K. Hodgetts

发表

The Role of Fluorine in the Discovery and Optimization of CNS Agents: Modulation of Drug-Like Properties

G. Harriman, A. Elder, K. Hodgetts, 2010 .

Asymmetric synthesis of (S)-2,6-dimethylchroman-4-one

K. Hodgetts, 2002 .

Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.

S. Boyce, J. Krause, Xiaozhang Zheng, 2010, Bioorganic & medicinal chemistry letters.

The preparation of substituted 3,4-dihydro-l(2H)-naphthalenones from benzocyclobutenones via sequential thermal electrocyclic reactions

K. Hodgetts, T. Wallace, Derek N. Hickman, 1996 .

Synthesis of 2-aryl-oxazolo[4,5-c]quinoline-4(5H)-ones and 2-aryl-thiazolo[4,5-c]quinoline-4(5H)-ones.

Mark T. Kershaw, K. Hodgetts, 2003, Organic letters.

Synthesis of (±)-trans-2,5-Diisopropylborolane

G. Laschober, K. Hodgetts, Massimo Zorzi, 2001, Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry.

Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy

John N. Hutchinson, D. Selkoe, C. Clish, 2022, NPJ Parkinson's disease.

Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships.

K. Hodgetts, R. Brodbeck, S. Rachwał, 2002, Bioorganic & medicinal chemistry letters.

Optimization of a series of heterocycles as survival motor neuron gene transcription enhancers.

C. Lorson, M. Glicksman, G. Cuny, 2017, Bioorganic & medicinal chemistry letters.

Ethyl 2-chlorooxazole-4-carboxylate: a versatile intermediate for the synthesis of substituted oxazoles.

Mark T. Kershaw, K. Hodgetts, 2002, Organic letters.

Identification of environmental factors that promote intestinal inflammation

A. Mildner, S. Snapper, J. Korzenik, 2022, Nature.

Short-duration splice promoting compound enables a tunable mouse model of spinal muscular atrophy

C. Lorson, E. Androphy, H. Lusic, 2020, Life Science Alliance.

Inter- and intramolecular Mitsunobu reaction based approaches to 2-substituted chromans and chroman-4-ones

K. Hodgetts, 2005 .

6-(4-Benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D(4) receptors.

K. Hodgetts, R. Brodbeck, A. Thurkauf, 2001, Bioorganic & medicinal chemistry.

Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: a novel series of mixed dopamine D2/D4 receptor antagonist.

J. Chandrasekhar, K. Hodgetts, R. Brodbeck, 2003, Bioorganic & medicinal chemistry letters.

From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist.

J. Chandrasekhar, S. De Lombaert, Xiaozhang Zheng, 2006, Bioorganic & medicinal chemistry letters.

Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution.

Mark T. Kershaw, J. Chandrasekhar, J. Krause, 2008, Bioorganic & medicinal chemistry letters.

3-Aryl pyrazolo[4,3-d]pyrimidine derivatives: Nonpeptide CRF-1 antagonists.

S. De Lombaert, K. Hodgetts, R. Brodbeck, 2002, Bioorganic & medicinal chemistry letters.

Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.

Mark T. Kershaw, S. Boyce, J. Krause, 2010, Journal of medicinal chemistry.

Inter- and Intramolecular Mitsunobu Reaction Based Approaches to 2-Substituted Chromans and Chroman-4-ones.

K. Hodgetts, 2005 .

Conjugate addition to 3-arylsulfinylchromones as a synthetic route to homochiral 2-substituted chromanones: Scope and limitations

R. Wootton, K. Hodgetts, T. Wallace, 2001 .

Approaches to 2-substituted chroman-4-ones: synthesis of (−)-pinostrobin

K. Hodgetts, 2001 .

Studies on the Stereoselective Synthesis of the Marine Antitumor Agent Eleutherobin

S. Wren, K. Hodgetts, P. Magnus, 2000 .

A stereocontrolled route to 2-substituted chromans

K. Hodgetts, 2000 .

Restoring tripartite glutamatergic synapses: A potential therapy for mood and cognitive deficits in Gulf War illness

J. Bruno, V. Valentini, Zan Xu, 2020, Neurobiology of Stress.

Carbotherma1 synthesis of binary (MX) and ternary (M1, M2X) carbides, nitrides and borides from polymeric precursors

J. Birchall, K. Hodgetts, D. R. Stanley, 1992 .

Carbothermal Synthesis of Binary (MX) and Ternary (M1,M2X) Carbides, Nitrides, and Borides from Polymeric Precursors.

