L. Krugman, 2012, The Journal of small animal practice.

Biliary excretion of technetium-99m-sestamibi in wild-type dogs and in dogs with intrinsic (ABCB1-1Delta mutation) and extrinsic (ketoconazole treated) P-glycoprotein deficiency.

G. Roberts, R. Tucker, J. Mattoon, 2009, Journal of veterinary pharmacology and therapeutics.

Systemic absorption of amitriptyline and buspirone after oral and transdermal administration to healthy cats.

K. Mealey, R. Sellon, K. Peck, 2004, Journal of veterinary internal medicine.

Pharmacokinetics of gallium maltolate after intragastric administration in neonatal foals.

Robert J. Taylor, N. Cohen, M. Chaffin, 2007, American journal of veterinary research.

Pharmacokinetics of flunixin meglumine in donkeys, mules, and horses.

K. Mealey, K. Peck, M. Coakley, 1999, American journal of veterinary research.

Comparative pharmacokinetics of caffeine and three metabolites in clinically normal horses and donkeys.

K. Mealey, K. Peck, T. Taylor, 1997, American journal of veterinary research.

Tolerance and Pharmacokinetics of Galliprant™ Administered Orally to Collies Homozygous for MDR1‐1Δ

M. Heit, K. Mealey, S. King, 2021, Journal of veterinary pharmacology and therapeutics.

The genomic architecture of segmental duplications and copy number variants in dogs

Thomas J. Nicholas, E. Eichler, Ze Cheng, 2009 .

Increased toxicity of P-glycoprotein-substrate chemotherapeutic agents in a dog with the MDR1 deletion mutation associated with ivermectin sensitivity.

N. Northrup, K. Mealey, S. Bentjen, 2003, Journal of the American Veterinary Medical Association.

Ivermectin toxicity in an Australian Shepherd dog with the MDR1 mutation associated with ivermectin sensitivity in Collies.

O. Nelson, K. Mealey, S. Bentjen, 2003, Journal of veterinary internal medicine.

Determination of optimal storage temperature and duration for analysis of total and isoenzyme lactate dehydrogenase activities in canine serum and cerebrospinal fluid.

K. Mealey, A. Kiszonas, A. Chen, 2015, Veterinary clinical pathology.

Synovial T-cell lymphoma of the stifle in a dog.

K. Mealey, R. Sellon, G. Haldorson, 2002, Journal of the American Animal Hospital Association.

Comparison of plasma disposition of alkaloids after lupine challenge in cattle that had given birth to calves with lupine-induced arthrogryposis or clinically normal calves.

A. Tibary, K. Panter, L. James, 2004, American journal of veterinary research.

Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics

L. Trepanier, B. Kukanich, M. Dacasto, 2013, Drug metabolism reviews.

Tyrosine Kinase Inhibitors Enhance Ciprofloxacin-Induced Phototoxicity by Inhibiting ABCG2

N. S. Burke, K. Mealey, S. Dassanayake, 2014, Oncology.

Hypercalcemia associated with granulomatous disease in a cat.

L. Nagode, R. Helman, K. Mealey, 1999, Journal of the American Veterinary Medical Association.

ABCB1-1 Delta (MDR1-1 Delta) genotype is associated with adverse reactions in dogs treated with milbemycin oxime for generalized demodicosis.

K. Mealey, J. Gay, T. Snook, 2009, Veterinary dermatology.

Ivermectin: Macrolide Antiparasitic Agents

K. Mealey, 2006 .

Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage.

M. Slatkin, N. Pedersen, M. Neff, 2004, Proceedings of the National Academy of Sciences of the United States of America.

P‐Glycoprotein Mediated Drug Interactions in Animals and Humans with Cancer

K. Mealey, J. Fidel, 2015, Journal of veterinary internal medicine.

Intravenous fat emulsion as treatment for ivermectin toxicosis in three dogs homozygous for the ABCB1-1Δ gene mutation.

R. Poppenga, K. Mealey, A. Chen, 2011, Journal of veterinary emergency and critical care.

Pharmacokinetics of sulfamethoxazole and trimethoprim in donkeys, mules, and horses.

K. Mealey, K. Peck, T. Taylor, 2002, American journal of veterinary research.

Breed distribution of the ABCB1-1Delta (multidrug sensitivity) polymorphism among dogs undergoing ABCB1 genotyping.

