M. Tintelnot-Blomley

发表

Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors.

Clive McCarthy, Jean-Michel Rondeau, Marina Tintelnot-Blomley, 2011, Bioorganic & medicinal chemistry letters.

Arylaminoethyl amides as inhibitors of the cysteine protease cathepsin K-investigating P1' substituents.

E. Altmann, Jonathan R. Green, M. Tintelnot-Blomley, 2003, Bioorganic & medicinal chemistry letters.

J. Lemasters, K. Zimmermann, T. Qian, 2003, Current medicinal chemistry.

New aza-dipeptide analogues as potent and orally absorbed HIV-1 protease inhibitors: candidates for clinical development.

J. Mestan, M. Eschbach, T. Klimkait, 1998, Journal of medicinal chemistry.

2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K.

E. Altmann, Jonathan R. Green, C. Betschart, 2007, Journal of medicinal chemistry.

Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity

M. Renatus, C. Wiesmann, F. Villard, 2020 .

Stereoselective synthesis of constrained oxacyclic hydroxyethylene isosteres of aspartic protease inhibitors: aldol and Mukaiyama aldol methodologies for branched tetrahydrofuran 2-carboxylic acids.

S. Hanessian, M. Bayrakdarian, M. Tintelnot-Blomley, 2005, The Journal of organic chemistry.

Stereoselective synthesis of constrained azacyclic hydroxyethylene isosteres as aspartic protease inhibitors: dipolar cycloaddition and related methodologies toward branched pyrrolidine and pyrrolidinone carboxylic acids.

S. Hanessian, M. Tintelnot-Blomley, H. Yun, 2005, The Journal of organic chemistry.

Aza-peptide analogs as potent human immunodeficiency virus type-1 protease inhibitors with oral bioavailability.

J. Mestan, R. Cozens, G. Bold, 1996, Journal of medicinal chemistry.

Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE).

Stephen Hanessian, Gaoqiang Yang, Jean-Michel Rondeau, 2006, Journal of medicinal chemistry.

Substrate-controlled and organocatalytic asymmetric synthesis of carbocyclic amino acid dipeptide mimetics.

S. Hanessian, Riccardo Matera, M. Tintelnot-Blomley, 2010, The Journal of organic chemistry.

Stereoselective synthesis of (4S,5R,6S)-4-(5,6-epoxy-6-phenyl)-γ-lactone

G. Bold, J. Fischer, A. Cian, 1996 .

Novel pseudosymmetric inhibitors of HIV-1 protease

G. Bold, M. Lang, M. Tintelnot-Blomley, 1993 .

Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo.

Jean-Michel Rondeau, Marina Tintelnot-Blomley, M. Staufenbiel, 2009, Bioorganic & medicinal chemistry letters.

Semicochliodinol A and B: inhibitors of HIV-1 protease and EGF-R protein tyrosine kinase related to asterriquinones produced by the fungus Chrysosporium merdarium.

H. Mett, J. Rösel, P. Hug, 1997, The Journal of antibiotics.

The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease

M. Staufenbiel, S. Vormfelde, N. Beckmann, 2018, EMBO molecular medicine.

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

M. Staufenbiel, G. Laue, D. Shimshek, 2015, Molecular Neurodegeneration.

Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors.

Jean-Michel Rondeau, Marina Tintelnot-Blomley, P. Paganetti, 2009, Bioorganic & medicinal chemistry letters.

Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease.

G. Laue, J. Rondeau, L. Jacobson, 2021, Journal of medicinal chemistry.

Corrigendum to “Structure-based design and synthesis of macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors” [Bioorg. Med. Chem. Lett. 19 (2009) 1361–1365]

Siem J. Veenstra, Jean-Michel Rondeau, Marina Tintelnot-Blomley, 2009 .

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

M. Staufenbiel, G. Laue, D. Shimshek, 2015, Molecular Neurodegeneration.

Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics.

Stephen Hanessian, Nicolas Moitessier, Gaoqiang Yang, 2005, Journal of medicinal chemistry.

Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.

M. Staufenbiel, P. Paganetti, J. Rondeau, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360.

Mathias Frederiksen, Philipp Holzer, M. Staufenbiel, 2021, Journal of medicinal chemistry.

Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors.

Stephen Hanessian, Jean-Michel Rondeau, Zhihui Shao, 2010, Bioorganic & medicinal chemistry letters.

THE BACE INHIBITOR NB-360 HAS EXCELLENT BRAIN PENETRATION AND EFFICACY ON AMYLOID-B LOAD IN ANIMAL MODELS

M. Staufenbiel, G. Laue, D. Shimshek, 2014, Alzheimer's & Dementia.

Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors.

Mathias Frederiksen, Philipp Holzer, M. Staufenbiel, 2018, Bioorganic & medicinal chemistry letters.