J. Birchall, K. Hodgetts, D. R. Stanley, 1992 .

Synthesis of the HIF-2α translation inhibitor compound 76 via a Japp-Klingemann coupling

O. Iliopoulos, K. Hodgetts, Shao-Liang Zheng, 2019, Tetrahedron Letters.

CLEAVAGE OR ACETYL-DE-ALKYLATION OF 4-METHOXYBENZYL (MPM)ETHERS USING ACETIC ACID

K. Hodgetts, T. Wallace, 1994 .

Barcoded viral tracing of single-cell interactions in central nervous system inflammation

A. Abate, F. Quintana, J. Antel, 2021, Science.

The preparation and electrocyclic ring-opening of cyclobutenes: Stereocontrolled approaches to substituted conjugated dienes and trienes

K. Hodgetts, T. Wallace, F. Binns, 1996 .

Use of cis-3-cyclobutene-1,2-dimethanol in stereoselective routes to some naturally occurring conjugated dienes and trienes

K. Hodgetts, T. Wallace, C. J. Wallis, 1993 .

Small Molecules in Development for the Treatment of Spinal Muscular Atrophy.

E. Androphy, K. Hodgetts, Alyssa N Calder, 2016, Journal of medicinal chemistry.

Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy.

C. Lorson, E. Androphy, M. Glicksman, 2017, Journal of medicinal chemistry.

Small Molecule Approaches to Upregulate SMN Expression From the SMN2 Locus

E. Androphy, K. Hodgetts, Alyssa N Calder, 2017 .

Case Studies of CNS Drug Optimization—Medicinal Chemistry and CNS Biology Perspectives

K. Hodgetts, 2015 .

Pyridazine-derivatives Enhance Structural and Functional Plasticity of Tripartite Synapse Via Activation of Local Translation in Astrocytic Processes

Zan Xu, K. Hodgetts, C. Lin, 2018, Neuroscience.

Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer’s disease: a preclinical study in rTg4510 mice

K. Hodgetts, C. Lin, C. Askwith, 2019, Alzheimer's Research & Therapy.

Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease

M. Glicksman, Yuchen Lin, G. Cuny, 2015, The Journal of experimental medicine.

Regiocontrolled synthesis of substituted thiazoles.

Mark T. Kershaw, K. Hodgetts, 2002, Organic letters.

Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist.

Ping Ge, Taeyoung Yoon, Dario Doller, 2011, Journal of medicinal chemistry.

2-Arylpyrimidines: novel CRF-1 receptor antagonists.

J. Kehne, J. Chandrasekhar, D. Hoffman, 2008, Bioorganic & medicinal chemistry letters.

The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists.

Mark T. Kershaw, J. Kehne, J. Chandrasekhar, 2008, Bioorganic & medicinal chemistry letters.

A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α‐Synuclein Mice

D. Selkoe, J. Winkler, Ulf Dettmer, 2020, Annals of neurology.

Nanotherapeutic approaches to overcome distinct drug resistance barriers in models of breast cancer

H. Jang, Younggeun Park, Shiladitya Sengupta, 2021, Nanophotonics.

trans-1-[(2-Phenylcyclopropyl)methyl]-4-arylpiperazines: mixed dopamine D(2)/D(4) receptor antagonists as potential antipsychotic agents.

D. Hoffman, H. Zhao, K. Hodgetts, 2000, Journal of medicinal chemistry.

Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer’s disease: a preclinical study in rTg4510 mice

K. Hodgetts, C. Lin, C. Askwith, 2019, Alzheimer's Research & Therapy.

contributed equally to this paper. Restored glial glutamate transporter EAAT2 function as a potential

M. Glicksman, Yuchen Lin, G. Cuny, 2015 .

Intraperitoneal delivery of a novel drug‐like compound improves disease severity in severe and intermediate mouse models of Spinal Muscular Atrophy

C. Lorson, E. Androphy, R. Kline, 2019, Scientific Reports.

Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.

S. Boyce, J. Krause, Xiaozhang Zheng, 2010, Bioorganic & medicinal chemistry letters.