Sookhee N. Ha

发表

Role of Mechanistic Transport Studies in Lead Optimization

M. Bock, Jiunn H. Lin, J. Hochman, 2006 .

A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

P Jeffrey Conn, Craig W Lindsley, Tsing-Bau Chen, 2003, Molecular pharmacology.

C. Lindsley, P. Conn, M. Jacobson, 2004 .

A Novel Selective Allosteric Modulator Potentiates the Activity of Native Metabotropic Glutamate Receptor Subtype 5 in Rat Forebrain

P Jeffrey Conn, Craig W Lindsley, C. Lindsley, 2004, Journal of Pharmacology and Experimental Therapeutics.

Establishment of P‐Glycoprotein Structure–Transport Relationships to Optimize CNS Exposure in Drug Discovery

R. Sheridan, J. Hochman, Sookhee N. Ha, 2015 .

Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus.

T. Roemer, S. Koseoglu, Jianping Pan, 2016, Bioorganic & medicinal chemistry letters.

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

T. Roemer, Xinwei Sher, S. Koseoglu, 2016, Science Translational Medicine.

Discovery of FabH/FabF Inhibitors from Natural Products

Jun Wang, John F. Barrett, Lynn L. Silver, 2006, Antimicrobial Agents and Chemotherapy.

Isolation, structure and biological activities of platencin A(2)-A(4) from Streptomyces platensis.

M. Motyl, Sheo B. Singh, J. Ondeyka, 2010, Bioorganic & medicinal chemistry.

Isolation, enzyme-bound structure, and activity of platensimycin A1 from Streptomyces platensis

J. W. Becker, S. Soisson, Sheo B. Singh, 2009 .

Synthesis and biological evaluation of platensimycin analogs.

M. Maccoss, Hong C Shen, S. Soisson, 2009, Bioorganic & medicinal chemistry letters.

Isolation and structure of platencin: a FabH and FabF dual inhibitor with potent broad-spectrum antibiotic activity.

F. Vicente, R. Cummings, Ó. Salazar, 2007, Angewandte Chemie.

Functional analysis of sites within PCSK9 responsible for hypercholesterolemias⃞s⃞ The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of one figure. Published, JLR Papers in Press, March 19, 2008.

R. Cummings, D. Wisniewski, S. Wright, 2008, Journal of Lipid Research.

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.

Sujata Sharma, J. Lisnock, P. Orth, 2019, Cell chemical biology.

Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.

K. Seyb, D. Johns, P. Orth, 2020, Journal of medicinal chemistry.

Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists.

J. Chen, L. V. D. van der Ploeg, L. Shearman, 2007, Bioorganic & medicinal chemistry letters.

Development of a Platform To Enable Efficient Permeability Evaluation of Novel Organo-Peptide Macrocycles.

Sookhee N. Ha, Graham F. Smith, L. Nogle, 2019, ACS medicinal chemistry letters.

Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties

Mohan R. Pradhan, D. Lane, J. Hochman, 2019, Molecules.

Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.

A. Swensen, G. Kaczorowski, B. Priest, 2016, Bioorganic & medicinal chemistry letters.

Investigation of piperazine benzamides as human β3 adrenergic receptor agonists for the treatment of overactive bladder.

M. Struthers, R. Berger, C. Moyes, 2017, Bioorganic & medicinal chemistry letters.

Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.

J. Chen, R. Bentley, J. Metzger, 2015, ACS medicinal chemistry letters.

Isolation, structure, and antibacterial activity of philipimycin, a thiazolyl peptide discovered from Actinoplanes philippinensis MA7347.

Scott K. Smith, F. Vicente, Ó. Salazar, 2008, Journal of the American Chemical Society.

Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.

G. Kaczorowski, B. Priest, Haifeng Tang, 2012, ACS medicinal chemistry letters.

Conformational analysis and receptor docking of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (taranabant, MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist.

W. Hagmann, R. Ball, G. Doss, 2008, Journal of medicinal chemistry.

5-Piperazinyl pyridine carboxamide bradykinin B1 antagonists.

M. Bock, S. Kuduk, T. Prueksaritanont, 2006, Bioorganic & medicinal chemistry letters.

Discovery of a potent, non-peptide bradykinin B1 receptor antagonist.

