Y. Tokunaga

发表

The provisional no-effect threshold of sugar alcohols on oral drug absorption estimated by physiologically based biopharmaceutics model.

K. Matsui, M. Yamane, Masahisa Sugihara, 2020, Journal of pharmaceutical sciences.

The Site-Specific Transport and Metabolism of Tacrolimus in Rat Small Intestine

G. Amidon, S. Yamashita, R. Ibuki, 2003, Journal of Pharmacology and Experimental Therapeutics.

Relationship Between Physicochemical and Osteotropic Properties of Bisphosphonic Derivatives: Rational Design for Osteotropic Drug Delivery System (ODDS)

H. Hirabayashi, Y. Tokunaga, T. Sawamoto, 2001, Pharmaceutical Research.

Bone-specific delivery and sustained release of diclofenac, a non-steroidal anti-inflammatory drug, via bisphosphonic prodrug based on the Osteotropic Drug Delivery System (ODDS).

H. Hirabayashi, Y. Tokunaga, T. Takahashi, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Improvement in the variation of inhalation properties of an FK888 dry powder inhaler using an E-haler, by adding coarse lactose in spherical soft agglomerates of fine drug particles, and its absorption in healthy volunteers

Y. Kawashima, A. Ohike, R. Ibuki, 2005 .

Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. I.v. effects of osteotropic estradiol on bone mineral density and uterine weight in ovariectomized rats.

Y. Tokunaga, T. Takahashi, S. Kimura, 1998, Journal of drug targeting.

Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. V. Biological disposition and targeting characteristics of osteotropic estradiol.

Y. Tokunaga, T. Takahashi, S. Kimura, 1997, Biological & pharmaceutical bulletin.

Physicochemical Characterization of Bisphosphonic Carboxyfluorescein for Osteotropic Drug Delivery

S. Murata, Y. Tokunaga, T. Takahashi, 1996, The Journal of pharmacy and pharmacology.

Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. III: Pharmacokinetics and targeting characteristics of osteotropic carboxyfluorescein.

Y. Tokunaga, T. Sawamoto, T. Takahashi, 1996, Journal of drug targeting.

Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. I: synthesis and in vivo characterization of osteotropic carboxyfluorescein.

Y. Tokunaga, T. Hirose, A. Kagayama, 1995, Journal of drug targeting.

Formulation development of inhalation powders for FK888 with carrier lactose using Spinhaler and its absorption in healthy volunteers.

Y. Kawashima, A. Ohike, R. Ibuki, 2004, Journal of controlled release : official journal of the Controlled Release Society.

Comparison of the lung absorption of FK224 inhaled from a pressurized metered dose inhaler and a dry powder inhaler by healthy volunteers.

Y. Kawashima, A. Ohike, R. Ibuki, 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Effect of experimental acute renal and hepatic failure on absorption of tacrolimus in rat small intestine.

G. Amidon, S. Yamashita, A. Ohike, 2004, Drug metabolism and pharmacokinetics.

Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine (II): in vivo evaluation.

R. Ibuki, K. Higaki, Toshikiro Kimura, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine.

A. Ohike, R. Ibuki, K. Higaki, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Development of a Novel Drug Release System, Time-Controlled Explosion System (TES). III. Relation between Lag Time and Membrane

R. Ibuki, Y. Tokunaga, S. Ueda, 1994 .

Development of a Novel Drug Release System, Time-Controlled Explosion System (TES). II. Design of Multiparticulate TES and in Vitro Drug Release Properties

Y. Tokunaga, S. Ueda, T. Hata, 1994 .

Establishment of new preparation method for solid dispersion formulation of tacrolimus.

Atsuo Ohike, Yuji Tokunaga, Kazutaka Higaki, 2003, International journal of pharmaceutics.

Liposomal sustained-release delivery systems for intravenous injection. II. Design of liposome carriers and blood disposition of lipophilic mitomycin C prodrug-bearing liposomes.

Y. Tokunaga, A. Kagayama, J. Fujisaki, 1988, Chemical & pharmaceutical bulletin.

Dose‐dependent pharmacokinetics and disposition of bisphosphonic prodrug of diclofenac based on osteotropic drug delivery system (ODDS)

H. Hirabayashi, Y. Tokunaga, T. Sawamoto, 2002, Biopharmaceutics & drug disposition.

Enhanced intestinal permeability to macromolecules. I. Effect of monoolein-bile salts mixed micelles on the small intestinal absorption of heparin.

S. Muranishi, H. Sezaki, Y. Tokunaga, 1978 .

Preparation of Fine Particles with Improved Solubility Using a Complex Fluidized-Bed Granulator Equipped with a Particle-Sizing Mechanism.

S. Hosaka, Y. Tokunaga, Yasufumi Okamura, 2016, Chemical & pharmaceutical bulletin.

Applicability of (SBE)7m-β-CD in controlled-porosity osmotic pump tablets (OPTs)

V. Stella, K. Uekama, T. Irie, 2004 .

FK506 (Tacrolimus) and Its Immunoreactive Metabolites in Whole Blood of Liver Transplant Patients and Subjects with Mild Hepatic Dysfunction

A. Alak, Y. Tokunaga, 2004, Pharmaceutical Research.

Potential absorption of heparin from the small intestine and the large intestine in the presence of monoolein mixed micelles.

S. Muranishi, H. Sezaki, Y. Tokunaga, 1977, Chemical and pharmaceutical bulletin.

Improvement of pulmonary absorption of cyclopeptide FK224 in rats by co-formulating with beta-cyclodextrin.

Y. Kawashima, A. Ohike, R. Ibuki, 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Liposomal sustained-release delivery systems for intravenous injection. I. Physicochemical and biological properties of newly synthesized lipophilic derivatives of mitomycin C.

Y. Tokunaga, A. Kagayama, J. Fujisaki, 1988, Chemical & pharmaceutical bulletin.

In vivo performance of time-controlled explosion system (TES) in GI physiology regulated dogs

Y. Tokunaga, S. Ueda, T. Hata, 1998 .

Liposomal sustained-release delivery systems for intravenous injection. III. Antitumor activity of lipophilic mitomycin C prodrug-bearing liposomes.

Y. Tokunaga, A. Kagayama, J. Fujisaki, 1988, Chemical & pharmaceutical bulletin.

Liposomal sustained-release delivery systems for intravenous injection. IV. Antitumor activity of newly synthesized lipophilic 1-beta-D-arabinofuranosylcytosine prodrug-bearing liposomes.

Y. Tokunaga, A. Kagayama, J. Fujisaki, 1988, Chemical & pharmaceutical bulletin.

Liposomal sustained-release delivery systems for intravenous injection V. Biological disposition of liposome-entrapped lipophilic prodrug of 1-beta-D-arabinofuranosylcytosine.

Y. Tokunaga, A. Kagayama, J. Fujisaki, 1988, Chemical & pharmaceutical bulletin.