K. Mealey, K. Meurs, 2008, Journal of the American Veterinary Medical Association.

The pharmacogenomics of P-glycoprotein and its role in veterinary medicine.

K. Mealey, M. Martinez, M. Sharkey, 2008, Journal of veterinary pharmacology and therapeutics.

Ophthalmic Pharmacotherapeutics

K. Mealey, T. Alessio, 2019, Pharmacotherapeutics for Veterinary Dispensing.

Frequency of the mutant MDR1 allele associated with multidrug sensitivity in a sample of collies from France.

K. Mealey, S. Bentjen, C. Hugnet, 2004, Journal of veterinary pharmacology and therapeutics.

Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.

G. Cantor, K. Mealey, J. Gay, 2001, Pharmacogenetics.

Lack of association of ABCB4 insertion mutation with gallbladder mucoceles in dogs

J. Cullen, K. Mealey, Jonathan D. Minch, 2014, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.

Endocrine Pharmacotherapeutics

K. Mealey, 2019, Pharmacotherapeutics for Veterinary Dispensing.

Comparative Pharmacokinetics and Pharmacodynamics

K. Mealey, Margo J. Karriker, 2019, Pharmacotherapeutics for Veterinary Dispensing.

Penicillins and β-lactamase inhibitor combinations

K. Mealey, 2001 .

The effects of inhibiting cytochrome P450 3A, p-glycoprotein, and gastric acid secretion on the oral bioavailability of methadone in dogs.

B. Kukanich, M. Papich, B. Lascelles, 2005, Journal of veterinary pharmacology and therapeutics.

Special Considerations for Service, Working, and Performance Animals

K. Mealey, 2019, Pharmacotherapeutics for Veterinary Dispensing.

copy number variants in dogs The genomic architecture of segmental duplications and associated Material

Thomas J. Nicholas, E. Eichler, Ze Cheng, 2009 .

Survival time, lifespan, and quality of life in dogs with idiopathic Fanconi syndrome.

J. Yearley, D. Hancock, K. Mealey, 2004, Journal of the American Veterinary Medical Association.

Dexamethasone treatment of a canine, but not human, tumour cell line increases chemoresistance independent of P-glycoprotein and multidrug resistance-related protein expression.

H. Hosick, K. Mealey, J. Gay, 2003, Veterinary and comparative oncology.

Doxycycline Induces Expression of P Glycoprotein in MCF-7 Breast Carcinoma Cells

S. Safe, R. Burghardt, R. Barhoumi, 2002, Antimicrobial Agents and Chemotherapy.

Frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample population of collies from the northwestern United States.

K. Mealey, D. Waiting, S. Bentjen, 2002, American journal of veterinary research.

Neuromuscular effects of doxacurium chloride in isoflurane-anesthetized dogs.

E. Martinez, K. Mealey, S. M. Hartsfield, 1998, Veterinary surgery : VS.

Pharmacokinetics, effects on renal function, and potentiation of atracurium-induced neuromuscular blockade after administration of a high dose of gentamicin in isoflurane-anesthetized dogs.

E. Martinez, K. Mealey, S. M. Hartsfield, 1996, American journal of veterinary research.

Normal dogs treated with famotidine for 14 days have only transient increases in serum gastrin concentrations.

K. Mealey, R. Sellon, A. Mordecai, 2011, Journal of veterinary internal medicine.

Canine orosomucoid (alpha-1 acid glycoprotein) variants and their influence on drug plasma protein binding.

N. S. Burke, K. Mealey, M. Court, 2020, Journal of veterinary pharmacology and therapeutics.

Transdermal absorption of a liposome-encapsulated formulation of lidocaine following topical administration in cats.

B. Fransson, Jennifer K. Smith, K. Mealey, 2002, American journal of veterinary research.

Relationship between the melanocortin-1 receptor (MC1R) variant R306ter and physiological responses to mechanical or thermal stimuli in Labrador Retriever dogs.

N. S. Burke, K. Mealey, M. Court, 2017, Veterinary anaesthesia and analgesia.

Polymorphisms in the canine glucocorticoid receptor alpha gene (NR3C1α).

