Yuzhong Deng

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An Integrated Analysis of Solid Form Change Impact on Solubility and Permeability: Case Study of Oral Exposure in Rats of an RAR Related Orphan Receptor C Inhibitor.

K. Nagapudi, E. Plise, Jia Liu, 2019, Journal of pharmaceutical sciences.

Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling

Harvey Wong, Xiling Song, Cornelis E C A Hop, 2010, Drug Metabolism and Disposition.

Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans

E. Choo, C. Hop, J. Halladay, 2016, Drug Metabolism and Disposition.

Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans

J. Trzăskos, T. Maduskuie, C. Garner, 2007, Drug Metabolism and Disposition.

Quantitation of drug metabolites in the absence of pure metabolite standards by high-performance liquid chromatography coupled with a chemiluminescence nitrogen detector and mass spectrometer.

T. Olah, Yuzhong Deng, Jing-tao Wu, 2004, Rapid communications in mass spectrometry : RCM.

Nanosuspension delivery of paclitaxel to xenograft mice can alter drug disposition and anti-tumor activity

Po-Chang Chiang, Stephen Gould, Harvey Wong, 2014, Nanoscale Research Letters.

Novel nanoparticles formulation for cassette dosing via intravenous injection in rats for high throughput pharmacokinetic screening and potential applications.

Y. Ran, H. Wong, K. Chou, 2012, Journal of nanoscience and nanotechnology.

N-in-1 dosing pharmacokinetics in drug discovery: experience, theoretical and practical considerations.

P. Lam, K. He, T. Olah, 2008, Journal of pharmaceutical sciences.

A reversed sulfonamide series of selective RORc inverse agonists.

Bohdan Waszkowycz, Emanuela Gancia, Peter Lockey, 2014, Bioorganic & medicinal chemistry letters.

Practical strategies when using a stable isotope labeled microtracer for absolute bioavailability assessment: A case study of a high oral dose clinical candidate GDC‐0810

E. Choo, Kelly Zhang, Buyun Chen, 2018, Journal of pharmaceutical and biomedical analysis.

Sample Collection for Targeted Biomarker Quantitation by LC–MS

Xiaorong Liang, Yuzhong Deng, 2017 .

A rugged and accurate liquid chromatography-tandem mass spectrometry method for the determination of asunaprevir, an NS3 protease inhibitor, in plasma.

Hao Jiang, Jianing Zeng, Yuan-Qing Xia, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A validated LC-MS/MS method for the simultaneous determination of BMS-791325, a hepatitis C virus NS5B RNA polymerase inhibitor, and its metabolite in plasma.

Hao Jiang, Z. Ouyang, Yuan-qing Xia, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Determination of cobimetinib in human plasma using protein precipitation extraction and high-performance liquid chromatography coupled to mass spectrometry.

E. Choo, L. Musib, S. Eppler, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Absolute bioavailability and effect of formulation change, food, or elevated pH with rabeprazole on cobimetinib absorption in healthy subjects.

E. Choo, L. Musib, S. Eppler, 2013, Molecular pharmaceutics.

Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody-Drug Conjugates.

R. Rowntree, James Lee, D. Stokoe, 2018, Molecular pharmaceutics.

Validated LC-MS/MS methods for the determination of dapagliflozin, a sodium-glucose co-transporter 2 inhibitor in normal and ZDF rat plasma.

M. Tirmenstein, J. Cai, Yuzhong Deng, 2010, Bioanalysis.

Assessment of the hepatic CYP reductase null mouse model and its potential application in drug discovery.

E. Choo, J. Boggs, K. West, 2014, Molecular pharmaceutics.

Evaluation of homogenization techniques for the preparation of mouse tissue samples to support drug discovery.

B. Liederer, Xiaorong Liang, S. Shahidi-Latham, 2011, Bioanalysis.

Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs

E. Choo, J. Boggs, C. Hop, 2017, Xenobiotica; the fate of foreign compounds in biological systems.

Single- and multiple-dose pharmacokinetics, potential for CYP3A inhibition, and food effect in patients with cancer and healthy subjects receiving ipatasertib

J. Tabernero, R. Meng, B. Liederer, 2021, Cancer Chemotherapy and Pharmacology.

Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation.

Jerry J. Lou, T. Cloughesy, L. Liau, 2013, Neuro-oncology.

Determination of unbound vismodegib (GDC-0449) concentration in human plasma using rapid equilibrium dialysis followed by solid phase extraction and high-performance liquid chromatography coupled to mass spectrometry.

Wenbin Liu, H. Wong, M. Meng, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

In Vitro and In Vivo Evaluation of Amorphous Solid Dispersions Generated by Different Bench-Scale Processes, Using Griseofulvin as a Model Compound

Y. Ran, J. Lubach, H. Wong, 2013, The AAPS Journal.

Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) inverse agonist.

Adam R. Johnson, P. Lockey, W. Ouyang, 2015, Journal of medicinal chemistry.

Simultaneous determination of itraconazole, hydroxy itraconazole, keto itraconazole and N-desalkyl itraconazole concentration in human plasma using liquid chromatography with tandem mass spectrometry.