M. Bock, R. M. Dipardo, R. Freidinger, 2003, Journal of the American Chemical Society.

Kibdelomycin Is a Bactericidal Broad-Spectrum Aerobic Antibacterial Agent

C. Garlisi, Carl J. Balibar, P. Dayananth, 2015, Antimicrobial Agents and Chemotherapy.

[P7-11] Survey on Sodium Contents in Meals of School Foodservice and Sodium Intakes of Students in Busan and Gyeongsangbuk-do

Su-Ok Kim, Sookhee N. Ha, Chang Hee Lee, 2010 .

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Jun Wang, Olga Genilloud, Sang Ho Lee, 2006, Nature.

Binding modes of dihydroquinoxalinones in a homology model of bradykinin receptor 1.

M. Bock, R. Freidinger, R. Chang, 2005, Biochemical and biophysical research communications.

Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.

M. Struthers, R. Berger, C. Moyes, 2016, Journal of medicinal chemistry.

Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.

C. Lindsley, P. Conn, M. Jacobson, 2007, Bioorganic & medicinal chemistry letters.

Side chain SAR of bicyclic beta-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem.

J. Hermes, N. Sharma, P. Fitzgerald, 2010, Bioorganic & medicinal chemistry letters.

Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.

A. Peier, D. Lane, J. Hochman, 2018, Bioorganic & medicinal chemistry.

Platensimycin and platencin congeners from Streptomyces platensis.

Z. Guan, Sheo B. Singh, D. Zink, 2011, Journal of natural products.

Nodulisporic acids D-F: structure, biological activities, and biogenetic relationships.

A. Dahl-Roshak, J. Tkacz, Sheo B. Singh, 2004, Journal of natural products.

Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®.

J. Hermes, G. Scapin, N. Sharma, 2014, Bioorganic & medicinal chemistry letters.

Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.

A. Peier, C. Strickland, Benjamin J Barlock, 2022, Journal of medicinal chemistry.

Discovery of benzamides as potent human β3 adrenergic receptor agonists.

M. Struthers, A. Weber, G. Salituro, 2016, Bioorganic & medicinal chemistry letters.

Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.

T. Roemer, S. Koseoglu, P. Tawa, 2017, Journal of medicinal chemistry.

A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9) C-terminal Domain Antibody Antigen-binding Fragment Inhibits PCSK9 Internalization and Restores Low Density Lipoprotein Uptake

J. Condra, M. Bottomley, R. Cummings, 2010, The Journal of Biological Chemistry.

A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.

Jeffrey T. Kuethe, D. Johns, P. Orth, 2021, Journal of medicinal chemistry.

Synthesis and evaluation of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists.

W. Hagmann, James P. Jewell, L. Lin, 2009, Bioorganic & medicinal chemistry letters.

Isolation, structure, and antibacterial activities of lucensimycins D-G, discovered from Streptomyces lucensis MA7349 using an antisense strategy.

F. Vicente, Ó. Salazar, O. Genilloud, 2009, Journal of natural products.

Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant.

L. V. D. van der Ploeg, W. Hagmann, James P. Jewell, 2010, Bioorganic & medicinal chemistry letters.

Potent Kv1.3 inhibitors from correolide-modification of the C18 position.

G. Kaczorowski, G. Doss, W. Parsons, 2005, Bioorganic & medicinal chemistry letters.

Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor

Jeffrey T. Kuethe, D. Johns, T. Tucker, 2023, Circulation.

Mini review on molecular modeling of P-glycoprotein (Pgp).

R. Sheridan, J. Hochman, Sookhee N. Ha, 2007, Current topics in medicinal chemistry.

A Gly/Ala switch contributes to high affinity binding of benzoxazinone‐based non‐peptide oxytocin receptor antagonists

M. Wheatley, Sookhee N. Ha, D. Pettibone, 2005, FEBS letters.

Identification of the critical residues of bradykinin receptor B1 for interaction with the kinins guided by site-directed mutagenesis and molecular modeling.

M. Bock, R. Chang, J. Hess, 2006, Biochemistry.

C-terminal Loop Mutations Determine Folding and SecretionProperties of PCSK9

D. Johns, T. Vogt, D. Wisniewski, 2016 .

Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.

A. Peier, D. Lane, J. Hochman, 2018, Bioorganic & medicinal chemistry.

Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.

A. Peier, C. Strickland, Benjamin J Barlock, 2021, Journal of medicinal chemistry.

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.

Sujata Sharma, P. Orth, J. Shipman, 2021, Cell chemical biology.