N. S. Burke, K. Mealey, R. Sellon, 2016, Journal of veterinary pharmacology and therapeutics.

Clinical pharmacology and therapeutics.

K. Mealey, Katrina L Mealey, 2013, The Veterinary clinics of North America. Small animal practice.

Immunosuppressant inhibition of P-glycoprotein function is independent of drug-induced suppression of peptide-prolyl isomerase and calcineurin activity

P. Sylvester, R. Burghardt, B. McIntyre, 1999, Cancer Chemotherapy and Pharmacology.

Doxorubicin induced expression of P-glycoprotein in a canine osteosarcoma cell line.

R. Barhoumi, K. Mealey, D. Kochevar, 1998, Cancer letters.

Human Over‐the‐Counter (OTC) Products

K. Mealey, P. Talcott, 2019, Pharmacotherapeutics for Veterinary Dispensing.

Canine ABCB4: Tissue expression and cDNA structure.

K. Lahmers, K. Mealey, Jonathan D. Minch, 2010, Research in veterinary science.

Pharmacotherapeutics for Veterinary Dispensing

K. Mealey, 2019 .

Tramadol Metabolism to O-Desmethyl Tramadol (M1) and N-Desmethyl Tramadol (M2) by Dog Liver Microsomes: Species Comparison and Identification of Responsible Canine Cytochrome P450s

K. Mealey, M. Court, Tania E Perez Jimenez, 2016, Drug Metabolism and Disposition.

Comparative pharmacokinetics of meloxicam in clinically normal horses and donkeys.

M. Sinclair, K. Mealey, K. Peck, 2006, American journal of veterinary research.

Pharmacokinetics of R(-) and S(+) carprofen after administration of racemic carprofen in donkeys and horses.

K. Mealey, K. Peck, B. S. Bennett, 2004, American journal of veterinary research.

Comparative pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone in clinically normal horses and donkeys.

K. Mealey, K. Peck, A. C. Ray, 1997, American journal of veterinary research.

Pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone in miniature donkeys.

K. Mealey, K. Peck, T. Taylor, 2001, American journal of veterinary research.

P-Glycoprotein Contributes to the Blood-Brain, but Not Blood-Cerebrospinal Fluid, Barrier in a Spontaneous Canine P-Glycoprotein Knockout Model

F. Nelson, K. Schmidt, K. Mealey, 2008, Drug Metabolism and Disposition.

Bioavailability of benzodiazepines following rectal administration of diazepam in dogs.

D. Boothe, K. Mealey, 1995, Journal of veterinary pharmacology and therapeutics.

Systemic Mycobacterium avium infection in a dog diagnosed by polymerase chain reaction analysis of buffy coat.

J. Oaks, K. Mealey, D. Bradway, 2005, Journal of the American Animal Hospital Association.

Impact of the canine double-deletion &bgr;1 adrenoreceptor polymorphisms on protein structure and heart rate response to atenolol, a &bgr;1-selective &bgr;-blocker

B. Keene, J. Stern, K. Mealey, 2015, Pharmacogenetics and genomics.

Evaluation of the flanking nucleotide sequences of sarcomeric hypertrophic cardiomyopathy substitution mutations.

K. Mealey, K. Meurs, 2008, Mutation research.

Personalized medicine: going to the dogs?

K. Mealey, Stephanie E. Martinez, S. E. Martinez, 2019, Human Genetics.

Canine Albumin Polymorphisms and Their Impact on Drug Plasma Protein Binding

N. S. Burke, K. Mealey, M. Court, 2019, Drug Metabolism and Disposition.

Pharmacokinetics and cardiopulmonary effects of guaifenesin in donkeys.

K. Mealey, K. Peck, A. C. Ray, 1997, Journal of veterinary pharmacology and therapeutics.

Pharmacokinetics of gentamicin in donkeys.

K. Mealey, T. Taylor, N. Matthews, 1996, Journal of veterinary pharmacology and therapeutics.

Canine and feline P‐glycoprotein deficiency: What we know and where we need to go

K. Mealey, E. Freeman, J. Owens, 2022, Journal of veterinary pharmacology and therapeutics.

Assessment of verdinexor as a canine P-glycoprotein substrate.