J. Ware, Yuan Chen, J. Mao, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties.

Adam R. Johnson, A. Barnard, H. Wong, 2016, Bioorganic & medicinal chemistry letters.

Ocular phenotypes in a mouse model of impaired glucocerebrosidase activity

W. Sandoval, W. Forrest, Jeffrey Hung, 2021, Scientific Reports.

High-speed gradient parallel liquid chromatography/tandem mass spectrometry with fully automated sample preparation for bioanalysis: 30 seconds per sample from plasma.

T. L. Lloyd, Yuzhong Deng, T. Olah, 2002, Rapid communications in mass spectrometry : RCM.

Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma

M. Hedehus, A. Daemen, F. Peale, 2014, Proceedings of the National Academy of Sciences.

Collagenase as an effective tool for drug quantitation in tissues.

Ann Qin, S. Shahidi-Latham, B. Dean, 2015, Bioanalysis.

Microsoft Word-54693261-file00

F. Theil, H. Wong, C. Hop, 2010 .

An alternative approach for quantitative bioanalysis using diluted blood to profile oral exposure of small molecule anticancer drugs in mice.

B. Liederer, L. Berezhkovskiy, Yuzhong Deng, 2013, Journal of Pharmacy and Science.

Evaluation of dried blood spot sampling following cassette dosing in drug discovery.

B. Liederer, Xiaorong Liang, L. Berezhkovskiy, 2011, Bioanalysis.

Measuring NAD(+) levels in mouse blood and tissue samples via a surrogate matrix approach using LC-MS/MS.

P. Dragovich, B. Liederer, C. Hop, 2014, Bioanalysis.

Fast analysis using monolithic columns coupled with high-flow on-line extraction and electrospray mass spectrometric detection for the direct and simultaneous quantitation of multiple components in plasma.

H. Zeng, Yuzhong Deng, Jing-tao Wu, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Surrogate analyte approach for quantitation of endogenous NAD(+) in human acidified blood samples using liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

Liling Liu, C. Hop, Xiaorong Liang, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates

Liling Liu, Yichin Liu, P. Dragovich, 2019, Drug Metabolism and Disposition.

Preclinical Disposition of GDC-0973 and Prospective and Retrospective Analysis of Human Dose and Efficacy Predictions

M. Belvin, K. Hoeflich, M. Merchant, 2012, Drug Metabolism and Disposition.

Effect of Hepatic Impairment on Cobimetinib Pharmacokinetics: The Complex Interplay Between Physiological Changes and Drug Characteristics

S. Girish, I. Chang, N. Choong, 2020, Clinical pharmacology in drug development.

Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists.

Adam R. Johnson, W. Ouyang, A. Barnard, 2015, Bioorganic & medicinal chemistry letters.

A rugged and accurate liquid chromatography-tandem mass spectrometry method for quantitative determination of BMS-790052 in plasma.

Hao Jiang, Jianing Zeng, Zheng Ouyang, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Exposure-Effect Relationships in Established Rat Adjuvant-Induced and Collagen-Induced Arthritis: A Translational Pharmacokinetic-Pharmacodynamic Analysis

W. Ouyang, H. Wong, C. Hop, 2019, The Journal of Pharmacology and Experimental Therapeutics.

In Vitro and In Vivo Evaluation of Amorphous Solid Dispersions Generated by Different Bench-Scale Processes, Using Griseofulvin as a Model Compound

Y. Ran, J. Lubach, H. Wong, 2013, The AAPS Journal.

C ] Cobimetinib , a MEK Inhibitor , in Humans

Isabelle, E. Choo, C. Hop, 2015 .

Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists.

Adam R. Johnson, P. Savy, P. Lockey, 2015, Bioorganic & medicinal chemistry letters.

Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists.

Adam R. Johnson, P. Lockey, W. Ouyang, 2014, Bioorganic & medicinal chemistry letters.

Tandem mass spectrometry with online high-flow reversed-phase extraction and normal-phase chromatography on silica columns with aqueous-organic mobile phase for quantitation of polar compounds in biological fluids.

T. Olah, Yuzhong Deng, Jing-tao Wu, 2005, Rapid communications in mass spectrometry : RCM.

Development and validation of sensitive and selective LC-MS/MS methods for the determination of BMS-708163, a gamma-secretase inhibitor, in plasma and cerebrospinal fluid using deprotonated or formate adduct ions as precursor ions.

Jian Wang, Mark E Arnold, Anne-Françoise Aubry, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

The Absolute Bioavailability and Absorption, Metabolism, and Excretion of Ipatasertib, a Potent and Highly Selective Protein Kinase B (Akt) Inhibitor

B. Liederer, R. Sane, Shuguang Ma, 2023, Drug Metabolism and Disposition.

Strategies of Drug Transporter Quantitation by LC-MS: Importance of Peptide Selection and Digestion Efficiency

Yuan Chen, J. Payandeh, Liling Liu, 2017, The AAPS Journal.

Determination of cobimetinib in human plasma using protein precipitation extraction and high-performance liquid chromatography coupled to mass spectrometry.

E. Choo, L. Musib, S. Eppler, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.