N. S. Burke, K. Mealey, 2023, Journal of veterinary pharmacology and therapeutics.

Role of an ABCB11930_1931del TC gene mutation in a temporal cluster of macrocyclic lactone-induced neurologic toxicosis in cats associated with products labeled for companion animal use.

N. S. Burke, K. Mealey, Rebecca L Connors, 2021, Journal of the American Veterinary Medical Association.

Adverse reaction to apomorphine in a Collie homozygous for the ABCB1-1∆ (MDR1) mutation.

K. Mealey, L. de Lorimier, O. Campbell, 2017, Journal of Small Animal Practice.

Identification of a nonsense mutation in feline ABCB1.

N. S. Burke, K. Mealey, 2015, Journal of veterinary pharmacology and therapeutics.

ABCB1-1Delta polymorphism can predict hematologic toxicity in dogs treated with vincristine.

P. Bergman, K. Mealey, J. Gay, 2008, Journal of veterinary internal medicine.

Assessment of antiepileptic drugs as substrates for canine P-glycoprotein.

K. Mealey, C. L. West, 2007, American journal of veterinary research.

Evaluation of Transdermal Administration of Phenobarbital in Healthy Cats.

M. Papich, S. Thomovsky, K. Mealey, 2019, Journal of the American Animal Hospital Association.

Association between ABCB1 genotype and seizure outcome in Collies with epilepsy.

K. Muñana, K. Mealey, R. Bergman, 2012, Journal of veterinary internal medicine.

Evaluation of vincristine-associated myelosuppression in Border Collies.

D. Lind, K. Mealey, J. Gay, 2013, American journal of veterinary research.

SA251 WHAT YOU DON’T KNOW ABOUT P-GLYCOPROTEIN CAN HURT YOU (& YOUR PATIENTS!)

K. Mealey, 2013 .

WHAT YOU DON ’ T KNOW ABOUT P-GLYCOPROTEIN CAN HURT YOU

K. Mealey, 2013 .

Sequence and structural analysis of the presumed downstream promoter of the canine mdr1 gene.

K. Mealey, S. Bentjen, 2003, Veterinary and comparative oncology.

Comparison of chemotherapeutic drug resistance in cells transfected with canine ABCG2 or feline ABCG2†

N. S. Burke, K. Mealey, M. Court, 2017, Veterinary and comparative oncology.

Development of prednisone resistance in naïve canine lymphoma: Longitudinal evaluation of NR3C1α, ABCB1, and 11β-HSD mRNA expression.

N. S. Burke, K. Mealey, R. Sellon, 2020, Journal of veterinary pharmacology and therapeutics.

Frequency of the mutant MDR1 allele in dogs in the UK

M. Day, K. Mealey, I. Peters, 2012, Veterinary Record.

Gallium Therapy: A Novel Metal-Based Antimicrobial Strategy for Potential Control of Rhodococcus equi Foal Pneumonia

Robert J. Taylor, N. Cohen, M. Chaffin, 2006 .

Identification of DNA variants in the canine beta-1 adrenergic receptor gene.

O. Nelson, K. Mealey, K. Meurs, 2013, Research in veterinary science.

An insertion mutation in ABCB4 is associated with gallbladder mucocele formation in dogs

S. White, J. Mattoon, K. Mealey, 2010, Comparative hepatology.

ResearchAn insertion mutation in ABCB 4 is associated with gallbladder mucocele formation in dogs

S. White, J. Mattoon, K. Mealey, 2015 .

Researchmutation in ABCB4 is associated with gallbladder mucocele formation in dogs

S. White, J. Mattoon, K. Mealey, 2010 .

Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine

J. Akey, K. Mealey, M. Jabbes, 2008 .

Impact of the canine double-deletion &bgr;1 adrenoreceptor polymorphisms on protein structure and heart rate response to atenolol, a &bgr;1-selective &bgr;-blocker

B. Keene, J. Stern, K. Mealey, 2015, Pharmacogenetics and genomics.

Cannabidiol and cannabidiolic acid: Preliminary in vitro evaluation of metabolism and drug-drug interactions involving canine cytochrome P-450, UDP-glucuronosyltransferase, and P-glycoprotein.

N. S. Burke, J. Wakshlag, K. Mealey, 2023, Journal of veterinary pharmacology and therapeutics.